ライフサイエンスコーパス: cell self-renewal

1 at are involved in maintenance of progenitor cell self-renewal.

2 further dissect the networks underlying stem cell self-renewal.

3 es organ size, tissue regeneration, and stem cell self-renewal.

4 s, suggesting an autocrine mechanism of stem cell self-renewal.

5 modifier proteins that is essential for stem cell self-renewal.

6 d the TWEAK-mediated inhibition of satellite cell self-renewal.

7 osines mediates an interaction central to ES cell self-renewal.

8 ed properties of tumor stem cells, including cell self-renewal.

9 cell cycle, senescence, DNA damage, and stem cell self-renewal.

10 the inhibitory effect of TWEAK on satellite cell self-renewal.

11 ption factors supporting embryonic stem (ES) cell self-renewal.

12 S transition to promote rapid embryonic stem cell self-renewal.

13 l H3K27me3 level, Hox gene expression, or ES cell self-renewal.

14 the response to muscle injury with satellite cell self-renewal.

15 ch signaling, a key determinant of satellite cell self-renewal.

16 ifferentiated state and is a regulator of ES cell self-renewal.

17 reased cell proliferation and decreased stem cell self-renewal.

18 ics of neurosphere formation and neurosphere cell self-renewal.

19 s in many cellular processes, including stem cell self-renewal.

20 ther Notch1 nor Notch2 affected repopulating cell self-renewal.

21 ral mechanism of organ size control and stem cell self-renewal.

22 ptide surfaces that sustain pluripotent stem cell self-renewal.

23 eration, differentiation, and embryonic stem cell self-renewal.

24 t role for TCFAP2C, SMARCA4, and EOMES in TS cell self-renewal.

25 s, Nr5a receptors play no evident role in ES cell self-renewal.

26 ctions, including organ development and stem cell self-renewal.

27 cells to control germ line and somatic stem cell self-renewal.

28 several genes that control cell division and cell self-renewal.

29 r Klf family proteins in embryonic stem (ES) cell self-renewal.

30 e and is necessary for trophoblast stem (TS) cell self-renewal.

31 of transcriptional networks that regulate TS cell self-renewal.

32 identify regulators of human embryonic stem-cell self-renewal.

33 r cells, may also be crucial for cancer stem cell self-renewal.

34 cal for the regulation of hematopoietic stem cell self-renewal.

35 ntify miR-99 as a critical regulator of stem cell self-renewal.

36 ion previously shown to be critical for stem cell self-renewal.

37 eptors that are essential for embryonic stem cell self-renewal.

38 -isolated, providing evidence of muscle stem cell self-renewal.

39 ch regulation is required for germ line stem cell self-renewal.

40 cardiovascular morphogenesis and progenitor cell self-renewal.

41 ns Nanog and Oct4 are essential for mouse ES cell self-renewal.

42 by Wnt signaling are proliferation and stem cell self-renewal.

43 uired for maintaining cell identity and stem cell self-renewal.

44 ssion pattern reflect the cycle of satellite cell self-renewal.

45 netic cellular memory, pluripotency and stem cell self-renewal.

46 ng that mago nashi is not necessary for stem cell self-renewal.

47 K1/2-STAT3 axis and enhances tumor stem-like cell self-renewal.

48 nes involved in fetal hematopoiesis and stem cell self-renewal.

49 ey transcription factor for pluripotent stem cell self-renewal.

50 mines the efficiency of mouse embryonic stem cell self-renewal.

51 (Fgf) signalling and is critical to drive TS cell self-renewal.

52 or normal mammary gland development and stem cell self-renewal.

53 nin signaling, which is involved in leukemia cell self-renewal.

54 Notch signaling, a key governor of satellite cell self-renewal.

55 reates an essential "niche" to maintain stem cell self-renewal.

56 including important regulators of ES and TS cells self-renewal.

57 ight into epigenetic mechanisms of ES and TS cells self-renewal.

58 tion of oocytes by maintaining germline stem cells self-renewal.

59 Ets2 is essential for trophoblast stem (TS) cells self-renewal.

60 -hEGFR increased SCP/neurofibroma-initiating cell self-renewal, a surrogate for tumour initiation, an

61 ine (5-hmC) and increased hematopoietic stem cell self-renewal accompanied by defective differentiati

62 regulations, and impairs haematopoietic stem-cell self-renewal activity and regenerative potential.

63 naling pathways that regulate mammalian stem cell self-renewal, adhesion, and migration.

64 role in promoting preleukemic hematopoietic cell self-renewal, AE represses DNA repair genes, which

65 tion of LRCs in vitro and impaired satellite cell self-renewal after muscle injury.

66 ormalities including a severe defect in stem cell self-renewal, alterations in thymocyte maturation a

67 ption factors such as Oct4 that control stem cell self renewal and multipotency.

68 short noncoding RNAs that are implicated in cell self- renewal and cancer development.

69 avenue for investigating mechanisms of stem cell self-renewal and achieving clinically significant e

70 onversely, Yap overexpression increases stem cell self-renewal and blocks terminal differentiation, r

71 cal processes associated with embryonic stem cell self-renewal and cell fate determination.

72 ) are crucial for normal embryonic stem (ES) cell self-renewal and cellular differentiation, but how

73 Here we investigate whether EG cell self-renewal and derivation are supported by 2i.

74 g, and sox-2, which are associated with stem cell self-renewal and developmental potential.

75 transcriptional changes associated with stem cell self-renewal and differentiation and followed the m

76 m cells in functional assays for cancer stem cell self-renewal and differentiation and form unique hi

77 tion, but the mechanisms by which progenitor cell self-renewal and differentiation are regulated duri

78 he cell and molecular biology of neural stem cell self-renewal and differentiation between invertebra

79 The search for genes that regulate stem cell self-renewal and differentiation has been hindered

80 Although the principles that balance stem cell self-renewal and differentiation in normal tissue h

81 etworks that control the switch between stem cell self-renewal and differentiation in the germline.

82 The signals that regulate stem cell self-renewal and differentiation in the lung remain

83 The balance between stem cell self-renewal and differentiation is controlled by i

84 Neural stem cell self-renewal and differentiation is orchestrated by

85 er, the mechanism that regulates Leydig stem cell self-renewal and differentiation is unknown.

86 role of matrix mechanics in regulating stem cell self-renewal and differentiation processes.

87 hough biochemical signals that modulate stem cell self-renewal and differentiation were extensively s

88 derstanding of the networks controlling stem cell self-renewal and differentiation, however, has not

89 e development and homeostasis depend on stem cell self-renewal and differentiation, the mechanisms th

90 ism for controlling the balance between stem cell self-renewal and differentiation.

91 tors that influence the balance between stem cell self-renewal and differentiation.

92 y regulated balance between renal progenitor cell self-renewal and differentiation.

93 on its functions in regulating hematopoietic cell self-renewal and differentiation.

94 mechanisms underlying human pluripotent stem cell self-renewal and differentiation.

95 l enhance our ability to control pluripotent cell self-renewal and differentiation.

96 expression, cell cycle progression, and stem cell self-renewal and differentiation.

97 cells are vital for proper control over stem cell self-renewal and differentiation.

98 g pathway is a key player in regulating stem cell self-renewal and differentiation.

99 oward understanding the coordination of stem cell self-renewal and differentiation.

100 f translational repression in balancing stem cell self-renewal and differentiation.

101 n important role in mammalian germ line stem cell self-renewal and differentiation.

102 cluding spermatogenesis, metabolism and stem cell self-renewal and differentiation.

103 ely unknown how DNA damage affects both stem cell self-renewal and differentiation.

104 known about Mediator function in adult stem cell self-renewal and differentiation.

105 transcriptional regulation of epidermal stem cell self-renewal and differentiation.

106 ics plays critical roles in controlling stem cell self-renewal and differentiation.

107 ormal developmental processes including stem cell self-renewal and differentiation.

108 a delicate balance between renal progenitor cell self-renewal and differentiation.

109 sion of a key transcription factor for basal cell self-renewal and differentiation: SOX2.

110 tem cells (neuroblasts) are a model for stem cell self-renewal and differentiation; they divide asymm

111 ever, Tspan3 deletion impaired leukemia stem cell self-renewal and disease propagation and markedly i

112 has been shown to enhance hematopoietic stem cell self-renewal and expansion ex vivo and in vivo.

113 lator of essential mechanisms governing stem cell self-renewal and fate decisions through transcripti

114 role in controlling the balance between stem cell self-renewal and fate determination by regulating t

115 re process of neurogenesis, from neural stem cell self-renewal and fate determination to neuronal mat

116 provides a unique model to study neural stem cell self-renewal and fate determination.

117 implicated in regulating pluripotency, stem cell self-renewal and fate specification.

118 Nanog has been identified as critical for ES cell self-renewal and for stabilizing a pluripotent gene

119 atopoietic stem cell (HSC) and leukemic stem cell self-renewal and functions in the context of the Po

120 Bmi1 is implicated in the control of stem cell self-renewal and has been shown to regulate cell pr

121 ing development that may participate in stem cell self-renewal and hematopoietic differentiation.

122 that Klf4 functions upstream of Nanog in ES cell self-renewal and in preventing ES cell differentiat

123 ncing Satb1 or Satb2 expression decreased TS cell self-renewal and increased differentiation, whereas

124 Nanog facilitates embryonic stem cell self-renewal and induced pluripotent stem cell gene

125 Balancing stem cell self-renewal and initiation of lineage specificatio

126 stem cell-niche adhesion is crucial for stem cell self-renewal and is dynamically regulated.

127 1-ETO-induced haematopoietic stem/progenitor cell self-renewal and leukaemogenesis.

128 ectively, elucidates new key players in stem cell self-renewal and leukemic transformation.

129 ng the molecular cues controlling progenitor cell self-renewal and lineage commitment is critical for

130 Both stem cell self-renewal and lineage differentiation are contro

131 attractive model in which to study both stem cell self-renewal and lineage differentiation at the mol

132 DNA damage-mediated disruption of adult stem cell self-renewal and lineage differentiation, and might

133 we report that Klf4 is required for both ES cell self-renewal and maintenance of pluripotency and th

134 0-15 somatic cells that is required for stem cell self-renewal and maintenance.

135 n 4 (ID4) is a key regulator of mammary stem cell self-renewal and marks a subset of BLBC with a puta

136 r dissecting the signalling pathways of stem cell self-renewal and may help develop more effective ch

137 coordinately to regulate haematopoietic stem cell self-renewal and mobilization.

138 ved pathway that promotes hematopoietic stem cell self-renewal and multipotency by limiting stem cell

139 ory features of the network that underpin NS cell self-renewal and multipotency.

140 has been found to be a key regulator of stem cell self-renewal and myogenesis in normal skeletal musc

141 here that Wnt7a is essential for neural stem cell self-renewal and neural progenitor cell cycle progr

142 nt advances in the regulation of neural stem cell self-renewal and neurogenesis by microRNAs.

143 (Sox2), a well established regulator of stem cell self-renewal and neurogenesis.

144 tnatal lethality with defects in neural stem cell self-renewal and neuronal/glial cell fate specifica

145 of RNA binding proteins act to promote stem cell self-renewal and oppose cell differentiation predom

146 ulators are required for embryonic stem (ES) cell self-renewal and pluripotency, but few have been st

147 cluding TF occupancy of genes involved in ES cell self-renewal and pluripotency, co-occupancy of TCFA

148 In contrast to the in-depth studies of ES cell self-renewal and pluripotency, few TE-specific regu

149 nscription factors play a major role in stem cell self-renewal and pluripotency, their integration wi

150 ical role in controlling embryonic stem (ES) cell self-renewal and pluripotency.

151 licated as regulators of embryonic stem (ES) cell self-renewal and pluripotency.

152 to moderate ROS levels is required for stem cell self-renewal and proliferation.

153 -2 (Msi2) RNA-binding protein maintains stem cell self-renewal and promotes oncogenesis by enhancing

154 major regulatory pathway in controlling stem cell self-renewal and quiescence.

155 eration in aged muscles, decreased satellite cell self-renewal and regenerative potential, and increa

156 ion, migration, invasion, angiogenesis, stem cell self-renewal and regulation of other tumor suppress

157 However, how Klf4 regulates ES cell self-renewal and somatic cell reprogramming is stil

158 lect trxG members, for the maintenance of ES cell self-renewal and somatic cell reprogramming.

159 that MUC1-C function is of importance to AML cell self-renewal and that inhibition of MUC1-C represen

160 est that Cdkn2c plays a critical role in B1a cell self-renewal and that its impaired expression leads

161 Cell self-renewal and the capacity to differentiate into

162 oblasts are a model system for studying stem cell self-renewal and the establishment of cortical pola

163 ulation of Arf by BCL6 is required for pre-B cell self-renewal and the formation of a diverse polyclo

164 in unearthing new molecules that govern stem cell self-renewal and tissue-regenerative potential.

165 eptor kinase inhibitor increases early BFU-E cell self-renewal and total erythroblast production, sug

166 therefore confer temporal changes upon stem cell self-renewal and tumor suppressor mechanisms.

167 ycomb repressive complexes also control stem cell self-renewal and tumorigenesis, but so far, no form

168 riptional regulation plays key roles in stem cell self-renewal and tumorigenesis.

169 he Notch signaling pathway and mediates stem cell self-renewal and vascular development.

170 issue type, the Wnt pathway can promote stem cell self-renewal and/or direct lineage commitment.

171 tworks that regulate embryonic stem cell (ES cell) self-renewal and pluripotency, little is know abou

172 often overexpressed and participated in stem cells self-renewal and tumorigenesis initiating of prost

173 icate that Sox2 is required for osteosarcoma cell self renewal, and that Sox2 antagonizes the pro-dif

174 ized our understanding of regeneration, stem cell self-renewal, and cancer; yet models for direct ima

175 egulating Pax7, a key regulator of satellite cell self-renewal, and downregulating MyoD and myogenin.

176 mTORC1 non-cell-autonomously regulates stem-cell self-renewal, and highlight a significant role of t

177 reen has implicated over 100 new genes in ES cell self-renewal, and illustrates the power of RNAi and

178 cal processes, including embryogenesis, stem cell self-renewal, and postnatal survival.

179 in ES cells, maintains trophoblast stem (TS) cell self-renewal, and promotes further trophoblastic di

180 of miRs in reprogramming and embryonic stem cell self-renewal, and specifically addresses the regula

181 erprint" is necessary for maintenance of hES cell self-renewal, and synthetic culture systems must ca

182 The molecular determinants supporting ES cell self-renewal are incompletely understood.

183 ut the signaling pathways that regulate stem cell self-renewal are largely unknown.

184 ivision, the mechanisms regulating satellite cell self-renewal are not understood.

185 he mechanisms that control adult neural stem cell self-renewal are still largely unknown.

186 ificant role in enhancing hematopoietic stem cell self-renewal as well as the production and differen

187 lls that inhibit stem-cell division and stem-cell self-renewal, as documented in the olfactory epithe

188 stem cells continued to show defects in stem cell self-renewal assays, suggesting a requirement for M

189 was required for normal haematopoietic stem cell self-renewal, Asxl2 loss promoted AML1-ETO leukemog

190 The network also controls embryonic stem cell self-renewal but is associated with distinct embryo

191 or protein LNK suppresses hematopoietic stem cell self-renewal, but its presence and role in the brai

192 pel-like factor 5 regulates pluripotent stem cell self-renewal, but its role in somatic stem cells is

193 his TF makes an important contribution to NS cell self-renewal by concurrently activating pro-prolife

194 ga2 thus promotes fetal and young-adult stem cell self-renewal by decreasing p16(Ink4a)/p19(Arf) expr

195 that linc-RoR maintains human embryonic stem cell self-renewal by functioning as a sponge to trap miR

196 in cellular proliferation and regulate stem cell self-renewal by maintaining expression of key pluri

197 Thus, although it promotes stem cell self-renewal by repressing a bam-dependent process,

198 ion factor is an important regulator of stem cell self-renewal, cancer cell survival, and inflammatio

199 associated with decreases in K562 and KU812 cell self-renewal capacity and with a more differentiate

200 unity, the regulation of autophagy, and stem cell self-renewal capacity, where evidence suggests an i

201 ghter cells, one of which retains the parent cell self-renewal capacity, while the other is committed

202 in embryonic development that controls stem cell self-renewal, chromatin organization, and the DNA d

203 However, the mechanisms of cell self-renewal, commitment, and functional integratio

204 rine/paracrine mediators of glioma stem-like cell self-renewal could potentially contribute to the tr

205 the role of Activin/Nodal signalling in stem cell self-renewal, differentiation and proliferation.

206 findings connect sexual identity to the stem cell self-renewal/differentiation decision and highlight

207 Precise regulation of stem cell self-renewal/differentiation is essential for embry

208 as a central player in promoting progenitor cell self-renewal during cortical development.

209 Embryonic stem (ES) cell self-renewal efficiency is determined by the Nanog

210 are essential for germline development, stem cell self-renewal, epigenetic regulation, and transposon

211 lpha signalling promotes haematopoietic stem-cell self-renewal, expanding splenic haematopoietic stem

212 omparison of GSC regulators with neural stem cell self-renewal factors identifies common and cell-typ

213 Despite expressing stem cell self-renewal factors, intermediate progenitor cells

214 attenuating their genomic responses to stem cell self-renewal factors.

215 neages that depend on a balance between stem cell self-renewal for continuity and the formation of pr

216 r without homeobox B4 (HOXB4), a potent stem cell self-renewal gene.

217 ork (GRN) that supports neural stem cell (NS cell) self-renewal has so far been poorly characterized.

218 Its specific role in mouse epiblast stem cell self-renewal, however, remains poorly understood.

219 al and has been also implicated in satellite cell self-renewal; however, the underlying molecular mec

220 chromosome 21q22 confers mouse progenitor B cell self renewal in vitro, maturation defects in vivo a

221 Retinoic acid (RA) has been linked to stem cell self-renewal in adults and also participates in yol

222 a but are required for maintaining satellite cell self-renewal in hypoxic environments.

223 r ROR overexpression leads to increased stem cell self-renewal in mammary stem cells.

224 agment of collagen VI alpha3, increased stem cell self-renewal in mammosphere assays and Wnt signalin

225 proliferation, cell fate and stem/progenitor cell self-renewal in many organs.

226 n nuclear receptor TLX regulates neural stem cell self-renewal in the adult brain and functions prima

227 signaling as an important regulator of stem cell self-renewal in the developing brain.

228 ffect on long-term, but not short-term, stem cell self-renewal in vitro.

229 ished that allow near unlimited (>10(16)) EP cell self-renewal in which they display a morphology and

230 es the expression of genes critical for stem cell self-renewal, including NOTCH1, and may be linked t

231 expression of numerous genes involved in ES cell self-renewal, including Sox2, Utf1, and Oct4.

232 Pbx1 is required to maintain stem cell self-renewal, including that of mesenchymal stem ce

233 antly inhibit VEGF secretion, decreased stem cell self-renewal, inhibited tumor growth, and increased

234 Nin regulates neural stem cell self-renewal, interkinetic nuclear migration, and m

235 ion of small molecules in modulation of stem cell self-renewal is a promising approach to expand stem

236 Satellite cell self-renewal is an essential process to maintaining

237 Stem cell self-renewal is controlled by concerted actions of

238 Stem cell self-renewal is controlled by concerted actions of

239 Because abnormal stem cell self-renewal is frequently observed during tumor fo

240 how the transcriptional network promoting ES cell self-renewal is interrupted, allowing cellular diff

241 Stem cell self-renewal is intrinsically associated with cell

242 Stem cell self-renewal is tightly controlled by the concerted

243 L4, a gene involved in the maintenance of ES cell self-renewal, is aberrantly expressed in 47.7% of p

244 loyment of gut epithelia as a niche for stem cell self-renewal may provide a mechanism for direct com

245 The stem cell self-renewal mediated by SALL4 is linked to epigene

246 hese findings provide new insights into stem cell self-renewal mediated by SALL4 via epigenetic machi

247 series of coordinated steps, including germ cell self-renewal, meiotic recombination, and terminal d

248 d with (1) embryonic development and/or stem cell self renewal (MSX, MEIS, ID, Hes1, and SIX homeodom

249 The regulation of stem cell self-renewal must balance the regenerative needs of

250 king Fgf/Erk activity is known to promote ES cell self-renewal, once cells have experienced a period

251 pment of exogenous molecules to control stem cell self-renewal or differentiation has arrived at natu

252 e plays a key role in the regulation of stem cell self-renewal or differentiation.

253 rs may develop through dysregulation of stem-cell self-renewal pathways.

254 ction of autophagy; augmentation of GBM stem cell self-renewal; possible implications of GBM-endothel

255 functions and are required to maintain stem cell self-renewal potential.

256 al NSPCs can provide insight into basic stem cell self-renewal principles important for tissue homeos

257 ed a loss of the hematopoietic/leukemic stem cell self-renewal program and an increase in the differe

258 h Noggin is sufficient to foster hippocampal cell self-renewal, proliferation, and multipotentiality

259 Embryonic stem cell self-renewal properties are attributed to critical

260 t by providing a humanized environment, stem cell self-renewal properties were better maintained as d

261 ole for post-transcriptional control in stem cell self-renewal, provide mechanistic insight on APA re

262 We found that the stem cell self-renewal regulator SOX2 is a novel target of mi

263 The determinants of normal and leukemic stem cell self-renewal remain poorly characterized.

264 t TLX, an essential regulator of neural stem cell self-renewal, represses the expression of miR-137 b

265 KDM2B (also known as FBXL10) controls stem cell self-renewal, somatic cell reprogramming and senesc

266 powerful model system for investigating stem cell self-renewal, specification of temporal identity, a

267 ion of several miRNAs involved in EMT and/or cell self-renewal such as miR-34a-5p, miR-34c-5p, miR-21

268 enes have been implicated in vertebrate stem cell self-renewal, suggesting that this core set of gene

269 T3 in the coordination of colonic epithelial cell self-renewal, suggesting this factor as a new bioma

270 ently described ability of p53 to limit stem cell self-renewal suppresses tumorigenesis in acute myel

271 lucidate a new role for beta-catenin in stem cell self-renewal that is independent of its transcripti

272 that miRNAs function in the silencing of ES cell self-renewal that normally occurs with the inductio

273 n of conditions and factors involved in stem cell self-renewal, the foundation of spermatogenesis, an

274 own to be required for postnatal neural stem cell self-renewal, the role of trxG genes remains unknow

275 demonstrates that TWEAK suppresses satellite cell self-renewal through activating NF-kappaB and repre

276 critical role in tooth development and stem cell self-renewal through beta-catenin.

277 Further, eliminating tumor cell self-renewal through deletion of Id1 has modest eff

278 Here we show that GV represses melanoma stem cell self-renewal through inhibition of SOX2.

279 aining stem cell identity and governing stem cell self-renewal through transcriptional repression.

280 enic effects, VEGF promotes tumor-initiating cell self-renewal through VEGFR-2/STAT3 signaling.

281 ell function and their consequences for stem cell self-renewal, tissue homeostasis, and regeneration.

282 However, the progression from stem cell self-renewal to overt signs of early differentiatio

283 hed in the prostate, promoting prostate stem cell self-renewal upon proteolytic activation via a gamm

284 Niches regulate lineage-specific stem cell self-renewal versus differentiation in vivo and are

285 model to understand how the balance of stem cell self-renewal versus differentiation is achieved.

286 Stem cell self-renewal versus differentiation is regulated by

287 ifferent signaling pathways involved in stem cell self-renewal versus lineage-specific differentiatio

288 xpression of BMI1, a known regulator of stem cell self-renewal, was modulated by miR-200c.

289 Significantly for the maintenance of stem cell self-renewal, we detected a reduction in the expres

290 t into mechanisms controlling embryonic stem cell self-renewal, we explore the molecular and cellular

291 investigations showed that KANSL2 regulates cell self-renewal, which correlates with effects on expr

292 Asxl1 deletion reduces hematopoietic stem cell self-renewal, which is restored by concomitant dele

293 cell-permeable alphaKG directly supports ES-cell self-renewal while cell-permeable succinate promote

294 during neural development in promoting NS/P cell self-renewal while restricting the generation and m

295 at Bmi1 promotes cell proliferation and stem cell self-renewal with a correlative decrease of p16(INK

296 n the epidermis, a tissue that balances stem cell self-renewal with differentiation, H3K27me3, occupi

297 re essential in regulating neural progenitor cell self-renewal, with the chromatin-modifying protein

298 ) leads to persistently enhanced neural stem cell self-renewal without sign of exhaustion.

299 ells responsible for tumorigenesis and tumor cell self-renewal would provide an important target for

300 ion factor implicated in embryonic stem (ES) cell self-renewal, yet its knockout causes intrauterine