ライフサイエンスコーパス: cell surface receptor

1 therapeutics targeting virus binding to this cell surface receptor.

2 h GPI-APs enable the signaling capacity of a cell surface receptor.

3 ells that differentially produce the alphaDG cell surface receptor.

4 ens stems from the broad diversity of immune cell surface receptors.

5 hat directly target neutrophils via specific cell surface receptors.

6 cytokines only when they are bound to their cell surface receptors.

7 erception of conserved microbial patterns by cell surface receptors.

8 autocrine or paracrine fashion via specific cell surface receptors.

9 he local environment through numerous innate cell surface receptors.

10 , with activation typically mediated through cell surface receptors.

11 atty acids act directly on intracellular and cell surface receptors.

12 ed by signals cells receive from outside via cell surface receptors.

13 s to a potential regulation of G proteins by cell surface receptors.

14 an be mobilized in response to activation of cell surface receptors.

15 ough its single PDZ domain with a variety of cell surface receptors.

16 ng proteolytic cleavage and interaction with cell surface receptors.

17 tility and rapid invasion by binding to host cell surface receptors.

18 e a family of 24 heterodimeric transmembrane cell surface receptors.

19 signaling through classical ion channels and cell surface receptors.

20 stems sense and respond to ligands that bind cell surface receptors.

21 our appreciation of the versatility of these cell surface receptors.

22 inflammatory modulators and activated immune cell surface receptors.

23 ers in signal transduction from a variety of cell surface receptors.

24 n response to ligand stimulation of upstream cell surface receptors.

25 following the receipt of inputs from various cell surface receptors.

26 and activation via signaling through various cell surface receptors.

27 umerous binding partners in ECM and multiple cell surface receptors.

28 high affinity recognition of sialic acid on cell surface receptors.

29 ated upon its binding to uPAR/CD87 and other cell surface receptors.

30 ate with their environment, in part, through cell surface receptors.

31 eter in the allosteric regulation of diverse cell surface receptors.

32 ignaling, cell migration and presentation of cell-surface receptors.

33 in regulating the trafficking of a number of cell-surface receptors.

34 selective and reversible internalization of cell-surface receptors.

35 al processes, on the precision of sensing by cell-surface receptors.

36 es, indicating that eNAD(+) may be sensed by cell-surface receptors.

37 teract through local signaling, possibly via cell-surface receptors.

38 unctions as a regulatory RLK of this type of cell-surface receptors.

39 using drug-like ligands selective for other cell-surface receptors.

40 GNE activity might affect signaling through cell-surface receptors.

41 In many families of cell surface receptors, a single transmembrane (TM) alph

42 rgdorferi internalization and that different cell surface receptors act simultaneously in cooperation

43 the membrane microenvironment in modulating cell surface receptor activation.

44 ing affinity of Nodal ligands to their major cell surface receptor, Acvr2b, and to the Nodal inhibito

45 e found that Lassa virus readily engaged its cell-surface receptor alpha-dystroglycan in avian cells,

46 of its C-terminal hemolysin moiety with the cell surface receptor alphaMbeta2 integrin, the N-termin

47 nvestigated whether mAbs directed at other B-cell surface receptors also engaged FcgammaRIIb and whet

48 et al. (2017) identify neuropilin (NRP)-2 as cell surface receptor and the tetraspannin protein CD63

49 of the Dbl family are activated by mitogenic cell surface receptors and activate the Rho family GTPas

50 Extracellular Reelin binds to cell surface receptors and activates phosphorylation of

51 1 regulates inflammation by engaging several cell surface receptors and by modulating activities of o

52 way that serves as an essential link between cell surface receptors and cellular processes including

53 m macrophages can modify the redox status of cell surface receptors and enable induction of inflammat

54 inin (HA) mediates virus entry by binding to cell surface receptors and fusing the viral and endosoma

55 late microRNAs (miRNAs) that control various cell surface receptors and gene-regulatory complexes inv

56 refolding inclusion-body-based, recombinant cell surface receptors and ligands in one day, a speed e

57 ways that serve as cytosolic bridges between cell surface receptors and nuclear transcription factors

58 Pases that act as signal transducers between cell surface receptors and several intracellular signali

59 We hypothesized that DSP interacts with cell surface receptors and subsequently activates intrac

60 aling lymphocytic activation molecule family cell surface receptors and the X-chromosome-defined sign

61 Production of membrane-associated cell surface receptors and their ligands is often a cumb

62 ein mediates virus entry by first binding to cell surface receptors and then fusing viral and endosom

63 cules derived from microbes are perceived by cell surface receptors and upon signaling to the nucleus

64 f oligomeric transmembrane domains (TMDs) of cell surface receptors and viral membrane proteins.

65 addition, they should bind reversibly to the cell-surface receptor and give rise to a large change in

66 ugh Rab5 GTPases that control endocytosis of cell-surface receptors and Abl nonreceptor tyrosine kina

67 To target cells, PA binds to cell-surface receptors and is then proteolytically proce

68 Cell-surface receptors and their ligands have traditiona

69 ase expression of MARCO (both transcript and cell surface receptor) and increase phagocytosis.

70 binds rIL-27, inhibits IL-27 binding to its cell surface receptor, and is a potent inhibitor of IL-2

71 s, an attachment protein (G), which binds to cell surface receptors, and a fusion (F) protein, which

72 al leukocyte counts, expression of leukocyte cell surface receptors, and changes in the leukocyte tra

73 ling, increased the expression of inhibitory cell surface receptors, and interfered with the ability

74 ightly regulated network of plasma proteins, cell surface receptors, and regulators.

75 ent MPNs, (iii) modular targeting of MPNs to cell-surface receptors, and (iv) control of spatial and

76 cotinic receptor has been a model system for cell-surface receptors, and specifically for ligand-gate

77 Cell surface receptors are central to the cell's ability

78 Many viral surface glycoproteins and cell surface receptors are homo-oligomers, and thus can

79 mers and the manner in which they cross-link cell surface receptors are suggested herein.

80 Although a range of different cell-surface receptors are bound by different picornavir

81 Given that all cell-surface receptors are glycosylated, we expect that

82 Among the cell-surface receptors are the G protein-coupled recepto

83 ical for ISG15 signaling, and identified the cell surface receptor as LFA-1 (CD11a/CD18; alphaLbeta2

84 disease were reflected by alterations of NK cell surface receptors as demonstrated by principal comp

85 ional to receptor concentration) of EGFR - a cell-surface receptor associated with cancer - was estim

86 igration to the lymph nodes, where IL-10 and cell-surface receptors associated with immune-suppressio

87 infection, the binding of poliovirus to its cell surface receptor at 37 degrees C triggers an expans

88 arget host colonocytes by binding to unknown cell surface receptors, at least in part via their combi

89 s6, bridges envelope phosphatidylserine to a cell surface receptor, Axl.

90 lly not taken into the target cell following cell surface receptor binding, in contrast to the use of

91 ated with aberrant O-glycosylation of cancer cell surface receptors, but the functional impact of suc

92 and facilitation of their interactions with cell-surface receptors, but deciphering the specific mol

93 As such, CME regulates signaling from cell-surface receptors, but whether and how specific sig

94 xobacteria that is governed by a polymorphic cell surface receptor called TraA.

95 The imaging of cell-surface receptors can be achieved using several met

96 We have fused antibodies targeting human B-cell surface receptors (CD19-22) to immunodominant T-cel

97 ), transcriptional factor (Brachyury T), and cell surface receptors (CD24, CD90, CD155 and CD221) wer

98 demonstrated variability in expression of a cell surface receptor, CD244 (SlamF4, 2B4), that correla

99 matrix polysaccharide hyaluronan to its main cell surface receptor CD44 is controlled by the affinity

100 inhibitors of hyaluronan (HA) binding to the cell surface receptor CD44 will have value as probes of

101 the binding of this glycosaminoglycan to its cell surface receptor, CD44.

102 undant, and functionally important family of cell surface receptors, CD44.

103 in part, by interacting with the ubiquitous cell-surface receptor CD47.

104 The cell surface receptor CD6 regulates T cell activation in

105 inating from cardiac tissue that express the cell surface receptor cKit are undergoing clinical testi

106 erential cellular responses through a shared cell surface receptor composed of the two subunits, IFNA

107 In many animal cells, stimulation of cell surface receptors coupled to G proteins or tyrosine

108 Siglec-1/CD169 is a myeloid-cell surface receptor critical for HIV-1 capture and inf

109 er cells as defined by the expression of the cell surface receptors CXCR5 and PD-1, are the major sou

110 while simultaneously reducing the remaining cell surface receptor density.

111 Cellular responses elicited by cell surface receptors differ according to stimulus stre

112 ocyte glycoprotein, using antibodies against cell surface receptors differentially expressed in these

113 The reduced level of cell surface receptors diminished GABAB receptor signali

114 g virus spike interactions with the MERS-CoV cell surface receptor dipeptidyl peptidase 4 (DPP4), and

115 Macrophages possess several cell surface receptors (e.g., the mannose receptor, MR)

116 how this African HNV targets the same human cell-surface receptor (ephrinB2) as the Asiatic HNVs.

117 ell production, erythropoietin (EPO) and its cell surface receptor (EPO receptor [EPOR]) have been in

118 lect pathogenic interactions between RAGE, a cell surface receptor expressed on malignant cells in ad

119 involved in cell adhesion, axonal guidance, cell surface receptor expression and actin (dis)assembly

120 MDSCs were phenotyped for cell surface receptor expression and enriched by cell so

121 Immune cells regulate cell surface receptor expression during their maturation

122 ction in signaling is due to lower levels of cell surface receptor expression.

123 Consistent with its predicted role as a cell-surface receptor, Fat3 functions cell-autonomously

124 ions between the Fc region and two principal cell surface receptors FcepsilonRI and CD23.

125 gation of the primary root by activating the cell surface receptor FERONIA in Arabidopsis thaliana.

126 binds transferrin receptor 1 (TfR1)-the host cell surface receptor for all New World hemorrhagic feve

127 We identified mouse SIGNR-1 as a cell surface receptor for LNFPIII conjugates.

128 While the cell surface receptor for MERS-CoV has been identified a

129 allows intoxication of predators that lack a cell surface receptor for the particular toxin, allowing

130 factor-inducible 14 (Fn14; TNFRSF12A) is the cell surface receptor for the tumor necrosis factor (TNF

131 We identify alpha11beta1 integrin as a cell surface receptor for TNX and show that this integri

132 tigen-presenting cells equipped with various cell surface receptors for the direct or indirect recogn

133 gamma receptor III (FcgammaRIII or CD16) are cell surface receptors for the Fc portion of IgG and imp

134 of immunoglobulin M (IgM) can function as a cell-surface receptor for secreted IgM on a variety of c

135 CD74 is a cell-surface receptor for the cytokine macrophage migrat

136 By investigating the role of cell-surface receptors for coagulation factors in mouse

137 Most cell-surface receptors for cytokines and growth factors

138 transmembrane proteins PLXDC1 and PLXDC2 as cell-surface receptors for PEDF.

139 no known host cell receptors for TcdA, three cell-surface receptors for TcdB have been identified: CS

140 play crucial roles in endocytic recycling of cell surface receptors from endosomes to the plasma memb

141 ed crops and, more generally, for inhibiting cell surface receptor function and manipulating signalin

142 foster metastasis by mechanically enhancing cell-surface receptor function.

143 r of granulocyte lineage development via its cell surface receptor (G-CSFR), can play a role in infla

144 Cell surface receptors govern a multitude of signalling

145 umans or animals, attenuation of the colonic cell surface receptor guanylyl cyclase C (GUCY2C) that o

146 Type I interferon (IFN-alpha/beta) binds to cell surface receptors IFNAR1 and IFNAR2 and triggers a

147 ich induce cellular activities by binding to cell surface receptors IFNAR1 and IFNAR2.

148 cytokine that functions through binding two cell surface receptors, IL-6Ralpha and gp130.

149 internalization of apoD involves a specific cell surface receptor in 293T cells, identified as the t

150 rated signals from inhibitory and activating cell surface receptors in a process termed NK cell educa

151 rimentally validate functional properties of cell surface receptors in biomimetic membrane environmen

152 tance and underlying molecular mechanisms of cell surface receptors in HCV cell-free and cell-to-cell

153 results place atomic, A-scale structures of cell surface receptors in the context of functional and

154 rogenic imaging of diverse targets including cell-surface receptors in cancer cells, mitochondria, an

155 st decade, monospecific antibodies targeting cell-surface receptors in different tumour types have ac

156 mechanical control over genetically encoded cell-surface receptors in live cells.

157 autocrine or paracrine fashion via specific cell surface receptors, in a variety of pathways that pr

158 WNT16B recognizes cancer cell surface receptors including frizzled (FZD) 3/4/6, a

159 hether and how APP may regulate functions of cell surface receptors, including GPCRs, remains largely

160 est was the increased expression of numerous cell surface receptors, including TLR4 and TLR15, which

161 A diverse group of cell-surface receptors, including many G protein-coupled

162 rent pools of mGluR5, both intracellular and cell surface receptors induced oscillatory Ca(2+) respon

163 g infection, binding of mature poliovirus to cell surface receptors induces an irreversible expansion

164 ll-cycle entry and reduced expression of the cell-surface receptor inducible T-cell costimulator liga

165 teria, their cytosolic toxins or ligands for cell surface receptors, inflammasomes have emerged as im

166 on is how the spatiotemporal distribution of cell surface receptors influences the transmembrane sign

167 the peptide A20FMDV2 selectively target the cell surface receptor integrin alphavbeta6.

168 Neuropilins (Nrps) are a family of essential cell surface receptors involved in multiple fundamental

169 -coupled receptors (GPCRs), a superfamily of cell-surface receptors involved in virtually all physiol

170 n) abrogated entry, indicating that the SHFV cell surface receptor is a protein.

171 However, activation of the gp130 cell surface receptor is both necessary and sufficient f

172 tion of influenza A virus glycoproteins with cell surface receptors is a major determinant of infecti

173 Although the protocadherin family of cell surface receptors is widely hypothesized to partici

174 The imaging of dysregulated cell-surface receptors is a potential means of identifyi

175 to specific types of cells, by altering the cell-surface receptor it binds, is desirable to generate

176 P4 complex (holo-RBP) can be recognized by a cell-surface receptor known as stimulated by retinoic ac

177 r other motifs that specifically recognize a cell-surface receptor, leading to internalization of NPs

178 mbined effect of type I IFNs, TNF-alpha, and cell surface receptor-ligand interactions in triggering

179 irst layer of plant immunity is activated by cell surface receptor-like kinases (RLKs) and proteins (

180 We identified the cell surface receptor-like protein CUSCUTA RECEPTOR 1 (C

181 ecent cloning of the elicitin response (ELR) cell surface receptor-like protein, from the wild potato

182 Not much is known about which cell surface receptors may be involved in the cell-to-ce

183 Differential expression of cell surface receptors may result in altered thresholds

184 Integrin alphabeta heterodimer cell surface receptors mediate adhesive interactions tha

185 affects endosomal receptor-mediated, but not cell surface receptor-mediated, recognition of Toll-like

186 nly cells that express the cognate chemokine cell surface receptor, migrate under the spot containing

187 cells, but signals they carry and deliver to cell surface receptors modulate gene expression and func

188 These mediators activate specific cell-surface receptors-namely, purinergic 1 and 2 (P1 an

189 to both BMP2 and the ubiquitously expressed cell surface receptor neogenin.

190 ndritic cells (mDC) and NK cells through the cell surface receptors NKp30 and DNAM-1 leads to their r

191 and found that DSP is a ligand and binds to cell surface receptor, occludin.

192 Cell surface receptors of the NOTCH family of proteins a

193 In our approach, a SNAP-tagged cell-surface receptor of interest is conjugated with a s

194 CTLA4 is a cell surface receptor on T cells that functions as an im

195 Via their cell surface receptors on surrounding cells, they induce

196 y involves genetic determinants that provide cell surface receptors or diffusible signalling chemical

197 nown whether APP family proteins function as cell surface receptors, or mainly via shedding of their

198 argeting epidermal growth factor receptor, a cell surface receptor overexpressed by many cancers.

199 Glypican-3 (GPC3) is a cell surface receptor overexpressed in most HCCs and pro

200 Cell-surface-receptor pathways amplify weak, rare and lo

201 increased mean expression of the regulatory cell surface receptor PD1 by 62.2% in the effector CD4 T

202 ological levels of receptor phosphorylation, cell surface receptors produced either enhanced or susta

203 The cell-surface receptor (Pvr) catalyzes a large structural

204 f its therapeutic payload to tumors based on cell-surface receptor recognition.

205 In uninfected cells, cell surface receptors recognize the secreted interferon

206 g modules specific for sialic acid, mask the cell-surface receptor recognized by the influenza virus

207 ptors (GPCRs) comprise the largest family of cell surface receptors, regulate a wide range of physiol

208 form as a result of myoblast fusion, yet the cell surface receptors regulating this process are unkno

209 ubcellular localization, the identity of the cell surface receptor remains undefined.

210 ndocytosis regulates turnover of the various cell surface receptors remains unclear.

211 Following attachment to cell surface receptors, reovirus is internalized by rece

212 d increased expression of MuSK and Lrp4, two cell surface receptors required for NMJ formation.

213 n associated with clathrin-coated pits where cell-surface receptors reside.

214 the cytoskeleton and tissue factor (TF), the cell surface receptor responsible for coagulation activa

215 n its target cells and the identities of the cell-surface receptors responsible for its activities.

216 These increases in effector communication by cell surface receptors resulted in an increase in EGFR u

217 Siglec-8 is a CD33 subfamily cell-surface receptor selectively expressed on human eos

218 The TraA cell surface receptor selects OME partners based on a va

219 between influenza hemagglutinin (HA) and its cell surface receptor sialic acid (SA) to identify a B c

220 lutinin (HA) and neuraminidase (NA) with the cell surface receptor sialic acid.

221 The cell surface receptor signal-regulatory protein-alpha (S

222 numbers of genes from the compendium encoded cell surface receptors, signaling molecules (hormones, n

223 ed from human AGM show similar expression of cell surface receptors, signaling molecules and transcri

224 mune response (P = 0.00001) and for multiple cell surface receptor signalling pathways.

225 the immune response, the host cell cycle and cell surface receptor signalling.

226 commonly determines antigenicity as well as cell-surface receptor specificity, and the protein is th

227 effect on the binding affinity of IFN to the cell surface receptors, STAT phosphorylation, or gene in

228 xically increase the affinity of RBP for its cell surface receptor, STRA6.

229 associated herpesvirus (KSHV) interacts with cell surface receptors, such as heparan sulfate, integri

230 sulting from the reliance of HCV on multiple cell surface receptors, suggesting that vaccine inductio

231 igen receptor biological activities for this cell-surface receptor system.

232 The type III transforming growth factor-beta cell surface receptor (TbetaRIII) functions as a suppres

233 This behavior requires TraA, a homophilic cell surface receptor that identifies kin based on simil

234 FLAGELLIN-SENSING2 (FLS2) is the plant cell surface receptor that perceives bacterial flagellin

235 protein 1 (LRP1) is a ubiquitously expressed cell surface receptor that protects from intracellular c

236 Integrins are cell surface receptors that bind cells to their physical

237 G protein-coupled receptors (GPCRs) are cell surface receptors that detect a wide range of extra

238 crease potency, many PFTs recognize specific cell surface receptors that increase the local toxin con

239 Receptor tyrosine kinases (RTKs) are cell surface receptors that initiate signal cascades in

240 n algorithm that predicts which species have cell surface receptors that make them susceptible to Mac

241 ADP activates a family of cell surface receptors that modulate signaling pathways

242 Several cell surface receptors that participate in B. burgdorfer

243 oncogene homolog (KIT) are two hematopoietic cell surface receptors that regulate the development and

244 Scavenger receptors were defined as cell surface receptors that typically bind multiple liga

245 eptor tyrosine kinases (RTKs) are a class of cell surface receptors that, upon ligand binding, stimul

246 mediated to a large extent by a multitude of cell-surface receptors that bind specific ligands.

247 Leukocytes express cell-surface receptors that bind to chemokines and trigg

248 Stimulation of cell-surface receptors that couple to phospholipase C to

249 In multimeric cell-surface receptors, the conformational changes of th

250 via interactions among transiently expressed cell surface receptors, their ligands, and the extracell

251 ing the binding of matrix molecules to their cell surface receptors through steric interactions, but

252 GABRP is a component of a cell surface receptor, thus, these findings suggest that

253 Cell surface receptors TIM-1 and -4 also enhance virus b

254 athway that couples the alphavbeta6 integrin cell surface receptor to androgen receptor via activatio

255 dynamic, involving a programmed switch from cell surface receptor to intracellular receptor.

256 med after the secreted proteins that bind to cell surface receptors to activate the pathway, plays cr

257 Here we show that Sema7A utilizes different cell surface receptors to control the proliferation and

258 We report that PAO1 activates cell surface receptors to elicit an intracellular signal

259 major" and "minor" groups that use different cell surface receptors to enter host cells.

260 s architecture allows SNAs to engage certain cell surface receptors to facilitate entry.

261 eins are well known to transmit signals from cell surface receptors to intracellular effector protein

262 rted previously that uPA is transported from cell surface receptors to nuclei through a mechanism tha

263 lian brain and controls functions of various cell surface receptors to regulate neurotransmission.

264 ogenic rheostat through a novel complex with cell surface receptors to regulate STAT3 activation, cyt

265 rward pathway that could link signaling from cell surface receptors to the regulation of CME.

266 step process that is initiated by binding of cell surface receptors to their ligands on the extracell

267 e disease, begins with identification of the cell surface receptors to which viruses bind and which m

268 expression data and matched PPC chemotactic cell-surface receptors to cognate ligands expressed in t

269 iew is that SRC acts primarily downstream of cell-surface receptors to control intracellular signalin

270 1P) is a bioactive lipid that interacts with cell-surface receptors to exert different cellular respo

271 Macrophages use various cell-surface receptors to sense their environment and un

272 ed that interlayer coordination required the cell-surface receptor TOO MANY MOUTHS (TMM).

273 fy related individuals through a polymorphic cell surface receptor, TraA.

274 OP pathway, upregulation of the proapoptotic cell surface receptor TRAIL-R2, and activation of proapo

275 Cell surface receptors, transcription factors, and the t

276 Members of two families of cell surface receptors transduce VEGF-C signals: neuropi

277 Recent evidence shows that these cell surface receptors translocate from cell surface to

278 Furthermore, whether specific cell surface receptors trigger entotic invasion in a sig

279 Activation of various cell surface receptors triggers the reorganization of do

280 Its binding to CD47, a cell surface receptor, triggers programmed cell death.

281 iple genes regulating vesicular trafficking, cell surface receptor turnover, and secretion of extrace

282 ablished anaplastic lymphoma kinase (ALK), a cell surface receptor tyrosine kinase, as a tractable mo

283 ll surfaces and allow ssMPs to interact with cell surface receptors under an environment closest to c

284 Cell surface receptor uptake via clathrin-mediated endoc

285 ers and intoxicates host cells after binding cell surface receptors using its B subunit (CTB).

286 s have been shown to block signaling through cell surface receptors using several mechanisms.

287 To internalize nutrients and cell surface receptors via clathrin-mediated endocytosis

288 cally signal through homo- or hetero-dimeric cell surface receptors via Janus Kinase (JAK/TYK), or Re

289 nvestigate the effect of cellular tension on cell surface receptors, we combined novel high-resolutio

290 Considering responses downstream of selected cell-surface receptors, we discuss how receptor internal

291 , to which biotinylated antibodies targeting cell surface receptors were bound.

292 hat extra-cellular ligands activate specific cell surface receptors, which orchestrate downstream res

293 llular prion protein (PrP(C)) functions as a cell-surface receptor, which binds to Abeta oligomers an

294 nals by expressing an array of cytokines and cell-surface receptors, which shape subsequent immune re

295 (GPs) mainly engage alpha-dystroglycan as a cell-surface receptor, while New World arenaviruses hija

296 utic antibodies that block signaling through cell surface receptors whose ligands are also cell surfa

297 bind to either CD40 or LOX-1, two dendritic cell surface receptors with different functions and tiss

298 The assembly of cell surface receptors with downstream signaling molecul

299 se, delivering piconewton forces to specific cell surface receptors with high spatial and temporal re

300 unoglobulin G-mediated immobilization of one cell-surface receptor with lateral mobility studies of a