ライフサイエンスコーパス: cell responsiveness

1 and number of mature B cells, and reduced B cell responsiveness.

2 o understanding the factors that determine T cell responsiveness.

3 growth factor bioavailability and/or Muller cell responsiveness.

4 abrogation of MDSC-mediated suppression of B-cell responsiveness.

5 may be important for regulating naive CD4 T cell responsiveness.

6 und to A2 cause large changes in AHIII12.2 T cell responsiveness.

7 uld be utilized as an additional marker of T cell responsiveness.

8 ynapse may contribute to the regulation of T cell responsiveness.

9 f a viral infection technique that preserves cell responsiveness.

10 egulation of this molecule in facilitating B cell responsiveness.

11 CTLA-4-B7 interactions restores memory CD4 T cell responsiveness.

12 rably in elucidating the mechanisms behind T cell responsiveness.

13 f mice and humans, is essential for normal B cell responsiveness.

14 ated mitomycin C-treated T cells to induce B cell responsiveness.

15 ddition of exogenous rIL-2 did not restore T cell responsiveness.

16 plex set of signals determines the fate of B cell responsiveness.

17 selection, and PTPN22-R620W alters mature T cell responsiveness.

18 ontributes to membrane fusion may modulate T-cell responsiveness.

19 receptors for MHC-I results in diminished NK cell responsiveness.

20 icense model for the reversible tuning of NK cell responsiveness.

21 ammed death-ligand 1 or 2, correlated with T cell responsiveness.

22 , resulting in ROS-mediated suppression of T-cell responsiveness.

23 cell IL-21 production and increased IL-21 B cell responsiveness.

24 th cognate peptide concentration on CD8(+) T cell responsiveness.

25 ures of TB-LM contribute to its diminished T cell responsiveness.

26 h a varying degree of correlation with the T-cell responsiveness.

27 "translate" BCR affinity for antigen into B cell responsiveness.

28 finities and rapid kinetics that determine T-cell responsiveness.

29 tion, indicating a central defect in early B cell responsiveness.

30 osphatase SHP-1 as a critical regulator of T cell responsiveness.

31 ic phosphatase 1 (SHP-1) digitally regulates cell responsiveness.

32 actions as the central parameter governing T cell responsiveness.

33 /-) mice was not caused by a deficiency in T cell responsiveness.

34 n is by maintaining and/or re-establishing T cell responsiveness.

35 lation between cancer clinical outcome and T-cell responsiveness after therapeutic vaccination in hum

36 ty of manipulating donor cells to maximize T cell responsiveness against lymphoma.

37 y genes in surrounding regions controlling B cell responsiveness and anergy induction.

38 e tumor, but reflected mutual paralysis of T-cell responsiveness and antigen processing by tumor cell

39 ying the differential regulation of memory T cell responsiveness and has clinical implications for va

40 ar basis for TbetaR-mediated inhibition of B cell responsiveness and indicate that TbetaR maintains h

41 t CD5-CK2 signaling sets the threshold for T cell responsiveness and is necessary for efficient gener

42 was associated with antigen-specific spleen cell responsiveness and markedly increased levels of IFN

43 m autoimmune disease by down-regulation of B-cell responsiveness and myeloid cell activation.

44 with decreased MSC retention, altered immune cell responsiveness and reduced vascularization in the h

45 mma production in HCV infection, and that NK cell responsiveness and refractoriness correlate to the

46 by which endothelial cells (EC) influence T cell responsiveness and that the Th-2 cytokine skewing s

47 I(T), plays a pivotal role in thalamic relay cell responsiveness and thus in the nature of the thalam

48 lular Asc redox state, which in turn affects cell responsiveness and tolerance to environmental ROS.

49 g the need to identify biomarkers for immune cell responsiveness and tumor susceptibility to be able

50 reased production of factors that suppress T cell responsiveness and underproduction of positive regu

51 ent for 8 wk to insulin sensitivity and beta cell responsiveness and whether effects of diet would va

52 Confirming the shift in B cell responsiveness, antigen-receptor-mediated activatio

53 uding the strong direct MDSC inhibition of B-cell responsiveness, are novel for murine retrovirus-ind

54 providing CD4(+) T cell help would improve T cell responsiveness as a function of effector T cell avi

55 stribution resulted in a global dampening of cell responsiveness, as illustrated by reduced ligand-me

56 topril did not directly affect Ag-specific T cell responsiveness because neither in vivo nor in vitro

57 Three weeks after the onset of egg laying, T-cell responsiveness began to increase and bacterial numb

58 atory T cells (Treg) and enhanced effector T-cell responsiveness, both associated with poorer outcome

59 signaling is a major determinant of CD8(+) T cell responsiveness, but the mechanisms underlying this

60 The inhibition of T-cell responsiveness by HCV core may have important impli

61 lative proportion to T cells, may suppress T-cell responsiveness by secretion of IL-10.

62 ber of CD14 monocytes in G-PBMCs may limit T-cell responsiveness by suppressing the induction of the

63 The fall in T-cell responsiveness coincided with the increase in numbe

64 sphingosine kinases are determinants of mast cell responsiveness, demonstrating a previously unrecogn

65 vide functional evidence for differential NK cell responsiveness depending on KIR/HLA genotype and ma

66 The effects of intestinal microbes on iNKT cell responsiveness did not require Toll-like receptor s

67 gically active, must function at a step in T cell responsiveness distinct from the acute production o

68 these data indicate that the decline in Th2 cell responsiveness during chronic schistosomiasis is th

69 have critical implications for sustaining T cell responsiveness during immunotherapy, as the develop

70 derived from studies on the regulation of T cell responsiveness during mammalian gestation are consi

71 Decreased T cell responsiveness during prolonged therapy was associa

72 V-1 infection demonstrated a reduction of NK cell responsiveness following stimulation with TLR ligan

73 that CD28 interaction with B7-2 regulates T cell responsiveness in anti-CD3-treated animals.

74 objective of this study was to measure beta-cell responsiveness in hypoglycaemic (H) fetal sheep and

75 Increased 1a-specific CD4 T-cell responsiveness in non-1a-infected patients was not

76 central B cell tolerance, whereas residual B cell responsiveness in patients with one, but not two, T

77 ced CALMODULIN: transcription and impaired T-cell responsiveness in RA.

78 re integrated to control natural killer (NK) cell responsiveness in the absence of antigen-specific r

79 ation, to what extent dietary lipids alter T cell responsiveness in the absence of obesity and inflam

80 with a lasting enhancement of HCV-specific T-cell responsiveness in the blood.

81 espite a documented decline in general CD8 T-cell responsiveness in the elderly, a subset of CD8 T ce

82 ance is the physiologic down-regulation of T cell responsiveness in the face of persistent antigenic

83 he endogenous peptide repertoire modulates T cell responsiveness in the thymus in order to enforce to

84 rone after HCG, confirm pituitary and Leydig cell responsiveness in these subjects.

85 The ability to modulate T-cell responsiveness in this manner may underlie the cont

86 Therefore, T cell responsiveness in tuberculoid leprosy may be mediat

87 eristic manifestations of impaired patient T-cell responsiveness in vitro.

88 hibitor, l-NMMA, restored antigen-specific T-cell responsiveness in vitro.

89 mmunization can therefore be used to probe T cell responsiveness in vivo and represents a tool to fur

90 Because its influence on CD8 T cell responsiveness in vivo is unknown, we investigated

91 sts a potential means of manipulating CD4+ T cell responsiveness in vivo.

92 study, we show in the murine system that NK cell responsiveness increases quantitatively with each a

93 liver does not significantly alter CD8(+) T cell responsiveness, indicating that CD103(+) DCs initia

94 roliferation suggests that the decrease in T cell responsiveness induced by rIL-16 may result from an

95 st cell activation, we examined whether mast cell responsiveness is altered in this model.

96 These findings suggest that NK cell responsiveness is comparable to a rheostat: it is t

97 sponsive to S1P gradients, suggesting that T cell responsiveness is regulated during their recirculat

98 To address whether NK cell responsiveness is set only during the NK cell diffe

99 of MAIDS-related pathology and maintained T-cell responsiveness longer than mice treated with contro

100 her alpha-MSH might similarly influence mast cell responsiveness, mast cells were examined to see if

101 iNKT cell responsiveness must be regulated to maintain effect

102 ations in cellular immune markers, and (4) T cell responsiveness of the host using one-way mixed lymp

103 roles in regulating monocytes and dendritic cells, responsiveness of these cells to IFNalpha/beta in

104 llular signalling is limited by the range of cell responsiveness, often mediated by repressors.

105 clonal deletion acquired peptide-specific T cell responsiveness only when the vector-encoded TCR tra

106 Estrogen did not affect mast cell responsiveness or anaphylaxis onset.

107 Importantly, MPA did not globally suppress B cell responsiveness or simply induce cell death, but rat

108 wild type, suggesting that, by decreasing T-cell responsiveness, p12(I) curtails viral expression.

109 e suppression of not only T-cell, but also B-cell, responsiveness paralleled the immunodeficiency dur

110 o, mainly due to the effect of TGF-beta on T cell responsiveness rather than DC stimulatory capabilit

111 -responsive and nonresponsive ovarian cancer cells (responsiveness refers to the IL-8 response).

112 A second infection to assess CD8+ T-cell responsiveness resulted in rapid suppression of HCV

113 ction to induce apoptosis and to dampen mast cell responsiveness, S1P functions as a chemoattractant

114 ion of an endogenous Ag, failed to restore T cell responsiveness specific for this Ag in the context

115 reased, or unmodified, but also increased, T cell responsiveness (superagonist ligands).

116 r, our results suggest that the defects in T cell responsiveness that occur subsequent to severe burn

117 d DNA methylation are key modulators of mast cell responsiveness to acute and chronic stimulation.

118 nted oral tolerance induction and restored T-cell responsiveness to Ag previously tolerized by oral a

119 s variant results in a profound deficit in T cell responsiveness to Ag stimulation.

120 ropriate alphabeta pairing confers optimal T cell responsiveness to Ag.

121 e dosage may regulate the extent of CD8(+) T cell responsiveness to Ag.

122 s of the anti-B7 antibodies in suppressing T cell responsiveness to alloantigen, their use does not r

123 ys an important role in primary and memory T cell responsiveness to allografts.

124 T cell responsiveness to an epitope is affected both by it

125 Our study is the first to show T cell responsiveness to an inner ear-specific protein in

126 togens and antigen also is regained, as is B-cell responsiveness to anti-IgM.

127 on, we found no evidence for alteration of T-cell responsiveness to antigen by the gag, pol, vif, tat

128 ay have substantial deleterious effects on B cell responsiveness to antigenic stimulation.

129 tion may be a critical variable in malignant cell responsiveness to antiproliferative therapy.

130 role of the Akt pathway in modulating tumor cell responsiveness to Apo2L/TRAIL, delineate molecular

131 Finally, IFN-I treatment increased B cell responsiveness to APRIL, a cytokine involved in B c

132 receptor expression by flow cytometry; for B cell responsiveness to BAFF by in vitro culture; for ser

133 he action of IFN-I, potentially increasing B cell responsiveness to cytokines.

134 teractions of BMP2 with HS and increased the cell responsiveness to endogenous and exogenous BMP prot

135 Thus, mucosal T cell responsiveness to environmental Ag is shaped in sit

136 BrCA cell responsiveness to exogenous Lcn2 was heightened in

137 but there was a persistent reduction of beta-cell responsiveness to glucose and arginine.

138 mechanistic basis for enhancing host defense cell responsiveness to GM-CSF at transendothelial migrat

139 is a central node in the tonic regulation of cell responsiveness to GPCR stimulation, acting both as

140 No effects on beta-cell responsiveness to hyperglycemia and GLP-1 infusion

141 Consistent with STAT's limiting cell responsiveness to IFN, we found that 5-Aza-CdR trea

142 We conclude that myeloma cell responsiveness to IFN-alpha is heterogeneous and th

143 neither CD4(+) T cell-produced TNF nor host cell responsiveness to IFN-gamma were necessary.

144 type II IFN (IFN-gamma), and reduced myeloid cell responsiveness to IFN-gamma.

145 mune response to tumors by inhibiting immune cell responsiveness to IFNs.

146 n of CD4(+) T-cell turnover and diminished T-cell responsiveness to IL-7 by IL-1beta and IL-6 exposur

147 increased IL-7 concentrations and enhanced T-cell responsiveness to IL-7 were observed throughout the

148 Importantly, Sle2 leads to a heightened B cell responsiveness to in vitro stimuli and to in vivo a

149 infection through modulation of the lymphoid cell responsiveness to infection, a condition that is cr

150 HHS), resulting in increased pancreatic beta-cell responsiveness to leucine and susceptibility to hyp

151 stem wherein cisplatin treatment has altered cell responsiveness to ligands of the erbB receptor fami

152 I MHC deprivation also enhanced naive CD8 T cell responsiveness to low-affinity (but not high-affini

153 fering with the expression of Bcl-3 restored cell responsiveness to LPS, thus confirming that CyPB ac

154 1/2(MAPK)) used as a prototypical marker for cell responsiveness to mechanical forces, Western blot a

155 psigargin-sensitive Ca(2+) stores as well as cell responsiveness to mitogens in terms of [Ca(2+)](i)

156 ld result in an enhancement of CA1 pyramidal cell responsiveness to nicotine.

157 These findings correlated with defective T-cell responsiveness to parasite stimulation in vivo and

158 ng alloreactivity while maintaining memory T-cell responsiveness to pathogens.

159 We show here that T cell responsiveness to peptide (termed "functional avidi

160 servations implicating impaired inflammatory cell responsiveness to PGE(2) as a pathogenetic mechanis

161 ting GLP-1 derivative, NN2211, restored beta-cell responsiveness to physiological hyperglycemia in ty

162 on of Raet1 on the lung epithelium primed NK cell responsiveness to poly(I:C), ssRNA40, or ODN1826 st

163 on defects, primarily due to reduced stromal cell responsiveness to progesterone.

164 late either the production of, or the target cell responsiveness to RANKL.

165 ease, we addressed the question of how CD8 T cell responsiveness to self-Ag is regulated during chron

166 Patients showed T cell responsiveness to snRNP polypeptides that parallele

167 re to Ag is correlated with a hierarchy of T cell responsiveness to Spry1.

168 pathways, and adaptor proteins governs mast cell responsiveness to stimuli.

169 tion of the CD3 complex leads to increased T cell responsiveness to TCR/CD3 stimulation and sets the

170 bility to inhibit colitis, suggesting that T cell responsiveness to TGF-beta is not required for the

171 peripheral tolerance affected both T- and B-cell responsiveness to the autoantigen.

172 Zeb1-dependent EMT enhances tumor cell responsiveness to the ECM composition and activates

173 Endothelial cell responsiveness to these pro-angiogenic BMP ligands

174 We investigated the mechanism for T cell responsiveness to this Ag according to the trimolec

175 ion and Treg depletion allowed recovery of T-cell responsiveness to this cytokine.

176 nds are known to activate APCs, but direct T cell responsiveness to TLR ligands is controversial.

177 To assess B-cell responsiveness to TLR9 agonists in human immunodefi

178 ing this threshold confers enhanced CD8(+) T cell responsiveness to tumor.

179 tion of VEGFR-3, Notch increased endothelial cell responsiveness to VEGF-C, promoting endothelial cel

180 xpression of C3aR or C5aR influences (1) the cells' responsiveness to intradermal injections of C3a o

181 The Kit(low)Cd44(+)Cd34(+) cells' responsiveness to Kit activation and blockade was

182 In other cells, responsiveness to microbial products requires exp

183 maintain the default potential to regulate T cell responsiveness via IDO.

184 Enhanced T-cell responsiveness was also observed upon immunization

185 Although originating in the spleen, T cell responsiveness was found to spread immediately and

186 ditionally, this ability of Eos to enhance B cell responsiveness was observed in both T-independent a

187 The 74-96-specific T cell responsiveness was revealed in the wild-type (V bet

188 cytokine IL-12 could account for enhanced T cell responsiveness, we investigated whether paclitaxel

189 Insulin sensitivity and beta cell responsiveness were assessed at baseline and 8 wk b

190 ct in concert to limit the magnitude of mast cell responsiveness when antigen is encountered.

191 for 8 wk resulted in down-regulation of beta cell responsiveness, which was influenced by baseline ph

192 cells is restraint of self-MHC-restricted T cell responsiveness, which, regardless of the presence o

193 Understanding the mechanisms that regulate T cell responsiveness will aid in the development of thera