ライフサイエンスコーパス: cell infiltration

1 interstitial fibrosis, and prevented immune cell infiltration.

2 zed by keratinocyte proliferation and immune cell infiltration.

3 fibroblast accumulation and macrophage and T cell infiltration.

4 stic stroma that functions as a barrier to T cell infiltration.

5 rdiomyocyte hydropic degeneration and immune cell infiltration.

6 vels of fibrosis and poor CD8(+) cytotoxic T cell infiltration.

7 ic index and markedly reducing CD45-positive cell infiltration.

8 8 and CCL20, and reduce further inflammatory cell infiltration.

9 ice where it was associated with increased T-cell infiltration.

10 d by the absence of cell death and no immune cell infiltration.

11 ng Akt activation and extensive inflammatory cell infiltration.

12 istant to immunotherapy and lacks baseline T cell infiltration.

13 sitive area, but a marked decrease in CD3(+) cell infiltration.

14 g, environments with elevated IL-33 and mast cell infiltration.

15 ant to NK cell-mediated immunity upon cancer cell infiltration.

16 d CNV size and eliminated ocular gammadeltaT-cell infiltration.

17 ment, and the surface area with inflammatory cell infiltration.

18 ed increased neuropeptide release and immune cell infiltration.

19 is, renal oxidative stress, and inflammatory cell infiltration.

20 al role for system Xc(-) in mediating immune cell infiltration.

21 DS), characterized by edema and inflammatory cell infiltration.

22 ohistochemical evidence for activated immune cell infiltration.

23 scopic signs of colon inflammation or immune cell infiltration.

24 graft-draining lymph nodes and preventing T-cell infiltration.

25 to postmortem measurements of colonic immune cell infiltration.

26 amage in A/J mice occurs before inflammatory cell infiltration.

27 ema and swelling, independent of mononuclear cell infiltration.

28 mmation, with increased myeloid and lymphoid cell infiltration.

29 rats and substantially reduced inflammatory cell infiltration.

30 more highly vascularized with higher myeloid cell infiltration.

31 em Xc(-) transporter in the CNS after immune cell infiltration.

32 lerosis in the absence of significant dermal cell infiltration.

33 vial tissue and correlates with inflammatory cell infiltration.

34 ion profiles associated with CD4, CD8, and B cell infiltration.

35 ppressor cells and inhibition of cytotoxic T-cell infiltration.

36 othelial cell activation, and intratumoral T-cell infiltration.

37 re associated with robust (10-fold) CD8(+) T cell infiltration.

38 uction in C3b/c and C9 deposition and innate cell infiltration.

39 sence of tumor cells was required for immune cell infiltration.

40 orresponding with patterns of greater immune cell infiltration.

41 ed fibrosis, increased vascularity, and mast cell infiltration.

42 cking of these chemokines inhibited CD8(+) T-cell infiltration.

43 ed by decreased macrophage, neutrophil and T-cell infiltration.

44 ental immune profile with decreased CD8(+) T-cell infiltration.

45 rginine induction, with obvious inflammatory cells infiltration.

46 of human MM, including bone malignant plasma cell infiltration, a monoclonal immunoglobulin peak, imm

47 disorder of the CNS characterized by immune cell infiltration across the brain vasculature into the

48 , skin inflammation, defined as the sum of T-cell infiltration/activation and IL-17-mediated epiderma

49 mic inflammation, oxidative cellular stress, cell infiltration/activation, and apoptosis.

50 oped portal tract expansion with increased T cell infiltration after immunosuppression withdrawal.

51 nitored over time, and alterations in immune cell infiltration after MI were examined through immunoh

52 erve fiber loss, axonal degeneration, immune cell infiltration, alterations in tubulin protein expres

53 MERS-CoV-infected lungs revealed mononuclear cell infiltration, alveolar edema, and microvascular thr

54 fects through its inhibition of inflammatory cell infiltration, alveolar structure disruption, and co

55 ilieu with a reduction of pathogenic myeloid cell infiltration and a marked accumulation of eosinophi

56 the complement system, as measured by immune cell infiltration and activated C3.

57 ingestion induced modest intestinal myeloid cell infiltration and activation, and release of inflamm

58 Regression correlated with immune cell infiltration and antibody responses against DFTD ce

59 GFbeta and CD103 and their contribution to T-cell infiltration and antitumor activity remain unknown.

60 y to degrade the ECM, which promoted tumor T cell infiltration and antitumor activity.

61 ll xenograft revealed a decrease of leukemic cell infiltration and BPDCN-induced cytopenia associated

62 Neutrophil and NK cell infiltration and capillary thrombosis were also sig

63 gly, an inverse correlation between CD8(+) T-cell infiltration and CD47 expression was observed in hu

64 ) loss and histomorphometry for inflammatory cell infiltration and collagen density.

65 stroglial scar formation and increase immune-cell infiltration and concomitant secondary tissue damag

66 mma(High)/RXRalpha(S427F/Y) impairs CD8(+) T-cell infiltration and confers partial resistance to immu

67 , in combination with chemotherapy, drives T cell infiltration and de novo responses against tumors,

68 SUNb-PM not only increased cytotoxic T-cell infiltration and decreased the number and percentag

69 and anti PD-1 cooperatively induces CD8(+) T-cell infiltration and decreases levels of proteins that

70 es contribute to DC activation, subsequent T-cell infiltration and end-organ damage in the kidney in

71 pression of PD-L1 was correlated with immune cell infiltration and event-free-survival (EFS).

72 ed WT and Sphk1(-/-) mice had greater immune cell infiltration and expression of fibrotic and inflamm

73 We observed equivalent levels of T cell infiltration and function within autophagy-competen

74 gh downregulation of CXCR3, reducing renal T cell infiltration and glycosphingolipid levels.

75 f Lactobacillus species, high pH, and immune cell infiltration and has been associated with an increa

76 anti-PD-1 correlated with increased T- and B-cell infiltration and IFN expression.

77 tary CTLA-4 expression was associated with T-cell infiltration and IgG-dependent complement fixation

78 while decreasing myeloid-derived suppressor cell infiltration and IL10 production in the TME.

79 mmadeltaT cells enhanced CD4(+) and CD8(+) T cell infiltration and immunogenicity and induced tumor p

80 th Cox2-/- BM had increased macrophage and T cell infiltration and increased M1- and Th1-associated m

81 receptors, and other angiogenesis and immune cell infiltration and inflammatory factors as candidates

82 hypoxia--in part by reducing Gr-1(+) myeloid cell infiltration and inhibits HCC growth.

83 o importantly resulted in encephalitogenic T-cell infiltration and lesion formation in normally unaff

84 Lungs were examined for cell infiltration and mucus hypersecretion, as well as t

85 in and chemokine CCL21, is correlated with T-cell infiltration and positive prognosis in breast cance

86 croglial activation, macrophage and CD4(+) T-cell infiltration and production of proinflammatory cyto

87 and is mainly manifested by increased immune cell infiltration and proinflammatory activation in inte

88 Finally, P2RX7 blockade also altered immune cell infiltration and promoted Treg accumulation within

89 bles chronically injured tissue, with immune cell infiltration and remodeling.

90 f functional CCR2 effectively reduced immune cell infiltration and rescued the retina from destructio

91 show that autochthonous tumors that lacked T cell infiltration and resisted current treatment options

92 dministration also enhanced tumor-specific T-cell infiltration and spatially redistributed CD8(+) T c

93 f cytotoxic CD8 T cells (CTLs) led to both T-cell infiltration and specific destruction of orexin(+)

94 was highly correlated to the level of CD8+ T cell infiltration and the expression of CCL5.

95 tween CLEC-2 and podoplanin regulates immune cell infiltration and the inflammatory reaction during s

96 inhibits pathways that lead to inflammatory cell infiltration and the production of inflammatory cyt

97 with talimogene laherparepvec on cytotoxic T cell infiltration and therapeutic efficacy of the anti-P

98 intervention markedly decreases swelling, T-cell infiltration and tissue fibrosis while significantl

99 LLC model, STING ablation enhanced CD8(+) T-cell infiltration and tumor cell killing while decreasin

100 er of CD8(+) T cells, resulted in enhanced T-cell infiltration and tumor rejection.

101 issue, independent of proliferation, stromal cell infiltration and tumour characteristics.

102 +) T cell infiltration, and a link between T cell infiltration and vascularization.

103 Pre-existing T-cell infiltration and/or the presence of PD-L1 in tumour

104 nflammation as evidenced by increased immune cells infiltration and release of cytokines and chemokin

105 tions between VEGF-A expression and CD8(+) T cell infiltration, and a link between T cell infiltratio

106 zed by increased collagen deposition, immune cell infiltration, and alpha-smooth muscle actin (alpha-

107 ressing livers display necrotic foci, immune cell infiltration, and altered hepatocyte morphology.

108 ted severe colitis, had greater inflammatory cell infiltration, and an increased presence of activate

109 erythema and induration, CD4(+) and CD8(+) T-cell infiltration, and attenuated global gene activation

110 ereas the C2 subtype is linked to obesity, T cell infiltration, and bile acid metabolism.

111 ssessed by changes in ear thickness, myeloid cell infiltration, and cytokine and chemokine secretion.

112 rentiation, increased myofibroblasts, immune cell infiltration, and increased matrix deposition.

113 entral nervous system (CNS), promotes immune cell infiltration, and influences clinical outcomes.

114 rs of donor-specific alloantibody, minimal T cell infiltration, and intense C4d deposition in the gra

115 or growth and stroma formation, alter immune cell infiltration, and prolong survival of mice.

116 ccumulation of damaged DNA, CD11b(+)-myeloid cell infiltration, and significant gene alterations in x

117 nding is followed by a lesional inflammatory cell infiltration, and the overall clinical picture may

118 is, degrades versican, promotes inflammatory cell infiltration, and thus contributes to sporadic AAD

119 cell-derived interferon-gamma and lesional T cell infiltration, and was abrogated in CD4(+) T cell-de

120 iers (BBB and BSCB, respectively) and immune cell infiltration are early pathophysiological hallmarks

121 (CD68), T (CD3), and Natural Killer (ANK61) cell infiltration as well as intragraft TNFalpha and IFN

122 veolar bone volume and enhanced inflammatory cell infiltration, as well as an increased number of ost

123 a interferon (IFN-gamma) production and Th17 cell infiltration, as well as restoring TJ protein expre

124 In this model, we documented increased T-cell infiltration associated with increased levels of CC

125 l hypertrophy, and perivascular inflammatory cell infiltration, associated with raised pulmonary arte

126 yed increased tissue damage and inflammatory cell infiltration at early time points during injury but

127 a distinction of patients with high CD8(+) T-cell infiltration but a high risk of death.

128 aggravated inflammatory cytokine response or cell infiltration but rather caused by reduced survival

129 cells and CSU lesions are characterized by T-cell infiltration, but antigen/disease-specific T cells

130 n, cell proliferation, apoptosis, and immune cell infiltration by means of high-resolution ultrasonog

131 ols the magnitude and extent of inflammatory cell infiltration by suppressing canonical BMP signaling

132 ninvasive method by which disease and immune cell infiltration can be explored simultaneously.

133 Although T-cell infiltration characterizes both diseases, T-cell po

134 allergic inflammation displayed reduced mast cell infiltration comparable with accumulation in mice w

135 -like disease, but revealed a considerable T-cell infiltration, comparable to EoE.

136 the nigra was found on 1 d of MPTP insult, T cell infiltration decreased afterward, becoming normal o

137 erity, associated with diminished CNS immune cell infiltration, decreased proinflammatory cytokine pr

138 persistence were also associated with immune cell infiltration, despite suppression of some inflammat

139 ties of the tumor microenvironment control T-cell infiltration, distribution, and function in tumor t

140 Neutrophil and mononuclear cell infiltration during inflammatory processes is highl

141 ed that IP deficiency increased inflammatory cell infiltration, eosinophilia, and IL-5 and IL-13 expr

142 s in its absence mice develop reduced immune cell infiltration, epithelial cell proliferation, and dy

143 ed groups showed virtually no sign of immune cell infiltration, except minimal infiltration in white

144 for remodeling characteristics (cell types, cell infiltration, extracellular matrix deposition, scaf

145 velop, with age, hepatocyte necrosis, immune cell infiltration, fibrosis, and micro- and macrosteatos

146 ation of beta-cell mass along with an immune cell infiltration-free pancreas 60 days after the end of

147 mation including increased lung inflammatory cells infiltration, goblet cell hyperplasia, and higher

148 were analyzed for vascularity, inflammatory cell infiltration, growth pattern, and tumor expression

149 ding marked and persistent liver mononuclear cell infiltration, hepatic fibrosis, hypergammaglobuline

150 y, mucus production, group 2 innate lymphoid cell infiltration, IL-5 and IL-13 production, as well as

151 the application of vaspin inhibited myeloid cell infiltration in a mouse model of a psoriasis-like s

152 t by instructing fibroblasts to support Th17 cell infiltration in a paracrine IL6/C/EBPbeta-dependent

153 n and decreased allergic airway inflammatory cell infiltration in Abx-treated mice.

154 ipocyte number, but it decreases HFD-induced cell infiltration in adipose tissues and reduces serum l

155 ysical disability and cleared the brain of T-cell infiltration in an EAE mouse model of multiple scle

156 growth regulatory kinase Erk5 can increase T-cell infiltration in an established Pten-deficient mouse

157 gene expression profile and decreased immune cell infiltration in an intradermal model of infection y

158 Despite adaptive immune cell infiltration in claudin-low tumors, treatment with

159 can (VCAN) strongly correlated with CD8(+) T cell infiltration in colorectal cancer, regardless of mi

160 as promoting myelin destruction after immune cell infiltration in EAE.

161 in peritumoral area; and (4) reduces glioma cell infiltration in healthy parenchyma.

162 derived from human cells) do not stimulate T-cell infiltration in immuno-competent mice.

163 enic pathway that contributes to a lack of T-cell infiltration in melanoma.

164 eria from blood, reduced pathogen and immune cell infiltration in multiple organs and decreased infla

165 he CNS is an important consequence of immune cell infiltration in neuroinflammatory demyelinating dis

166 e delivery is likely due to attenuation of T-cell infiltration in pancreatic islets in NOD mice.

167 CD3(+) T cell infiltration in primary tumors from 77 metastatic m

168 o kidneys, which correlated with decreased T cell infiltration in renal tissue.

169 hymal transition, IL-17 production, and Th17 cell infiltration in response to dialysis fluid treatmen

170 Autoantibody deposition and inflammatory cell infiltration in target organs such as kidneys and b

171 tion of inflammatory cytokines, inflammatory cell infiltration in the bone, and unremitting bone infl

172 ytokine and chemokine expression, and immune cell infiltration in the brain compared to mice infected

173 Recently, we reported increased T cell infiltration in the fibrotic myocardium of nonische

174 survival and decreased perivascular CD68(+) cell infiltration in the ischemic hind limbs of diabetic

175 RP3 inflammasome activation and macrophage/T cell infiltration in the kidney and T cell activation in

176 sed MRL.Fas(lpr) mouse survival, decreased T cell infiltration in the kidneys, and reduced T cell cyt

177 igh levels of viral antigen and inflammatory cell infiltration in the liver, the characteristic histo

178 with release of cytokines and innate immune cell infiltration in the liver.

179 ults in increases in inflammation and immune cell infiltration in the lung.

180 We observed spontaneous monocytic-cell infiltration in the lungs of Serpine2-deficient (SE

181 duced morphological changes and inflammatory cell infiltration in the mouse lung, and production of i

182 CD4(+) T-cell infiltration in the murine vaginal tissue and local

183 ion of renal injury markers and inflammatory cell infiltration in the postischemic kidney, which was

184 Osteoclast density and inflammatory cell infiltration in the RvE1 groups were lower than tho

185 sion of proinflammatory cytokines and immune cell infiltration in the scar early after MI compared wi

186 is an autoimmune disease characterized by T-cell infiltration in the skin that leads to fibrosis, wh

187 t decreases epidermal thickness as well as T cell infiltration in the skin.

188 We detected increased T cell infiltration in the tumor microenvironment after ac

189 ssues showed significantly more inflammatory cell infiltration in the WT ligated but not in the TLR9(

190 Here, we demonstrate that sufficient T cell infiltration in tumor tissues is a prerequisite for

191 work establishes a role for VE-cadherin in T-cell infiltration in tumors and offers a preclinical pro

192 ents with high levels of suppressive myeloid cell infiltration in tumours.

193 roduction from splenocytes, and inflammatory cell infiltrations in the lesions 48 h after intradermal

194 ibited chemokine expression and inflammatory cells infiltration in the dorsal root ganglia (DRG).

195 tory mediators (decreasing polymorphonuclear cell infiltration), increasing anti-inflammatory TLRs, r

196 al nucleation and increased focal macrophage cell infiltration, indicating exacerbated dystrophic mus

197 neous hyperplasia in this model, decreased T cell infiltration, interleukin (IL)-22 transcription, an

198 tion, a hallmark of obesity, involves immune cell infiltration into expanding adipose tissue.

199 ) T cells and beta-cells, and reduced immune cell infiltration into islets.

200 In conclusion, T-cell infiltration into primary melanoma is a strong pred

201 lso inhibited CD3(+) T-cell and gammadelta T-cell infiltration into skin regions.

202 pneumoniae infection by facilitating immune cell infiltration into the airspace and providing a more

203 the system Xc(-) transporter in mediating T cell infiltration into the CNS as well as promoting myel

204 T cell infiltration into the CNS is a significant underlyi

205 ompared with control mice, indicating that T cell infiltration into the CNS is CXCL1-independent.

206 Although T and B cell infiltration into the CNS of infected T-bet(-/-) mi

207 result of reduced demyelination and myeloid cell infiltration into the CNS tissue.

208 s the clinical presentation of EAE, CD4(+) T-cell infiltration into the CNS, and demyelination by inc

209 c(-) 7 d after induction of EAE attenuated T cell infiltration into the CNS, but not T cell activatio

210 s functional BBB integrity and limits immune cell infiltration into the CNS.

211 and activator of transcription 3, and immune cell infiltration into the colon.

212 emerged only upon studying peripheral immune cell infiltration into the dorsal root ganglion, suggest

213 N694 markedly reduces disease progression, T cell infiltration into the intestinal lamina propria, an

214 autoimmune process initiates first with a T cell infiltration into the islets, where they have restr

215 , CXCL16 deficiency reduced macrophage and T cell infiltration into the kidneys in response to DOCA-s

216 e affiliated with lowered allergy-associated cell infiltration into the lung, IgE production, develop

217 In the humanized mouse model, T-cell infiltration into the salivary and lacrimal glands

218 that NSD1 inactivation results in reduced T cell infiltration into the tumor microenvironment, impli

219 mor-suppressor miR-132 and inhibited stromal cell infiltration into the tumor tissues.

220 iated with extensive tumor destruction and T-cell infiltration into the tumor.

221 Systemic DLL-1 administration increased T-cell infiltration into tumors and elevated numbers of CD

222 Strategies that improve T-cell infiltration into tumors may therefore be able to f

223 erized by synovial hyperplasia, inflammatory cell infiltration, irreversible cartilage and bone destr

224 tract integrity is degraded in areas where T-cell infiltration is highest, providing a noninvasive me

225 distribution of desmoplastic elements and T-cell infiltration is necessary to delineate their roles.

226 Reduction of T-cell infiltration is thus identified as a novel translat

227 (TNBCs) have high and others have low immune cell infiltration is unknown.

228 Immune cell-infiltration is controlled by activated PPARgamma/R

229 wed decreased fibrogenesis, hepatic stellate cell infiltration, Kupffer cells and inflammatory cytoki

230 spond to immune checkpoint therapies where T-cell infiltration may be a key limiting factor.

231 and host cells, and baseline intratumoral T cell infiltration may improve response likelihood to ant

232 dAPN mice by suppressing aortic inflammatory cell infiltration, medial degeneration and elastin fragm

233 rs, since the potential adverse effect on NK cell infiltration might limit the antitumor activity of

234 reduced weight loss, pulmonary inflammatory cell infiltration, mucus production, and airway resistan

235 mined in vivo by measuring lung inflammatory cells infiltration, mucus production, serum lgE levels,

236 ne, and adhesion molecule expression, immune cell infiltration, myocardial injury, and contractile dy

237 vation of the LV endothelium results in LV T-cell infiltration negatively contributing to HF progress

238 c analysis was used to evaluate inflammatory cell infiltration, numbers of osteoblasts and osteoclast

239 d into the mechanisms leading to a lack of T cell infiltration of cancers and primary immune resistan

240 D with residual beta-cell mass and ongoing T-cell infiltration of islets.

241 that deletion of TSP-1 reduced inflammatory cell infiltration of muscle fibers, but only early in di

242 T cell infiltration of solid tumors is associated with fav

243 T-cell infiltration of solid tumors is associated with imp

244 challenge and normal IL-4 production, but B cell infiltration of the airways was abrogated.

245 rse analysis showed an evolution from immune cell infiltration of the bronchioles and vessels at day

246 Initial T cell infiltration of the CNS occurred normally in muMT m

247 ing and migration and thus enables efficient cell infiltration of the construct through the colloidal

248 Recipient T cell infiltration of the donor lung was significantly di

249 these T cells to athymic mice resulted in T-cell infiltration of the gut, loss of Paneth cells, micr

250 es and chemokines and decreased inflammatory cell infiltration of the heart, as well as in attenuated

251 hich concomitantly prevents autoaggressive T-cell infiltration of the liver.

252 However, although there is considerable T cell infiltration of the maternal decidua, the functiona

253 how to maximize BiTE((R)) penetration and T-cell infiltration of the tumor while simultaneously mini

254 Mast cell infiltration of tumour islets represents a survival

255 pear to be associated with baseline CD8(+) T cell infiltration or baseline IFN-gamma signature.

256 t have increased adipose tissue inflammatory cell infiltration or greater expression of inflammatory

257 -miR-2137 significantly reduced inflammatory cell infiltration, osteoclast activity, and bone loss.

258 ted good tissue compatibility with extensive cell infiltration over 2 weeks.

259 ociated with neutrophils, eosinophils, and B-cell infiltration (P < 0.05).

260 shed extracellular matrix deposition, immune cell infiltration, PanIN formation, and tumor growth.

261 Endothelial damage and T cell infiltration play a pivotal role in the development

262 Importantly, gammadeltaT17 cell infiltration positively correlated with tumor stage

263 ity while anti-VEGF augments intra-tumoral T-cell infiltration, potentially through vascular normaliz

264 ties of pancreas, including increased immune cell infiltration, proliferation rate and DNA damage.

265 mor antigenicity or promoting intratumoral T cell infiltration, provide a rationale for combining the

266 ic beta-catenin signaling and intratumoral T cell infiltration, providing an explanation for potentia

267 mor cytokine/chemokine signature, improved T-cell infiltration, reduced markers of T-cell exhaustion,

268 OECs attenuated immune cell infiltration, reduced secondary tissue damage, prot

269 or 10 of 11 mediator release and 6 of 7 mast cell infiltration-related symptoms including urticaria p

270 s using an immune infiltration score and a T cell infiltration score and find that clear cell renal c

271 The model selection process for cell infiltration score yielded 2 variables: age at mesh

272 ness LCR rats displayed greater inflammatory cell infiltration, serum alanine transaminase, expressio

273 PD-1(+) cell infiltration significantly decreased in the resista

274 survival after DC vaccination had stronger T-cell infiltration than patients with shorter survival in

275 ity of neurons, due to cell death and immune cell infiltration that may account for the observed unde

276 and T cell priming, diminishing recipient T cell infiltration, the hallmark of acute rejection.

277 ithelium (RPE) injury associated with immune cell infiltration, the nature of immune cell responses t

278 he disease are characterized by inflammatory cell infiltration, tissue destruction and neovasculariza

279 ed in T cell trafficking, drove continuous T cell infiltration to the nigra and incessant glial infla

280 Intratumoral basophils enhanced CD8(+) T-cell infiltration via production of chemokines CCL3 and

281 e were drastically reduced, and inflammatory cell infiltration was abrogated nearly completely.

282 aortic constriction and the kinetics of LV T-cell infiltration was directly associated with the devel

283 Host cell infiltration was much prominent on both scaffolds w

284 Inflammatory cell infiltration was observed in both MG and conjunctiv

285 Neutrophil and CD8 T cell infiltration was reduced in inflamed ear tissue, wh

286 Foam cell infiltration was responsible for 70% of false IVOCT

287 Interestingly, less CD8 T cell infiltration was secondary to reduction of T-cell e

288 T cell infiltration was verified by immunohistochemistry.

289 a and head and neck exhibited hallmarks of B cell infiltration, we examined B cell-deficient mice and

290 In the induction phase, PBL and inflammatory cell infiltration were significantly reduced in group PP

291 In the recovery phase, PBL and inflammatory cell infiltration were significantly reduced, and signif

292 thelial barrier function, and induces immune cell infiltration, which further augments local producti

293 pecific biomarkers and instead focusing on T-cell infiltration, which has been previously correlated

294 to two distinct groups with respect to CD8 T-cell infiltration, which might influence clinical respon

295 eratinocytes associated with a marked CD4+ T cell infiltration, which peaked on days 10-11 after trea

296 associated with macrophage, CD4, CD8, and B cell infiltration with increased formation of tertiary l

297 firmed by the findings of bone marrow plasma cell infiltration, with t(11;14) chromosomal abnormality

298 deposition of collagens and increased immune cell infiltration within the depots.

299 by IHC and semiquantitative evaluation of T-cell infiltration within the tumor corresponding to the

300 tumour, as evidenced by a baseline CD8(+) T-cell infiltration within the tumour microenvironment.