ライフサイエンスコーパス: cell shape change

1 coordination of actomyosin contractility and cell shape change.

2 rearrangement, apical domain elongation and cell shape change.

3 t cytoskeletal reorganization and epithelial cell shape change.

4 ortical dynamics, mechanics, and cytokinesis cell shape change.

5 AJs, uncoupling actomyosin constriction and cell shape change.

6 ons (AJs) mediate cell adhesion and regulate cell shape change.

7 mponents and induces a mesenchymal-cell-like cell shape change.

8 pattern consistent with a role in regulating cell shape change.

9 two daughter cells, is a simple and dramatic cell shape change.

10 re provides a direct link from patterning to cell shape change.

11 mination, we focused on apoptosis induced by cell shape change.

12 esting that the ventral cells are primed for cell shape change.

13 ay require specific mechanisms to coordinate cell shape change.

14 clot to promote clot retraction and support cell shape change.

15 holipase C activation and may play a role in cell shape change.

16 ransmit the force of bundle contraction into cell shape change.

17 ical actomyosin redistribution together with cell shape change.

18 ge and, putatively, diseases associated with cell shape change.

19 ns to mediate cytoskeletal rearrangement and cell-shape change.

20 they modulate the dynamics and mechanics of cell-shape change.

21 esents a novel cellular strategy for driving cell shape changes.

22 s, driving both actin- and microtubule-based cell shape changes.

23 twork that regulate NF-kappaB in response to cell shape changes.

24 ing protein that promotes cell migration and cell shape changes.

25 ublished data argue that this is mediated by cell shape changes.

26 f equatorial and global proteins to regulate cell shape changes.

27 ndrial function with both agents resulted in cell shape changes.

28 uced up-regulation of FRNK is independent of cell shape changes.

29 ions that collaborate to orchestrate complex cell shape changes.

30 phosphorylation, microtubule disassembly, or cell shape changes.

31 rkII and Dock180 to promote phagocytosis and cell shape changes.

32 MTs along "track" MTs, resulting in dramatic cell shape changes.

33 ption factor Snail that triggers the ventral cell shape changes.

34 to induce actin filament assembly leading to cell shape changes.

35 ownstream events such as MAPK activation and cell shape changes.

36 B caused a severe loss of actin staining and cell shape changes.

37 ate or chondroitinase reversed the apoptotic cell shape changes.

38 stent with disruption of actin filaments and cell shape changes.

39 gamma complex and that might be involved in cell shape changes.

40 a 1 with actin and vinculin has no effect on cell shape changes.

41 Tissue morphogenesis is orchestrated by cell shape changes.

42 axis is cancelled by cell rearrangements and cell shape changes.

43 s of cell divisions, cell rearrangements and cell shape changes.

44 on, a process driven by asymmetric epidermal cell shape changes.

45 wound healing relies on tissue movements and cell shape changes.

46 osis, polarity establishment, migration, and cell shape changes.

47 ans, these sheets are folded and reshaped by cell-shape changes.

48 and internal components of the M-line during cell-shape changes.

49 the precise temporal and spatial control of cell-shape changes.

50 acking the FABD fully rescued morphogenesis, cell shape change, actin regulation, and viability, wher

51 L3 significantly inhibits activation-induced cell shape changes, adhesion and recruitment to sites of

52 In addition to these cell rearrangements, cell shape changes also contribute to tissue deformation

53 During development, coordinated cell shape changes alter tissue shape.

54 HKB controls polarized cell shape change and apical membrane growth during sali

55 These membrane reservoirs facilitate cell shape change and buffer mechanical stress, but we d

56 e to form a longer, narrower tissue and that cell shape change and cell division contribute little to

57 of cell behavior, namely tensorial rates of cell shape change and cell intercalation.

58 at drive two important processes-cytokinesis cell shape change and cell mechanics.

59 nal myosins (myosin-IIs) generate forces for cell shape change and cell motility.

60 of tissue organization and the basis of all cell shape change and cell movement in development.

61 myosin-II is a key motor protein that drives cell shape change and cell movement.

62 r mediates specific aspects of morphogenetic cell shape change and cytoskeletal organization.

63 One of the EGFR ligands, EGF, caused a cell shape change and increased neurofilament phosphoryl

64 ntify the time-dependent correlation between cell shape change and intracellular factors that may pla

65 in Shroom3 is a potent inducer of epithelial cell shape change and is required for lens and neural pl

66 uggesting that they may be key regulators of cell shape change and migration during development.

67 The Rho GTPase, which mediates cell shape change and migration, is also an essential re

68 keleton-dependent cellular processes such as cell shape change and migration.

69 is interface is indeed involved in mediating cell shape change and migration.

70 ON in murine resident macrophages results in cell shape change and migration.

71 actin-based cell protrusion into persistent cell shape change and migration.

72 on of cytoskeletal dynamics is essential for cell shape change and morphogenesis.

73 te that strongly activates Rho-GTP pathways, cell shape change and motility, and MAPK signaling.

74 ARP2/3 is an essential component of dynamic cell shape change and motility.

75 , is crucially involved in the regulation of cell shape change and motility.

76 The molecular and cellular bases of cell shape change and movement during morphogenesis and

77 nts are likely sources of forces that direct cell shape change and movement we explicitly model the d

78 s must reorganize the cytoskeleton to affect cell shape change and promote cell invasion and motility

79 s most to elongation at the growth zone, but cell shape change and rearrangement contribute as much a

80 Independent of mew, Rac regulates cell shape change and rearrangement in the proximal glan

81 of possibilities: division, differentiation, cell shape change and so on.

82 Vinblastine caused cell shape change and the expected MT disruption.

83 Cell shape change and the restructuring of the cytoskele

84 l for many developmental processes involving cell shape change and tissue deformation.

85 utse as a new model system for understanding cell shape change and, putatively, diseases associated w

86 l migration fate, including gene expression, cell shape changes and accumulation of cytoskeletal comp

87 However, long-term absence of MreB led to cell shape changes and an eventual loss of MreC localiza

88 efined series of steps, involves coordinated cell shape changes and begins with the dorsal-posterior

89 the precise orchestration of cell migration, cell shape changes and cell adhesion.

90 in several morphogenetic processes requiring cell shape changes and cell migration.

91 HTM cells by MK571 or probenecid resulted in cell shape changes and decreases in actin stress fibers

92 with growing MTs are important to coordinate cell shape changes and directed migration into the surro

93 In cardioblasts, Slit and Robo modulate the cell shape changes and domains of E-cadherin-based adhes

94 noncanonical pathways that involve polarized cell shape changes and migrations, but also more recentl

95 how in Xenopus that Shroom3 is essential for cell shape changes and morphogenesis in the developing v

96 oderm which is the tissue that undergoes the cell shape changes and movements during germ-band retrac

97 he epidermal ectoderm, thus coordinating the cell shape changes and movements that drive germ-band re

98 ms of contraction have been elusive for many cell shape changes and movements.

99 d considerable interspecies variation in the cell shape changes and neighbor exchanges underlying app

100 In addition, gross cell shape changes and organelle movements buffer local

101 dynamic arrangements of actin and, thus, for cell shape changes and process formation.

102 ue shape and architecture that are driven by cell shape changes and rearrangements within cohesive ce

103 Tissue morphogenesis requires control over cell shape changes and rearrangements.

104 system in which neurogenesis is coupled with cell shape changes and regulated steps of cell intercala

105 is regulated by Rock proteins, disrupted KV cell shape changes and the anteroposterior distribution

106 dicated by the presence of periodic waves of cell shape changes and the localized translocation of cy

107 of cytoplasm accounts quantitatively for the cell shape changes and the nucleus movement in Drosophil

108 h on tissue specification, the regulation of cell shape changes and tissue interactions during morpho

109 oscopy to follow actin dynamics and document cell shape changes and tissue movements in living, unper

110 Cell shape changes and tissue movements like these are a

111 to provide the driving force for aspects of cell-shape change and locomotion.

112 ling is required within the fat body for the cell-shape changes and cell detachment that are characte

113 In wild-type embryos, spatially regulated cell-shape changes and rearrangements organize cells int

114 ctrical resistance (a measure of endothelial cell shape change) and increased transendothelial (125)I

115 eciprocal epitheliomesenchymal interactions, cell shape change, and cell rearrangement.

116 ed increase in endothelial cell contraction, cell shape change, and consequently to the mechanism of

117 e regulation of the PINCH-1-ILK interaction, cell shape change, and migration.

118 ed agonists on actin stress fiber formation, cell shape change, and ROS production.

119 ionship among extracellular matrix turnover, cell shape changes, and apoptosis during angiogenesis in

120 in ECs, demonstrate that GIT1 is involved in cell shape changes, and suggest a role for GIT1 as a neg

121 is the result of coordinated cell movements, cell shape changes, and the organisation of pigment cell

122 esis is accompanied by a columnar-to-conical cell shape change (apical constriction or AC) and is kno

123 Omega7536 locus is expressed at the time of cell shape change appropriate to each process, early aft

124 Although these cell shape changes are accompanied by an apparent large

125 These cell shape changes are controlled by nonmuscle myosin II

126 Cell shape changes are critical for morphogenetic events

127 Cell shape changes are determined by the interplay of ce

128 Individual cell shape changes are essential for epithelial morphoge

129 Individual cell shape changes are the basis for the morphogenetic e

130 Cell-shape changes are insured by a thin, dynamic, corti

131 apable of both growth inhibition and causing cell shape changes as shown by the use of a chimeric int

132 crotubule dynamics prevents both the initial cell shape changes as well as cell migration.

133 increase levels of phospho-EGFR and promote cell shape changes as well as leading edge formation in

134 essed at high levels has a role in eliciting cell shape changes associated with epithelial-to-mesench

135 ster together and fail to undergo any of the cell-shape changes associated with notochord differentia

136 Cell-shape changes associated with processes like cytoki

137 maginal discs undergo a cuboidal-to-squamous cell shape change at distinct larval stages.

138 kinase signaling is required to initiate the cell shape change at the onset of the epithelial wound h

139 These differences in protrusive activity and cell shape changes between the neural and mesodermal reg

140 emonstrated that SPEC1 altered Cdc42-induced cell shape changes both in COS1 cells and in NIH-3T3 fib

141 cortical actin network controls many animal cell shape changes by locally modulating cortical tensio

142 m, we show that DRhoGEF2 induces contractile cell shape changes by stimulating myosin II via the Rho1

143 shortens in Drosophila melanogaster embryos, cell shape changes cause segments to narrow anteroposter

144 n of cytokinesis, we focused on the earliest cell shape change, cell elongation, which occurs during

145 rises from a number of mechanisms, including cell shape change, cell proliferation, and cell sorting

146 three-dimensional patterns of cell motility, cell shape change, cell rearrangement and tissue deforma

147 4D enables quantification of the dynamics of cell shape changes, cell interfaces and neighbor relatio

148 astrulation, the archenteron is formed using cell shape changes, cell rearrangements, filopodial exte

149 at the cell cortex is critical for mediating cell shape changes, cell surface composition, or cell si

150 l and hormonal controls that orchestrate the cell shape changes, cell-cell junction remodeling and po

151 These coincide with a novel cell shape change--cell extension along the anterior-pos

152 te cell migration (chemotaxis), or localized cell shape changes (chemotropism).

153 These results indicate that regional cell shape changes control the development of anteropost

154 We have found that the cell shape changes correlate with changes in electrical

155 Cell-shape change demands cell-surface growth, but how g

156 Net cell shape change depends on whether cell shape is stabi

157 actin, which provides the driving force for cell shape change, dissociates from the apical membrane

158 nts2, and PIN1a suggests that PAN2-dependent cell shape changes do not involve any of these proteins,

159 ion in the adult leg reflects aberrations in cell shape changes driven by myosin-based contraction du

160 model underlying epithelial folding involves cell shape changes driven by myosin-dependent apical con

161 This coordinated cell shape change drives epithelial cell sheet involutio

162 oth cell migration during body enclosure and cell shape change during body elongation.

163 nase (Rok) to induce apical constriction and cell shape change during invagination.

164 Tjp1a is a novel regulator of cell shape changes during colour pattern formation and t

165 Cell shape changes during cytokinesis in eukaryotic cell

166 decapentaplegic expression and to coordinate cell shape changes during dorsal closure.

167 e DRhoA is responsible for the regulation of cell shape changes during early Drosophila morphogenesis

168 tracellular matrix (ECM) adhesions regulates cell shape changes during embryonic development and tiss

169 h concertina, a G(alpha) protein involved in cell shape changes during gastrulation.

170 unction is essential for the coordination of cell shape changes during gastrulation.

171 f actomyosin accumulation that drive initial cell shape changes during gastrulation.

172 t initiate the regulation of NMII to mediate cell shape changes during MHB morphogenesis are not know

173 oter were generated and used for analysis of cell shape changes during morphogenesis of various devel

174 orphogenesis driven by cell migration and/or cell shape changes during oogenesis, embryogenesis, larv

175 e is required specifically for the epidermal cell shape changes during the morphogenetic process of d

176 ative analysis of the fast dynamics of whole-cell shape changes during tissue folding and points to a

177 We find that the specific sequence of cell-shape changes during VF formation is critically con

178 Alterations in cytoskeleton and subsequent cell shape changes exert specific effects on the express

179 tiation when cytoskeletal reorganization and cell shape change from fibroblastic preadipocytes to sph

180 y, the suppressive mutations lead to a major cell shape change, from the normal cylindrical shape to

181 aminin induces multiple responses, including cell shape changes, growth arrest, and, in the presence

182 hanical structure and generate forces during cell shape changes, growth, and migration.

183 her the physical basis for the regulation of cell shape changes, here, we use a cell-like system with

184 de independent, time-resolved information on cell shape changes (impedance) and dynamic mass redistri

185 criptional network that underlies epithelial cell shape change in developing vertebrates.

186 n cytoskeleton to cell-cell junctions drives cell shape change in development and homeostasis.

187 rtant as so far, key downstream effectors of cell shape change in Drosophila appear not to be conserv

188 FKN also induced cell shape change in firmly adherent monocytes and IL-2-

189 aces contributes to physiologically relevant cell shape change in intact organisms.

190 2/3-dependent actin filament nucleation and cell shape change in migrating cells.

191 Mitotic cell rounding is the process of cell shape change in which a flat interphase cell become

192 t are likely to be required for the numerous cell shape changes in a developing embryo.

193 tracellular signals, signaling pathways, and cell shape changes in a noisy background.

194 the study of chemotaxis, we demonstrate that cell shape changes in a wave-like manner.

195 apical actomyosin contractions began before cell shape changes in both Caenorhabitis elegans and Dro

196 ignaling pathways for cell proliferation and cell shape changes in corneal endothelial cells.

197 Cell shape changes in cytokinesis are driven by a cortic

198 ll as the Rho1 GTPase, mediate a pathway for cell shape changes in dorsal closure that is independent

199 end largely on active cell rearrangement and cell shape changes in dorsal tissues, we find that the n

200 second round of Dpp signaling then specifies cell shape changes in ectodermal cells leading to dorsal

201 The ARF6 GTPase mediates cell shape changes in interphase cells through its effec

202 ubule/actin filament interactions underlying cell shape changes in response to guidance cues, plays a

203 sented that DRhoGEF2 mediates these specific cell shape changes in response to the extracellular liga

204 y any of these procedures results in ectopic cell shape changes in the gastrula.

205 Pkn provides a GTPase effector function for cell shape changes in vivo, which acts together with a R

206 rphogenesis, the actin cytoskeleton mediates cell-shape change in response to growth signals.

207 veal how signals from one cell type regulate cell-shape changes in another to establish a critical pa

208 onsible for generating the forces that drive cell-shape changes in each of the force-generating tissu

209 laminin fragment and heparin both inhibited cell shape changes induced by laminin, thereby implicati

210 Localized cell shape change initiates epithelial folding, while ne

211 r of the polar lobe and characteristic early cell shape changes involving protrusion of the 3D macrom

212 A transcriptional network for epithelial cell shape change is emerging in Drosophila, but this ar

213 n of apical cell surfaces, and the resulting cell shape change is thought to cause tissue folding.

214 racterized; however, the mechanical basis of cell shape changes is largely unknown because of a lack

215 However, the cell biology driving cell shape changes is poorly understood, especially in v

216 how pheromone-dependent signalling leads to cell shape changes is unclear.

217 nd contractile systems coordinate to promote cell shape changes is unclear.

218 At the core of cell-shape changes is the ability of the cell's machiner

219 Apical constriction is a widely utilized cell shape change linked to folding, bending and invagin

220 equent membrane association and induction of cell shape changes, linking pRb activity to cytoskeletal

221 s in many developmental processes, including cell-shape changes, localisation of RNA and apoptosis.

222 atrix to the actin cytoskeleton and regulate cell shape change, migration, and other cellular process

223 to ECM is an important process that controls cell shape change, migration, proliferation, survival, a

224 ntact the notochord, as do other patterns of cell shape change, movement and tissue deformation that

225 The mechanisms of such cell shape changes must integrate developmental patterni

226 ely downstream of Pitx2 to directly regulate cell shape changes necessary for early gut tube morphoge

227 The dramatic cell-shape changes necessary to form a multicellular org

228 ty overcomes cortical tension to produce the cell shape changes needed for locomotion.

229 stributions of active myosin can explain the cell shape changes observed during invagination both in

230 efore be an underlying mechanism for overall cell shape changes observed during oxidative stress.

231 Specific cell shape changes occur at the point of deepest constri

232 mutant for folded gastrulation (fog), these cell shape changes occur but the timing and synchrony of

233 This cell shape change occurs prior to, and is required for,

234 s involved segregation, local alignment, and cell-shape changes of presumptive epitheloid border cell

235 To understand the role of cell shape changes on matrix metalloproteinase expressio

236 onic mesoderm, pole plasm and other sites of cell shape change or movement.

237 ly expressed in cells and tissues undergoing cell shape changes or cell migration.

238 sis precisely coordinated cell movements and cell shape changes organize the newly differentiated cel

239 of other elongation mechanisms, specifically cell shape change, orientated cell division and cell rea

240 rer, an approach for quantifying rapid whole-cell shape changes over time, and we combined it with de

241 ments requires precise measurements of whole-cell shape changes over time.

242 unfolding allows bleb inflation and dynamic cell-shape changes performed by migrating cells.

243 catenin may also regulate cell migration and cell shape changes, possibly by regulating the microtubu

244 urrow ingression during cytokinesis, a model cell-shape-change process.

245 Cell shape changes require the coordination of actin and

246 Rac-mediated signaling pathways regulate the cell shape changes required for dorsal closure and that

247 ated at the base of fissures fail to undergo cell shape changes required for fissure initiation.

248 l boundaries to regulate cell migrations and cell shape changes required for proper morphogenesis and

249 hoGEF2 fail to gastrulate due to a defect in cell shape changes required for tissue invagination, and

250 nor beta1-blocking antibodies perturbed the cell shape changes resulting from cell exposure to lamin

251 Cell shape changes such as cytokinesis are driven by the

252 ia, force imbalance at cell contacts induces cell shape changes, such as apical constriction or polar

253 ateral otocyst, occurring concomitantly with cell shape change, suggesting that BMP/SMAD signaling re

254 ls and activity at adherens junctions during cell shape change, suggesting that Diaphanous helps coor

255 Apical constriction is a cell shape change that promotes epithelial bending.

256 Apical constriction is a cell shape change that promotes tissue remodeling in a v

257 llow by transmission electron microscopy the cell shape changes that accompany boundary formation.

258 s being a critical determinant governing the cell shape changes that accompany progression through th

259 cortex that regulates the complex series of cell shape changes that accompany these two processes.

260 alterations in Shg-mediated adhesion control cell shape changes that are essential for vein morphogen

261 polymerization, filopodia formation, and the cell shape changes that are required for migration of th

262 ded gastrulation pathway triggers epithelial cell shape changes that drive gastrulation and tissue fo

263 e cytoskeletal rearrangements that cause the cell shape changes that drive tubulogenesis are not well

264 cytoskeleton within individual cells drives cell shape changes that fold tissues.

265 wever, the kinetics of actin changes and the cell shape changes that follow FcepsilonRI signaling wer

266 that layer; there they participate in subtle cell shape changes that further expand the blastoderm.

267 les, and is required during gastrulation for cell shape changes that mediate epithelial folding.

268 imaging of KV cells revealed region-specific cell shape changes that mediate tight packing of ciliate

269 Morphogenesis is driven by small cell shape changes that modulate tissue organization.

270 nction must be maintained during the complex cell shape changes that occur during cytokinesis in vert

271 e been implicated in the dramatic epithelial-cell shape changes that occur during gastrulation and mo

272 ed the role of NMIIA and NMIIB in regulating cell shape changes that occur during MHB morphogenesis.

273 ation and is important for the migration and cell shape changes that precede fusion.

274 and even more regulatory events driving the cell shape changes that produce tubes of specific dimens

275 nt involving activation, ligand binding, and cell shape changes that ultimately result in enhanced ad

276 ilin inhibited the specific cytoskeletal and cell shape changes that were induced in response to a re

277 rive VF formation along the same sequence of cell-shape change that we observed in the actual embryo,

278 We investigated the apical cell-shape changes that characterize amnioserosa cells d

279 The cytoskeleton is a major determinant of cell-shape changes that drive the formation of complex t

280 rane folding/unfolding can contribute to the cell-shape changes that promote embryonic morphogenesis.

281 eling both a-cells and alpha-cells and their cell shape changes, the extracellular diffusion of matin

282 nduced actin cytoskeletal reorganization and cell shape change; these responses could be rescued by t

283 RhoA, Rac1, and Cdc42 are known to regulate cell shape changes through effects on the cytoskeleton a

284 RhoA, Rac1, and Cdc42 are known to regulate cell shape changes through effects on the cytoskeleton,

285 ponsible for a surprisingly diverse array of cell shape changes throughout development.

286 regulation of cell contractility coordinates cell shape change to construct tissue architecture and u

287 when grown in permissive conditions, but the cell shape changed to polygonal after 14 d in growth-res

288 ase transition, in coupling moesin-dependent cell shape changes to mitotic exit.

289 heir apices, undergo a series of coordinated cell-shape changes to form a ventral furrow (VF) and are

290 Cell shape change was determined by phase-contrast micro

291 that an NADPH oxidase-dependent endothelial cell shape change was required for lymphocyte migration.

292 g antibody to alpha4 alone induced apoptotic cell shape changes, whereas co-treatment with this antib

293 ction (AC) is a widely utilized mechanism of cell shape change whereby epithelial cells transform fro

294 e transition from reversible to irreversible cell shape change, which defines the onset of tissue sha

295 gel transitions of the cytoskeleton modulate cell shape changes, which are required for essential cel

296 The mechanisms controlling cell shape changes within epithelial monolayers for tiss

297 l closure (DC) involves a coordinated set of cell-shape changes within the epidermis and the amnioser

298 ich induced microtubule depolymerization and cell shape changes without affecting stress fibers, did