ライフサイエンスコーパス: cell type

1 at neutrophils are the most prevalent immune cell type.

2 transcriptional regulation by the GR in this cell type.

3 lutionarily conserved central nervous system cell type.

4 ture, and are highly expressed regardless of cell type.

5 the cell differentiation to that particular cell type.

6 by Cre at a specific time and in a specific cell type.

7 lar stores and has an important role in many cell types.

8 regulates histone acetylation levels in many cell types.

9 vesicles (50-1000nm), derived from different cell types.

10 bility and repolarization in a wide range of cell types.

11 ntiation and maintenance of specific retinal cell types.

12 ly capture the contribution of less abundant cell types.

13 etion, are differentially expressed in these cell types.

14 sensitivity enables differentiation between cell types.

15 e-related effects on gene expression between cell types.

16 enitors and for differentiation of pituitary cell types.

17 ones in the retina, but not in other retinal cell types.

18 sses, as well as the heterogeneity of immune cell types.

19 ntiation and function of innate and adaptive cell types.

20 to humans upon differentiation into specific cell types.

21 zed basement membrane that lies between both cell types.

22 ct consequences for infectivity in different cell types.

23 hrin supports specific functions in multiple cell types.

24 ial-lateral coordinates that we interpret as cell types.

25 s, whose progeny differentiate into distinct cell types.

26 d to the endo-lysosomal compartments in both cell types.

27 ipocytes, osteoblasts, and multiple neuronal cell types.

28 e inhibitor and onco-suppressor in different cell types.

29 and early differentiation of various retinal cell types.

30 ay regulate charge distribution in different cell types.

31 rphology, adhesion, and migration in various cell types.

32 ferent lineages form the appropriate missing cell types.

33 derivation of the entire range of ectodermal cell types.

34 ulomas, but lacks specificity for particular cell types.

35 m cell niches, without altering other midgut cell types.

36 g IgE-dependent antigen presentation in both cell types.

37 naling, autophagy and apoptosis in different cell types.

38 chondrial matrices of a variety of mammalian cell types.

39 avior by employing a wide array of different cell types.

40 hin mature organs to ensure proper ratios of cell types.

41 mponent of nuclear fractions in a variety of cell types.

42 ucin domain 3, which down-regulates T-helper cell type 1 proinflammatory responses and is associated

43 ity to suppress lymphadenopathy and T helper cell type 2 activation.

44 ll metaplasia, accumulation of ILC2s and TH2 cells, type 2 cytokine production, and airway hyperrespo

45 rse cellular ecosystems composed of multiple cell types, accompanied by genetic diversity in antigen

46 nts analysis revealed distinct clustering of cell types across samples, while differential expression

47 ory RGMa is markedly upregulated in multiple cell types after clinically relevant impact-compression

48 We find that other cell types also exhibit sporadic expression of many of t

49 es TRPC6 expression and activity in nonrenal cell types, although the mechanism is unknown.

50 ut differed in other signatures both between cell type and between activation mode.

51 may allow for an improved standardisation of cell type and cell line nomenclature as well as can be u

52 R detection of biological cells based on the cell type and corresponding particle association with th

53 ole cell transcriptomes in the expression of cell type and metabolic modeling markers, but less so fo

54 vealed generality of the genes active in one cell type and silent in the other tend to share demethyl

55 ariation on gene regulation across different cell types and as models for studies of complex disease.

56 test, followed by correlations between these cell types and B cells.

57 evelop efficient text mining applications on cell types and cell lines.

58 quantitative marker to discriminate between cell types and conditions.

59 namic mechanics on cell behavior across many cell types and contexts.

60 -throughput approaches, patterning different cell types and generating gradients without specialised

61 nic model that can prioritize trait-relevant cell types and genes from GWAS summary statistics and ge

62 e of the dynamic interplay between these two cell types and how this interaction influences the proce

63 dynamics, density, and length, from multiple cell types and in a range of microenvironments.

64 ve fitting approach for linear comparison of cell types and introduced a novel spillover compensation

65 a stable epigenetic mark that distinguishes cell types and marks regulatory elements.

66 Comprehensive analysis of multiple cell types and mediators was performed by using flow cyt

67 the specialized functions of differentiated cell types and opens new research avenues into epithelia

68 Specialized cell types and organoids have been derived from human pl

69 The cell types and receptors on which opioids act to initiat

70 neural tissues, and by spatially patterning cell types and scaffold properties in three dimensions.

71 pertensive patients and further identify the cell types and signaling pathways involved in this proce

72 d single-cell microscopy for a wide range of cell types and sizes.

73 matin profiling datasets across individuals, cell types and species.

74 djacent mesenchyme were composed of distinct cell types and that each tissue contained two subgroups.

75 n, and differentiation of appropriate kidney cell types and the integration of these cells into compl

76 in regulating immune responses in different cell types and the rationale for targeting Tim-3 for eff

77 s - aggregates with multiple tissue-specific cell types and three-dimensional structure mimicking nat

78 Immune responses involve coordination across cell types and tissues.

79 s 1,829 samples from the major human primary cell types and tissues.

80 downstream procaspase-3 cleavage in several cell types and under multiple conditions.

81 adiotracers that can identify other neuronal cell types and would allow visualization and in-depth ch

82 Biogenesis of CoV svRNAs was RNase III, cell type, and host species independent, but it was depe

83 apped exhaustively across different species, cell types, and cellular states.

84 After adjustment for batch effects, cell types, and covariates, we used robust linear regres

85 ylation (DNAm) can be used as a biomarker of cell types, and through deconvolution approaches, to inf

86 ges from mRNA fold-changes between different cell-types, and highlight the contribution of post-trans

87 lopment and Ig rearrangement are governed by cell type- and developmental stage-specific transcriptio

88 o-RNA switch technologies that purify target cell types are also outlined.

89 Since cells derived from other normal human cell types are fully supportive of FeLV replication, inn

90 provides new understanding of how different cell types are maintained in the adult lung.

91 loping tissues where material is limited and cell types are mixed.

92 We identified discrete cell types as well as temporally and spatially restricte

93 tudies demonstrate the importance of another cell type, astrocytes, for biological timekeeping.

94 e identification of non-activated lymphocyte cell types at the single-cell level using refractive ind

95 Depending on the cell type, ATAC-seq samples may contain 20-80% of mitoc

96 rs enable identification of three lymphocyte cell types (B, CD4+ T, and CD8+ T cells) with high sensi

97 enables the quantitative characterization of cell types based on global transcriptome profiles.

98 esulting explosion in the number of distinct cell types being identified is challenging the current p

99 thin individual cell populations and between cell types, but also between different pol III promoter

100 k for the simultaneous formation of multiple cell types by the same transcriptional regulator.

101 Our results show that both basket cell types can powerfully regulate the activity in amygd

102 show that selective dysfunction of neuronal cell types cannot account for the specific vulnerability

103 on pathway found in most if not all metazoan cell types characterized to date.

104 The BF contains at least three different cell types (cholinergic, glutamatergic, and gamma-aminob

105 To construct cell type classification models, various statistical cla

106 he differentiation process by correcting for cell type composition boosted the SZ signal and increase

107 majority of these effects were influenced by cell type composition.

108 imal boundary enrichment in CTCF and maximal cell-type conservation.

109 cytokine secretion from other ROCK-positive cell types, corroborating the selective in vivo effect o

110 ates conserved combinations, for example, of cell types cospecified by Gata1/2/3 and Tal transcriptio

111 ammatory response in which a multiplicity of cell types, cytokines, and growth factors participate.

112 Recent advances in cell-type deconvolution approaches are adding to our und

113 fied is challenging the current paradigm for cell type definition in the Cell Ontology.

114 The results across six different cell types demonstrate that our method is effective in p

115 l to understanding how the wide diversity of cell types develops.

116 monly used at multiple times and in multiple cell types during development.

117 us thyroid epithelial lineages, as these two cell types each originate from Nkx2-1(+) foregut progeni

118 Lowly expressed cell-type-enriched genes were preferentially disrupted b

119 Each cell type exhibits hallmarks of its primary islet cell c

120 This cell type expresses the Ir68a gene, and Ir68a mutation p

121 onist or antagonist of M3R, depending on the cell type, expression level, and signaling pathway downs

122 macrophage (Mreg) has emerged as a promising cell type for use as a cell-based adjunct immunosuppress

123 acute or chronic, in liver or any tissue or cell type for which transgenic or viral Cre drivers are

124 mensional (3D) culture model including these cell types for investigating brain functions.

125 en functionally shown to generate all mature cell types for the lifetime of the organism.

126 Using in vitro cultures of several cell types found in the heart, we delineate the Wnt sign

127 self-renew as well as generating all of the cell types found within the nasal epithelium.

128 diseases do not address the heterogeneity of cell types from one CNS region to another and are compli

129 yze 32 datasets from different hematopoietic cell types from the Blueprint Epigenome project.

130 ss range (m/z 700-850) distinguishes several cell types from the rat central nervous system, largely

131 pG on single-cell methylation data from five cell types generated using alternative sequencing protoc

132 tuned complex interactions between different cell types, growth factors, or cytokines and their recep

133 of experimental models, several alternative cell types have been proposed as the source of this meta

134 , proliferation, and differentiation of many cell types; hence, it may affect regeneration of injured

135 In either cell type, high-frequency low-threshold spike burst or l

136 ite changes observed with the two SOD1(G93A) cell types highlight the role of the astrocyte-motor neu

137 cytokine response to IL-1beta in the tested cell types, i.e., neutrophils, macrophages, and fibrobla

138 ceptor profiles could be a reliable tool for cell type identification.

139 dentity mediated by Pcdh diversity, a single cell-type identity mediated by the common C-type Pcdh is

140 d hepatic morphogenesis, differentiation and cell-type identity, depends on the formation of a tripar

141 uripotency factor in seam cells, a stem-like cell type in Caenorhabditis elegans, thereby ensuring pr

142 Requirements for cell contact and specific cell type in ORMDL3 induction were examined by transwell

143 UCP1 expression, and are an important immune cell type in the beiging response of WAT.

144 bryonic stem cells to differentiate into any cell type in the body makes them invaluable in the field

145 nsiderable understanding of the role of each cell type in the process of wound repair, the nature of

146 view recent progress in identifying multiple cell types in addition to T cells and new molecular path

147 (MultiMAP) to record from 22 neuromodulatory cell types in behaving zebrafish during a reaction-time

148 quantified on the basis of the diversity of cell types in individual patient samples using the Shann

149 a paucity of markers that distinguish these cell types in malignant tissue.

150 nd theca-interstitium) are two major somatic cell types in mammalian gonads, but the mechanisms that

151 this framework, we consider the question of cell types in medial entorhinal cortex (MEC), a region l

152 esentation overlapped with the known spatial cell types in the circuit, such as place cells and grid

153 strictions of the mesenchymal and epithelial cell types in the developing and mature mouse ureter.

154 imited understanding of the role of specific cell types in the eye vs. systemic influences (e.g., ser

155 previous work has not distinguished diverse cell types in the neocortex, even though different cell

156 o simultaneously target different tissues or cell types in the same organism.

157 nce unveiled the existence of different stem cell types in various tissues with efficient capability

158 higher titers in human neurons than in other cell types in vitro and that the number of total virus g

159 involving both neuronal and oligodendrocyte cell types in vitro.

160 d P19/Nsg2 are not expressed in all neuronal cell types in vitro.

161 from diverse activities on different immune cell types in vivo, and the need to conduct mechanistic

162 t despite expression on astrocytes and other cells types in the brain, ADAM17 upregulation during deo

163 Wake-promoting cell types include hypocretin and GABA (gamma-aminobutyr

164 sive overlap of regulatory circuitry between cell types including a network centered on the transcrip

165 mechanobiology of the cell surface in other cell types, including animal cells.

166 hair and supporting cells but also to other cell types, including glia, in cochlea undergoing develo

167 The Tec tyrosine kinase is expressed in many cell types, including hematopoietic cells, and is a memb

168 hal and buffering gene pairs across multiple cell types, including MAPK pathway genes and apoptotic g

169 ows the study of protein function in diverse cell types, including non-dividing primary cells where g

170 or the generation and patterning of multiple cell types, including stomata.

171 macrophages and LLC1 cells showed that both cell types increased PGE2 release in response to IH.

172 random forest model was built using a set of cell type-independent features such as specific sequence

173 us to infer genes that are specific in each cell type, indicating the genes are involved in directin

174 nded to problems in metagenome profiling and cell type inference.

175 ion of the asthma phenotype in mice, but the cell types involved are unknown.

176 Derivation of these cell types is a critical step toward understanding the b

177 The comparative study of cell types is a powerful approach toward deciphering ani

178 t the basal concentration of cAMP in several cell types is about 1 muM.

179 Common to most cell types is the asymmetric establishment and regulatio

180 non-neurons, and show enrichment with known cell type markers, promoters and enhancers.

181 tion with platelet quantitative traits using cell type-matched epigenomic data and promoter long-rang

182 le onset encephalopathy, suggesting multiple cell types may be involved.

183 n induces cell type-specific signals in both cell types, mediated by the SLAM-associated protein (SAP

184 In vitro cultures of different cell types (monocyte-derived dendritic cells [moDCs], PB

185 of targeted transcripts, and we focus on one cell type (monocytes) and on a small set of highly edite

186 In other cell types, Munc13 (mammalian homolog of Caenorhabditis

187 These specialized cell types not only characterize the normal functioning

188 Osteocytes are the terminally differentiated cell type of the osteoblastic lineage and have important

189 aracterized by their ability to generate all cell types of an adult organism.

190 s and differentiated into presumably all the cell types of the human body in vitro.

191 lls, allowing specific signaling in selected cell types only.

192 olution analysis is applied to obtain single cell-type or tissue specific signatures from a mixed sig

193 Of all known cultured stem cell types, pluripotent stem cells (PSCs) sit atop the l

194 ypes in the neocortex, even though different cell types possess distinct functions in cortical comput

195 ic TEM for various migrating and endothelial cell types possesses the capacity to be high-throughput,

196 the RNm-IN feedback pathway targets multiple cell types, potentially influencing both motor output pa

197 Individual neuronal cell types predominantly express a single FXG type, with

198 of lateral root development is a product of cell-type preferential activities, we tracked transcript

199 econvolution approaches, to infer underlying cell type proportions.

200 This response is cell type- rather than proliferation-dependent and does

201 ture and strength of eQTLs may help identify cell types relevant to pathophysiology and the regulator

202 liferation of all epithelial and mesenchymal cell types remained low but intermediate cells still gav

203 ented neutrophils to determine whether these cell types represent truly different neutrophil subsets

204 termined Fic in multiple cellular assays and cell types representing different targets from a number

205 s able to infect a wide range of tissues and cell types requires a thorough understanding of viral ad

206 type 2 innate lymphocytes (ILC2s) as a novel cell type resident in the healthy meninges that are acti

207 ease, the combined loss of autophagy in both cell types resulted in a lethal sepsis-like environment,

208 These data collectively demonstrate a cell type-selective entrainment of SPN firing to parkins

209 ed distinct alpha, beta, delta, and PP/gamma cell-type signatures.

210 of pulse amplitudes and pulse widths, for 21 cell types spanning the inner two layers of the rabbit r

211 compared whole tissue profile and sub-region/cell-type specific datasets and estimated a potential so

212 the molecular mechanism responsible for this cell-type specific function remains unknown.

213 ese tools, we find granular brain-region and cell-type specific signatures with corresponding biomark

214 inhibit intra-cellular signaling kinases are cell-type specific.

215 een FcalphaRI and different TLRs, leading to cell type-specific amplification of proinflammatory cyto

216 Here, using optogenetic circuit analysis and cell type-specific deep-brain recordings in behaving mic

217 th T-47D as reference, we identified 106,252 cell type-specific differentially-methylated CpGs catego

218 t of beta-catenin, our characterization of a cell type-specific enhancer for the Wnt9b/beta-catenin t

219 Genetic mosaic and cell type-specific expression studies indicate that vpr-

220 optogenetic or DREADD cellular control, and cell type-specific expression.

221 Fs and evolutionary conservation, as well as cell type-specific features derived from chromatin acces

222 r regulatory effects are directly related to cell type-specific function in the immune system.

223 nnate immune responses in vivo, we created a cell type-specific knock-out mouse model.

224 r input, feedback and redundancy to generate cell type-specific levels of dve expression and stable p

225 we show that the NGB gene is regulated by a cell type-specific loop formed between its promoter and

226 erturb complex transcriptional networks in a cell type-specific manner.

227 a global MyD88, TLR7, or TLR9 deficiency and cell type-specific MyD88 deficiency to study the functio

228 deconvolution, using indication-specific and cell type-specific reference gene expression profiles (R

229 tection of common regulatory elements and/or cell type-specific regulatory elements an interactive an

230 This interaction induces cell type-specific signals in both cell types, mediated

231 s regulated by GR across cell types than for cell type-specific target genes.

232 Candidate genes, including cell type-specific transcription factors, neurotransmitt

233 in activity is regulated by cooperation with cell type-specific transcription factors.

234 d sequences that control pancreatic and beta-cell type-specific transcription, which are found within

235 is therefore critical to accurately annotate cell type-specific TSS and PAS.

236 ease 5-HT and glutamate onto BA neurons in a cell-type-specific and frequency-dependent manner.

237 Strikingly, cGAMP exerts cell-type-specific anti-inflammatory effects on macropha

238 We apply demuxlet to assess cell-type-specific changes in gene expression in 8 poole

239 Consequently, a dynamic and cell-type-specific connectivity map has never been const

240 at 5-HT neurons exert a frequency-dependent, cell-type-specific control over BA circuitry via 5-HT an

241 We find a highly cell-type-specific expression of G-protein-coupled recep

242 Correlation of these regions with cell-type-specific gene expression and plasma protein le

243 Moreover, the change of PGRN levels led to a cell-type-specific increase of insoluble TDP-43.

244 ethionyl-tRNA synthetase (L274G) enables the cell-type-specific labeling of nascent proteins with a n

245 This intrinsic ISG expression varies in a cell-type-specific manner, and many ISGs decrease upon d

246 nucleosome core that are often regulated in cell-type-specific manner.

247 ion of histone H3 at lysine 4 (H3K4me1) in a cell-type-specific manner.

248 tely controlled by GABAergic inhibition in a cell-type-specific manner.

249 lations, it has not been possible to isolate cell-type-specific proteomes in vivo.

250 on factors, allowing us to better understand cell-type-specific regulation of inflammation mediators

251 ct cis-regulatory motifs, constitute much of cell-type-specific splicing, are highly dynamic during c

252 profiling regarding other cells demonstrated cell-type-specific synthesis of, among others, eicosanoi

253 This protocol provides comparative cell-type-specific telomere-length measurements in relat

254 al and long-range structures that help shape cell-type-specific transcription patterns.

255 large-scale behavior of brain circuits with cell type specificity is a major goal of neuroscience.

256 CREs show tissue- and cell-type specificity and disease-associated variants ar

257 Moreover, differences in cell-type specificity of tau aggregate transmission were

258 Moreover, the effect of MED12 mutations has cell-type specificity on IEG expression.

259 factors act on these enhancers to determine cell-type specificity.

260 As predicted by our model, cell types strongly sort by shape, with round cells at t

261 on, genome size, and radioresistance between cell types studied here support that IR resistance is no

262 kidney function involves numerous different cell types, such as tubular epithelial cells, endothelia

263 ed lung infections, the identity of the lung cell types targeted by peroral arsenic and the associate

264 CD47 isoforms 3 and 4 are expressed in all cell types tested except mature erythrocytes, but do not

265 GR binding for genes regulated by GR across cell types than for cell type-specific target genes.

266 n VTA GABA neurons, a currently understudied cell type that is critical for the brain's reward circui

267 data characterize ILC2s as a novel meningeal cell type that responds to SCI and could lead to new the

268 ample space gives us insights on the healthy cell types that are more epigenetically similar to the d

269 ghlight key genes, biological processes, and cell types that can be targeted for mechanistic study an

270 The immune system is composed of diverse cell types that coordinate responses to infection and ma

271 ertebrate species consists of many different cell types that have distinct functional roles and are s

272 distance between each pair of veins, and the cell-types that develop between them, differs depending

273 o phenotypically different human endothelial cell types (the human brain capillary endothelial cell l

274 ic analysis at the level of one single plant cell type, the root hair cell, and between two model pla

275 In most untreated cell types, the majority of STAT2 is phosphorylated on T

276 tigen load, its cadre of infiltrating immune cell types, the T or B cell receptor repertoire, and dir

277 Dox and HT treatment were favorable for both cell types, the therapeutic efficacy in vivo was remarka

278 d cells because of the loss of only a single cell type-the insulin-producing beta-cell.

279 A comprehensive characterization of neuronal cell types, their distributions, and patterns of connect

280 f many tumours associated immune and stromal cell types, their therapeutically relevant ratios, as we

281 expression in multiple primary human somatic cell types, thereby representing a highly attractive gen

282 res such as their non-tumorigenic epithelial cell type, three-dimensional growth, latrunculin-A-induc

283 tem and progenitor cells interact with other cell types to actively regulate their extracellular envi

284 ed dendritic cells (MDDCs), one of the first cell types to encounter virus in the peripheral mucosal

285 d glioblastoma stem cells, we subjected both cell types to in-vitro differentiation conditions and me

286 we tested the capacity of different stromal cell types to support human HSCs.

287 n of As3MT-mediated methylation in different cell types to the development of atherosclerosis after i

288 We harmonized 1822 pure human cell type transcriptomes from various sources and employ

289 The activity of multiple molecularly defined cell types was found to reflect this representation with

290 In both cell types, we found genotype-dependent differences for

291 Retinal thickness was measured, retinal cell types were labeled by immunohistochemistry and the

292 . to determine the spatiotemporal domains or cell-types where it drives expression.

293 zation of intermediate filaments in multiple cell types, which impacts the cellular distribution of o

294 imulations of electrical activity in various cell types, which show that BKCa-CaV stoichiometry can a

295 s in the SVZ), (2) neuronal cells, and (3) a cell type with an intermediate phenotype, possibly repre

296 e-wide analysis of DNA methylation across 19 cell types with T-47D as reference, we identified 106,25

297 multiple signaling pathways generate diverse cell types with varied regional identities.

298 er these effects are mediated via a specific cell type within the kidney remains unknown.

299 product of a complex interplay among diverse cell types within the skin.

300 implicated in the biology of different stem cell types, yet they have not been studied in HFSCs.