ライフサイエンスコーパス: cell junction

1 n-4-dependent recruitment of vinculin to the cell junction.

2 the retinal Muller glia (RMG)/photoreceptor cell junction.

3 esion as well as insight on dynamics of cell-cell junction.

4 nd each protein localized as a ring near the cell junction.

5 actor receptor 2) and E-cadherin at the cell-cell junction.

6 tors and signaling molecules within the cell-cell junction.

7 orces along different parts of an individual cell junction.

8 srupts the targeting of microtubules to cell-cell junctions.

9 dissociating VEGFR2 from VE-cadherin at the cell junctions.

10 syndecan-4 rescues focal adhesions and cell-cell junctions.

11 ate endothelial permeability via endothelial cell junctions.

12 nculin-dependent mechanotransduction at cell-cell junctions.

13 gues accumulate at mammalian epithelial cell-cell junctions.

14 r integrity by affecting the organization of cell junctions.

15 isplayed increased elongation and tighter EC-cell junctions.

16 well as DSG1, a component of desmosomal cell-cell junctions.

17 he cleavage furrow and RhoA and Rac1 at cell-cell junctions.

18 on of polysaccharide from pores close to the cell junctions.

19 lial cell interactions and inter-endothelial cell junctions.

20 wnstream destabilization of endothelial cell-cell junctions.

21 epithelial monolayers with compromised cell-cell junctions.

22 inesis and formation and maintenance of cell-cell junctions.

23 to generate tangential forces to break cell-cell junctions.

24 that invade luminally along neighboring cell-cell junctions.

25 complex transduces mechanical forces at cell-cell junctions.

26 tently appearing lamellipodia at established cell junctions.

27 formation and disruption of endothelial cell-cell junctions.

28 y system maintained through endothelial cell-cell junctions.

29 le for Anillin in regulating epithelial cell-cell junctions.

30 iled to support normal localization of gE to cell junctions.

31 localization at the level of individual cell-cell junctions.

32 extensions between adjacent cells along cell-cell junctions.

33 al tension stimulates actin assembly at cell-cell junctions.

34 eural plate, being enriched at medial apical cell junctions.

35 ression, as well as breakdown of endothelial cell junctions.

36 with the appearance of ARHGAP21 at the cell-cell junctions.

37 atial distribution of RhoA signaling at cell-cell junctions.

38 ough control of E-cadherin stability at cell-cell junctions.

39 s Src-dependent endocytosis of E-cadherin at cell junctions.

40 colocalized with filamentous actin and cell-cell junctions.

41 on of rete pegs, and apparent dissolution of cell junctions.

42 tive inhibition with lactose stabilizes cell-cell junctions.

43 sitive adhesion and its strength across cell-cell junctions.

44 to study actin assembly at cadherin-enriched cell junctions.

45 he mobility of VE-cadherin at recovered cell-cell junctions.

46 hment of top signals among genes involved in cell junctions.

47 etion reduces recruitment of F-actin at cell-cell junctions.

48 RHGAP18 in endothelial cells is important in cell junctions.

49 d -2 might regulate cytoskeletal activity at cell junctions.

50 growth factor act oppositely on endothelial cell junctions.

51 nucleation abolished actin assembly at cell-cell junctions.

52 suggesting a common feature for signaling at cell junctions.

53 masks the motif, stabilizing the cadherin at cell junctions.

54 ension probes to visualize tensile forces at cell junctions.

55 depend on the regulation of endothelial cell-cell junctions.

56 malformed vascular walls with leaky cell-to-cell junctions.

57 -dependent formation of epithelial-like cell-cell junctions.

58 ylation and subsequent transmigration across cell junctions.

59 ction by contracting while connected to cell-cell junctions.

60 he levels of phosphorylated Src42A (pSrc) at cell junctions.

61 formin-mediated actin polymerization at cell-cell junctions.

62 VE-cadherin clusters Pals1 at cell-cell junctions.

63 nt of Rasip1 to and stabilization of EC cell-cell junctions.

64 d the platform to measure forces of (1) cell-cell junctions, (2) single cells undergoing cyclic pertu

65 ion but is transiently redistributed to cell-cell junctions 4 h after initiation of cell-cell adhesio

66 s of </=200 mum; these included an arborised cell junction, a diagonal-plane junction and an osteocho

67 creased presence of luminal endothelial cell-cell junctions, a transient configuration in the forming

68 this process because the disruption of cell-cell junctions abolishes directed collective migration a

69 ed with various cellular functions including cell junction, adhesion and neurogenesis.

70 hanism by which the AMPK-GIV axis reinforces cell junctions against stress-induced collapse and also

71 However, disruption of cell-cell junctions allowed the additional infection of cells

72 (invade) either singularly by breaking cell-cell junctions analogous to release of a stretched rubbe

73 characterized the structural determinants in cell junction and communication.

74 onset blockage near the terminal cell-stalk cell junction and the ectopic extension of autocellular,

75 rtion of cells undergo a serial loss of cell-cell junctions and a progressive loss of apical area, be

76 r (VEGF), have been reported to disrupt cell-cell junctions and abolish GJIC.

77 h all CLC channels tested, targeting them to cell junctions and activating them by stabilizing the op

78 N-WASP depletion increased the width of cell-cell junctions and altered the organization of F-actin a

79 co analysis also showed that tension on cell-cell junctions and apical stress is not homogeneous acro

80 PrP(c) regulates intestinal epithelial cell-cell junctions and barrier function.

81 ired for proper Rho-GTP distribution at cell-cell junctions and for maintenance of a robust apical ac

82 ed, c-Src-mediated regulation of endothelial cell junctions and for vascular permeability.

83 vivo evidence for mechanosensitivity of cell-cell junctions and imply that myosin-mediated tension ca

84 lliculin and p0071 partially co-localized at cell junctions and in mitotic cells, at the midbody duri

85 mechanical disruption of retinal endothelial cell junctions and increased vasopermeability, as well a

86 in epithelial-like tumor cells perturbs cell:cell junctions and increases membrane protrusion and ove

87 ology and dynamics of native epithelial cell-cell junctions and induced the same polarity transition

88 l cell adhesion molecule-1 (PECAM-1) at cell-cell junctions and integrins at cell-matrix adhesions.

89 PrP(c) is located in cell-cell junctions and interacts with desmosome proteins in

90 y sensor of metabolic stress stabilizes cell-cell junctions and maintains epithelial polarity; its ac

91 of Crumbs in regulating actomyosin dynamics, cell junctions and morphogenesis.

92 k synergized with interferon-beta to tighten cell junctions and prevent virus transit across brain mi

93 exchange factor (GEF) that localizes at cell-cell junctions and promotes junction stability by activa

94 t RASSF1C targets SRC/YES to epithelial cell-cell junctions and promotes tyrosine phosphorylation of

95 teins has implications for signaling at cell-cell junctions and protein sorting at intracellular cont

96 tion, endothelial cells (ECs) establish cell-cell junctions and rearrange to form multicellular tubes

97 on, as its loss results in disorganized cell-cell junctions and reduced focal adhesions.

98 Antagonizing VE-cadherin widened cell-cell junctions and reduced the applied shear stress for

99 is accompanied by tightening of endothelial cell junctions and reduction in vascular leakage.

100 Scribble (SCRIB) localizes to cell-cell junctions and regulates establishment of epithelial

101 alizes to forming endothelial cell (EC) cell-cell junctions and silencing HEG1 prevents this localiza

102 aptor protein CCM2 to strengthen endothelial cell junctions and stabilize vessels.

103 3 and DDR1-Par3 differentially regulate cell-cell junctions and the actin cytoskeleton to mediate inv

104 p of cells that require coordination of cell-cell junctions and the actin cytoskeleton.

105 n proteins form critical connections between cell junctions and the cytoskeleton; their disruption wi

106 gulates focal adhesion, cell spreading, cell-cell junctions and the formation of lamellipodia in brea

107 of desmoglein 2-specific interactions along cell junctions and the mean desmoglein 2-mediated bindin

108 classification and analysis of lobes at two-cell junctions and three-cell junctions, respectively.

109 s is crucial to direct the formation of cell-cell junctions and tissue barriers.

110 Angiopoietins are pivotal modulators of cell-cell junctions and vascular integrity.

111 expression leading to an increased level of cell-junction and extracellular matrix proteins and an a

112 red to occur paracellularly, or between cell-cell junctions, and driven by local pressure and concent

113 r endothelial cadherin (VE-cadherin) at cell-cell junctions, and mechanical wounding of the monolayer

114 eta-catenin and E-cadherin protein levels at cell junctions, and these defects can be rescued by reac

115 eeded for direct spread of the virus through cell junctions, and these studies show that UL21 is requ

116 proteins related to actin cytoskeleton, cell-cell junctions, and Weibel-Palade body release.

117 ers in multicellular organisms by regulating cell junction- and proliferation-related genes.

118 ffusive percolation, penetrating areas where cell junctions are absent.

119 Cell-cell junctions are an integral part of epithelia and are

120 Membrane interfaces formed at cell-cell junctions are associated with characteristic patter

121 nd the putative PilA protein to rings at the cell junctions are consistent with the hypothesis that t

122 In multicellular organisms, cell-cell junctions are involved in many aspects of tissue mo

123 Furthermore, we reveal that cell-cell junctions are key players in this aECM patterning a

124 Cell junctions are scaffolds that integrate mechanical a

125 es associated with the establishment of cell-cell junctions are transduced across the cell cortex via

126 single transmembrane domain and localize to cell junction area at the apical surface of epithelia.

127 Loss of the cell junction-associated Motin protein Amotl2a leads to

128 nes and at the slit diaphragm, a specialized cell junction at the filtration slit of glomerular podoc

129 cin is a key component of the slit diaphragm cell junction at the kidney filtration barrier and part

130 Whereas podocin resides at a specialized cell junction at the podocyte slit diaphragm, MEC-2 is f

131 phatase Pten are specifically lost from cell-cell junctions at epithelial edges.

132 that in static culture, VE-cadherin in cell-cell junctions bears significant myosin-dependent tensio

133 flammation, acinar cell differentiation, and cell junctions being specifically targeted.

134 Loss of crumbs function disrupts the apical cell junction belt and crumbs overexpression expands the

135 2010), we discovered that RhoU regulates the cell junctions between cardiomyocytes through the Arhgef

136 K activation, rapid FAK localization to cell-cell junctions, binding of the FAK FERM domain to the va

137 erized by pericyte loss and endothelial cell-cell junction breakdown.

138 ificantly influenced by the strength of cell-cell junctions but is an emergent property, similar to c

139 in endocytosis assembled normally into cell-cell junctions but potently suppressed cell migration in

140 on and the plasma membrane, not only at cell-cell junctions but throughout the cell surface.

141 forms lateral clusters within adherens cell-cell junctions, but its association state outside these

142 imic receptor-ligand binding within the cell-cell junction by engaging Notch1-eGFP expressing cells t

143 In MDCK cells, Yap1 was sequestered to cell-cell junctions by Amot, and aPKC overexpression resulted

144 n the recovery of disrupted endothelial cell-cell junctions by dephosphorylating VE-cadherin-associat

145 f local prevention of cell adhesion at three-cell junctions by fluidlike extracellular material and a

146 force-activatable mechanotransducer at cell-cell junctions by using an engineered alpha-catenin conf

147 or how large-scale interactions through cell-cell junctions can feed back to regulate the organizatio

148 It is a cell-to-cell junction cardiomyopathy, typically caused by geneti

149 lar endothelial (VE)-cadherin at established cell junctions causes actin-driven and actin-related pro

150 ors were highly vascularized with tight cell-cell junctions, compared with EMT tumors where cells dis

151 We show disruption of multiple types of cell junction complexes in peripheral nerve, resulting i

152 hin individual blood samples, identifies the cell junction component plakoglobin as highly differenti

153 ll cycle factors mps1, cdc37, and PA2G4, and cell junction components cx43 and cldn5, are miR-133 tar

154 Cell permeability was measured by cell-cell junction confocal microscopy and a dextran permeabi

155 and Arf1 is required for maintenance of cell-cell junction connectivity and focal adhesion assembly.

156 mplies that the inhibited complexes at virus-cell junctions contain several 2G12's that must dissocia

157 ECs tightly regulate their cell-cell junctions, controlling the passage of soluble mater

158 to ask whether changes in forces across cell-cell junctions correlated with E-cadherin molecular tens

159 g of ion transport and enables regulation of cell junctions critical to the cell and molecular biolog

160 Maintenance and remodeling of endothelial cell junctions critically depend on the VE-cadherin/cate

161 within the lymphatic vasculature led to cell-cell junction defects, regression of valves, and focal v

162 cadherin-dependent adhesion forces for cell-cell junction development and enhance local integrin-dep

163 es toward pericellular collagen degradation, cell junction disassembly, and blood endothelial transmi

164 not only makes cells more resistant to cell-cell junction disassembly, but also accelerates the kine

165 as well as an increase in RhoA activity and cell junction disassembly, which suggests an overall rep

166 arrhythmogenic cardiomyopathy as desmosome, cell junction disease.

167 Because cadherins bind beta-catenin at cell-cell junctions, disruption of adherens junctions destabi

168 nkage of the actomyosin cytoskeleton to cell-cell junctions drives cell shape change in development a

169 ormation may reduce tension building at cell-cell junctions during morphogenesis.

170 agen chains in the BM, was found to modulate cell junction dynamics at the BTB and apical ES.

171 We show that tension at cell junctions equilibrates over a few seconds, a short

172 lly related processes, including cell cycle, cell junction, focal adhesion, and WNT signaling.

173 el function for UL37 in virus trafficking to cell junctions for cell-cell spread.

174 asmic budding destinations and further on to cell junctions for spread to nearby cells.

175 We investigated the dynamics of cell-cell junction formation and the corresponding architectu

176 hgef7b/Pak signaling, which helps coordinate cell junction formation between atrioventricular cardiom

177 individual cells, lateral migration and cell-cell junction formation precede matrix invasion.

178 equired for focal adhesions, epithelial cell-cell junction formation, and microfibril deposition.

179 s sequential molecular processes during cell-cell junction formation; hence, mechanisms must exist th

180 ased N-cadherin internalization and abnormal cell junctions, generating an ectopic neuronal layer tha

181 ated that the aggregation of aPKC around the cell junctions had disintegrated in zBves morphants.

182 Maintenance of nephrin within this unique cell junction has been proposed to require dynamic phosp

183 The endothelial cell-cell junction has emerged as a major cell signaling stru

184 At the level of cell-to-cell junctions, HGF attenuates the linkage of stress fib

185 lpha-actinin-4 and actin accumulation at the cell junction in a time- and tension-dependent manner du

186 g the plasma membrane (PM) at the PD cell-to-cell junction in Arabidopsis thaliana.

187 and increases E-cadherin expression and cell-cell junction in epithelial cells.

188 s the reorganization of microtubules to cell-cell junctions in a desmosome-dependent manner.

189 Levels of PrP(c) were decreased at cell-cell junctions in colonic epithelia from patients with C

190 herin and Notch signaling components to cell-cell junctions in Drosophila, human intestinal epithelia

191 the apical region (zonula adherens) of cell-cell junctions in epithelia, where clusters of the adhes

192 ibronectin-induced focal adhesions, and cell-cell junctions in epithelial cultures.

193 , leading to disruption of inter-endothelial cell junctions in human brain microvascular endothelial

194 essed, and protein is mislocalized from cell-cell junctions in human breast cancers.

195 N-WASP was not present at cell-cell junctions in monolayers under resting conditions, b

196 wed reduced localization at endothelial cell-cell junctions in postnatal retinas after Vegfr3 deletio

197 aracellular diapedesis by opening their cell-cell junctions in response to the presence of an adherin

198 demonstrate an enhanced dissociation of cell-cell junctions in stiffer and more confined three-dimens

199 robe the mechanical properties of epithelial cell junctions in the early Drosophila embryo.

200 ostaining revealed impaired endothelial cell-cell junctions in the presence of either metastatic TCM

201 Retinoschisin (RS1) is involved in cell-cell junctions in the retina, but is unique among known

202 tion, which requires the dissolution of cell-cell junctions in the upper granular layers.

203 including: disruption of ZO-1-positive cell-cell junctions in tumour blood vessels; abnormal distrib

204 e localization of neutrophils to endothelial cell junctions, in which receptor-ligand interactions an

205 forces and was evenly distributed along cell-cell junctions independent of cell spread area and total

206 By regulating cell-cell junctions, integrin alpha5beta1 expression, and cel

207 Numb regulates cell junctions, integrins, and the activity of embryonic

208 lin plays a critical role in regulating cell-cell junction integrity.

209 actomyosin belt, which is required for cell-cell junction integrity.

210 no-signal transduction, and endothelial cell-cell junction integrity.

211 s and spread of extracellular virions across cell junctions into adjacent epithelial cells.

212 ia is the subdivision of the cell surface by cell junctions into apical and basolateral domains.

213 show that formin activity at epithelial cell-cell junctions is important for adhesion and the mainten

214 f the ligand that activates vinculin in cell-cell junctions is not known.

215 which recovery of VE-cadherin-mediated cell-cell junctions is regulated.

216 stinal tract suggest that disruption of cell-cell junctions is required to initiate epithelial immune

217 The maintenance of endothelial cell-cell junctions is vital for the control of blood vessel

218 ned between adjacent projections is a unique cell junction known as the slit diaphragm, which is phys

219 tracellular matrix (ECM) adhesions, and cell-cell junctions lead to significant changes in intracellu

220 epithelium, the aberrant regulation of cell/cell junctions leads to intestinal barrier defects, whic

221 f AHI1 at the basal bodies of PC and at cell-cell junctions, likely through decreased binding of muta

222 VE-cadherin at endothelial cell-cell junctions links the contractile acto-myosin cytoske

223 and the interacting kinesin Kif1B coordinate cell junction maintenance and planar spindle positioning

224 llel to the axis of channels lose their cell-cell junctions more readily than those oriented in the p

225 pathway inhibition via Y27632 disrupted cell-cell junction morphology, showing that cell contractilit

226 Rs were enriched among the genes involved in cell junction, neuronal morphogenesis and neurodevelopme

227 Chimeric reads that match a known virus-cell junction of HPV18 integrated in HeLa cells were als

228 Bves is widely observed in the cell junction of the skin, epicardium, intestine, and co

229 he lipid raft marker GM1 ganglioside in cell-cell junctions of mammary epithelial cancer cells.

230 Furthermore, Shp2 deletion impaired the cell junctions of the primary Sertoli cells and failed t

231 ected, Shp2 restoration largely restores the cell junctions of the primary Sertoli cells and the clon

232 particles that transmit to the next cell via cell junctions or induced polarized contacts.

233 ld is not impacted by the maturation of cell-cell junctions or pressure gradient across the monolayer

234 Epithelial (E)-cadherin-mediated cell-cell junctions play important roles in the development a

235 VEGF caused translocation of Syx from cell junctions, promoting junction disassembly, whereas

236 ssion of E-cadherin, an essential epithelial cell junction protein.

237 cell cytosol, perturbing the localization of cell junction proteins (e.g., occluden-ZO-1, N-cadherin-

238 tic capillaries with upregulated endothelial cell junction proteins and a continuous basement membran

239 gment homeobox (Msx) genes alters epithelial cell junction proteins during embryo implantation.

240 ients exhibit changes in the distribution of cell junction proteins similar to those seen in the hear

241 f differentiation markers switches from cell-cell junction proteins such as E-cadherin to mesenchymal

242 echanisms linking mechanical strain and cell-cell junction proteins to cellular responses are poorly

243 t heart revealed Pitx2 target genes encoding cell junction proteins, ion channels, and critical trans

244 st its PDZ-binding motif that interacts with cell junction proteins.

245 However, force studies at cell-cell junctions remain a challenge.

246 isms regulating actin polymerization at cell-cell junctions remain poorly understood.

247 In addition, Mgc's function at cell-cell junctions remains unclear.

248 hat orchestrate the cell shape changes, cell-cell junction remodeling and polarized membrane growth t

249 that ARHGAP21 is a Rho-GAP involved in cell-cell junction remodeling and that ARHGAP21 affects migra

250 wed overexpression of genes involved in cell-cell junction remodeling, adhesion, and diapedesis, whic

251 notype, in which MET inhibitors restore cell-cell junctions, rescue claudin 1 expression, and abrogat

252 sis of lobes at two-cell junctions and three-cell junctions, respectively.

253 nding protein that also co-localizes to cell-cell junctions, reversed the effects of Galpha13 knockdo

254 C permeability was linked to dissociation of cell junction scaffold afadin from the adherens junction

255 ce to apoptosis, immune evasion, and loss of cell junctions seen in H. pylori-infected host cells.

256 re on lipid metabolism, oxidative stress and cell junction signaling in testes.

257 cture and are connected via specialized cell-cell junctions (slit diaphragms) that restrict passage o

258 sin II [3, 8, 9], all of which regulate cell-cell junction structure and function.

259 ecessary for successful cytokinesis and cell-cell junction structure.

260 Transmission electron microscopy reveals cell junction structures likely to be involved in interc

261 rtion of extracellular matrix fluid at three-cell junctions such that cell adhesion is locally disrup

262 endothelial cells, and widening of the cell-cell junctions, suggesting that uptake occurs in regions

263 tis-specific anchoring junction) is the only cell junction that anchors and maintains the polarity of

264 focal adhesion-like structures near the cell-cell junction that degrade force transmission between ce

265 al process that requires formation of a cell-cell junction that is rich in active force generation.

266 ns': an array of pore-like structures at the cell junctions that allow intercellular communication by

267 Adherens junctions are one of the three cell-cell junctions that are essential to the establishment a

268 functionally important interendothelial cell-cell junctions that form during lymphatic development.

269 Desmosomes are cell-cell junctions that maintain tissue integrity especially

270 Desmosomes are macromolecular cell-cell junctions that provide adhesive strength in epithel

271 ression induced a loss of E-cadherin at cell-cell junctions that was linked to epithelial-mesenchymal

272 h N25Q PECAM-1 concentrates normally at cell-cell junctions, the ability of this mutant form of PECAM

273 At acutely stretched cell-cell junctions, the immediate, reversible conformation c

274 er dynamic force loading at reannealing cell-cell junctions, the R551A mutant bound more vinculin tha

275 s are established and become cleared of cell-cell junctions, thereby allowing continuous central lume

276 in surprisingly localizes to epithelial cell-cell junctions throughout the cell cycle, whereas it was

277 t the concept that the ZO-1 shuttle from the cell junction to the cytonuclear compartment may affect

278 e extracellular spread from axon tips across cell junctions to epithelial cells.

279 Epithelial cells connect via cell-cell junctions to form sheets of cells with separate cel

280 the Hippo pathway kinases Lats1/2 at apical cell junctions to induce Yap phosphorylation and cytopla

281 in cell migration CDCP1 relocates from cell-cell junctions to punctate structures on filopodia after

282 rs (VEGFRs) that resides at endothelial cell-cell junctions transduces signals important for flow-dep

283 Leu (P305L)] that fails to localize to cell-cell junctions, under the control of the mouse mammary t

284 Little movement of the tether-cell junction was observed during tangential tether extr

285 g this experimental platform to mimic a cell-cell junction, we found that the signaling complex is no

286 apparatus to apply mechanical stress to cell-cell junctions, we showed that knockdown of FSGS3/CD2AP

287 ctivation and remodeling of endothelial cell-cell junctions were addressed by using human endothelial

288 1 interacts with endothelial cell PECAM-1 at cell junctions where transmigration occurs, we considere

289 mic "flares" of Rho-GTP are observed at cell-cell junctions, whereas overall junctional F-actin and m

290 and the attachment of actin networks to cell-cell junctions, which allows forces to be transmitted be

291 tegrity of cell clusters is dictated by cell-cell junctions, which depend on subcellular forces and a

292 cell-cell interfaces and measure tension at cell junctions, which is on the order of 100 pN.

293 undergo molecular specification and remodel cell junctions while remaining connected to their epithe

294 ating CTLs subsequently arrested at the beta cell junction, while duration of stable CTL-target cell

295 ates the linkage of stress fibers to cell-to-cell junctions with concomitant decrease in intercellula

296 earance of polarized apical microtubules and cell junctions with increased levels of stable PCP compo

297 min to align with Z disks and disrupted cell-cell junctions, with no effect on sarcomeric organizatio

298 al growth reduces cytoskeletal tension along cell junctions within faster-growing cells.

299 increase in beta-catenin at Jup mutant cell-cell junctions without altering its signaling activities

300 mistry confirmed the presence of markers for cell junction (ZO1, Desmoplakin), basement membrane asse