ライフサイエンスコーパス: cell size

1 pass through a constriction smaller than the cell size.

2 elial cell density, but decreased epithelial cell size.

3 echanism linking mitochondrial biogenesis to cell size.

4 ween vacuole biogenesis rates and vacuole or cell size.

5 ometry to analyze mitochondrial scaling with cell size.

6 ivision events is independent of the newborn cell size.

7 drives nuclear downscaling independently of cell size.

8 ction in absolute gene expression levels and cell size.

9 yclinB and entry into mitosis with a smaller cell size.

10 S6K1 and increased synthesis of proteins and cell size.

11 and explains the scaling of the spindle with cell size.

12 tensile stiffness, construct alignment, and cell size.

13 eveal a novel role of ZO-2 as a modulator of cell size.

14 butes to ileal villus maintenance and goblet cell size.

15 ositioning is asymmetric and proportional to cell size.

16 , decreased nutrient reliance, and increased cell size.

17 he interface with a depth resolution of unit cell size.

18 ute to continued outgrowth through increased cell size.

19 n, which can be attributed to an increase in cell size.

20 e-tuned on a cell-by-cell basis according to cell size.

21 pabilities and an associated extremely small cell size.

22 rdination between cell cycle progression and cell size.

23 caling of Cln3 and Whi5 synthesis rates with cell size.

24 he larger hybrids and promote increased leaf cell size.

25 ols have opposing effects on cardiac myocyte cell size.

26 ic to the spindle and largely independent of cell size.

27 in which organelle size depends linearly on cell size.

28 hanistic link between organelle assembly and cell size.

29 physiological states can result in the same cell size.

30 and how archaeal cells exhibit control over cell size.

31 ive to cell adhesion but not to stiffness or cell size.

32 r nutrients, leading to a large reduction in cell size.

33 ll envelope capacity, which in turn dictates cell size.

34 scover that ploidy correlates with Stentor's cell size.

35 phosphorylation are highest at intermediate cell sizes.

36 n is imperfect and they still bud at smaller cell sizes.

37 sinking 'pull' the community towards smaller cell sizes.

38 anelle growth is independent of organelle or cell size?

39 cal variation, cells consistently have small cell size (0.009+/-0.002 mum(3)).

40 evis and C. elegans, the spindle scales with cell size [1, 2], a phenomenon regulated by molecules th

41 odeling was used to produce high-resolution (cell size: 500m x 500m) maps for Avian Influenza (AI) su

42 Rather, smaller cell size, a high degree of phenotypic plasticity, and i

43 ith increased driving pressure and decreased cell size according to a power law.

44 principle allows quantitative predictions of cell size across a range of growth conditions in both or

45 phyla, mitotic spindle length decreased with cell size across an approximately 30-fold difference in

46 caling relationship between spindle size and cell size across metazoans, which indicates a conserved

47 tic designation, but closely correlated with cell size across types, whereas PSII light utilization i

48 ns) more than 70 cell descriptors, including cell size, age and fluorescence.

49 e cellular content scales isometrically with cell size, allometric laws indicate that metabolism per

50 ing yeast, cell-cycle progression depends on cell size, although it is still unclear how size is asse

51 rade-off emerging from relationships between cell size and (1) nutrient uptake, (2) zooplankton grazi

52 of chromosome length regulation: one through cell size and a second in response to nuclear size.

53 liminate confounding that may originate from cell size and cell cycle differences.

54 the models predict anticorrelated changes in cell size and cell cycle duration under different enviro

55 ristem and perturbs the relationship between cell size and cell cycle progression.

56 lacking TAX1BP1 exhibit delays in growth of cell size and cell cycling.

57 Moreover, knockdown of ZNRF2 decreases cell size and cell proliferation.

58 Here, we disentangle mutual contributions of cell size and cell stiffness to cell deformation by a th

59 nts and stochastic modeling of mycobacterial cell size and cell-cycle timing in both slow and fast gr

60 yos, we have quantified the relation between cell size and chromosome length.

61 rom complex samples are largely dependent on cell size and density, with limited application scope as

62 A lack of correlation between guard cell size and DNA content, lack of arabinans in cell wal

63 during early hypertrophy before a change in cell size and DNA content.

64 lly, giving rise to significant variation in cell size and elongation rate among closely related cell

65 ntermediates, subject to constraints of unit cell size and energy.

66 Smaller baseline adipose cell size and greater enlargement with weight gain predi

67 Cell size and growth kinetics are fundamental cellular p

68 Here, we show that nutrients modulate cell size and growth rate via the TORC2 signaling networ

69 ceramide signaling strongly influences both cell size and growth rate.

70 In this study, to characterize cell size and growth regulation in a multicellular conte

71 ociated with a faster growth rate and larger cell size and is not simply due to a delay in the transi

72 s mutant showed that ClpXP activity controls cell size and is required for growth at low temperature.

73 suggest that the quantitative laws governing cell size and its dependence on growth rate may arise as

74 L4-3 in detail and found increased mesophyll cell size and leaf ploidy levels, suggesting that endore

75 rated by treatment, most notably hippocampal cell size and lifespan.

76 adipose tissue (WAT), including decreases in cell size and lipid content and increases in mitochondri

77 ed backscattering coefficient related to the cell size and mechanical properties.

78 osmotic regulation can robustly control the cell size and membrane tension against external mechanic

79 was characterized by a profound increase in cell size and morphological alterations in cellular ultr

80 itulated the impact of altering nutrients on cell size and morphology, whereas defects in other biosy

81 macrophage functional phenotypes using their cell size and morphology.

82 cell cycle arrest at S phase with increased cell size and nuclei.

83 ked to fat distribution can be linked to fat cell size and number (morphology) and/or adipose tissue

84 g above-ground biomass, leaf size, epidermal cell size and number and stomatal density and index.

85 tion of leaflet laminae due to a decrease in cell size and number, change of adaxial cell identity, o

86 n those of the parents and have increases in cell size and number.

87 dimensions reveals fundamental links between cell size and other cellular processes in the bacterium

88 his paper we investigate the relationship of cell size and patterning, airspace and photosynthesis by

89 implements cell division and thus influences cell size and shape that couple to the continuum compone

90 in phenotype categories related to abnormal cell size and shape.

91 that SAC strength is determined primarily by cell size and the number of kinetochores.

92 in the bladder SMCs significantly increased cell size and up-regulated SM22, SM alpha-actin, and SM

93 mposition and to exhibit, on average, bigger cell sizes and higher size diversity than in the tropics

94 e these forces leading to persistently small cell sizes and reduced size diversity.

95 l division may provide a link between mother cell-size and mitotic division number.

96 s protein synthesis dysregulation, increased cell size, and aberrant neuronal connectivity.

97 promoted cell fission at an abnormally small cell size, and caused cell shape and integrity defects u

98 regulation of atx-2 increases the body size, cell size, and fat content of dietary-restricted animals

99 tanding the relationships among DNA content, cell size, and gene expression variability in single cel

100 ure was modified by control of the honeycomb cell size, and hence surface area to enable control of d

101 CDKG1 in pre-mitotic cells is set by mother cell size, and its progressive dilution and degradation

102 The organismal phenotypes of cell cycle, cell size, and phototactic behavior exhibited substantia

103 min pH, thick albumin ratio, yolk index, air cell size, and S-ovalbumin content of UC were significan

104 ation delays cell cycle progression, reduces cell size, and suppresses the replicative longevity of c

105 int activity increases during development as cell size, and the cytoplasm-to-kinetochore ratio, decre

106 morphology in this model does not scale with cell size, and we recently found evidence for non-centro

107 escues dTorsin-KO defects, including adipose cell size, animal growth, and survival.

108 ata suggest a model in which growth rate and cell size are mechanistically linked by ceramide-depende

109 isclassification error rates (MER) by taking cell sizes as weights.

110 ypertrophy, transcription did not scale with cell size, as smaller myofibers (<1000 mum(2)) demonstra

111 h 5-bromo-2'-deoxyuridine incorporation, and cell size assessed by fluorescence-activated cell sortin

112 proteins to the cell cortex and maintaining cell size asymmetry during asymmetric cell division of D

113 tal potentials, can be manifested in sibling cell size asymmetry.

114 ity maintenance and initial establishment of cell size asymmetry.

115 tal process responsible for creating sibling cell size asymmetry; however, how the cortex causes the

116 ntry, and that such a memory is reflected in cell size at a coarse scale.

117 We show cell size at division and cell cycle length is effective

118 Mean cell size at division is generally constant for specific

119 n of the fusion protein, the distribution of cell size at division is unusually broad, an observation

120 hibition experiments, and we discovered that cell size at replication initiation per origin, namely t

121 of progression through Start increases with cell size, because cell growth dilutes the cell-cycle in

122 ructures such as mitotic spindles scale with cell size, but less is known about the scaling of actin

123 size of MAG is contributed by an increase in cell size, but not cell number.

124 Many mutations have been identified to alter cell size, but pleiotropic effects have largely hampered

125 hed by cell proliferation patterns and final cell sizes, but the underlying molecular mechanisms coor

126 oscopic nonadherent areas much larger than a cell size by purse-string closure and that active epithe

127 al organisms showed that this homogeneity in cell size can be accomplished by growing a constant size

128 ns and constraints on the local expansion of cell size cause inhibition of cell motion and reductive

129 ile methanol-water fractions (MWFs) increase cell size, cell-cell adhesion, and cell death.

130 We found that a cell size checkpoint is not the trigger for G2/M or cyto

131 tic changes in morphology, with reduction in cell size, chromatin and nuclear condensation, and enucl

132 tion of Notch signaling results in increased cell size commensurate with increased K(+) current ampli

133 the observed biogeographical differences in cell size composition of phytoplankton communities.

134 These cells efficiently decrease cell size, condense their nucleus, and undergo nuclear p

135 ork, is the principal factor that determines cell size; consequently, cells grow in groups.

136 nt of growth in mitosis play a major role in cell size control in budding yeast.

137 yces cerevisiae, finding, surprisingly, that cell size control in this organism is very well describe

138 ntal model, suggesting a common strategy for cell size control with bacteria.

139 understand the molecular basis of bacterial cell size control.

140 ely explains this biphasic 'mixer' model for cell size control.

141 itions, we found that well-studied models of cell-size control are insufficient to explain the mycoba

142 is external or cell autonomous, the role of cell-size control in the development of multicellular or

143 ent noise sources in well-known paradigms of cell-size control, such as adder (division occurs after

144 analysis reveals that a simple law governing cell-size control-a noisy linear map-explains the origin

145 enology with the molecular mechanism of G1/S cell-size control.

146 linear map implements a negative feedback on cell-size control: a cell with a larger initial size ten

147 Thus, the scaling of the spindle with cell size controls its variation over both ontogeny and

148 owth--as a molecular mechanism through which cell size controls proliferation.

149 in cell growth, this biophysical readout of cell size could provide a novel feedback mechanism for g

150 that the effect of quorum sensing causes the cell size decrease as the cell density on surfaces incre

151 n stationary phase, the distribution of frik cell sizes decreases and approaches wild-type length dis

152 Arabidopsis show dynamic regulation of mean cell size dependent on developmental stage, genotype and

153 Cell-size-dependent accumulation of limiting cell cycle

154 Proliferating cells adjust their cell size depending on the nutritional environment.

155 tric cell division that can generate sibling cell size differences.

156 -law statistics in the tail of C. crescentus cell-size distribution, although there is a discrepancy

157 The device cannot only accurately measure cells size distribution and concentration but also detec

158 ochannel has a close correspondence with the cells' size distribution.

159 Although this rule explains narrow cell-size distributions, its mechanism is still unknown.

160 ased models of size control and heavy-tailed cell-size distributions.

161 To maintain a constant cell size, dividing cells have to coordinate cell-cycle

162 , such as widespread nonmonotonic changes in cell size down generations in response to parameter chan

163 have shown that the spindle also scales with cell size during early development.

164 ding sites, as well as possible variation of cell size during exposure to metal ions.

165 ct of apoptotic targets on PTEC cell growth (cell size during G1 phase of the cell cycle).

166 responsive to DNA content but uncoupled from cell size during hypertrophy.

167 ular, we show that the increase of bacterial cell size during Lenski's long-term evolution experiment

168 e-dimensional changes and rapidly decreasing cell sizes during early development of the embryo.

169 d critical increment paradigms, meaning that cell size fluctuations decay by approximately 75% in one

170 fluctuations and variable cell strain due to cell size fluctuations therefore cause significant varia

171 ling with ME-SIMS is suitable for a range of cell sizes, from Aplysia californica neurons larger than

172 Recent experimental studies showed that when cell-sized giant unilamellar vesicles (GUVs) are exposed

173 Cell-sized giant unilamellar vesicles (GUVs) would be id

174 s, high LMA resulted principally from larger cell sizes, greater major vein allocation, greater numbe

175 enable mycobacterial populations to regulate cell size, growth, and heterogeneity in the face of vary

176 alter nuclear size, together indicating that cell size helps dictate nuclear proportions.

177 tained typical immaturity traits (e.g. small cell size, high amino acid contents and reduced sucrose)

178 ive and stable phase consists of single unit cell sized hollandite-like structural domains that are c

179 PP2A plays a hitherto unappreciated role in cell size homeostasis during metabolic rewiring of the c

180 on the subject, the mechanisms that maintain cell-size homeostasis are largely mysterious [1].

181 that the cell cycle was adjusted to maintain cell-size homeostasis.

182 e of mitotic chromosomes is coordinated with cell size in a manner dependent on nuclear trafficking.

183 eleton has a direct impact on the control of cell size in animal cells, but its mechanistic contribut

184 acid synthesis is the primary determinant of cell size in bacteria and in budding yeast.

185 work with quantitative predictive power over cell size in bacteria.

186 ionship between growth, gene expression, and cell size in cyanobacteria.

187 ind that nucleolar size directly scales with cell size in early C. elegans embryos.

188 We show that cell size in Escherichia coli can be predicted for any s

189 e maintained after we systematically altered cell size in Escherichia coli using the antibiotic A22,

190 caling relationship between spindle size and cell size in metazoans.

191 how optimum filter mesh size increases with cell size in microbial filter feeders, a prediction that

192 sion biosynthetic capacity-positively impact cell size in organisms throughout the tree of life.

193 educed energy status, protein synthesis, and cell size in ovarian and pancreatic cancer cells.

194 ere, we reveal a role of actin in regulating cell size in plants.

195 mature cardiomyocytes showed an increase in cell size in response to the drug.

196 Here we present evidence that cell size in the fission yeast Schizosaccharomyces pombe

197 esponses are related to larger organ and cap cell size in the proximal part of the hearing organ whil

198 scale with cell length over a wide range of cell sizes in embryos and larvae.

199 r allele aged, nephrocyte function declined, cell size increased, and nephrocytes died prematurely.

200 on and FACS, to obtain genomic sequences and cell size information from uncultivated microbial cells

201 ells of S6K1-/- mice restored embryonic beta cell size, insulin levels, glucose tolerance, and RPS6 p

202 responses, we measured subcutaneous adipose cell size, insulin suppression of lipolysis, and regiona

203 While optimal cell size is controlled by growth factor signaling, its

204 However, it has not been understood how cell size is coordinated with biosynthesis and robustly

205 Cell size is determined by the duration and rate of grow

206 Proper cell size is essential for cellular function.

207 In animals, it has been suggested that cell size is modulated primarily by the balance of exter

208 Analysis reveals that variation in cell size is most sensitive to errors in partitioning of

209 nd metazoans, but why this occurs at a given cell size is not fully understood.

210 In bacteria, cell size is reduced 3-fold in response to nutrient star

211 istal part of the organ, small organ and cap cell size is related to high-frequency representation.

212 Cell size is specific to each species and impacts cell f

213 How a particular cell size is specified by differentiation programs and p

214 esource allocation, we explain why the total cell size is the sum of all unit cells.

215 In budding yeast, cell size is thought to be controlled almost entirely by

216 The conventional strategy to increase unit cell size is tweaking membrane composition to include ch

217 We show that the cell size is under the density-dependent pathway control

218 e nuclear/cytoplasm ratio (NCR), rather than cell size, is a key predictor of response for cells trea

219 convergence, although subsequent changes in cell size lead to medial-lateral spreading.

220 proterenol (isoprenaline) with a decrease in cell size, mature cardiomyocytes showed an increase in c

221 suggests that, in the context of evolution, cell size may be a 'spandrel'.

222 lso exists in intact plant tissues, and that cell size may be an emergent rather than directly determ

223 Elevated ploidy is associated with enhanced cell size, metabolic capacity, and the capacity to diffe

224 specific characteristics such as cell shape, cell size, metaphase/anaphase delays, and mitotic abnorm

225 akhpA mutations reduce growth rate, decrease cell size, minimally affect shape and induce expression

226 was selectively required for regulation of B cell size, mitochondrial biogenesis, glycolysis and prod

227 nticipated collective dynamism in epithelial cell size, mobility, and interactions.

228 nlinearity of mitochondrial functionality is cell size, not cell cycle, dependent, and it results in

229 ge signal is generally coarser than the grid cell size of downscaled climate model output.

230 al processes such as growth, cell cycle, and cell size of model organisms such as Escherichia coli.

231 ncreased levels of ppGpp resulted in reduced cell size of PssB728a when grown in a minimal medium and

232 we are able to analyze genomic sequences and cell sizes of hundreds of individual, uncultured bacteri

233 Using cell-sized oil droplets with controlled physicochemical

234 Analysis of mutants that alter cell size or ploidy revealed that SAC strength is determ

235 lect adaptations to the demands of different cell size or range of physiological growth temperatures.

236 biosynthetic capacity as a whole determines cell size or whether particular anabolic pathways are mo

237 t differences in pigmentation, yolk content, cell size, or position in the embryo.

238 isy linear map-explains the origins of these cell-size oscillations across all strains.

239 l chromosome segregation but also influences cell size, position, or fate [1].

240 In budding yeast, cell size primarily modulates the duration of the cell-d

241 Cell size, protein synthesis, and fat and glycogen stora

242 s with (a/w) > 0.3, and notch length-to-unit cell size ratios of (a/l) > 5.2, failed at a lower peak

243 fferences from wild type, including enlarged cell size, reduced growth, and increased division defect

244 olated expression of the M25 proteins led to cell size reduction, confirming that they contribute to

245 recovered proportional to the extent of fat cell size reduction.

246 owth rates, broad proteome restructuring and cell size reductions relative to steady-state growth lim

247 , the authors provide insight into bacterial cell size regulation and propose that a threshold level

248 ling cell growth and cell cycle control with cell size regulation are poorly understood in intact tis

249 Various phenomenological models for cell size regulation have been proposed, but recent work

250 ently on bacteria, have identified rules for cell size regulation in single cells, but in the more co

251 Rather, cell size regulation was intermediate between the critic

252 a conserved domain previously implicated in cell size regulation, suggesting a similar role in Trich

253 new insights into the dynamics of bacterial cell-size regulation with implications for the physiolog

254 by modulating DNA accessibility of hypocotyl cell size regulatory genes.

255 rmined by cell stiffness, but also depend on cell size relative to channel size.

256 ellular organization achieves consistency in cell size, replication dynamics, and chromosome position

257 of let-7 family members in hESC-CMs enhances cell size, sarcomere length, force of contraction, and r

258 omputer simulations to show that the uniform cell sizes seen in the meristem likely require coordinat

259 comprehensive ribosome profiling of a yeast cell size series from the time of cell birth, to identif

260 However, the coupling between cell size, shape and constriction remains poorly underst

261 In this way, cell size specific electroporation is conveniently carri

262 ve largely hampered our ability to probe how cell size specifically affects fundamental cellular prop

263 ize cell behavior and measure simultaneously cell size, speed of motion and magnitude of the associat

264 In cell-sized spheres, the dose delivered by (111)In and (1

265 Because of the small cell sizes, subcellular structures have long been diffic

266 )), with no change in construct alignment or cell size, suggesting maturation of excitation-contracti

267 Evidence from fossil guard cell size suggests that polyploidy in Sequoia dates to t

268 aluate its association with spring budbreak, cell size, summer leaf production rate, and photosynthet

269 logy and characteristics, including critical cell size, terminal morphology, and protein subcellular

270 rturbations can lead to changes in bacterial cell size that are not predicted by current models.

271 ell divisions with concomitant reductions in cell size, the first major developmental transition is t

272 ies have identified many mutations affecting cell size, the molecular mechanisms underlying size cont

273 orrectly predicting the divergent pattern of cell sizes, this model reveals allometric growth of cell

274 cellular integrity, organelle size adapts to cell size throughout development.

275 ation, termination, and division, as well as cell size throughout the cell cycle.

276 ixed amount of growth each generation causes cell size to converge on a stable average [4-6].

277 herein a 'counting' mechanism couples mother cell-size to cell division number allowing production of

278 spite of higher genetic damage and a larger cell size typical of differentiation.

279 dy presents a model that accurately predicts cell size under a variety of environmental conditions, f

280 in archaeal cell cycle events contribute to cell size variability and control.

281 4D image analysis to measure the sources of cell-size variability in the meristem and then used thes

282 of insulin resistance and changes in adipose cell size, VAT, IHL, and insulin suppression of lipolysi

283 emonstrated no significant change in adipose cell size, VAT, or insulin suppression of lipolysis and

284 new physiological state leads to a change in cell size via reallocation of cellular resources.

285 A genetically induced transient increase in cell size was quickly corrected by more frequent cell di

286 Mean cell size was smallest in heterografts and correlated ne

287 By manipulating C. elegans cell size, we change nucleolar component concentration a

288 To rationalize this emergent pattern of cell sizes, we propose a tractable mathematical model th

289 sponsible for coordinating cell division and cell size; when the clustered cells are at high populati

290 razing 'pushes' the community towards larger cell sizes, whereas nutrient uptake and sinking 'pull' t

291 cle, dependent, and it results in an optimal cell size whereby cellular fitness and proliferative cap

292 ther, our data indicate that small bacterial cell size, which is signified by the absence of DivIVA,

293 RIM15 overexpression lowers cell size while IGO1,2 deletion delays START in cells wi

294 wever, the correlation between organ and cap cell size with continuous frequency representation along

295 on cellular physiology over a large range of cell sizes with high resolution.

296 results in a power-law distribution for the cell size, with an exponent that depends inversely on th

297 hich maintains population-level variation in cell size within a certain range and returns the populat

298 Cells in growing populations maintain cell size within a narrow range by coordinating growth a

299 se mechanisms combine to drive variations in cell size within an isoclonal population is not well und

300 This leads to asymmetric cell size, yielding a smaller differentiating daughter c