ライフサイエンスコーパス: cell shape

1 constriction behavior are biased by initial cell shape.

2 expression, actomyosin complex activity and cell shape.

3 s in a tissue with heterogeneity in starting cell shape.

4 ntify some of the underlying determinates of cell shape.

5 wever, N-cadherin has an indirect control on cell shape.

6 ty (DCO2) in RBCs and related our results to cell shape.

7 alyzing three-dimensional images of MreB and cell shape.

8 a potential mechanism of phase variation of cell shape.

9 of the underlying topography and neglecting cell shape.

10 e apical surface of epithelial cells follows cell shape.

11 CPs) are important determinants of bacterial cell shape.

12 ses is involved in determining the bacterial cell shape.

13 Pressure modulated endothelial cell shape.

14 contributes to the maintenance of a uniform cell shape.

15 hages causing stellation and arborization of cell shape.

16 e elastic cell wall to generate a particular cell shape.

17 esenting the second C. jejuni gene affecting cell shape.

18 and cell wall synthesis, cell division, and cell shape.

19 morphology, causes ER stress and defects in cell shape.

20 l approach to study the mechanisms governing cell shape.

21 es match those calculated from instantaneous cell shapes.

22 geometries attempting to replicate realistic cell shapes.

23 ich modulate GREM1 expression and epithelial cell shapes.

24 echanism for the generation of complex plant cell shapes.

25 pressure acting within guard cells to alter cell shape [1].

26 lso show that interfacial geometry modulates cell shape, adhesion through integrin alpha5beta1, MAPK

27 rix (ECM) are critical for the regulation of cell shape, adhesion, and migration.

28 Cell shape affects proliferation and differentiation, wh

29 is their shape, but we do not understand how cell shape affects the dense communities, known as biofi

30 into how Notch signals are triggered and how cell shape affects these events, and we use the new insi

31 Cs and quantitatively measured the resulting cell shape, alignment, and expression of smooth muscle (

32 in disordered arrangement of cells, deformed cell shapes, altered cell structure, and a shorter lengt

33 cell motility that includes the mechanics of cell shape and a minimal chemical model for CIL, we are

34 t spindle-positioning mechanism and controls cell shape and alignment through a transcriptional pathw

35 are critical for cell envelope integrity and cell shape and also represent key antigenic determinants

36 iclinal microtubules are not correlated with cell shape and are unstable at the time scales of cell e

37 tile array assembly, it dramatically altered cell shape and barrier function in response to elevated

38 ionship between the alignment of topography, cell shape and cell differentiation to osteogenic and my

39 ts into the relationship between topography, cell shape and cell differentiation.

40 es for the coordination and control of plant cell shape and cell growth.

41 noi (SPV) model that links cell mechanics to cell shape and cell motility, we formulate a generalized

42 nter-intuitive relationship between jamming, cell shape and cell-cell adhesive stresses that is borne

43 le for microtubules for maintaining skin TRM cell shape and cellular integrity.

44 keletal framework responsible for regulating cell shape and contributes to cytokinesis fidelity.

45 ces well the features of cytokinesis such as cell shape and cortical flows toward the equator.

46 perturbations suggest the parameter linking cell shape and division orientation contributes to epith

47 although both kinases are known to modulate cell shape and division, their modes of action are likel

48 nA and PknB play crucial roles in modulating cell shape and division.

49 RBCs to shear flow and probe the effects of cell shape and effective membrane viscosity on their tan

50 nvelope in Gram-negative bacteria, maintains cell shape and endows osmotic robustness.

51 bo1 as a protective mechanism that maintains cell shape and facilitates ECM adherence.

52 ory modeling incorporating variation of both cell shape and flagellum number predicts qualitative spe

53 To predict the dynamics and steady states of cell shape and forces without any a priori knowledge of

54 to reveal the physical processes underlying cell shape and forces, but it is notoriously difficult t

55 ia, is critical for division and maintaining cell shape and hydrostatic pressure.

56 at an abnormally small cell size, and caused cell shape and integrity defects under certain condition

57 macromolecule peptidoglycan, which maintains cell shape and is responsible for resisting osmotic stre

58 ve biochemical events that iteratively alter cell shape and location.

59 ivity to enhance cell tension by maintaining cell shape and matrix adhesion.

60 lagen-fibrin comparisons of gene expression, cell shape and mechanotransduction, with an in vivo refe

61 pression profiles for putative regulators of cell shape and meristem determinacy as well as a general

62 rchitecture of the ECM promotes an elongated cell shape and migration along the fibrils.

63 down in wild-type fibroblasts showed altered cell shape and migration, consistent with known roles of

64 ts of the actin cytoskeleton are crucial for cell shape and migration.

65 methods, we explore the relationship between cell shape and nuclear shape.

66 ify the mechanical checkpoint for persistent cell shape and organelle polarization, which are critica

67 The cortex is the main determinant of cell shape and plays a fundamental role in cell division

68 tial context, explicitly taking into account cell shape and polarity and the presence of cell walls.

69 the endothelial cell cytoskeleton to control cell shape and polarity.

70 junctions (AJs) remodel to allow changes in cell shape and position while preserving adhesion.

71 in cytoskeleton to ensure correct epithelial cell shape and prevent epithelial-to-mesenchymal transit

72 ructure of the bacterial cell by determining cell shape and providing resistance to internal turgor p

73 Protein patterns are known to adapt to cell shape and serve as spatial templates that choreogra

74 We observed aberrant cell shape and severe growth defects when PknA was deple

75 us and in the ependyma, such as asymmetrical cell shape and size, misplacement and abnormal beating o

76 ls mitotic FAs as a key link between mitotic cell shape and spindle orientation, and may have importa

77 an integral organelle critical for bacterial cell shape and stability.

78 vidual-based modeling to systematically vary cell shape and study its impact in simulated communities

79 We analyzed the effects of cell shape and substrate stiffness on the shortening and

80 ial cell wall is critical for maintenance of cell shape and survival.

81 g/mL for 24 h) produced small alterations in cell shape and that as the dose was increased, cell spee

82 n cytoskeleton is a structure that gives the cell shape and the ability to migrate.

83 mitotic spindles is sensitive to interphase cell shape and the direction of extrinsic mechanical for

84 Thus, forces are key regulators of stem cell shape and the targeted engineering of specific MSC

85 as a potential driving force in establishing cell shape and topology within tissues.

86 mp that maintains intracellular homeostasis, cell shape and turgor under conditions in which potassiu

87 nsic determinants of differentiation such as cell shape and/or seeding density inform this transcript

88 eveal an unprecedented role of N-cadherin on cell shapes and cell arrangements.

89 homeostasis, how adhesion molecules control cell shapes and cell patterns in tissues remains unclear

90 explicitly incorporate information about the cell shapes and interfacial energy between cells; noneth

91 FlpOut (MCFO) approach can be used to reveal cell shapes and relative cell positions and to track the

92 zed how the functional polarization of CD4 T cells shapes and structures the reservoirs of HIV-1-infe

93 ractile ring and cortex do contribute to the cell shape, and can work together with water permeation

94 cell cortex is essential to maintain animal cell shape, and contractile forces generated within it b

95 Arabidopsis altered cellular MT orientation, cell shape, and organ morphology.

96 plays a critical role in retaining a defined cell shape, and, in the case of pathogenic Gram-positive

97 marks, encoding information about interphase cell shape anisotropy to orient division in the rounded

98 Transporting and sensory epithelial cells shape apical specializations using protocadherin-b

99 These changes in cell shape are both influenced by, and feed back onto EC

100 s responsible for the evolution of bacterial cell shape are not understood.

101 Dramatic and rapid changes in cell shape are perhaps best exemplified by phagocytes, s

102 In conclusion, gene expression and cell shape are similar on plastic and 3D collagen wherea

103 These studies build on the view that cell shape arises from the physical properties of an ela

104 We track changes in cell shape as cells deform into microfluidic constrictio

105 This suggests the chiral T. brucei cell shape (associated with the lateral attachment of th

106 work, this allows the direct measurement of cell shape at a given time rather than defining the morp

107 easured 4D live-imaging data, features of V2 cell-shape at each time point prior to division were ext

108 incorporate a detailed time lapse record of cell shape, beginning with neurons.

109 We analyze cell shape between the different topographies, using flu

110 riaxone), amikacin and phages did not modify cell shape but produced intracellular inclusion bodies.

111 lsr1 polarity is not a direct consequence of cell shape but rather reflects the restructuring of cell

112 t mouth opening is accompanied by changes in cell shape, but not cellular rearrangements as previousl

113 We show that cell shape, but not size, changes with resource levels a

114 , that are required for polarized growth and cell shape, but their functional mechanisms and connecti

115 we probe the effects of mechanical strain on cell shape by modelling the mechanical strains caused by

116 rotubules at the plant cell cortex influence cell shape by patterning the deposition of cell wall mat

117 tissue specialization of anti-inflammatory T cells shaped by discrete niches of the intestine.

118 In addition to cortical cues, cell shape can also serve as a division orientation cue

119 relationships, we find that information from cell shape can be resolved from mechanical signals.

120 Highly symmetric cell shape can give highly directional swimming but is a

121 a wide range of patterns that, combined with cell shape, can generate unique physical, mechanical, or

122 on indicated hydrodynamic drag on the chiral cell shape caused rotation, and the predicted geometry o

123 ry and identified a wecE mutant that altered cell shape, causing cells to filament and swell.

124 Here we use SEGGA to analyze changes in cell shape, cell interactions and planar polarity during

125 to analyze specific characteristics such as cell shape, cell size, metaphase/anaphase delays, and mi

126 These membrane reservoirs facilitate cell shape change and buffer mechanical stress, but we d

127 of tissue organization and the basis of all cell shape change and cell movement in development.

128 ntify the time-dependent correlation between cell shape change and intracellular factors that may pla

129 actin-based cell protrusion into persistent cell shape change and migration.

130 keleton-dependent cellular processes such as cell shape change and migration.

131 Net cell shape change depends on whether cell shape is stabi

132 n cytoskeleton to cell-cell junctions drives cell shape change in development and homeostasis.

133 aces contributes to physiologically relevant cell shape change in intact organisms.

134 n of apical cell surfaces, and the resulting cell shape change is thought to cause tissue folding.

135 Apical constriction is a widely utilized cell shape change linked to folding, bending and invagin

136 acking the FABD fully rescued morphogenesis, cell shape change, actin regulation, and viability, wher

137 y, the suppressive mutations lead to a major cell shape change, from the normal cylindrical shape to

138 e transition from reversible to irreversible cell shape change, which defines the onset of tissue sha

139 ical actomyosin redistribution together with cell shape change.

140 urrow ingression during cytokinesis, a model cell-shape-change process.

141 In addition to these cell rearrangements, cell shape changes also contribute to tissue deformation

142 During development, coordinated cell shape changes alter tissue shape.

143 the precise orchestration of cell migration, cell shape changes and cell adhesion.

144 d considerable interspecies variation in the cell shape changes and neighbor exchanges underlying app

145 Tissue morphogenesis requires control over cell shape changes and rearrangements.

146 Although these cell shape changes are accompanied by an apparent large

147 These cell shape changes are controlled by nonmuscle myosin II

148 Cell shape changes are determined by the interplay of ce

149 cortical actin network controls many animal cell shape changes by locally modulating cortical tensio

150 Tjp1a is a novel regulator of cell shape changes during colour pattern formation and t

151 Cell shape changes during cytokinesis in eukaryotic cell

152 tracellular matrix (ECM) adhesions regulates cell shape changes during embryonic development and tiss

153 f actomyosin accumulation that drive initial cell shape changes during gastrulation.

154 t initiate the regulation of NMII to mediate cell shape changes during MHB morphogenesis are not know

155 tracellular signals, signaling pathways, and cell shape changes in a noisy background.

156 Cell shape changes in cytokinesis are driven by a cortic

157 ubule/actin filament interactions underlying cell shape changes in response to guidance cues, plays a

158 racterized; however, the mechanical basis of cell shape changes is largely unknown because of a lack

159 ty overcomes cortical tension to produce the cell shape changes needed for locomotion.

160 Specific cell shape changes occur at the point of deepest constri

161 Cell shape changes such as cytokinesis are driven by the

162 cytoskeleton within individual cells drives cell shape changes that fold tissues.

163 Morphogenesis is driven by small cell shape changes that modulate tissue organization.

164 nction must be maintained during the complex cell shape changes that occur during cytokinesis in vert

165 is the result of coordinated cell movements, cell shape changes, and the organisation of pigment cell

166 ia, force imbalance at cell contacts induces cell shape changes, such as apical constriction or polar

167 eling both a-cells and alpha-cells and their cell shape changes, the extracellular diffusion of matin

168 MTs along "track" MTs, resulting in dramatic cell shape changes.

169 axis is cancelled by cell rearrangements and cell shape changes.

170 Tissue morphogenesis is orchestrated by cell shape changes.

171 s of cell divisions, cell rearrangements and cell shape changes.

172 on, a process driven by asymmetric epidermal cell shape changes.

173 twork that regulate NF-kappaB in response to cell shape changes.

174 Cell-shape changes are insured by a thin, dynamic, corti

175 Cell-shape changes associated with processes like cytoki

176 At the core of cell-shape changes is the ability of the cell's machiner

177 unfolding allows bleb inflation and dynamic cell-shape changes performed by migrating cells.

178 The cytoskeleton is a major determinant of cell-shape changes that drive the formation of complex t

179 heir apices, undergo a series of coordinated cell-shape changes to form a ventral furrow (VF) and are

180 ed quantitatively how chirality in T. brucei cell shape confers highly directional swimming.

181 Bacteria have remarkably robust cell shape control mechanisms.

182 long-term time-lapse imaging to test current cell shape control models.

183 CetZ2 was also implicated in H. volcanii cell shape control.

184 oskeletal protein MreB for subtle changes in cell shape, cumulatively spanning approximately 5-fold v

185 zation and quantification of fine details in cell shape, cytoplasm, nucleus, lipid bodies and cytoske

186 ls defective for both Amj and MurJBs exhibit cell shape defects and lyse.

187 ese motile cells: cytoplasmic flow driven by cell shape deformation.

188 We show that cone cell shapes depend little on adhesion bonds and mostly o

189 hts into not only mechanisms responsible for cell-shape determination and growth, but also cellular p

190 gene expression variability in infected host cells shapes different cellular environments, some of wh

191 oserosal (AS) cells--as models to define how cells shape distinct protrusions during morphogenesis.

192 to conduct many different tasks, controlling cell shape, division, and DNA segregation.

193 these data strongly suggest that changes in cell shape, driven by gene expression and/or mechanical

194 li that grow at a similar rate but differ in cell shape due to single amino acid changes in the actin

195 o stabilize the cleavage furrow and maintain cell shape during cytokinesis [1-14].

196 er phase also play a role in determining the cell shape during cytokinesis.

197 cytoskeleton that are essential to maintain cell shape during infection.

198 IIB perform distinct functions in regulating cell shape during MHB morphogenesis.

199 FtsZ/tubulin superfamily to include archaeal cell shape dynamics, suggesting that a cytoskeletal role

200 ophila embryos and quantified differences in cell-shape dynamics in wild-type and mutant embryos.

201 gradation, matrix remodeling, and changes in cell shape each require cells to expend energy.

202 nstraints on the lamellipodia that result in cell shape elongation and enforce migration direction.

203 hat a 2-mum spacing is sufficient to promote cell shape elongation and migration parallel to the ECM,

204 lopment, already before the typical pavement cell shapes emerge, with topological homeostasis maintai

205 e activity and promote cell polarization and cell shape emergence.

206 We present the Real-time Accurate Cell-shape Extractor (RACE), a high-throughput image ana

207 influx of experimental evidence of enhanced cell-shape fluctuations related to metabolically driven

208 wall is an important factor for determining cell shape, function and response to the environment.

209 Cell shape has long been thought to be the main cue for

210 Quantitative analysis of cell shape helps to reveal the physical processes underl

211 ng at different rates indicates existence of cell-shape homeostasis.

212 Non-hematopoietic lymph node stromal cells shape immunity by inducing MHC-I-dependent deletio

213 ated the interplay between cortical cues and cell shape in a proliferating tissue.

214 ed models, at least for the establishment of cell shape in B. subtilis.

215 effect of the aspect ratio of the interphase cell shape in defining the final alignment axis.

216 y, we show microtubule alignment responds to cell shape in diverse epithelia.

217 olic pathways is required to maintain normal cell shape in E. coli.

218 ify novel mechanisms that create or maintain cell shape in Escherichia coli, we used flow cytometry t

219 s, they efficiently restored FA turnover and cell shape in FAK-deficient cells.

220 of the time-based morphological behaviors of cell shape in response to differing topographies.

221 on by SLAIN2 and CLASP1 supports mesenchymal cell shape in soft 3D matrices by enabling microtubules

222 nscription, signaling, myosin activation and cell shape in the Drosophila mesoderm.

223 Rac is critical for MSC cell shape in vitro, whereas its function in MSCs in viv

224 Change of cell shape in vivo plays many roles that are central to

225 The stereotypic pattern of cell shapes in the Arabidopsis shoot apical meristem (SA

226 model may be distinguished by differences in cell shapes in the P compartment, as quantified through

227 Cell shape influences function, and the current model su

228 We conclude that 3-D cell shape information, transduced through tension-indep

229 nstrate the generality of RACE by extracting cell-shape information from entire Drosophila, zebrafish

230 offer a mechanism for translating changes in cell shape into dramatic intracellular remodeling.

231 Bacterial cell shape is a genetically encoded and inherited featur

232 ming path geometry showed that highly chiral cell shape is a robust mechanism through which microscal

233 Finally, we found that mitotic cell shape is also abnormal in the mutant VZ.

234 gdoms of life, yet little is known about how cell shape is controlled.

235 Cell shape is determined by cellular mechanics.

236 li using the antibiotic A22, indicating that cell shape is largely decoupled from the biochemistry of

237 Net cell shape change depends on whether cell shape is stabilized, or ratcheted, between pulses.

238 A defining feature of Trypanosoma brucei cell shape is the lateral attachment of the flagellum to

239 tatistics were nearly the same regardless of cell shape, length, and flagellation; however, swarm cel

240 ontaneous activity of the sensory inner hair cells shapes maturation of the developing ascending (aff

241 The changes in cell shape may alter endothelial Ca(2+) signals by modul

242 ggested that nanoridge formation and conical cell shape may contribute to the reduction of physical a

243 teering stem cell fate - through controlling cell shape - may substantially accelerate progress towar

244 nally, Rab35 represents a common contractile cell-shaping mechanism, as mesoderm invagination fails i

245 opment and adhesion strength, and determines cell shape, migration and differentiation.

246 lators of the cell cytoskeleton, controlling cell shape, migration and proliferation.

247 (NMM-II), a protein involved in maintaining cell shape, migration, and cytokinesis.

248 ysical forces exerted by or felt by cells on cell shape, migration, and cytoskeleton arrangement is n

249 ically reduced amount of this protein alters cell shape, migration, proliferation, and gene expressio

250 athogenesis-associated phenotypes, including cell shape, motility, biofilm formation, cell surface hy

251 chemical fixation and dehydration alter the cell shape of Parachlamydia and that the crescent body i

252 e' problem, and the effects of diffusion and cell shape on direction sensing are also investigated.

253 tions of T2DM RBCs and explore the effect of cell shape on the fluctuation amplitudes.

254 Our method maps an arbitrary cell shape onto a tree graph that, unlike traditional sk

255 physiological or pathological alterations in cell shape or movement.

256 ing cells tend to have strong asymmetries in cell shape or propulsion.

257 ugh not all of them are cytoskeletal, affect cell shape, or maintain intracellular organization.

258 imary role for alpha-Spectrin in controlling cell shape, perhaps by modulating actomyosin.

259 f many organs in the body through changes in cell shape, polarity and behavior and is a major area of

260 , cell tracking and quantitative analysis of cell shape, polarity and behavior in epithelial tissues.

261 cargos and organelles, as well as changes in cell shape, polarity, and motility.

262 Changes in cell shape produce a geometric microdomain regulation of

263 understand these processes, the evolution of cell shape, proliferation and gene expression must be qu

264 gly, modulation of fascin-1 expression tunes cell shape, quantified as the number of morphological ex

265 er that microtubule organization responds to cell shape, rather than the converse.

266 Highly specific cell shape recognition can also be achieved by cell inte

267 After removal of the mechanical load, the cell shape recovers only incompletely to its original un

268 that it encounters, but can information from cell shape regulate cellular phenotype independently?

269 ular machinery is critical for understanding cell-shape regulation.

270 urprisingly, we find that neither the global cell shape regulators Cdc42-Scd1-Scd2 nor the major cell

271 sms that control the concerted regulation of cell shape remain understudied.

272 Quantification of cell shapes revealed that NMIIA is required for the shor

273 ne expression, collagen fibril alignment and cell shape seen in vivo.

274 The mechanisms underlying interphase cell shape sensing in tissues are therefore unknown.

275 Thus, in-cell SHAPE-Seq represents an easily approachable tool fo

276 t a simple, high-throughput method called in-cell SHAPE-Seq that combines in-cell probing of RNA stru

277 We use in-cell SHAPE-Seq to study the structure-function relations

278 racted the precise 3D cellular arrangements, cell shapes, sizes, and global morphological features du

279 of the eukaryotic cytoskeleton, controlling cell shape, structure and dynamics, whereas its bacteria

280 nd organelles, which may ultimately modulate cell shape, structure, and function.

281 has demonstrated that individual features of cell shape, such as length or curvature, arise through t

282 Shh-dependent suprabasal cell shape suggests convergent migration and intercalati

283 network results in a regulation of force and cell shape that adapts to the stiffness of the environme

284 Apical constriction is a change in cell shape that drives key morphogenetic events includin

285 s system (CNS), requires profound changes in cell shape that lead to myelin sheath initiation and for

286 netically controlled, yet the means by which cells shape the skeleton remains to be fully illuminated

287 cular mechanism by which cervical neoplastic cells shape their local microenvironment by instructing

288 Cell shape thus provides a rigorous structural signature

289 he jamming transition in asthma is linked to cell shape, thus establishing in that system a structura

290 at couples specific aspects of breast cancer cell shape to signaling and transcriptional events.

291 lopment in mice to orient overall changes in cell shape towards the IPL.

292 Many cell behaviors involve cell-shape transformations that impose considerable chan

293 Modeling cell shape variation is critical to our understanding of

294 l capturing the successive changes of the V2 cell-shape was developed.

295 ment occur simultaneously, but by perturbing cell shape, we discover that microtubule organization re

296 en turgor pressure, cell wall properties and cell shape, we focused on kidney-shaped stomata and deve

297 tersoni is formed through extreme changes in cell shape, whereas Drosophila funebris appears to displ

298 membrane-bound organelles and for changes in cell shape, which are particularly critical during cell

299 Our models predict that cell shape will strongly influence the fate of a cell li

300 at the simplest scenario to explain pavement cell shapes within an epidermis under tension must invol