ライフサイエンスコーパス: cell growth factor

1 ding the localized delivery of an epithelial cell growth factor.

2 ls and is thought to be the quintessential T cell growth factor.

3 yrosine kinase that is the receptor for mast cell growth factor.

4 factor, an angiogenesis and Kaposi's-spindle-cell growth factor.

5 Interleukin-2 (IL-2) is recognized as a T cell growth factor.

6 lar permeability and a selective endothelial cell growth factor.

7 ses (MMP-2 and -9), and vascular endothelial cell growth factor.

8 because IL-21 can substitute for IL-2 as a T cell growth factor.

9 ard the chemoattractant vascular endothelial cell growth factor.

10 4 is a cytokine originally identified as a B cell growth factor.

11 leukin-2 (IL-2) is historically known as a T-cell growth factor.

12 n require T cell costimulatory signals and T cell growth factors.

13 ing lymph node macrophages to produce plasma cell growth factors.

14 ty was largely reversed in the presence of T cell growth factors.

15 tentiate Wnt signalling and function as stem-cell growth factors.

16 ocompromised mice that express human myeloid cell growth factors.

17 potentially through induction of paracrine B-cell growth factors.

18 the lung expression of Th2 cell-derived mast cell growth factors.

19 ing thymidine phosphorylase (TP; endothelial cell growth factor 1).

20 ylase (TYMP; previously known as endothelial cell growth factor 1, ECGF1) as a second key astrocyte-d

21 rosis factor-alpha, and vascular endothelial cell growth factor 165 do not.

22 Vascular endothelial cell growth factor A (VEGF) is a biologically and therap

23 Vascular endothelial cell growth factor A (VEGF-A) and hypoxia play important

24 tory activity is due to vascular endothelial cell growth factor A (VEGF-A).

25 Vascular endothelial cell growth factor-A(165) (VEGF-A(165)) is critical for

26 IL-2, the first cytokine discovered with T cell growth factor activity, is now known to have pleiot

27 IL-15 is a novel cytokine with potent T cell growth factor activity.

28 lar endothelial growth factor or endothelial cell growth factor-alpha + IGF-1 provided no advantage c

29 cular endothelial growth factor, endothelial cell growth factor-alpha and pancreatic islet neogenesis

30 endothelial biology because some endothelial cell growth factors also exert anti-apoptotic effects.

31 s of endothelial cells, vascular endothelial cell growth factor and basic fibroblast growth factor fu

32 growth factors such as vascular endothelial cell growth factor and basic fibroblast growth factor, i

33 the chemokine's biologic activity as a pre-B-cell growth factor and chemoattractant.

34 r cancer cells in response to the urothelial cell growth factor and EGFR ligand heparin-binding EGF-l

35 tivity was dependent on vascular endothelial cell growth factor and had an ED50 of 10 microg/ml in me

36 It was initially identified as a B cell growth factor and inducer of plasma cell differenti

37 vitro manipulation and culture of progenitor cells, growth factors and biomaterial scaffolds.

38 broblast growth factor, vascular endothelial cell growth factor, and phorbol myristate acetate.

39 --have been engineered from mesenchymal stem cells, growth factor, and/or gene therapy approaches.

40 Vascular smooth muscle cell growth factors are postulated to contribute to card

41 mitogenic stimulus for ductal and periductal cells, growth factors are necessary for survival, motili

42 direct AAV-mediated in vivo delivery of beta-cell growth factors as a novel therapeutic strategy for

43 iming and stimulated the production of the B cell growth factors Baff and April.

44 yS, TALL-1, zTNF-4, THANK, and TNSF13B), a B cell growth factor belonging to the TNF family.

45 e declined lungs from control lungs was stem cell growth factor -beta [P < 0.001, AUC (area under the

46 applied to dendritic cells, UA suppressed T-cell growth factors but up-regulated B cell-activating c

47 n proteins (RSPOs1-4) function as adult stem cell growth factors by potentiating Wnt signaling.

48 In these cells growth factor can almost completely prevent cell d

49 R-spondin proteins are adult stem cell growth factors capable of stimulating gut developme

50 atient, one peptide derived from endothelial cell growth factor (ECGF) caused his PBMCs to proliferat

51 Mesangial cell growth factors elevate intracellular free [Ca2+]i,

52 In this study we combined a dendritic cell growth factor, Flt3 ligand, with a dendritic cell a

53 was initially characterized as the primary T-cell growth factor following in vitro activation, less i

54 (dsAAV)-mediated in vivo expression of beta-cell growth factors, glucagon-like peptide-1 (GLP-1) and

55 Endothelial cell growth factor has been recently proposed as a poten

56 IL-15, a T cell growth factor, has been linked to exacerbating auto

57 aling component by receptors for all known T cell growth factors (i.e., IL-2, IL-4, IL-7, IL-9, IL-15

58 e leukemia virus-based vector encoding the T-cell growth factor IL-15.

59 by acting as a sensor of the essential Treg cell growth factor IL-2 and its downstream target STAT5.

60 The T cell growth factor IL-2 has potential for expanding and

61 in a marked increase in production of the T cell growth factor IL-2, it does not result in a signifi

62 sed the majority of cells that made the mast cell growth factor IL-9.

63 8+ cells, is not regulated directly by the T-cell growth factors IL-2 or IL-15.

64 at p53 directly inhibits expression of the T cell growth factor (IL-2) in activated T cells.

65 Discovered as a T cell growth factor, IL-2 additionally promotes CD8(+) T

66 liferation and accumulation of the primary T cell growth factor, IL-2, by cells stimulated with anti-

67 ytoprotective cytokines vascular endothelial cell growth factor, IL-6, and IL-11 were decreased in th

68 ce that diminished production of the major T cell growth factors, IL-2 and IL-4, is responsible for t

69 ls of other established IFN-gamma inducing T-cell growth factors, IL-2, and IL-12 in this culture sys

70 Soluble BLyS functioned as a potent B cell growth factor in costimulation assays.

71 IL-2 is a critical T cell growth factor in vitro, but predominantly mediates

72 amino acids may be essential for other beta-cell growth factors in addition to insulin and IGF-I to

73 With the introduction of white blood cell growth factors in the early 1990s, dose-intensive r

74 t cells and express increased levels of mast cell growth factors in the lung.

75 ased expression of the Th2 cell-derived mast cell growth factors, including IL-4 and IL-9, but not wi

76 kinase-3 (Flt3) ligand (Flt3L), a dendritic cell growth factor, increase the resistance of mice to a

77 y reductions in transformation of fibroblast cells, growth factor independence of hematopoietic cell

78 changes in cellular morphology and rendered cells growth-factor independent by upregulating the MAPK

79 etic experiments showed that both of these T cell growth factors induce a distinct and sustained phas

80 We found that vascular endothelial cell growth factor induced the kinase insert domain rece

81 iferation but abrogated vascular endothelial cell growth factor-induced and basic fibroblast growth f

82 RK1/2 but inhibited the vascular endothelial cell growth factor-induced and basic fibroblast growth f

83 n of 15d-PGJ2 inhibited vascular endothelial cell growth factor-induced angiogenesis in the rat corne

84 blast growth factor and vascular endothelial cell growth factor-induced MAPK phosphorylation in endot

85 In cultured cells, growth factor-induced phosphorylation of two tran

86 tors are known to induce the expression of T-cell growth factor interleukin (IL)-2, it is unclear how

87 ding expression of the autocrine/paracrine T cell growth factor interleukin (IL)-2.

88 Stimulation via the T-cell growth factor interleukin 2 (IL-2) leads to tyrosin

89 n vitro by exposure to the same TA and the T-cell growth factor interleukin 2 (IL-2).

90 yR down-regulated T cell proliferation and T-cell growth factor interleukin 2 production.

91 ociated with a defect in production of the T-cell growth factor interleukin-2 (IL-2).

92 nanoparticles containing magnetite and the T-cell growth factor interleukin-2 (IL-2).

93 Coexpression of the T-cell growth factor interleukin-2, however, greatly expan

94 Expression of the gene is enhanced by the T cell growth factor interleukin-2, suggesting a role for

95 on by either Toll-like receptor ligand or NK cell growth factor, interleukin (IL)-15.

96 leads to increased production of the major T-cell growth factor, interleukin (IL)-2.

97 ed by the receptors for vascular endothelial cell growth factor KDR/Flk1, and Flt1.

98 Stem cell factor (SCF), also known as mast cell growth factor, kit ligand, and steel factor, is the

99 on are strongly induced by the critical mast cell growth factor, kit ligand, which is produced by fib

100 strongly with autoantibodies to endothelial cell growth factor, matrix metalloproteinase 10, and apo

101 blast growth factor and vascular endothelial cell growth factor-mediated cell proliferation and migra

102 In CD34(+) cells and MO7e cells, growth factor-mediated upregulation of survivin w

103 tors for hepatocyte and vascular endothelial cell growth factors (MET and VEGFR2, respectively) are c

104 ontain either structural alterations in mast cell growth factor (Mgf) or regulatory mutations that af

105 The Steel (Sl) locus encodes mast cell growth factor (Mgf) that is required for the develo

106 e, KIT, and require its cognate ligand, Mast cell growth factor (MGF), for survival and differentiati

107 0Mit162/D10Mit122 and cosegregates with mast cell growth factor (Mgf).

108 r, endothelial cells by vascular endothelial cell growth factor, neuronal cells by nerve growth facto

109 last growth factor, and vascular endothelial cell growth factor on allogeneic stimulation.

110 ent of PVR without the addition of exogenous cells, growth factors, or cytokines typically found in P

111 d haemopoietic precursor proliferation (stem cell growth factor p<0.0001).

112 ctor (VEGF) and platelet-derived endothelial cell growth factor (PD-ECGF)].

113 ; also known as platelet-derived endothelial cell growth factor, PD-ECGF) is an angiogenic factor tha

114 ine kinase inhibitor of vascular endothelial cell growth factor, platelet-derived growth factor, and

115 Vascular endothelial cell growth factor plays a pivotal role in angiogenesis

116 nce coexpression of a T-cell chemokine and T-cell growth factor potentiates antitumor responses in vi

117 L, Itch and Nedd4 each negatively regulate T cell growth factor production and proliferation.

118 Here, we identify the mammary cell growth factor prolactin as a potent suppressor of B

119 6, and this activity is counteracted by stem cell growth factor R-spondin.

120 aspartate and spontaneous activation of mast cell growth factor receptor (P = 0.0001).

121 lar mutations causing activation of the mast cell growth factor receptor are found in children appare

122 Studies using mice with defective mast/stem cell growth factor receptor c-Kit have suggested key rol

123 The tyrosine kinase mast/stem cell growth factor receptor KIT is an example of a clini

124 al cells down-regulates vascular endothelial cell growth factor receptor-2 (VEGFR2) mRNA levels and b

125 th factor B (PDGFB) and vascular endothelial cell growth factor receptor-2 (VEGFR2), while at the sam

126 without involvement of vascular endothelial cell growth factor receptor-3.

127 , bone marrow lineage-negative (lin(-)) stem cell growth factor receptor-positive (c-kit(+)) Sca-1(-)

128 reduced mRNA levels of vascular endothelial cell growth factor receptors 1 (Flt-1) and 2 (Flk/KDR) a

129 s discussed include the vascular endothelial cell growth factor receptors, Eph receptors, Tie1, and T

130 induced by contact inhibition (NIH 3T3 mouse cells), growth factor removal (bromodeoxyuridine-blocked

131 g strategies, whereby the traditional triad (cells, growth factors, scaffolds) or a combination there

132 nd 4, endosomal TLRs 7 and 8 as well as stem cell growth factor (SCF).

133 sulin-like growth factor II (IGF-II) or stem cell growth factor (SCF).

134 pigment (hemozoin [PfHz]) revealed that stem cell growth factor (SCGF; also called C-type lectin doma

135 leukin 14 (IL-14) or high molecular weight B cell growth factor secreted by activated T and B cells a

136 Interleukin-2 is the primary T cell growth factor secreted by activated T cells.

137 re is crosstalk between vascular endothelial cell growth factor signaling and XBP1 pathway.

138 ed in the regulation of vascular endothelial cell growth factor signaling, offers a unique opportunit

139 PLD2 determines the output of ERK in cancer cell growth factor signaling.

140 ression was regulated negatively by the mast cell growth factor stem cell factor (SCF), and its expre

141 nase is Kit ligand (Kitl; also known as mast cell growth factor, stem cell factor, and Steel factor),

142 s is Kit ligand (or Kitl; also known as mast cell growth factor, stem cell factor, and Steel factor),

143 , but not with the non-Th2 cell-derived mast cell growth factor, stem cell factor.

144 actors inhibited basal, vascular endothelial cell growth factor-stimulated, and fibroblast growth fac

145 The addition of beta-cell growth factors, such as exendin-4, to immunotherapy

146 mediates myelin breakdown induced by Schwann cell growth factors, such as neuregulin and FGF-2.

147 al signaling component shared by all known T cell growth factor (TCGF) receptors (i.e., IL-2, IL-4, I

148 IL-15 is a powerful T cell growth factor (TCGF) with particular importance for

149 T cell growth factors (TCGFs) play a critical role in allo

150 n (gamma(c)) that is activated by multiple T-cell growth factors (TCGFs) such as IL-2, -4, and -7.

151 n (IL)-2, IL-4, IL-7, IL-9, and IL-15, all T-cell growth factors (TCGFs), utilize the common IL-2 rec

152 IL-2 is a known potent T cell growth factor that amplifies lymphocyte responses i

153 IL-2 is a T cell growth factor that has pleiotropic functions in T c

154 IL-14alpha is a B-cell growth factor that is expressed in a number of high

155 tance is associated with a circulating islet cell growth factor that is independent of glucose and ob

156 JAG1 is a hematopoetic cell growth factor that may regulate normal B-cell devel

157 -15 is a proinflammatory and antiapoptotic T-cell growth factor that plays an important role in a var

158 IL-15 is a T cell growth factor that shares many biological activitie

159 Thus IL-15 is a mast cell growth factor that utilizes a novel receptor and di

160 Angiopoietins are endothelial cell growth factors that function in concert with VEGF b

161 Gastrin also acts as a potent cell-growth factor that has been implicated in a variety

162 A distinct signature, including B cell growth factor TNFRS17, predicted the neutralizing a

163 We investigated the ability of IL-15, a T cell growth factor, to modulate prenyl phosphate-induced

164 e phosphorylase/platelet-derived endothelial cell growth factor (TP/PD-ECGF) has diverse functions wi

165 ce lacking the vascular-specific endothelial cell growth factor VEGF or its receptor Flt-1, both of w

166 al stimulating factors, vascular endothelial cell growth factor (VEGF) and basic fibroblast growth fa

167 Vascular endothelial cell growth factor (VEGF) binds to and promotes the acti

168 Vascular endothelial cell growth factor (VEGF) can promote vessel dilation an

169 blast growth factor and vascular endothelial cell growth factor (VEGF) families.

170 Vascular endothelial cell growth factor (VEGF) has been implicated in the pat

171 Vascular endothelial cell growth factor (VEGF) has been implicated in vascula

172 tors were examined with vascular endothelial cell growth factor (VEGF) homodimers and VEGF/placental

173 duced the expression of vascular endothelial cell growth factor (VEGF) in a time- and Src-STAT-3-depe

174 ted a sizable amount of vascular endothelial cell growth factor (VEGF) in malignant ascites.

175 been demonstrated that vascular endothelial cell growth factor (VEGF) induction of angiogenesis requ

176 Vascular endothelial cell growth factor (VEGF) is a multifunctional cytokine

177 Vascular endothelial cell growth factor (VEGF) is a potent angiogenic factor

178 Although vascular endothelial cell growth factor (VEGF) is important in the regulation

179 -glutamine (Arg-Gln) on vascular endothelial cell growth factor (VEGF) levels in primary human retina

180 novel trophic effect of vascular endothelial cell growth factor (VEGF) on photoreceptor cells.

181 Vascular endothelial cell growth factor (VEGF) plays a crucial role in the de

182 rowth factor (bFGF) and vascular endothelial cell growth factor (VEGF) present within the tumor micro

183 ET increases vascular endothelial cell growth factor (VEGF) production in vitro, and VEGF

184 Ligand binding to vascular endothelial cell growth factor (VEGF) receptors activates the mitoge

185 growth factor (HGF) and vascular endothelial cell growth factor (VEGF) regulate normal development an

186 zes the contribution of vascular endothelial cell growth factor (VEGF) to the angiogenic environment

187 Vascular endothelial cell growth factor (VEGF) was originally described as a

188 etes, oxidative stress, vascular endothelial cell growth factor (VEGF), and intercellular adhesion mo

189 f the EC growth factor, vascular endothelial cell growth factor (VEGF), is stimulated by a variety of

190 s of the major inducer, vascular endothelial cell growth factor (VEGF), that were also produced.

191 KDR-IC), a receptor for vascular endothelial cell growth factor (VEGF), was identified by two-hybrid

192 These include vascular endothelial cell growth factor (VEGF), which stimulates the incorpor

193 Tumor production of vascular endothelial cell growth factor (VEGF)-C is associated with tumor lym

194 dly increased basal and vascular endothelial cell growth factor (VEGF)-stimulated NO release compared

195 n of survivin in ECs by vascular endothelial cell growth factor (VEGF).

196 s 1 and 2 (ERK1/2), and vascular endothelial cell growth factor (VEGF).

197 ggered by tumor-derived vascular endothelial cell growth factor (VEGF).

198 sel growth by secreting vascular endothelial cell growth factor (VEGF).

199 Frequently vascular endothelial cell growth factors (VEGFs) are mainly responsible for t

200 -induced stimulation of vascular endothelial cell growth factors (VEGFs) production.

201 lar permeability factor/vascular endothelial cell growth factor (VPF/VEGF) can both potently enhance

202 of amphiregulin, a potent mammary epithelial cell growth factor was down regulated in mammary glands

203 permeability induced by vascular endothelial cell growth factor was potently reversed by FTY720-P.

204 differentiation in the presence of different cell growth factors, we have determined that the populat

205 yrosine phosphatase and vascular endothelial cell growth factor were significantly decreased in trans

206 elopment of mast cells is stimulated by mast cell growth factor, which is also known as kit ligand be

207 suggest that there could be a hierarchy of T-cell growth factors with regard to their ability to bloc

208 sympathetic neurons, unlike most nonneuronal cells, growth factor withdrawal-induced apoptosis requir