ライフサイエンスコーパス: cell polarity

1 Biologists workshop to discuss 'Coordinating Cell Polarity'.

2 velopment and across the metazoa to regulate cell polarity.

3 anied by reduced filamentation or defects in cell polarity.

4 t cell types and regulate various aspects of cell polarity.

5 his cavitation process along with changes in cell polarity.

6 egional polarity is not controlled by tissue cell polarity.

7 , affect microtubule dynamics and interphase cell polarity.

8 a novel role of PHLPP in regulating aPKC and cell polarity.

9 stochastic model of spontaneous emergence of cell polarity.

10 s directed cell migration and causes loss of cell polarity.

11 n and subsequent collagen remodeling but not cell polarity.

12 ved in cell proliferation, cell motility and cell polarity.

13 microvilli density and maintenance of apical cell polarity.

14 ric intracellular complexes that couple cell-cell polarity.

15 cascade that regulates the establishment of cell polarity.

16 stablishment and maintenance of apical-basal cell polarity.

17 fficient spindle formation, orientation, and cell polarity.

18 s the regulation of energetic metabolism and cell polarity.

19 he apical surface, thereby generating arcade cell polarity.

20 on for polyQ-driven assemblies in regulating cell polarity.

21 mechanisms involved in regulating bacterial cell polarity.

22 RIB) plays an evolutionary conserved role in cell polarity.

23 oliferation, organ size, cell migration, and cell polarity.

24 lopment, generation of cortical F-actin, and cell polarity.

25 disk-shaped cells exhibiting a novel radial cell polarity.

26 in long-term HSC frequency and loss of stem cell polarity.

27 ns and regulates establishment of epithelial cell polarity.

28 in these various systems achieve coordinated cell polarity.

29 ility, with concomitant effect on epithelial cell polarity.

30 sms depends on the spatiotemporal control of cell polarity.

31 polarized coordinately and display a planar cell polarity.

32 ortant role in the maintenance of epithelial cell polarity.

33 NMIIB-rich stress fibers, thus strengthening cell polarity.

34 icated to be important for cell division and cell polarity.

35 y distributed ZO-1 mRNA leads to the loss of cell polarity.

36 ator of eukaryotic cellular organization and cell polarity [1].

37 roughout the subpallium, consistent with the cell polarity abnormalities we observed in vitro.

38 n 3D cell culture revealed morphogenetic and cell polarity abnormalities.

39 rumental in identifying common principles of cell polarity across diverse systems.

40 which the mutual interdependence of Cdx2 and cell polarity affects the cytoskeleton-dependent positio

41 expression and is associated with a loss of cell polarity, an increase in invasiveness, and an incre

42 ent, decreased HSC frequency, increased stem cell polarity and a restored balance of lymphoid and mye

43 served Ski2-family helicase, is required for cell polarity and adherens junction organization in the

44 Contractile forces are implicated in cell polarity and asymmetric division, but their contrib

45 an epithelial tight junctions and preserving cell polarity and barrier function in the face of energe

46 cient mouse embryos displayed defects in BCT cell polarity and basement membrane integrity at the cho

47 Both cell polarity and c-Jun N-terminal kinase (JNK) activity

48 e physical and functional connection between cell polarity and cell-cell adhesion machineries in mamm

49 n function in different settings to regulate cell polarity and cellular signaling.

50 trategy and has uncovered four new potential cell polarity and colorectal tumor suppressor genes (RAS

51 Additional Kin1 substrates for cell polarity and cytokinesis (Tea4, Mod5, Cdc15, and Cy

52 Kin1 regulates cell polarity and cytokinesis through unknown mechanisms

53 chanistic connection with Pom1 signaling for cell polarity and cytokinesis.

54 stream regulator of chemoattractant-mediated cell polarity and cytoskeletal reorganization functionin

55 Thus, CDC42 loss suppresses AML cell polarity and division asymmetry, and CDC42 constitu

56 Maintenance of epithelial cell polarity and epithelial barrier relies on the spati

57 ve 1 (Par1) proteins have been implicated in cell polarity and epithelial morphogenesis; however, the

58 tyrosine kinase (RTK) activity can modulate cell polarity and establish phototaxis in fibroblasts.

59 Kin kinases in the UPR beyond their role in cell polarity and exocytosis.

60 ventricular cardiomyocytes due to disrupted cell polarity and extrusion from the heart tube.

61 tribute to multiprotein complexes that drive cell polarity and fate in invertebrates.

62 importance of KISC for the establishment of cell polarity and for plant development.

63 diated Cdc42 activation in the regulation of cell polarity and force anisotropy that drives CCM.

64 receptor cells and NHE8 is important for RPE cell polarity and function.

65 ssential for the establishment of epithelial cell polarity and functional maturation of alveolar cell

66 are important for centrosome clustering and cell polarity and further suggest that disruption of int

67 ompromised LKB1 function affects lung cancer cell polarity and invasion.

68 e the established connection between loss-of-cell polarity and JNK activation, much less is known abo

69 The Rho-family GTPase Cdc42 regulates cell polarity and localizes to the cell division site.

70 Integrin beta3 regulates cell polarity and migration when localized appropriately

71 on, we are able to monitor the initiation of cell polarity and migration with a remarkable reproducib

72 extracellular matrix plays a crucial role in cell polarity and migration.

73 metric protein localization is essential for cell polarity and migration.

74 ss response and adaptation, cell signalling, cell polarity and morphology, vacuole trafficking, trans

75 LD2 and mTORC2) feedback loops in organizing cell polarity and motility-the indirect loop is better s

76 PIP3 and are defective in the initiation of cell polarity and motility.

77 n in part by suppressing anterior/animalward cell polarity and movement.

78 , which is required for the establishment of cell polarity and normal subcellular organization.

79 ngate, and endoderm organization, ectodermal cell polarity and patterning along the oral-aboral axis

80 usion injury causes loss of renal epithelial cell polarity and perturbations in tubular solute and fl

81 ng as a key regulator of Cdx2 transcription, cell polarity and position-dependent HIPPO signaling.

82 in discs large homolog 5 (DLG5) functions in cell polarity and regulates cellular proliferation and d

83 inase) family members determines proper beta cell polarity and restricts beta cell size, total beta c

84 a known microtubule-binding protein, control cell polarity and spindle orientation of NBs.

85 se RHO GTPASE OF PLANTS (ROP) promote mother cell polarity and subsequent division asymmetry in devel

86 In neurons, it is involved in the control of cell polarity and synaptic plasticity and is locally and

87 rgence seems to involve genes with a role in cell polarity and that likely function in the maintenanc

88 ancient role for brachyury in morphogenesis, cell polarity and the patterning of both ectodermal and

89 lar functions including the establishment of cell polarity and the remodeling of the actin cytoskelet

90 here it helps to establish proper epithelial cell polarity and tissue homeostasis during lactation.

91 ithelial cells employ mechanisms to preserve cell polarity and tissue integrity.

92 asolateral proteins had different effects on cell polarity and tissue size.

93 w C. difficile infection is affected by host cell polarity and whether TcdA and TcdB contribute to su

94 hat these defects might arise due to altered cell polarity and/or changes in cell proliferation/diffe

95 cell machineries, such as cell-cell contact, cell polarity, and actin cytoskeleton, as well as a wide

96 cluding enhanced F-actin assembly, disturbed cell polarity, and increased cell motility.

97 vement is critical for developmental events, cell polarity, and migration and is usually mediated by

98 While cell polarity appears normal, and chromosome and furrow

99 characterized proteins that are required for cell polarity are needed for actin assembly or activatio

100 the downstream signaling events that promote cell polarity are not well understood.

101 PRICKLE2 distribution reveals the planar cell polarity axis in the underlying epithelium is organ

102 The Frz chemosensory pathway regulates the cell polarity axis through MglA, a Ras family GTPase; ho

103 We show that tissue cell polarity, based on localization of the auxin transp

104 ns of Par3/Bazooka suggest a self-organized, cell polarity-based origin for the variability of append

105 escue experiments using Pard6b mRNA restored cell polarity but only partially corrected position-depe

106 PKC) isozymes modulate insulin signaling and cell polarity, but how their activity is controlled in c

107 uronal membrane/lipid rafts (MLRs) establish cell polarity by clustering progrowth receptors and teth

108 MLCK activity influences cell polarity by increasing myosin accumulation in lamel

109 We found that Ssp1 promotes cell polarity by phosphorylating the activation loop of

110 ling pathway that controls growth and planar cell polarity by regulating the membrane localization of

111 ar processes, including the establishment of cell polarity, cell migration, tissue integrity, and mor

112 biased localization and function within the cell, polarity complex proteins are necessary to establi

113 Adherens junctions (AJs) and cell polarity complexes are key players in the establish

114 e, genetically separable inputs from AJs and cell polarity complexes into Yki/YAP regulation.

115 cell growth, providing a novel mechanism of cell polarity control apart from the one involving prote

116 s depends on formation of epidermal sites of cell polarity convergence with high intracellular auxin

117 We propose that aspects of host cell polarity create a more efficient budding process at

118 conserved signaling pathways that translate cell polarity cues into mitotic spindle positioning to c

119 aPKC-mediated overgrowth but did not restore cell polarity defects, indicating that the two are separ

120 d other ciliopathies may in part result from cell polarity defects.

121 ng protein known primarily for its role as a cell polarity determinant, orchestrates the intracellula

122 The inhibition of protrusive activity and cell polarity disables confinement-dependent cell scatte

123 red downregulation of PARD6B, loss of apical cell polarity, disorganization of F-actin, and activatio

124 Active Cdc42 GTPase, a key regulator of cell polarity, displays oscillatory dynamics that are an

125 troys contact inhibition potentially through cell polarity disruption, and results in increased tumor

126 anar polarity pathway coordinates epithelial cell polarity during animal development, and loss of its

127 egulation of cell differentiation and planar cell polarity during development.

128 formins, mediate intracellular transport for cell polarity establishment and maintenance.

129 s are implicated in focal adhesion turnover, cell polarity establishment, and migration, illustrating

130 for generation of convergence sites is that cell polarity for the auxin transporter PIN1 orients up

131 roles (promoting cell survival and altering cell polarity) for genetic alterations of CTCF in endome

132 gene, the human homologue of the Drosophila cell polarity gene dachsous (ds), that segregates with M

133 not basolateral, recycling, implicating this cell polarity gene in assembly or maintenance of the api

134 an in vivo invasion model via knocking down cell polarity gene in Drosophila wing discs, and identif

135 fl)), a mammalian ortholog of the Drosophila cell polarity gene lgl, exhibit MCCs resembling severe p

136 based matrix, epithelial cilia or the planar cell polarity genes Vangl2 and Ptk7 In wild-type mice, c

137 bules are known to play an important role in cell polarity; however, the mechanism remains unclear.

138 tic effects through interplay between tissue cell polarity, identity, and growth.

139 n in amphibians and zebrafish by controlling cell polarity in a cell contact-dependent manner.

140 Establishment of cell polarity in animal and fungal cells involves locali

141 lates microtubule-dependent establishment of cell polarity in Arabidopsis.

142 ught that microtubules are not essential for cell polarity in asymmetrically dividing Drosophila mela

143 ulator of toll-like receptor 4 responses and cell polarity in biliary epithelial cells; this mechanis

144 y important roles in vesicle trafficking and cell polarity in eukaryotic cells.

145 or aPKC, but not Aurora kinases, can restore cell polarity in lgl mutants but reveals defects in mito

146 oid reveals that vinculin knockdown disrupts cell polarity in microtracks.

147 We show that MLL-AF9 leukemia cells maintain cell polarity in the context of elevated Cdc42-guanosine

148 f the mitotic spindle and maintaining proper cell polarity in the ductal epithelium was discovered.

149 Establishment of cell polarity in the mammalian embryo is fundamental for

150 mbryo.The molecular trigger that establishes cell polarity in the mammalian embryo is unclear.

151 Mutant gonads showed a loss of cell polarity in the surface epithelial layers, large in

152 l information is an important contributor to cell polarity in uni- and multicellular systems [1-3].

153 gnized as fundamental signaling switches for cell polarity in various cellular and developmental proc

154 in vitro and cannot be explained by altered cell polarity, increased beta cell number, or increased

155 pathway, promoting cell invasion, a loss of cell polarity, increased cell survival, and other hallma

156 ut the molecular mechanism by which aberrant cell polarity induces JNK-mediated cell migration and tu

157 enesis potentially through the regulation of cell polarity integrity.

158 enetic analysis of proteins linked to planar cell polarity (Inturned, Fuzzy and Wdpcp), we identified

159 Although disruption of cell polarity is a prerequisite in epithelial tumor init

160 Cell polarity is characterized by the asymmetric distrib

161 rates stable force-independent FAs, although cell polarity is compromised.

162 e myosin II (NMII)-B in front-back migratory cell polarity is controlled by a short stretch of amino

163 Dynamic maintenance of cell polarity is essential for development and physiolog

164 The generation of cell polarity is essential for the development of multi-

165 Cell polarity is essential for various cellular function

166 in Nematostella embryos, we demonstrate that cell polarity is established by the four-cell stage and

167 For motility, a leading-lagging cell polarity is established that is inverted during cel

168 Establishment of cell polarity is important for epithelial lumen formatio

169 sly normal in the cochlea, indicating planar cell polarity is not markedly affected.

170 Instead, cell polarity is overseen by the kinase-independent func

171 Cell polarity is regulated by highly conserved cell pola

172 essary for invadopodia formation, as well as cell polarity, lamellipodial assembly, membrane ruffling

173 In migrating cells, CARMIL2 is important for cell polarity, lamellipodial assembly, ruffling, and mac

174 provides a novel mechanistic insight on how cell polarity loss contributes to cell invasion, but als

175 s coordinate cell division and contribute to cell polarity maintenance and membrane remodeling.

176 RB control of cell polarity may be an evolutionarily conserved functio

177 foundation for understanding how the correct cell polarity may be recognized by the cell to ensure pr

178 llular signals, including cell-cell contact, cell polarity, mechanical cues, ligands of G-protein-cou

179 We study the effect of various cell polarity mechanisms on rotational motion, including

180 n angiomotin (Amot), known to be involved in cell polarity, migration, and Hippo pathway, as a compon

181 s robust to relatively high levels of planar cell polarity misalignment and to the presence of non-ac

182 the growing pollen tube, a well-established cell polarity model system, and performed large-scale ex

183 protein kinases that function within complex cell polarity networks are poorly understood.

184 Cell polarity, often associated with polarized cell expa

185 s that choreograph downstream processes like cell polarity or cell division.

186 Here we show that the Dchs1-Fat4 planar cell polarity pathway controls cell orientation in the e

187 lar control via the non-canonical Wnt/planar cell polarity pathway, Shh/BMP signalling, and the trans

188 ng novel and unexpected functions for planar cell polarity pathways in HSC fate.

189 s not by signalingviathe WNT/Ca(2+)or planar cell polarity pathways, but rather by inhibiting the can

190 the highly conserved apical-basal and planar cell polarity pathways, suggesting a possible regulatory

191 We find that in the shoot, cell polarity patterns follow MP expression, which in tu

192 nalling has been proposed to regulate planar cell polarity (PCP) and activity of the Hippo effectors

193 strate that several components of the planar cell polarity (PCP) arm of non-canonical Wnt signaling i

194 The absence of planar cell polarity (PCP) core proteins Prickle1 and Prickle2

195 h1) in epithelial cell patterning and planar cell polarity (PCP) in Drosophila.

196 sous (Ds) have been found to underlie planar cell polarity (PCP) in many tissues.

197 rry night (fz/stan) pathway regulates planar cell polarity (PCP) in vertebrates and invertebrates.

198 Planar cell polarity (PCP) is a ubiquitous property of animal t

199 dividing cells of the mammalian skin, planar cell polarity (PCP) is maintained through the bulk inter

200 A key step in generating planar cell polarity (PCP) is the formation of restricted junct

201 organ to exhibit a particular form of planar cell polarity (PCP) necessary for mechanotransduction.

202 n is the rotational and translational planar cell polarity (PCP) of E1 cells.

203 e divisions, and the re-expression of planar cell polarity (PCP) pathway components.

204 The planar cell polarity (PCP) pathway is best known for its role i

205 Recent studies established that the planar cell polarity (PCP) pathway is critical for various aspe

206 The evolutionarily conserved planar cell polarity (PCP) pathway regulates CE, and Wnts regul

207 r3 and Vangl2, core components of the planar cell polarity (PCP) pathway, are localized at developing

208 The Wnt planar cell polarity (PCP) pathway, through the recruitment of

209 ericytes for abnormalities in the Wnt/planar cell polarity (PCP) pathway, which has been shown to reg

210 lanar axis specified by the conserved planar cell polarity (PCP) pathway.

211 hereupon cell division, transmembrane planar cell polarity (PCP) proteins are removed from the cell s

212 Core planar cell polarity (PCP) proteins are well known to regulate

213 The core planar cell polarity (PCP) proteins coordinate the orientations

214 Asymmetric localization of planar cell polarity (PCP) proteins is essential for tissue int

215 Planar cell polarity (PCP) refers to the collective alignment o

216 Core planar cell polarity (PCP) signaling controls OCD and CE in oth

217 Wnt-Frizzled/planar cell polarity (PCP) signaling establishes cell orientati

218 ignaling pathways and the role of Wnt/Planar cell polarity (PCP) signaling in adult neurogenesis rema

219 Planar cell polarity (PCP) signaling is essential for mediolate

220 This regulatory link between Shh and planar cell polarity (PCP) signaling may also occur in other de

221 Much of the Hippo and planar cell polarity (PCP) signaling mediated by the Drosophila

222 Here we provide evidence that planar cell polarity (PCP) signaling orchestrates directed epit

223 Planar cell polarity (PCP) signaling orients developmental even

224 The planar cell polarity (PCP) signaling pathway is crucial for tis

225 E) defects, arising from impaired Wnt/planar cell polarity (PCP) signaling.

226 n-canonical pathways, WNT5A activates planar cell polarity (PCP) signaling.

227 Planar cell polarity (PCP) signalling is a well-conserved devel

228 SP was dependent on components of the planar cell polarity (PCP) system in the disc, and neither Dpp-

229 iology of tissues and organs requires planar cell polarity (PCP) systems that orient and coordinate c

230 lls across the tissue plane, known as planar cell polarity (PCP), is manifested by the segregation of

231 Planar cell polarity (PCP), the coordinated and consistent orie

232 exists, and sometimes intersects with planar cell polarity (PCP), which orients cells in the epitheli

233 The Ciona notochord displays planar cell polarity (PCP), with anterior localization of Prick

234 osette dynamics are regulated by both planar cell polarity (PCP)-dependent and -independent pathways.

235 been implicated in the generation of planar cell polarity (PCP).

236 lly in flies to coordinate epithelial planar cell polarity (PCP).

237 anonical and noncanonical (Ca(2+) and planar cell polarity [PCP]) Wnt pathways, including IWP-2, whic

238 We propose that, in addition to cell polarity, PCP components control basal body organiz

239 tyrosine kinase receptor involved in planar cell polarity, plays a role in epithelial Wnt signaling;

240 m1 mouse mutants originate from defective LE cell polarity, proliferation and cell adhesion.

241 ll polarity is regulated by highly conserved cell polarity protein complexes such as the Par3-aPKC-Pa

242 nctional interaction of VE-cadherin with the cell polarity protein Pals1.

243 0c further targets and suppresses PKCzeta, a cell polarity protein that has a pivotal role in directi

244 ow and exhibit high expression of the planar cell polarity protein VANGL2.

245 hese data reveal a direct connection between cell polarity proteins and Hippo, which is essential for

246 Cell polarity proteins control cellular and tissue organ

247 While it is well known that cell polarity proteins govern the formation of AJCs, the

248 ediated through its interaction with the two cell polarity proteins Pals1 and Par3.

249 epithelial architecture with proliferation, cell polarity proteins undergo extensive remodeling duri

250 d cancer; however, the mechanisms connecting cell polarity proteins with intracellular signaling path

251 nd the trophectoderm, a process regulated by cell polarity proteins, HIPPO signaling and lineage-spec

252 In plants, cell polarity (re)establishment is intimately linked to

253 Cell polarity refers to a functional spatial organizatio

254 gs define PARD3 as a recurrently inactivated cell polarity regulator in LSCC that affects tumor aggre

255 ere, we investigated the contribution of the cell polarity regulator PARD3 to the development of lung

256 h downregulation of the tumor suppressor and cell polarity regulator, PARD3, reduced the CFD, in agre

257 between developmental timing regulators and cell polarity regulators could underlie transitions betw

258 hering complex exocyst is one of the crucial cell polarity regulators.

259 In planar tissues like the Drosophila wing, cell polarity reorients during growth as cells divide an

260 we showed Hug mutant cells cannot establish cell polarity required for directional cell migration.

261 Development of cell polarity requires apical trafficking of podocalyxin

262 The latter - planar cell polarity - requires long-range regulation of orient

263 s of actin organization in determining plant cell polarity, shape and plant growth.

264 d organelles and controls dynamic changes in cell polarity, shape, and movement.

265 play critical roles in vesicular transport, cell polarity, signal transduction, and neurologic devel

266 First, PAPC attenuates planar cell polarity signaling at the ectoderm-mesoderm boundar

267 phosphorylation and is antagonized by planar cell polarity signaling components Van Gogh (VANG-1) and

268 erturbation analyses demonstrate that planar cell polarity signaling enables cells to pivot in the di

269 Fat2/Lar signaling is similar to planar cell polarity signaling in terms of sub-cellular protein

270 r understand how Scribble PDZ domains direct cell polarity signaling, we investigated here their inte

271 lial migration, angiogenesis, cell adhesion, cell polarity, spermatogenesis, and metastasis.

272 wnstream effector of Bcl11a required for the cell polarity switch and for the migration of upper laye

273 mutants, and the PCM-dependent induction of cell polarity that defines the anterior-posterior body a

274 e is a highly conserved protein regulator of cell polarity that has been demonstrated to function as

275 As a central regulator of cell polarity, the activity of CDC42 GTPase is tightly c

276 ilamentous growth, which involves changes in cell polarity through mechanisms that remain obscure.

277 Kif26b, together with Dvl3/Daam1, initiates cell polarity through the control of PCP signaling pathw

278 canonical Wnt-dependent regulation of planar cell polarity through the Formin homology protein Daam.

279 evolutionarily conserved regulator of planar cell polarity, tissue size and cell adhesion.

280 ack module represents a mechanism connecting cell polarity to fate differentiation during asymmetric

281 lls; these processes range from establishing cell polarity to powering cell migration to driving cyto

282 cell to morula transition TFAP2C potentiates cell polarity to suppress HIPPO signaling in the outside

283 se that Cki3 acts as a critical inhibitor of cell polarity transition under S-phase arrest.

284 portant molecular link that mediates loss-of-cell polarity-triggered JNK activation and cell invasion

285 Cell polarity underlies many aspects of metazoan develop

286 ects SoPIN1 patterns, suggesting that tissue cell polarity underpins oriented cell differentiation.

287 ovel MLCK-specific mechanism for controlling cell polarity via regulation of myosin activity in protr

288 g in a disorganized cytoskeleton and reduced cell polarity, which likely accounts for the dominant ge

289 al transition (EMT) and disrupted epithelial cell polarity, which was associated with altered express

290 PAR proteins coordinate the establishment of cell polarity with the physical process of cytokinesis d

291 lations through the continual realignment of cell polarity with the tissue axes.

292 al protein kinase C zeta, a mediator of stem cell polarity, with C5aR1 inhibition reducing proliferat

293 ling was shown to promote the maintenance of cell polarity, with exogenous C5a increasing the retenti

294 C5a was identified as a regulator of cell polarity, with inhibition of C5a receptors during e

295 Rho kinase, JNK and, to some extent, planar cell polarity within the epidermis.

296 ves early chondrogenesis is intact, and that cell polarity within the sclerotome is unperturbed.

297 The non-canonical Wnt/planar cell polarity (Wnt/PCP) pathway plays a crucial role in

298 The non-canonical WNT/planar cell polarity (WNT/PCP) pathway plays important roles in

299 precocious cell division before establishing cell polarity would lead to failure in ACD, these two pr

300 nesis (in particular the emergence of planar cell polarity), wound healing, and disease-progression p