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1  IL-15, which is important for T cell and NK cell homeostasis.
2  regulator of actin dynamics important for T-cell homeostasis.
3 hose levels are tightly controlled to secure cell homeostasis.
4 plete function in DNA repair and tissue stem cell homeostasis.
5 egulatory T (Treg)-cell development and Treg cell homeostasis.
6 global change of gene expression to maintain cell homeostasis.
7 ing a generalized role for Notch in innate T cell homeostasis.
8 e implicated in Treg and follicular helper T cell homeostasis.
9 hen ISR signaling is insufficient to restore cell homeostasis.
10 re reportedly involved in the maintenance of cell homeostasis.
11 nhibitory NK cell receptors contribute to NK cell homeostasis.
12 e miR-142 target through which it controls B-cell homeostasis.
13 development and neonatal epithelial and mast cell homeostasis.
14 gulated either T-bet or GATA-3 to maintain T cell homeostasis.
15  regulatory mechanisms controlling satellite cell homeostasis.
16 ficiency on signaling pathways involved in B cell homeostasis.
17  conserved requirement for IL-33 in VAT-Treg cell homeostasis.
18 cating an important role of the S1P2 in beta-cell homeostasis.
19 opmental pathways and a role for E4BP4 in NK cell homeostasis.
20 and collectively influence intestinal immune cell homeostasis.
21 nd ILCs in the regulation of intestinal Th17 cell homeostasis.
22 fy a novel molecular pathway that controls T-cell homeostasis.
23  mitophagy is an essential process to ensure cell homeostasis.
24 e detailed mechanistic understanding of stem cell homeostasis.
25 normal peripheral immune response and immune cell homeostasis.
26 al dynamics is crucial for the regulation of cell homeostasis.
27 a tumor suppressor to maintain hematopoietic cell homeostasis.
28 ng-lived proteins and organelles to maintain cell homeostasis.
29 g of metabolic regulation in intestinal stem cell homeostasis.
30  proteins in controlling apoptosis in normal cell homeostasis.
31 mice and is crucial for the maintenance of B cell homeostasis.
32 hagy is a major regulator of pancreatic beta cell homeostasis.
33 teraction may regulate pancreatic epithelial cell homeostasis.
34 nce of intracellular signaling to maintain T cell homeostasis.
35 plasma membrane in every cell, are vital for cell homeostasis.
36 lineage specification and peripheral naive T cell homeostasis.
37  human diseases associated with altered stem cell homeostasis.
38  suggesting its role in the regulation of NK cell homeostasis.
39 autophagy and cell metabolism in maintaining cell homeostasis.
40 liver and intestines and maintains liver NKT cell homeostasis.
41 the regulation of insulin secretion and beta-cell homeostasis.
42 ctor on intervertebral disc (IVD) matrix and cell homeostasis.
43 abolic pathways that may be involved in stem cell homeostasis.
44  T cells indirectly caused dysregulated Treg cell homeostasis.
45 of the TCR as the basis for in vivo CD8(+) T cell homeostasis.
46 ulb progenitor cells in contributing to stem cell homeostasis.
47 activation pathways to intestinal epithelial cell homeostasis.
48 al role of AhR signaling in maintaining mast cell homeostasis.
49 ltiple functions, including the control of B cell homeostasis.
50 tified IL-15 as an important cytokine for NK cell homeostasis.
51 d T cell populations, and even to control NK cell homeostasis.
52 lays an important role in mucosal epithelial cell homeostasis.
53 gulation of water flow that is necessary for cell homeostasis.
54 gnal transduction pathway that controls stem cell homeostasis.
55 malignancy without dramatically perturbing T cell homeostasis.
56 ulate cell fate choice to control epithelial cell homeostasis.
57 ciation with a defect in peripheral CD4(+) T cell homeostasis.
58 ell maintenance and specifically in Foxp3(+) cell homeostasis.
59  complex genetic circuitry that governs stem cell homeostasis.
60 al B1 cells, implicating this receptor in B1 cell homeostasis.
61 SC size is, thus, essential for normal blood cell homeostasis.
62 lator of hematopoietic stem cell (HSC) and T cell homeostasis.
63 tial role in melanoblast and melanocyte stem cell homeostasis.
64 function is crucial for the maintenance of T cell homeostasis.
65         Autophagy is crucial for maintaining cell homeostasis.
66 n how S1P1 signaling regulates Th17 and Treg cell homeostasis.
67 -binding protein (GABP) in T cells impairs T-cell homeostasis.
68 ophagic degradation of Rph1 is important for cell homeostasis.
69 way annotations indicative of roles in basic cell homeostasis.
70 r and its receptor, KIT, are central to mast-cell homeostasis.
71 ion of cellular components, is essential for cell homeostasis.
72 restored disturbances in peripheral B- and T-cell homeostasis.
73 going requirement of LUBAC activity for Treg cell homeostasis.
74 ver, and spleen, thereby maintaining myeloid cell homeostasis.
75 regulator of naive, memory, and regulatory T cell homeostasis.
76 ploid yeast, is a key regulator of aneuploid cell homeostasis.
77 ion of CLV3 levels that is critical for stem cell homeostasis.
78 merization and subcellular localization in T-cell homeostasis.
79 ontributing to the regulation of neural stem cell homeostasis.
80 ndent DCs in the maintenance of intestinal T cell homeostasis.
81 are required for optimal CD4(+) and CD8(+) T cell homeostasis, activation, and effector development i
82 antly activated B cells and restore normal B-cell homeostasis after allogeneic stem cell transplantat
83    However, the mechanisms which govern iNKT cell homeostasis after thymic emigration are incompletel
84 d ligand binding result in disrupted T and B cell homeostasis and a complex immune dysregulation synd
85 ncover novel mechanisms contributing to beta-cell homeostasis and a resource for therapeutic target a
86                We assessed Treg and CD8(+) T-cell homeostasis and activation during the changing syst
87  Lyn-dependent signaling pathways regulate B cell homeostasis and activation, which in concert with B
88 lasmodium infection that regulates dendritic cell homeostasis and adaptive immunity through Flt3 liga
89 t stromal cells play in orchestrating immune cell homeostasis and adaptive immunity.
90 microbiota composition controls intestinal T cell homeostasis and alters T cell responses of mice in
91  Rag1(-/-) mice restored Mdr1-deficient Teff cell homeostasis and attenuated ileitis.
92 important for regulating tDC-mediated T(reg) cell homeostasis and autoimmunity.
93 e-6-phosphate transporter mutation on immune cell homeostasis and CD4(+) T cell functions.
94 nciple for histone modification, during both cell homeostasis and cell death.
95 y regulated protease complex fundamental for cell homeostasis and controlled cell cycle progression.
96 Egr)-2 is important for the maintenance of T cell homeostasis and controls the development of autoimm
97 ' protein METTL3 in mouse T cells disrupts T cell homeostasis and differentiation.
98 ion within the murine gut that alters immune cell homeostasis and disease susceptibility.
99 e of lipid peroxyl radical production during cell homeostasis and disease.
100 -digestion pathway with fundamental roles in cell homeostasis and diseases.
101 d identifies a subset of FRCs that control B cell homeostasis and follicle identity.
102 gnals were dispensable for steady-state Treg cell homeostasis and for Treg cell suppression of T cell
103 ta support a critical role for DOCK8 in Treg cell homeostasis and function and the enforcement of per
104  interleukin-7 (IL-7) influence gammadelta T cell homeostasis and function by regulating expression o
105 mechanisms that regulate haematopoietic stem cell homeostasis and function remain largely unknown.
106 reg)-cell-commitment stage to control T(reg) cell homeostasis and function remains largely unexplored
107 ized as an important mediator of endothelial cell homeostasis and function that impacts upon vascular
108 pected to interfere with T regulatory (Treg) cell homeostasis and function, recently, substantial con
109 ng differentiation factor controlling T(reg) cell homeostasis and function, whereas the early T(reg)-
110 nase 1 (TAK1) is important in satellite stem cell homeostasis and function.
111  BAFFR and TACI on B cells is critical for B cell homeostasis and function.
112 ablation of Vps34 had a profound impact on T cell homeostasis and function.
113 hese molecular switches in regulating immune cell homeostasis and functions.
114 tions for an improved understanding of CD8 T-cell homeostasis and functions.
115 a pleiotropic cytokine that regulates immune cell homeostasis and has been used to treat a range of d
116 f the RANKL-RANK axis in the regulation of B cell homeostasis and highlight an unexpected link betwee
117 extensive genetic networks that control stem cell homeostasis and highlight the intricate regulation
118 elper T cells are critical for proper immune cell homeostasis and host defense but are also major con
119 nderlying the governance of peripheral CD4 T cell homeostasis and identify p27(Kip1) as a target to e
120  has a nonredundant role in the control of T-cell homeostasis and immunity.
121 s that is mandatory for the maintenance of T cell homeostasis and immunological self-tolerance later
122 as in autoimmune disease, can disturb immune cell homeostasis and induce the expansion of normally ra
123  activation stimuli to regulate gammadelta T cell homeostasis and inflammatory responses.
124 hat dysregulated IEC gene expression, Paneth cell homeostasis and intestinal barrier function were la
125 cal for lung development and lung epithelial cell homeostasis and is predicted to target fibrotic gen
126 lation of this pathway can negatively affect cell homeostasis and is responsible for the development
127 olecule is an important regulator of naive T cell homeostasis and it has been linked to immune defici
128 ts into how ROS signaling can influence stem cell homeostasis and lineage commitment, and discuss the
129 plication without causing a loss of CD4(+) T cell homeostasis and lymphoid tissue damage that lead to
130 ell survival and can thereby contribute to B-cell homeostasis and lymphomagenesis.
131 st the importance of FAK in regulating pro-B cell homeostasis and maintenance of their spatial distri
132 ene playing key roles in haematopoietic stem cell homeostasis and malignant haematopoiesis.
133 illations and analyze their origins in guard cell homeostasis and membrane transport.
134  These data demonstrate that CIC maintains T-cell homeostasis and negatively regulates TFH cell devel
135 ckdown in mice results in altered epithelial cell homeostasis and neonatal death.
136 n the role of cell death in maintenance of T-cell homeostasis and outline novel therapeutic strategie
137 al degradation machinery that is involved in cell homeostasis and pathogenicity.
138 he importance of the thymus in human naive T cell homeostasis and premature aging.
139 ing Ifng mRNA stability to maintain CD8(+) T cell homeostasis and prevent CD8-mediated autoimmunity.
140 on of humoral immunity via their impact on B cell homeostasis and proliferation upon activation.
141 ant cytokine that plays a critical role in T-cell homeostasis and promotes immunologic reconstitution
142 ule 1 (STIM1)-mediated SOCE is essential for cell homeostasis and regulates numerous processes includ
143 hogenesis and reveals a novel mechanism of T cell homeostasis and signal-dependent induction of mRNA
144 ects DC development, indirectly modulating T cell homeostasis and supporting T reg cell expansion.
145 he ubiquitin-proteasome system is central to cell homeostasis and survival.
146 ght a new mechanism that regulates dendritic cell homeostasis and T cell responses to infection.
147 ay is critical for maintaining lung alveolar cell homeostasis and that loss of its expression can con
148 ggest that Lis1 plays an important role in T cell homeostasis and the generation of memory T lymphocy
149 nant cells is also known to be involved in T cell homeostasis and the response to viral infections an
150 m-bone marrow communication in hematopoietic cell homeostasis and their impact on hypertension pathop
151 , both of which are critical aspects of stem cell homeostasis and tightly linked to their functional
152 -only protein, was shown to play a role in B-cell homeostasis and to mediate cell death in response t
153  that the dominant regulator of peripheral B-cell homeostasis and tolerance is the B-lymphocyte stimu
154 e ligand/receptor axis controls (progenitor) cell homeostasis and trafficking.
155 -mediated histone acetylation in maintaining cell homeostasis and tumor development.
156 rtant implications in our understanding stem cell homeostasis and tumorigenesis.
157 ays important roles in nutrient utilization, cell homeostasis and virulence.
158 e role(s) that autocrine TGF-beta plays in T cell homeostasis and, in particular, the balance of effe
159  Protein synthesis is crucial for regulating cell homeostasis and, when unrestricted, it can lead to
160 hesin silencing in vivo rapidly altered stem cells homeostasis and myelopoiesis.
161  implicated as important mediators of cancer cell homeostasis, and accumulating data suggest compelli
162 on the development of immune responses, mast cell homeostasis, and anaphylactic food allergy was asse
163 he regulation of energy balance, tissue/stem cell homeostasis, and disease pathogenesis.
164 IL system is best known for its control of B cell homeostasis, and it is a target of therapeutic inte
165 oles in protective immunity, control of mast cell homeostasis, and its more recently revealed immunom
166 hils and inflammatory monocytes, disrupted T-cell homeostasis, and prevented effective T-cell priming
167 -7 (IL-7) is fundamental for thymopoiesis, T-cell homeostasis, and survival of mature T cells, which
168     We propose that TGF-beta1 regulates mast cell homeostasis, and that this feedback suppression may
169                                 Furthermore, cell homeostasis appeared to be carefully maintained by
170 timately, organelle structure, function, and cell homeostasis are maintained by modulating protein an
171 ated whether apoptosis pathways regulating T-cell homeostasis are perturbed in CD28(null) T cells in
172 ic molecular mechanisms that control naive T-cell homeostasis are poorly understood.
173 atory pathways, typically involved in immune cell homeostasis, are co-opted by cancer cells to thwart
174 ion-inducing ligand (APRIL), which control B cell homeostasis, are therapeutic targets in autoimmune
175 te ROS sensing into decisions regarding stem cell homeostasis, are unclear.
176 s CD80/CD86, signals needed for regulatory T cell homeostasis, are upregulated less on NOD cDCs.
177 e an essential role of CYLD in maintaining T cell homeostasis as well as normal T regulatory cell fun
178 gomeric protein complexes that contribute to cell homeostasis as well as virulence regulation in bact
179 st patients had disturbed naive B-cell and T-cell homeostasis, as evidenced by low cell numbers, incr
180 severe defects in lymphoid development and T cell homeostasis associated with impaired PI3K signaling
181 w commensal microbiota contributes to immune cell homeostasis at barrier surfaces is poorly understoo
182 tophagy is a catabolic process essential for cell homeostasis, at the core of which is the formation
183                    Despite its importance in cell homeostasis, autophagy is not fully understood.
184 ochondria is critical for the maintenance of cell homeostasis, because damaged organelles cannot be d
185  one more hierarchical layer regulating stem cell homeostasis beneath the stem cell-dermal papilla-ba
186  Blimp1 is required to control Treg and Teff cells homeostasis but, unexpectedly, it is dispensable t
187                  BAFF is a key cytokine in B cell homeostasis, but its potential contribution to the
188 n unappreciated mechanism for restoring stem cell homeostasis, but one with some associated risk in a
189 ask of controlling cutaneous epithelial stem cell homeostasis by balancing TGF-beta-mediated growth-i
190 and the indirect maintenance of intestinal T cell homeostasis by both limiting effector T cell expans
191 d control intestinal stem cell and secretory cell homeostasis by downregulation of multiple target mR
192  citZ transcript in order to maintain proper cell homeostasis by preventing the overaccumulation of c
193      B7-H4 plays a key role in maintaining T-cell homeostasis by reducing T-cell proliferation and cy
194     Thus, ARF1 can regulate Drosophila blood cell homeostasis by regulating Asrij endocytic function.
195 ovide an insight in regulation of adult stem cells homeostasis by two major pathways with opposing fu
196 ive syndrome (ALPS) is a human disorder of T cell homeostasis caused by mutations that impair FAS-med
197 emia 5 (MLL5) protein mediates hematopoietic cell homeostasis, cell cycle, and survival; however, the
198 ll-specific ablation of TRAF3 impaired CD4 T cell homeostasis, characterized by an increase in the Th
199 rophil differentiation and restoring myeloid cell homeostasis could limit the formation of survival n
200 known pathway of regulation of innate-like T-cell homeostasis depending on XIAP and PLZF.
201 on (PTM) of proteins is a process central to cell homeostasis, development and responses to external
202 s a profound NK lineage-intrinsic role in NK cell homeostasis, development, education, and cytokine p
203                           The loss of acinar cell homeostasis, differentiation, and identity is direc
204                                  Moreover, T cell homeostasis driven by cytokine or TCR-mediated sign
205 une system employs ATLOs to organize aorta T cell homeostasis during aging and that VSMC-LTbetaRs par
206 xpressed transcription factors important for cell homeostasis during dynamic oxygen levels.
207 , as it is an essential pathway to control T cell homeostasis during immune activation.
208 of Fas-driven T cell apoptosis to maintain T cell homeostasis during infection.
209 R4(+)/IgG(+) PCs might play a role in immune cell homeostasis during inflammatory processes of the gu
210 ights into a critical mechanism in satellite cell homeostasis during muscle regeneration could help i
211  pivotal role in the regulation of satellite cell homeostasis during regenerative myogenesis.
212                                    Mammalian cell homeostasis during starvation depends on initiation
213                  Ultimately, CD4(+) memory T-cell homeostasis fails and critical effector populations
214 ish Rictor as an important signal relay in B-cell homeostasis, fate, and functions.
215 munosuppression; however, a restoration of T cell homeostasis following depletion leads to increased
216 ry for maintaining naive CD4(+) and CD8(+) T cell homeostasis for subsequent optimal T cell expansion
217 rtance for peripheral T cell tolerance and T cell homeostasis has been studied intensively.
218 role of endothelial cells in supporting beta-cell homeostasis has been vastly investigated, the role
219  of thymic cortical and medullary epithelial cell homeostasis has yet to be addressed.
220 ption factors involved in hematopoietic stem cell homeostasis, hematopoiesis, and lymphocyte differen
221 on of inflammatory cytokines and disturbed T-cell homeostasis, however, the precise mechanism of this
222 pancreatic beta-cells but also regulate beta-cell homeostasis in a divergent manner.
223 er of lipids onto CD1d, regulates liver iNKT cell homeostasis in a manner dependent on hepatocyte CD1
224 b altered MP Treg and MP CD4(+) and CD8(+) T cell homeostasis in a manner similar to that observed wi
225 ich cholesterol accumulation can influence T cell homeostasis in atherosclerosis.
226 ells, virus persistence and CMV-associated T cell homeostasis in blood, lymphoid, mucosal and secreto
227 e-B cells, we propose that modification of B cell homeostasis in deficient animals was caused by "wea
228 xamined whether Lyp620W impacts peripheral B cell homeostasis in healthy individuals heterozygous for
229  these effects may adversely affect CD4(+) T cell homeostasis in HIV patients.
230 th distinct and joint influence upon blood T cell homeostasis in humans.
231 d its closest homolog, AGO10, maintains stem cell homeostasis in meristems by sequestration of miR165
232 en implicated as a key regulator of T and NK cell homeostasis in multiple systems; however, its speci
233 icipates in signaling pathways essential for cell homeostasis in multiple tissues, however, its funct
234 his issue, we characterized glucose and beta-cell homeostasis in pregnant mice lacking c-Met in the p
235 ized as an important regulator of epithelial cell homeostasis in several tissues.
236 ts in Th17 cell cytokine expression and Treg cell homeostasis in the absence of Mir155 could be parti
237 indicate that Ikaros is required to limit B1 cell homeostasis in the adult.
238 d regenerative thymopoiesis and peripheral T-cell homeostasis in the adulthood.
239 We further show how apoptosis regulates germ cell homeostasis in the gonad, and propose a role for in
240 ate sensor AIM2 regulates microbial and stem cell homeostasis in the gut to protect against colorecta
241 nfiltrating monocytes in maintaining myeloid cell homeostasis in the retina following AMD-relevant RP
242  were high in IL-6 and IL-10 and disrupted T cell homeostasis in vivo.
243 Interleukin-33 (IL-33) regulated muscle Treg cell homeostasis in young mice, and its administration t
244      Despite the significance of the UPR for cell homeostasis, in plants the regulatory circuitry und
245 he role of IL-7, a key cytokine regulating T-cell homeostasis, in suppressor capacity of Treg.
246 generally, Notch regulation of innate-like T cell homeostasis involves both cell-intrinsic and -extri
247 der certain pathological conditions, myeloid cell homeostasis is altered and immature forms of these
248                 Maintenance of appropriate T-cell homeostasis is essential to promote protective immu
249                                        How T cell homeostasis is maintained in barrier tissues is sti
250 ole in carcinogenesis, depending on how stem cell homeostasis is maintained.
251                          In the periphery, B cell homeostasis is not affected, but survivin-deficient
252 ss, the role of these pathways in adult beta-cell homeostasis is not well defined.
253 lectively, these results demonstrate that NK cell homeostasis is obligatorily dependent upon IL-15 in
254                                    Because B-cell homeostasis is perturbed in patients with WAS and r
255 cular, the regulation of resident progenitor cell homeostasis is vital for guiding the future develop
256 acellular defense mechanism and regulator of cell homeostasis, is a major immune recognition and regu
257         Expression of S1P2, which controls B-cell homeostasis, is also impaired in CLL B cells but in
258                     Essential for eukaryotic cell homeostasis, it plays central roles in bone remodel
259   Thus, PEP-R619W uniquely modulates T and B cell homeostasis, leading to a loss in tolerance and aut
260  disrupts basal Stat1 signaling and alters T-cell homeostasis, leading to impaired progenitor mainten
261 dox-sensitive protein with multiple roles in cell homeostasis, levels of which are altered in patient
262 deling proteins regulate multiple aspects of cell homeostasis, making them ideal candidates for misre
263     To assess B cell function in promoting T cell homeostasis, mature B cells were either acutely or
264 endent changes in factors supporting naive T cells homeostasis may also be involved.
265                   In addition to maintaining cell homeostasis, MCS formation recently emerged as a me
266                           They contribute to cell homeostasis, morphogenesis, and pathogen defense.
267  deleted genes, playing diverse functions in cell homeostasis, offers a rich repertoire of pharmacolo
268               Autophagy is critical for beta-cell homeostasis, particularly under conditions of stres
269 ral competition, an emerging feature of stem cell homeostasis, posits that individual stem cells can
270  this article, we document disturbances in T cell homeostasis present in PSGL-1(null) mice.
271 lved in autoimmunity, because it regulates T cell homeostasis, proliferation, and antiapoptotic signa
272              Despite these disturbances in T cell homeostasis, PSGL-1(null) mice exhibited a normal a
273 n, indicating a crucial role for Blimp1 in T cell homeostasis regulation.
274 ion of epidermal Wnt secretion in epithelial cell homeostasis remains poorly understood.
275 cial functions in food digestion, and acinar cell homeostasis required for secretion of digestive enz
276                          We report that hair cell homeostasis requires a specific sub-branch of the D
277                       Maintenance of myeloid cell homeostasis requires continuous turnover of phagocy
278  AT correlates with disturbances in B- and T-cell homeostasis resulting in reduced immune repertoire
279 ith which to explore the links between guard cell homeostasis, stomatal dynamics, and foliar transpir
280 cs, a non-standard theoretical approach to T cell homeostasis that accounts for clone diversity as ar
281 ity of the RELB and NF-kappaB2 subunits in B cell homeostasis that cannot be compensated for by the c
282 genous netrin-1 plays a role in NG2(+) glial cell homeostasis that is distinct from its role in myeli
283  responses to pathogens, autoimmunity, and B cell homeostasis, the biologic consequences of its bindi
284 l epithelial cells, and which impairs immune cell homeostasis, thereby promoting MIA-CID development.
285  protein in modulating intestinal epithelial cell homeostasis through ADAM17-mediated HB-EGF release,
286  unfolded protein response, UPR, to regulate cell homeostasis through both gene expression and protei
287       Thus, CD103(+) LP DC subsets control T cell homeostasis through both nonredundant and overlappi
288 n the skin that contribute to skin dendritic cell homeostasis through chemokine production.
289  for various cellular processes and maintain cell homeostasis through cross talk.
290 erations in lipid metabolism may affect iNKT cell homeostasis through effects on CD1d-associated lipi
291 s an important role in maintaining endocrine cell homeostasis through feedback mechanisms that govern
292 s, often working in networks, is to maintain cell homeostasis through interaction with substrate prot
293 ty and suggest that IL-10 may influence Treg cell homeostasis through its effect on Treg cell Bcl-2 e
294 s tTreg cell development and peripheral Treg cell homeostasis through the regulation of BIC/microRNA
295 ose a new model for maintaining peripheral T cell homeostasis via memory CD4 T cells and CD8(+) DC-de
296 c reticulum (ER) and the nucleus to maintain cell homeostasis via proper folding of proteins.
297 tions in Evc2 affect dental mesenchymal stem cell homeostasis, which further leads to hypomorphic ena
298 hronic immune activation and disruption of T-cell homeostasis, which impact the rate of disease progr
299 omotes cholesterol accumulation and alters T cell homeostasis, which may contribute to progression of
300 itical role in maintaining pancreatic acinar cell homeostasis, whose dysregulation promotes pancreati

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