ライフサイエンスコーパス: cell spreading

1 tensin-rich mature fibrillar adhesions, and cell spreading.

2 e expression of a T66-mutated moesin reduced cell spreading.

3 extension, thereby causing a defect in early cell spreading.

4 , and substrate binding from its function in cell spreading.

5 embrane protrusions during integrin-mediated cell spreading.

6 lar area followed by actin densification and cell spreading.

7 migration, a process that is accelerated by cell spreading.

8 ivation and focal adhesion maturation during cell spreading.

9 of focal adhesion kinase (FAK) and enhanced cell spreading.

10 uired for secreted HSP90alpha to enhance CRC cell spreading.

11 pH at focal adhesions as they mature during cell spreading.

12 TCR stimulation triggered a rapid and active cell spreading.

13 l rounding or to mediate negative effects on cell spreading.

14 gth and identified a nonlinear dependence on cell spreading.

15 in intracellular growth rate but in cell-to-cell spreading.

16 airs integrin activation, cell adhesion, and cell spreading.

17 olecules and cytoskeletal changes leading to cell spreading.

18 -2 prevents IFN-gamma-mediated inhibition of cell spreading.

19 NHS knockdown led to a striking increase in cell spreading.

20 Rac is required for cell spreading.

21 sion results in increased isotropic daughter-cell spreading.

22 t, and induced apoptosis despite recovery of cell spreading.

23 ted RhoA leads to stress fiber formation and cell spreading.

24 AGAP1 slowed cell migration and accelerated cell spreading.

25 is unable to respond to agonists and mediate cell spreading.

26 -2 expression inhibits Rac activation during cell spreading.

27 tein complex with p110, is unable to inhibit cell spreading.

28 on fibers and influences subsequent daughter-cell spreading.

29 vercome the amino-Nogo-induced inhibition of cell spreading.

30 ediated cleavage; this variant also retarded cell spreading.

31 ty in reducing cellular F-actin contents and cell spreading.

32 esion to fibronectin and the early stages of cell spreading.

33 haIIbbeta3-mediated outside-in signaling and cell spreading.

34 e periphery of platelets but without obvious cell spreading.

35 to Arp2/3 impairs lamellipodia formation and cell spreading.

36 began flattening during the early stages of cell spreading.

37 e bacterial adhesion and supported mammalian cell spreading.

38 mpetitor, and cytochalasin D as inhibitor of cell spreading.

39 a novel actin structural organization during cell spreading.

40 cling endosomes containing EHD1 and inhibits cell spreading.

41 lear surface shapes the nucleus during early cell spreading.

42 gand-1 (PSGL-1) inhibited integrin-dependent cell spreading.

43 igid substrates allowed stable adhesions and cell spreading.

44 Thus, during cell spreading, a balance between the biochemical and bi

45 igration defect is correlated with decreased cell spreading, abnormal focal adhesions, changes in the

46 and the ILK inhibitors significantly reduced cell spreading, actin polymerization, and the localizati

47 ssion of oxidation-resistant cofilin impairs cell spreading, adhesion, and directional migration.

48 veloped to study cellular processes (such as cell spreading, adhesion, invasion, toxicology and mobil

49 ws attachment, but not integrin ligation and cell spreading) also induced apoptosis.

50 The depletion of KIF14 led to increased cell spreading, altered focal adhesion dynamics, and inh

51 humoral immune responses, while stimulating cell 'spreading', an initiating event in cellular immuni

52 lium leads to a reduction of alveolar type 1 cell spreading and a disruption of lung sacculation.

53 triphosphatase RhoA, consequently inhibiting cell spreading and accelerating cell retraction.

54 AA exhibited a diminished ability to support cell spreading and actin organization compared with wild

55 of either Pvf2 or Pvr inhibits GBP-mediated cell spreading and activates AMP expression.

56 cultured cells reveals severe impairment of cell spreading and adhesion on fibronectin, indicative o

57 s, Rap1a(G12V) or Radil cause an increase in cell spreading and adhesion to fibronectin, which are bo

58 This led to impaired cell spreading and adhesion to selected extracellular ma

59 effector pathways associated with control of cell spreading and adhesion.

60 ignificant impedance changes contingent upon cell spreading and adhesion.

61 s to phosphatidylinositol 3-kinase-dependent cell spreading and Akt-dependent protection from apoptos

62 This enhanced cell spreading and BCR clustering is concurrent with inc

63 in specific for RAC, which in vivo regulates cell spreading and bleb formation.

64 g BAR domain contributed to ASAP1 control of cell spreading and CDRs.

65 lular matrix and functions in cell adhesion, cell spreading and cell migration.

66 checkpoint in the spatiotemporal control of cell spreading and cell motility.

67 It also supported fibrillogenesis and cell spreading and controlled cell migration speed.

68 l-derived factor 1/CXCR4 inhibition impaired cell spreading and delayed the resolution of permeabilit

69 Cell spreading and differentiation were unaffected by po

70 C and localization in FA was enhanced during cell spreading and ECM stiffness mechanosensing, suggest

71 RGD resulted in increased cell viability and cell spreading and encouraged cell migration into the hy

72 We show that S1P promotes cell spreading and endothelial barrier function through

73 in 1 (Rasip1) as a Rap1-effector involved in cell spreading and endothelial barrier function.

74 all processes dynamically coordinated during cell spreading and endothelial barrier function.

75 We found higher cell spreading and enhanced surface expression of TCR/CD

76 n polymerization into dynamic filaments upon cell spreading and fibronectin stimulation, both of whic

77 ivo lacking talin1 are unable to undergo the cell spreading and flattening required to form vessels.

78 olated from talin1-null EBs exhibit impaired cell spreading and focal adhesion formation.

79 ad attenuated FAK-pY397 as well as defective cell spreading and focal adhesions.

80 signaling are required for antigen-mediated cell spreading and force generation.

81 degradation exhibited high (low) degrees of cell spreading and high (low) tractions, and favoured os

82 red ACLP-deficient lung fibroblasts restored cell spreading and increased the contraction of collagen

83 In contrast, RhoC depletion increased cell spreading and induced Rac1 activation around the pe

84 depletion of beta2-adaptin by RNAi increases cell spreading and inhibits directional cell migration v

85 Accordingly, PTN promoted Mac-1-dependent cell spreading and initiated intracellular signaling man

86 Moreover, cell spreading and intercellular contacts together contr

87 concomitant augmented membrane protrusions, cell spreading and invasive phenotype.

88 ely, silencing Mfn proteins resulted in more cell spreading and lamellipodia formation, causing accum

89 Cell spreading and levels of GTP-bound RhoA were increas

90 Cytoskeletal changes, such as decreased cell spreading and lowered F-actin content, were also ob

91 tinct mechanisms by which integrins regulate cell spreading and matrix assembly through the beta(1) i

92 to 67% in hMSCs coincident with increases in cell spreading and membrane ruffling.

93 for the cortical actin cytoskeleton during B cell spreading and microcluster formation and function.

94 ys viscous behavior on the same timescale as cell spreading and migration and thus enables efficient

95 G alpha 12-integrin regulation of epithelial cell spreading and migration necessary for normal tubulo

96 actin dynamics involved in the regulation of cell spreading and migration through its actin depolymer

97 oduced no effect on cell proliferation, both cell spreading and migration were markedly inhibited.

98 g as an important Rap effector implicated in cell spreading and migration, but the molecular mechanis

99 ulus and robustness, but critically inhibits cell spreading and migration, hampering tissue regenerat

100 In turn, this causes reduced cell spreading and migration, highlighting the importanc

101 /3 to the plasma membrane and with increased cell spreading and migration, phenotypes that depend on

102 nt defects in adhesion, as well as increased cell spreading and migration.

103 calpain 2 abrogated the effects of hGAAP on cell spreading and migration.

104 erminus that contribute to the regulation of cell spreading and migration.

105 of focal adhesions is required for efficient cell spreading and migration.

106 e that crosses the cell membrane inhibits A7 cell spreading and migration.

107 LNA and organization of actin and diminishes cell spreading and migration.

108 FLNA and integrin beta1, which then promotes cell spreading and migration.

109 ns (FAs) and circular dorsal ruffles (CDRs), cell spreading and migration.

110 s and intracellular F-actin is essential for cell spreading and migration.

111 ction and inhibited beta1 integrin-dependent cell spreading and migration.

112 ng and proliferation, as well as endothelial cell spreading and monolayer formation.

113 eptor (EGFR) interacts with integrins during cell spreading and motility, but little is known about t

114 H3C modulates the Abl-mediated phenotypes of cell spreading and motility.

115 We studied these domains alongside cell spreading and observed that these very closely foll

116 ay system was demonstrated through localized cell spreading and osteogenic differentiation of human m

117 ow that ASB2alpha is a critical regulator of cell spreading and podosome rosette formation in immatur

118 n neutrophils impaired actin polymerization, cell spreading and polarization, dysregulated Rac-1 acti

119 show that PKD3 depletion strongly inhibited cell spreading and proliferation of TNBC cells, identify

120 ssion of Klf4 inhibited stiff matrix-induced cell spreading and proliferation, suggesting that Klf5/K

121 t hydrogel surfaces induced mesenchymal stem cell spreading and proliferation; however, increasing fi

122 w that Cdc42 was required in vivo for cancer cell spreading and protrusion extension along blood vess

123 the mechanisms that induce integrin-mediated cell spreading and provide mechanosensing on different e

124 e we unveil the molecular mechanism by which cell spreading and RhoA GTPase activity control FA forma

125 imary KO oral keratinocytes showed defective cell spreading and robust focal adhesions.

126 surface of antigen-presenting cells leads to cell spreading and signaling activation.

127 ell-specific protein 1 (HS1) is required for cell spreading and signaling in lymphocytes, but the sco

128 ional (2D) confinement of clusters restricts cell spreading and simultaneously blunts the confinement

129 sponses to mechanical stimuli and dissociate cell spreading and stiffening by contrasting responses o

130 ll proliferation but dramatically suppressed cell spreading and stress fibre organization, while knoc

131 Hippo and MST1/2, as a negative regulator of cell spreading and substrate attachment.

132 The spectrin cytoskeleton influences cell spreading and surface expression of TCR/CD3 and the

133 is not regulated by G1 arrest but rather by cell spreading and the level of contractile actomyosin.

134 Both cell spreading and the localization of talin and ILK to

135 ld-type protein efficiently rescues both the cell spreading and the lumen polarity defects in Par1b M

136 show that in the absence of IFT20, although cell spreading and the polarization of the centrosome we

137 slowed, cell protrusions are disordered, and cell spreading and traction forces are decreased.

138 VAP-1 enhanced stromal cell spreading and wound closure and modulated expressio

139 nization of actin during cell cortex repair, cell spreading and wound healing, and induces long-lasti

140 each other's effects on FAs, cell migration, cell spreading, and CDRs.

141 tion, resulting from impeded actin dynamics, cell spreading, and cell cycle arrest.

142 cell-cell adhesion, integrin-based adhesion, cell spreading, and cell migration.

143 ignaling, actin cytoskeleton reorganization, cell spreading, and cell migration.

144 elopment, proliferation, cell-cell adhesion, cell spreading, and cellular differentiation.

145 y, leading to abnormal actin belt formation, cell spreading, and migration.

146 mediated cell-extracellular matrix adhesion, cell spreading, and migration.

147 yocyte alpha(IIb)beta(3)-dependent adhesion, cell spreading, and mobility that relied on signaling th

148 go-A-Delta20-induced inhibition of adhesion, cell spreading, and neurite outgrowth, as well as for Rh

149 esults in defects in lamellipodia formation, cell spreading, and redistribution of Ena to the tips of

150 overexpression impacts MT stability, impairs cell spreading, and reduces activation-associated phenot

151 l adhesive processes such as cell migration, cell spreading, and survival.

152 d unexpected proteins that are important for cell spreading, and the computational tools developed in

153 receptor (BCR) induces receptor clustering, cell spreading, and the formation of signaling microclus

154 the kinetics of receptor redistribution from cell spreading, and to precisely define the initial cont

155 , nuclear translocation and Id-1 expression, cell spreading, and tubulogenesis of endothelial cells (

156 Although cell spreading appears normal in R760A mutant-integrin c

157 In addition, cell adhesion and cell spreading are also significantly impacted by cysmet

158 establish that ASB2alpha-mediated effects on cell spreading are due to loss of filamins.

159 integrin-dependent cell-matrix adhesion and cell spreading are independently controlled, offering ne

160 We quantified the T cell spreading area and cell edge dynamics using quantit

161 the nucleus shape, whereas variations in the cell spreading area modulated the nucleus volume, indica

162 crease in DNA synthesis in the case of small cell spreading area were achieved by micropatterning SMC

163 the first time, that two spatial regimes in cell-spreading area exist that uniquely govern the struc

164 ibuting the same adhesive area over a larger cell-spreading area significantly enhanced cell-adhesion

165 o direct FA assembly to the periphery of the cell-spreading area to delineate the cell-adhesive area

166 to delineate the cell-adhesive area from the cell-spreading area.

167 ogenic, softer gels are more adipogenic, and cell spreading areas increase with the silicone gel subs

168 tial equations in multiple compartments, and cell spreading as a three-dimensional stochastic model.

169 ffects the number of focal adhesions formed, cell spreading as well as cellular stiffening in respons

170 d from homogenates of HCD-fed larvae induced cell spreading as well as ERK1/2, Akt, and JNK phosphory

171 e stimulus and originated in the apex of the cell, spreading as a fast Ca(2+) wave.

172 ted that TTK boosts cell growth and promotes cell spreading; as well as protects against senescence a

173 gy and demonstrate altered actin assembly in cell spreading assays.

174 Using cell-spreading assays on lipid bilayers, solid substrate

175 to restore defective autophosphorylation and cell spreading at low pHi.

176 lection microscopy, we study the kinetics of cell spreading at the micron scale, as well as the topog

177 with P529 significantly (P < 0.05) inhibited cell spreading, attachment, proliferation, migration, an

178 h p110 seems important for the inhibition of cell spreading because S52N mGBP-2, which does not incor

179 ptures the experimentally observed isotropic cell-spreading behavior.

180 Conversely, Pvf2 overexpression enhances cell spreading but inhibits AMP expression.

181 ight and width correlated with the degree of cell spreading, but over time, reached steady-state valu

182 Accordingly, the Rap1-Rasip1 complex induces cell spreading by inhibiting Rho signaling.

183 Suppression of cell spreading by miR149 could be rescued, at least in p

184 ent to induce beta3 integrin-dependent C2C12 cell spreading by overriding the soft signal of the biom

185 Lastly, inhibition of cell spreading by v-Src was rescued partially by coexpre

186 SSeCKS also induced increased cell spreading, cell flattening, integrin beta1 clusteri

187 n cell viability but promoted cell adhesion, cell spreading, cell proliferation, cell migration, and

188 USD3-deficient cells demonstrated diminished cell spreading, cell-cell adhesion and motility.

189 110delta-deficient mice, but also aberrant T-cell spreading, cell-cell interaction, and migration.

190 show that miR-23b regulates focal adhesion, cell spreading, cell-cell junctions and the formation of

191 er PMA stimulation was mediated by increased cell spreading/cell migration but not proliferation.

192 Changes in [Ca(2+)](i), cell spreading, cellular proliferation, and eotaxin-1 re

193 Mechanical forces are critical to modulate cell spreading, contractility, gene expression, and even

194 s as functions of the same RGD nanopatterns: cell spreading correlates with the number of bound integ

195 acellular Brucella lifecycle and for cell-to-cell spreading, demonstrating that Brucella selectively

196 protein-coupled receptors (GPCRs) to induce cell spreading, differentiation, migration, and cell pol

197 of focal adhesions and coordinated daughter cell spreading during mitotic exit.

198 ERCA2 in ASM from healthy subjects increased cell spreading, eotaxin-1 release and proliferation.

199 Cell spreading experiments carried out on particle-free

200 rexpression inhibits basal lamina formation, cell spreading, focal adhesion, stress fiber formation,

201 The advantage of using the model system of cell spreading from the unattached state is that it is h

202 In the scratch wound assay of cell spreading, HIF stabilization accelerated, whereas H

203 grin activation, podocyte cell adhesion, and cell spreading; however, the actin cytoskeleton of podoc

204 Loss of Hook1 also led to an inhibition of cell spreading, implicating a role for Hook1 sorting of

205 Cell spreading in differentiated HTM cells required ILK,

206 t of VASP for optimal development of FAs and cell spreading in LX2 liver myofibroblasts, which expres

207 tein, Nogo-A, inhibits neurite outgrowth and cell spreading in neurons and Nogo-A-responsive cell lin

208 itude of BCR aggregation into clusters and B cell spreading in response to an Ag-tethered lipid bilay

209 We developed a hybrid model of whole-cell spreading in which we modeled the integrin signalin

210 paxin and localize to focal adhesions during cells spreading in an actopaxin dependent manner.

211 ies of cross-linked keratin filaments affect cell spreading; in addition, our results provide details

212 bly, this chimera fully rescues the impaired cell spreading induced by ASB2alpha expression.

213 is known about how it transits from cell to cell, spreading infection.

214 Both IFN-gamma and mGBP-2 also inhibit cell spreading initiated by platelet-derived growth fact

215 indlin-2 localization to focal adhesions and cell spreading (integrin outside-in signaling) but dispe

216 t for confluently grown cells, in which case cell spreading is already finished and, thus, excluded.

217 oped a mathematical model in which isotropic cell spreading is considered as a first approximation.

218 When cell spreading is controlled, the presence of partial ce

219 growth of BCR clusters are inhibited, and B cell spreading is increased.

220 Together, these results show that cell spreading is necessary and sufficient to drive nucl

221 Cell spreading is regulated by signaling from the integr

222 n, suggesting that v-Src-mediated changes in cell spreading is, at least in part, through inhibiting

223 hat kindlin-2 has a dual role during initial cell spreading: it binds paxillin via the pleckstrin hom

224 was utilized to determine the dependence of cell spreading kinetics on the average surface density (

225 to the plasma membrane, as well as promoting cell spreading, lamellipodia formation, and membrane ruf

226 In this study, we show that during cell spreading, lamellipodia protrusion flattens plasma

227 l cells where CD93 was attenuated, decreased cell spreading led to a severe reduction in cell adhesio

228 e show that cell confinement, by controlling cell spreading, limits peripheral actin contractility an

229 Furthermore, increased cell spreading mediates TGFbeta1-induced alphaSMA expres

230 cAbl kinase is involved in the regulation of cell spreading, microbial pathogenesis, and cancer metas

231 lacking type VI collagen displayed increased cell spreading, migration speed, and persistence.

232 to focal adhesions (FAs) where it regulates cell spreading, migration, and growth factor receptor si

233 show that miR149 expression severely impairs cell spreading, migration, and invasion of basal-like br

234 ntract soft ECMs, we can dynamically control cell spreading, migration, and matrix remodeling.

235 al growth factor receptors (EGFR) to control cell spreading, migration, and proliferation.

236 d mechanotransduction precipitate changes in cell spreading, migration, and survival.

237 Cell-to-cell spreading of misfolded alpha-synuclein (alpha-syn)

238 r RALBP1, as well as inhibiting Ral-mediated cell spreading of murine embryonic fibroblasts and ancho

239 go-A has been shown to inhibit migration and cell spreading of neuronal and nonneuronal cell types.

240 RUNX1 siRNA decreased cell spreading on collagen and fibrinogen.

241 te that Net1A, but not Net1, is required for cell spreading on collagen, myosin light chain phosphory

242 significantly elevated in protrusions during cell spreading on collagen.

243 Cell spreading on E-cadherin-coated surfaces and the for

244 ndlin-3 decreased soluble ligand binding and cell spreading on fibrinogen compared with wild-type kin

245 the beta(1) cytoplasmic domain can regulate cell spreading on fibronectin and fibronectin matrix ass

246 We observed that cell spreading on fibronectin is enhanced upon inhibitio

247 PI3-K activation during cell spreading on fibronectin was inhibited in the prese

248 2 also inhibits the activation of Akt during cell spreading on fibronectin.

249 for cell stiffening on collagen, but not for cell spreading on fibronectin.

250 its lysosome-dependent degradation; reduced cell spreading on fibronectin; decreased Rac1 activation

251 d that cadherin-mediated adhesion stimulated cell spreading on FN-PAG, and this was modulated by the

252 of F-actin at the B-cell surface, enhanced B-cell spreading on the antigen-presenting membrane, delay

253 either surface, but selectively enhanced the cell spreading on the machined surface.

254 rength of alpha4beta1-VCAM-1 interaction and cell spreading on VCAM-1 are targets of regulation by th

255 ibition leads to significant inhibition of T cell spreading on VCAM-1.

256 an, at least in part, explain the effects of cell spreading on YAP nuclear localization and represent

257 at exhibit stress relaxation is greater than cells spreading on elastic substrates of the same modulu

258 of the same modulus, but similar to that of cells spreading on stiffer elastic substrates.

259 es, but was not involved in adhesion-induced cell spreading or activation of superoxide production.

260 on act as dominant negative mutants to block cell spreading or cell migration that depends on HER2 or

261 and components of the nuclear lamina couple cell spreading or integrin activation by fibronectin to

262 o effect on alpha 4-mediated cell migration, cell spreading, or recruitment of leukocytes to an infla

263 TSC2 plays a critical role in the control of cell spreading, polarity, and migration.

264 C) model, we observed defects in SCF-induced cell spreading, polarization, and chemotaxis.

265 duce very different phenotypes, encompassing cell spreading, polarized motility, and production of lo

266 llular average uptake rate during the entire cell spreading process accounts for three particles per

267 arly integrin-RGD binding and the subsequent cell spreading process, and their separate detection by

268 ed activation of Src/FAK pathways and slowed cell spreading processes.

269 re cultured on collagen exhibited changes in cell spreading, proliferation, and contraction of the co

270 We find that cell spreading, proliferation, and osteogenic differenti

271 mTORC1, and mTORC2, and inhibition of keloid cell spreading, proliferation, migration, and invasive p

272 Cell spreading required ref(2)P, the Drosophila p62 mult

273 The stimulating effect of tumor promoters on cell spreading requires activation of protein kinase D a

274 servation that Gadkin-mediated inhibition of cell spreading requires its binding to ARP2/3, these dat

275 Cell spreading requires the coupling of actin-driven mem

276 ms of duration of conjugation periods and NK cell spreading response in conjugates that led to killin

277 These results suggest that the observed cell-spreading response to gel thickness is not explaine

278 nsmit signals within the cell that stimulate cell spreading, retraction, migration, and proliferation

279 act printing and micropost arrays to control cell spreading, substrate stiffness, and post density to

280 Application of cell spreading surface-active coating materials in combi

281 dhesion surface in a process more similar to cell spreading than to migration.

282 Thus, although ABS2 mutants support cell spreading, the cells lack FAs, fail to polarize and

283 te marked inhibition of actin remodeling and cell spreading, the induction of MCs containing TCR-CD3

284 Despite numerous studies of cell spreading, the nanometer-scale dynamics of the memb

285 Rasip1 mediates Rap1-induced cell spreading through its interaction partner Rho GTPas

286 ional, with the T188Ibeta1 subunit promoting cell spreading to a greater extent than WTbeta1.

287 n AMPK-depleted fibroblasts impedes enhanced cell spreading, traction stress, and fibronectin fiber f

288 ed amino-Nogo, inhibits axonal outgrowth and cell spreading via a largely unknown mechanism.

289 CLEC-2 activation triggered cell spreading via downregulation of RhoA activity and m

290 Cell spreading was inhibited by pre-coating the sensor s

291 A second lamellipodia-based function-cell spreading-was also defective in the ndm(-) cells.

292 lydimethylsiloxane pillars as substrates for cell spreading, we show that periodic edge retractions c

293 lular activities such as cell attachment and cell spreading were concentration-dependently suppressed

294 Pulling events and cell spreading were mimicked by pharmacological phosphol

295 errides rigid phenotypes, inhibiting SMA and cell spreading, whereas cytoplasm-localized NKX2.5 mutan

296 s show a high uptake rate at early stages of cell spreading, which decreases steadily until it reache

297 icient cells expressing alpha4 have impaired cell spreading, which is rescued by WT Abi1 but not an A

298 An understanding of viral cell-to-cell spreading will enhance our ability to intervene in

299 ATPase with the drug blebbistatin decreased cell spreading with associated nuclear rounding.

300 is increase is accompanied by an increase in cell spreading, with the result that the density of TCR