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1 ed from a single dominant hematopoietic stem cell lineage.
2 s a key mechanism for commitment to the iNKT cell lineage.
3 ster regulatory genes necessary to specify a cell lineage.
4 e no effect on cell viability, regardless of cell lineage.
5 nset of differentiation in the germline stem cell lineage.
6 aques are known to define the distinct B1a B-cell lineage.
7 imprinted expression in the extra-embryonic cell lineage.
8 was blocked in mice lacking IKK1/2 in the T cell lineage.
9 ansdifferentiation, or constitute a distinct cell lineage.
10 es, they also occur in malignancies of the T-cell lineage.
11 usly detected, even in the closely related T-cell lineage.
12 in mice with Ilk deficiency in the ureteric cell lineage.
13 th cell subpopulations spanning the entire B cell lineage.
14 en added at the time of commitment to the NK cell lineage.
15 ls-these differentiated toward the secretory cell lineage.
16 cation of numerous enhancers active in the B-cell lineage.
17 7 can be dispensable for commitment to the B-cell lineage.
18 his N276 glycan-dependent CD4 binding site B-cell lineage.
19 asymmetric division that segregates the germ cell lineage.
20 on of self-reactive thymocytes into the Treg cell lineage.
21 e indefinitely, because of its immortal germ-cell lineage.
22 se in the Drosophila sensory organ precursor cell lineage.
23 ntiates them from other cells in the Schwann cell lineage.
24 MHC class II expression restricted to the B-cell lineage.
25 herin (Cdh1) and p53 in the gastric parietal cell lineage.
26 ferentiation toward mesodermal or endodermal cell lineage.
27 were not from the Zbtb46-dependent dendritic-cell lineage.
28 , and author online at cell.com/i3/cell-stem-cell/lineage.
29 nd a loss of differentiated cells in somatic cell lineages.
30 ionship with defects in epithelial secretory cell lineages.
31 ations of immune, epithelial and mesenchymal cell lineages.
32 that specify the alternative islet endocrine cell lineages.
33 tiation of pluripotent stem cells to somatic cell lineages.
34 on in both adaptive cell lineages and innate cell lineages.
35 of neurulation, during the establishment of cell lineages.
36 nd did not significantly contribute to other cell lineages.
37 nt tissues derived from different primordial cell lineages.
38 ation of mesenchymal stem cells into various cell lineages.
39 erentiation from the mesothelium and related cell lineages.
40 n vitro, generating both ciliated and goblet cell lineages.
41 gregating the parental genomes into distinct cell lineages.
42 ed into frog embryos, cause CFAs in the same cell lineages.
43 and impaired development of virtually all T-cell lineages.
44 plasticity toward three different glomerular cell lineages.
45 otipotent zygote into an embryo with defined cell lineages.
46 ffiliated functional features of host immune cell lineages.
47 plasmic reticulum (ER) in multiple secretory cell lineages.
48 afish to define erythroid, myeloid, B, and T cell lineages.
49 and efficiently stained MCF-7 breast cancer cell lineages.
50 any desired developmental stage in specific cell lineages.
51 of efficacy and contained all differentiated cell lineages.
52 s polysaccharide components in myeloid and B cell lineages.
53 stance in EGFR-dependent cancers of multiple cell lineages.
54 erentiation and function of other effector T cell lineages.
55 ot and coldspot motifs in the evolution of B-cell lineages.
56 can present alternative antigens to other T cell lineages.
57 function of both adaptive and innate immune cell lineages.
58 merged chromatin profiles from distinct stem cell lineages.
59 cibility and depicting interrelationships of cell lineages.
60 gy for in vivo tracing of stem or progenitor cell lineages.
61 h give rise to endothelial and hematopoietic cell lineages.
62 primary cells, and maintainable immortalised cell lineages.
63 es aegypti Aag2 cells - an immune responsive cell lineage - accumulates LDs when challenged with Ente
64 luripotency factors, increased expression of cell-lineage-affiliated developmental regulators, and in
65 ence and propagation of genetic variation in cell lineages after fertilization, is increasingly recog
67 al-computational platform for generic single-cell lineage analysis that is retrospective, cost-effect
69 DNA, thereby arresting development of the T-cell lineage and disrupting hematopoietic stem-cell migr
70 e differentiation of the ILC lineage and LTi cell lineage and establish a high-resolution 'blueprint'
71 technology provides more precise analysis of cell lineage and fate decisions and facilitates the in v
73 SCs can be differentiated into the male germ cell lineage and functional sperm that can be used in in
74 tant IDH1 contributes to malignancy in the T-cell lineage and may alter the metabolic profile of mali
75 Finally, differences in infection status, cell lineage and MHC class II expression by antigen-bear
76 ommitment of multipotent precursors to the T cell lineage and their subsequent maturation into alphab
77 s, hematopoietic progenitors commit to the T cell lineage and undergo sequential differentiation to g
78 ell ablation is a powerful tool for studying cell lineage and/or function; however, current cell-abla
80 y excess accumulation of one or more myeloid cell lineages and a tendency to transform to acute myelo
83 nic histories select evolutionary paths of B cell lineages and determine the predominant mode of anti
84 complex mixtures of cancer cells by tracing cell lineages and discovering cryptic genetic variations
86 e (Zea mays) that includes several different cell lineages and present whole-genome replication timin
87 provide insights into early human embryonic cell lineages and their contributions to adult tissues.
88 rventions that target specific cancer stroma cell lineages and their interactions are being sought.
90 inal center B-cell responses to favor bNAb B-cell lineages and to foster their maturation to full neu
91 grated RACE with our framework for automated cell lineaging and performed joint segmentation and cell
92 s sufficient to induce expansion of the tuft cell lineage, and ectopic stimulation of this signalling
93 tial for the genesis and maturation of the T cell lineage, and GATA3 dysregulation has pathological c
94 only detectable cells that label with Hoxb8 cell lineage appear to be microglia, we suggested that d
95 f Tregs and that NRF2 activation in multiple cell lineages appears to be required for sufficient anti
100 cal view of hematopoiesis, the various blood cell lineages arise via a hierarchical scheme starting w
101 c progenitor cells toward alpha- and epsilon-cell lineages at the expense of beta-cell formation.
102 anscription factor required to specify the B-cell lineage, bound to and regulated the expression of 1
103 ough the HR inhibits ETP maturation to the T cell lineage but enacts commitment toward the myeloid ce
105 s (iPSCs) efficiently generate all embryonic cell lineages but rarely generate extraembryonic cell ty
106 imprinting is largely lost in the embryonic cell lineage, but at least five genes maintain their imp
107 is essential for the maintenance of the Th17 cell lineage, but not immunopathology during experimenta
108 entiation of multiple innate and innate-like cell lineages, but how Zbtb16 itself is regulated remain
109 mpetence for other fates and commit to the T cell lineage by turning on Bcl11b, which encodes a trans
111 the feminization of the testis somatic stem cell lineage caused by loss of chinmo is enhanced by exp
112 on of BRAF(V600E) in the haematopoietic stem cell lineage causes leukaemic and tumoural diseases but
113 expression frequency was a function of the T cell lineage (CD8 > CD4) and a function of the memory di
117 vestigators highlights the importance of the cell lineage-chromatin modification interaction in deter
118 ficient stem cells may interfere with normal cell lineage commitment and cause the accumulation of un
120 of transcription 5) signaling to regulate T cell lineage commitment and SRC family kinase LCK and ST
121 ized role for Car enzymes in regulating mast cell lineage commitment and suggest that Car enzyme inhi
122 rly understood, especially since efficient T-cell lineage commitment requires a reduction in Notch si
123 GATA3, in contrast to TCF1, controls human T-cell lineage commitment through direct regulation of thr
124 ic process orchestrated by exquisitely timed cell lineage commitment, divisions, migration, and morph
130 cross-reactive primary virus neutralizing B cell lineages could be elicited by vaccination as detect
131 a powerful new methodology to predict single cell lineage decisions by integrating high content super
132 nd multilineage differentiation are distinct cell lineage decisions that are both controlled by HSC n
133 ar emphasis has been placed on SOX9 roles in cell lineage determination in a number of discrete tissu
134 an elaborate developmental program involving cell lineage determination, morphogenesis, and dynamic s
135 lthough it is well established that unique B-cell lineages develop through distinct regulatory mechan
136 lecular pathways governing the hemangiogenic cell lineage development.How haematopoietic and endothel
137 tores data from recent systematic studies of cell lineage differentiation in the C. elegans embryo co
138 e present Digital Development, a database of cell lineage differentiation with curated phenotypes, ce
142 /-) mice lacking PTP1B in the innate myeloid cell lineage displayed a dysregulation of bone marrow ce
143 el and independent bifunctional regulatory T cell lineage distinct from cTregs, Treg17 cells, and Th1
145 xample of how microenvironmental factors and cell lineage drive the generation of regulatory alphavbe
147 egate entire parental genomes into different cell lineages during the first post-zygotic cleavage div
148 lineages, including blood and blood-related cell lineages, during developmental and adult stages of
149 ll specificities differentiate into the Treg cell lineage; dysregulation of this process results in t
150 us, SOX2 is a master regulator of the acinar cell lineage essential to the establishment of a functio
151 therefore expected to evolve only when the B cell lineage evolving breadth is consistently capturing
152 ase activity are required in the muscle stem cell lineage for muscle regeneration in response to inju
155 gesting that they are potentially a distinct cell lineage from Th17 cells under in vitro culture cond
156 analysis promote the generation of specific cell lineages from NSCs in vivo, during postnatal life a
157 ssor (VHL) protein in the forkhead box FOXD1 cell lineage, from which stromal progenitors arise.
159 neage specification during which the first T-cell lineage genes are expressed and myeloid and dendrit
160 thylation affects the expression of nearby B-cell lineage genes by impairing enhancer activity, thus
161 epression of NK-cell fate, upregulation of T-cell lineage genes to promote further differentiation an
162 Hierarchical clustering using pancreatic cell lineage genes was used to assign cells into cell-ty
163 Many multicellular organisms produce two cell lineages: germ cells, whose descendants produce the
164 on of complex molecular programs in specific cell lineages governs mammalian heart development, from
167 e self-renewal and differentiation of a stem cell lineage have been extensively studied, it remains p
168 s from indirect observations, often when the cell lineages have been subject to rigorous selective pr
169 us infection and systemic diseases such as B-cell lineage hematologic malignancies and connective tis
170 out functional contributions made by Blimp1+ cell lineages here we perform the first single-cell RNA-
171 Yet, the lack of genetic tools to evaluate B-cell lineages hinders potential use of this unique non-h
172 nships between genes specific to a tissue or cell lineage, identify the changing roles of genes acros
174 ells and to both supporting and interstitial cell lineages, implying that cells in the CE domain are
175 he block in positive selection into the iNKT cell lineage in CD4-cre NKAP conditional knockout mice.
177 can be used to generate large-scale maps of cell lineage in multicellular systems for normal develop
178 ch ligands Jagged1b and Jagged2b induce duct cell lineage in the liver and pancreas of the zebrafish.
180 e different regulatory programs in alternate cell lineages in ACC, cooperating with TP63 in myoepithe
181 w the progress to date in elucidating bnAb B cell lineages in HIV-1 infection, discuss new research l
183 ents that lead to the establishment of three cell lineages in the blastocyst: trophectoderm, primitiv
187 primarily into endothelial and smooth muscle cell lineages in vitro, and contribute extensively to co
188 at later developmental stage in the Schwann cell lineage, in addition to biallelic Nf2 gene inactiva
189 n the ability to differentiate down multiple cell lineages including chondrocytes, adipocytes, osteob
191 nt, the lung mesoderm generates a variety of cell lineages, including airway and vascular smooth musc
192 and encode proteins involved in a variety of cell lineages, including blood and blood-related cell li
193 re differentiation of TGF-beta1-dependent Th cell lineages, including Th17, Th9, and induced regulato
199 ferentiation of hPSCs to clinically relevant cell lineages is needed to achieve the goal of hPSC-base
200 required for differentiation of other blood cell lineages, its function during granulopoiesis has re
201 pite widespread Shox2 expression in multiple cell lineages, lack of the stylopod observed upon Shox2
202 with a specific deletion of NKAP in the iNKT cell lineage, leading to severe reductions in thymic and
203 Deletion of Kdm6a in the mammary luminal cell lineage led to a paucity of luminal cells and an ex
204 profound upregulation of markers of non-mast cell lineages, loss of proliferative control, chromatin
205 stood how tissues that contain multiple stem cell lineages maintain balanced proliferation among dist
207 dent bispecific antibody (TDB) targets the B cell lineage marker FcRH5 expressed in multiple myeloma
211 The final stages of restriction to the T cell lineage occur in the thymus after the entry of thym
212 enew indefinitely and differentiate into all cell lineages of an organism, pluripotent stem cells (PS
213 iruses have been reported to infect multiple cell lineages of hematopoietic origin, including all phe
214 s our current understanding of the different cell lineages of the adult mammalian lung and their resp
216 are human conditions in which one or several cell lineages of the hemopoietic system are affected.
219 tency, based on their capacity to test donor cell lineage potential in the context of an organized, n
221 lated in M. leprae-infected human macrophage cell lineages, primary monocytes, and skin lesion specim
226 onal method for the statistical inference of cell lineage relationships from single-cell gene express
227 e lung at E16.5 to identify lung mesenchymal cell lineage relationships that currently remain poorly
228 HSCs), which sustain production of all blood cell lineages, rely on glycolysis for ATP production, ye
229 ins in regulating CNS structure and ensuring cell lineages remain fixed in place have not been uncove
231 cause some genetic disorders affect distinct cell lineages, researchers are utilizing HSC gene transf
232 /invertible genetic strategy to identify the cell lineage(s) responsible for the development of heart
234 ell-intrinsic factor that controlled an iNKT-cell lineage-specific gene-expression program and epigen
238 acted in ETPs to establish and maintain a T-cell-lineage-specific enhancer repertoire, including reg
239 adigm in which de novo methylation creates a cell-lineage-specific epigenetic signature that controls
243 her, Lhx6 and -8 are important regulators of cell lineage specification and may act as one of the piv
244 report that the Hippo pathway controls liver cell lineage specification and proliferation separately
246 ndent Treg-SE activation is crucial for Treg cell lineage specification in the thymus and that its pe
247 the NFI proteins may play distinct roles in cell lineage specification or maintenance, and establish
249 regulation of gene expression is central for cell-lineage specification during embryonic development
250 2R results in reduced expression of the Treg cell lineage-specification factor Foxp3, which has confo
251 y which cell-ECM interactions determine stem cell lineage specificity and offer additional molecular
252 terstitial cells eventually develop into two cell lineages: steroid-producing fetal Leydig cells and
253 functional attributes characteristic of this cell lineage, suggesting a lymphatic endothelial cell of
254 e conclude that targeting ACAT1 in a myeloid cell lineage suppresses atherosclerosis progression whil
255 ate to perform flow cytometric analyses on T cell lineage, T cell activation and inhibitory receptor
257 we show in the Drosophila male germline stem cell lineage that a spermatocyte-specific zinc finger pr
258 hat TLR10 has a functional role within the B cell lineage that is distinct from that of other TLR fam
259 iple transposition bursts in a given somatic cell lineage that later contributes to differentiation o
261 Clonally transmissible cancers are somatic cell lineages that are spread between individuals via th
263 permatogenesis is a classic model of cycling cell lineages that depend on a balance between stem cell
264 in differentiation of intestinal epithelial cell lineages that may influence the levels of released
266 ing pharmacogenomics to focus on neural stem cell lineage, they identified specific compounds that ca
268 egeneration through the reprogramming of one cell lineage to another occurs in fish and amphibians, i
270 Using these recordings we are able to track cell lineages, to generate fate maps of the blastema and
273 he luminal and basal pathways, together with cell lineage tracing studies, postulates the origin of m
274 re at the Ins2 locus and demonstrated with a cell lineage tracing study that the Ins2 gene is not tra
279 ort-wavelength cones in developing rods, and cell-lineage tracing validated the genesis of rods from
280 t the origin of melanoma, we combined single-cell lineage-tracing and transcriptomics approaches with
282 this Review, we discuss these techniques for cell lineage tracking, with attention both to those that
286 accomplishes this feat within the mature NK cell lineage via regulation of a subset of homing recept
287 human dermal fibroblasts towards the cardiac cell lineage via the induced expression of transcription
288 dh1 mutation as an oncogenic driver in the T-cell lineage, we crossed Idh1-KI mice with conditional T
290 d contribute progeny to all major pancreatic cell lineages, we also identify numerous unipotent endoc
291 rive cellular differentiation into secretory cell lineages, we show that although goblet cells resist
292 shape will strongly influence the fate of a cell lineage: we describe a mechanism through which cocc
295 ifferentiation towards the trophoblast giant cell lineage, whereas lack of Plet1 preferentially induc
296 ifferentiation of two distinct types of stem cell lineages, which opens new directions for understand
297 ells acquire phenotypic characteristics of a cell lineage whose survival no longer depends on the dru
298 nd mixoploidy are defined by the presence of cell lineages with different parental genomes or differe
299 classify these leukemias into either B or T-cell lineages with the high-risk early T-cell precursor
300 g CRISPR/Cas, we genetically labelled unique cell lineages within the developing axolotl embryo and t
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