ライフサイエンスコーパス: cell volume

1 rough 140 K, with a 23 % contraction in unit cell volume.

2 zed by electron microscopy and a decrease in cell volume.

3 ock, and that cell shape recovers along with cell volume.

4 hormogonia might be accelerated by reducing cell volume.

5 egulate intracellular pH, sodium levels, and cell volume.

6 ce cellular water and solute homeostasis and cell volume.

7 ta-cell insulin secretion and decreased beta-cell volume.

8 t in response to an osmotic gradient changes cell volume.

9 ins do not uniformly decrease but scale with cell volume.

10 ells were also examined to assess changes in cell volume.

11 ng approximately 5-fold variation in average cell volume.

12 raction is captured by rescaling the average cell volume.

13 et size without enlarging cytoplasmic and/or cell volume.

14 ntrol and scaling of centrosomes relative to cell volume.

15 to increase oxygen carrying capacity and red cell volume.

16 itioning of the protein fluorescence and the cell volume.

17 of many organelles, and a large reduction in cell volume.

18 E1 activity, but modulated during changes of cell volume.

19 ansporters which are sensitive to changes in cell volume.

20 o lower cognitive test scores and lower mean cell volume.

21 of ion channels aiding dynamic regulation of cell volume.

22 nel in mediating NO-induced reductions in SC cell volume.

23 dogenous NOS resulted in a 7% increase in SC cell volume.

24 carbon biomass and 8 orders of magnitude in cell volume.

25 volume, but higher concentrations decreased cell volume.

26 ntiated the BAY-58-2667-induced decreases in cell volume.

27 -1- and BAY-58-2667-induced regulation of TM cell volume.

28 ycling, ionic homeostasis, and regulation of cell volume.

29 icroM) each elicited a biphasic effect on TM cell volume.

30 lume, but higher concentrations decreased TM cell volume.

31 occupying only approximately 4% of the unit cell volume.

32 x across the cell membrane and in regulating cell volume.

33 sensitive to osmotically induced changes in cell volume.

34 increased nutrient supply results in larger cell volume.

35 trations as they accumulate in proportion to cell volume.

36 xceeds that of a smooth sphere enclosing the cell volume.

37 e size is positively correlated with the egg cell volume.

38 n either corrective or pathologic changes in cell volume.

39 s ("popping"), without detectable changes in cell volume.

40 n essential adaptive mechanism for restoring cell volume.

41 aberrant numbers of centrosomes and altered cell volumes.

42 e useful for tracking Delta[Ca(2+)] in small cell volumes.

43 family, PST-20 and PST-25, with much larger cell volumes (166,988 and 275,178 cubic angstroms, respe

44 ry low symmetry (triclinic) and a large unit cell volume (1874.6 A(3)), containing 16 silicon and 32

45 These two zeolites have much larger unit cell volumes (422,655 A(3) and 614,912 A(3), respectivel

46 multaneously monitoring pH(i) and markers of cell volume, a functional link between membrane ion tran

47 Vesicle motility recovered long after cell volume, a process that required functional regulato

48 f DNA and the key division protein FtsZ with cell volume, a strong dependency of sensitivity to speci

49 Nevertheless, we know little of how cell volume affects neuronal dynamics.

50 les constitute approximately 2% of the total cell volume and are evenly spaced along the long cell ax

51 the surface area of the membrane relative to cell volume and can be modulated by changing membrane co

52 ifferentiation leads to a marked increase in cell volume and dilution of corneal crystallins associat

53 tropic growth and tight coordination between cell volume and DNA synthesis.

54 Cell volume and dry mass are typically correlated.

55 RPV4) functions to control airway epithelial cell volume and epithelial and endothelial permeability;

56 rtant cellular osmolyte in autoregulation of cell volume and fluid balance, particularly for mammalia

57 ost reliable for demonstrating increased red cell volume and for monitoring response to therapy; also

58 tion-chloride cotransporters (CCC), regulate cell volume and gamma-aminobutyric acid (GABA)-ergic neu

59 ta-cell volume, and increased relative alpha-cell volume and hyperglucagonemia.

60 characterized by a simultaneous decrease in cell volume and increase in cell density, which occurs b

61 te cells and is crucial in the regulation of cell volume and intracellular chloride concentration.

62 Cell volume and its regulation are key factors for cellu

63 lar components during a cell cycle, doubling cell volume and membrane area, achieving periodic change

64 ted sodium channels are temporarily blocked, cell volume and membrane potential normalize, yielding a

65 system for maintaining homeostatic values of cell volume and membrane tension could explain cell tens

66 (-)](i) and have implications for control of cell volume and neuronal function.

67 nduced decreases in trabecular meshwork (TM) cell volume and NO-induced increases in outflow facility

68 to that of DPN, with increased pigmentation, cell volume and nuclear cyclin D1 levels.

69 Cell volume and phagocytosis was analyzed by fluorescent

70 g invasion represent the smallest achievable cell volume and require glioma cells to release all free

71 most cell functions including the control of cell volume and resting membrane potential.

72 normal PMN chemotaxis through regulation of cell volume and shape change.

73 stress, membrane fracturing, and changes in cell volume and shape leading to an overcrowded cytoplas

74 ovement and gravity, and to sense changes in cell volume and shape.

75 me and label-free observations of changes in cell volume and shape.

76 gravity, detect touch, and sense changes in cell volume and shape.

77 , intestine length, intestine weight, packed cell volume and spleen weight.

78 sional mobility is induced by a reduction in cell volume and subsequent increase in molecular crowdin

79 n these drastic shape changes occur rapidly, cell volume and surface area are approximately conserved

80 t that endogenous NOS regulates steady state cell volume and the involvement of the NOS/NO/sGC/cGMP/P

81 e cyclase (sGC), YC-1, and BAY-58-2667 on TM cell volume and the signal transduction pathways and ion

82 functionally cooperate and regulate mitotic cell volume and tumor progression.

83 lutes that drive reversible changes in guard cell volume and turgor.

84 more than a century, of how plants regulate cell volume and turgor.

85 tochondria were larger, occupied more of the cell volume and were more densely clustered.

86 dent algorithm for the precise estimation of cell volumes and surface areas to overcome the shortfall

87 observation that crystals with reduced unit-cell volumes and tighter macromolecular packing often pr

88 esults and a novel stochastic model tracking cell-volume and cell-cycle predicts the experimental res

89 vel, reticulocyte hemoglobin level, and mean cell volume) and parental assessment of neurodevelopment

90 is robust to changes of tissue surface area, cell volume, and cell number, which we confirm in vivo.

91 ystem that quantifies the oxygen saturation, cell volume, and Hb concentration for individual RBCs in

92 as associated with a decreased relative beta-cell volume, and increased relative alpha-cell volume an

93 ith experimental data on lactate production, cell volume, and O2 consumption revealed that glycolysis

94 significantly higher, while hematocrit, mean cell volume, and platelet counts were significantly lowe

95 eukin-1 (IL-1), changes in Ca(2+) signaling, cell volume, and prostaglandin E(2) (PGE(2)) production

96 yses showed lower total cell number, smaller cell volume, and reduced level of endoreduplication in t

97 We propose that increased cell volume ( approximately 37% at the basal layer) is t

98 Mechanisms that underlie the regulation of cell volume are of particular importance to cells in the

99 space of up to approximately 24% of the unit-cell volume as highly positive-charged organic templates

100 the lattice parameter axial ratios, the unit cell volume, as well as in specific interatomic bond len

101 l Polarity (PCP) pathway-independent sibling cell volume asymmetries that precede notochord cell inte

102 Specifically, variation in cell volume at the time of infection can be used to help

103 In response to increases in cell volume, BECs release ATP, which was dependent on in

104 ria remain JAK2 positivity and increased red cell volume, but Cr-51 RCM is mandatory for patients who

105 Similarly, BAY-58-2667 (100 nM) increased TM cell volume, but higher concentrations decreased cell vo

106 YC-1 (1 microM) increased TM cell volume, but higher concentrations decreased TM cell

107 reas hypotonic media significantly increased cell volume by 11.2%.

108 Hypertonic media significantly decreased SC cell volume by 14%, whereas hypotonic media significantl

109 th of the microalga, up to six-fold, and its cell volume by about three-fold.

110 We control cell volume by modulating media osmotic pressure and obs

111 VRACs) play an important role in controlling cell volume by opening upon cell swelling.

112 adverse impact that even small increases in cell volume can have on their function.

113 In eukaryotic cells, small changes in cell volume can serve as important signals for cell prol

114 Furthermore, the distributions of local cell volumes can be collapsed onto a universal curve usi

115 Here, general formulations concerning cell volume change are presented in the context of devel

116 is first-order and is accompanied by a unit cell volume change of about 10%.

117 There is a correlation between cell volume changes and changes in the rate of aqueous h

118 Cell volume changes are ubiquitous in normal and patholo

119 d (iv) exocytosis of vesicles in response to cell volume changes depends upon a complex series of sig

120 Detailed "sub-models" describe cell volume changes during proliferation and necrosis; w

121 The extent, mechanism, and function of cell volume changes during specific cellular events, suc

122 stems to visualize and quantitatively assess cell volume changes of human glioma cells invading withi

123 Our results suggest that cell volume changes the migration of the cells after inj

124 nsition under compression with ca. 22 % unit-cell volume changes, which was found to be coupled with

125 s to 0.22 in brainstem, and was sensitive to cell volume changes.

126 Rapid changes in cell volume characterize macrophage activation, but the

127 rogels, these results reveal cell sensing of cell volume confinement as an adhesion-independent mecha

128 The cell volume continuously changes in response to varying

129 tors, from the regulation of ion channels to cell volume control and axon guidance.

130 r changes in the AKT pathway, this defective cell volume control is specifically associated with hype

131 cytoskeletal dynamics, mTor regulation, and cell volume control.

132 These decreases in cell volume correlated with the time-course for NO-induc

133 36.2 +/- 2.58 and 31.5 +/- 4.66 mumol L(-1) cell volume (CV) h(-1) in comparison with the +CO2 treat

134 in vivo, manifesting as a loss of regulatory cell volume decrease following osmotic swelling.

135 uces endogenous VRAC currents and regulatory cell volume decrease in various cell types.

136 The YC-1-induced cell volume decrease was mimicked by 8-Br-cGMP and aboli

137 The BAY-58-2667-induced cell volume decrease was mimicked by 8-Br-cGMP and was a

138 enopus laevis embryogenesis both nuclear and cell volumes decrease with the nuclear-to-cytoplasmic (N

139 Although the unit cell volume decreases over 27%, the quality of the singl

140 thway and the BK(Ca)-channel in mediating SC cell volume decreases.

141 els indicates a constant ratio of nucleus-to-cell volume, despite MSCs' lineage plasticity.

142 otic bodies and can be used on samples where cell volume determination alone would be difficult or in

143 and sodium that results in an 80-85% loss in cell volume, DNA degradation, and apoptotic body formati

144 rimarily associated with a reduced red blood cell volume due to a reduction in red blood cell number,

145 the relationship between nuclear number and cell volume during atrophy.

146 or retention (incompressibility) of original cell volume during compression.

147 romoting MB tumor progression via regulating cell volume dynamics, the perturbation of which activate

148 medulloblastoma (MB) cells to regulate local cell volume dynamics, thereby facilitating cell motility

149 Furthermore, the increase in maximal cell volume elicited by hypoosmotic stimulation was sign

150 instead, extracellular matrix deposition and cell volume enlargement are the key contributors to embr

151 In slower relaxing gels, restriction of cell volume expansion by elastic stresses led to increas

152 rsal is associated with a 20-40% decrease in cell volume, externalization of phosphatidylserine, loss

153 Measurements of red cell volume, hemoglobin (Hb) concentration and Hb conten

154 monitoring multiple system quantities (e.g., cell volume, Hog1, glycerol) and using varied input wave

155 ration ([Cl(-)]i) regulation impacts on both cell volume homeostasis and Cl(-)-permeable GABAA recept

156 Cell volume homeostasis is vital for the maintenance of

157 Cell volume homeostasis requires the dynamically regulat

158 reby modulate a range of processes including cell volume homeostasis, blood pressure, hearing, and ki

159 orted morphological observations on the beta-cell volume, implying that [(11)C]5-HTP retention is a u

160 sion and release in response to increases in cell volume in a protein kinase C-dependent manner.

161 t number per cell varied proportionally with cell volume in all three clones, indicating concentratio

162 Langerhans remodeling and relative endocrine-cell volume in baboons.

163 he DNA, RNA, and protein levels decline with cell volume in both bacteria and eukaryotes.

164 As mitochondria occupy up to 40% of the cell volume in highly metabolically active heart and fli

165 glutamate, ion concentrations, and dynamics cell volume in other brain pathologies and normal brain

166 rofluidic volume sensor can sense changes in cell volume in real time, which enables perfusion of var

167 Maintenance of a constant cell volume in response to extracellular or intracellula

168 , and it plays a central role in maintaining cell volume in response to osmotic challenges.

169 the MCS volume, linked to a reduction of the cell volume in the core of the MCS.

170 rs, and functions as a molecular rheostat of cell volume in the mammalian brain.

171 dose-dependent manner and reduced prostatic cell volume in vitro.

172 arly demyelination with loss of cells and/or cell volumes in cortical and white matter lesions, with

173 We found pyramidal cell volumes in layers III and V in the dorsolateral pre

174 However, the increased cell volumes in rpn10-1 and rpn12a-1 mutants translated

175 aging of up to 15-mum-thick whole eukaryotic cell volumes in three to five imaging planes.

176 Biphalin also significantly decreased the cell volume increase in primary neuronal cells exposed t

177 sis of pancreas indicated a significant beta-cell volume increase in transplanted rats, compared with

178 gents that decrease trabecular meshwork (TM) cell volume increase the rate of aqueous humor outflow.

179 ition from telophase to cytokinesis, whereas cell volume increased slightly in metaphase and was rela

180 brevetoxin production remained low, average cell volume increased.

181 RPV4 channels as transducers of mouse Muller cell volume increases into physiological responses.

182 uch as electrical plasma membrane potential, cell volume, intracellular [Ca(2+)] and pH, endocytosed

183 solateral domain of epithelia that regulates cell volume, ion transport, and acid-base balance; mice

184 ed paradigm, TRPV4 is activated by increased cell volume irrespective of the molecular mechanism unde

185 nd malignant cells and that the reduction of cell volume is accomplished by Cl(-) efflux through ClC3

186 ession, which will inevitably occur whenever cell volume is decreased during such biologically import

187 Dilution caused by increasing cell volume is included.

188 ggest that the NO-independent decrease in TM cell volume is mediated by the sGC/cGMP/PKG pathway and

189 A 5% reduction in unit cell volume is observed upon temperature reduction, wher

190 unique structure in which nearly the entire cell volume is occupied by one large lipid droplet.

191 Regulation of cell volume is of great importance because persistent sw

192 Cell volume is restored rapidly by ion influx but at the

193 model whereby TRPV4 differentially regulates cell volume, lipid, and calcium signals in NPE and PE ce

194 nds isolated by fine dissection, SubP caused cell volume loss, lumen expansion, and mucus flow, but i

195 Moreover, cell volume lost apically due to constriction largely ba

196 ed resulting in larger band gap, larger unit cell volume, lower trap-state density, and much longer c

197 participates in epithelial transport and in cell volume maintenance by mediating the movement of ion

198 ggesting that the NO-induced reduction in SC cell volume may also influence outflow facility.

199 Cell volume may be altered either by variations in the e

200 This raises the possibility that cell volume may be the reason the SAC is weak, and chrom

201 d using only three red cell parameters: mean cell volume (MCV), red cell distribution width (RDW) and

202 ed single-molecule mRNA counting with single-cell volume measurements to quantify the statistics of b

203 undamental physiological parameters, such as cell volume, membrane potential, and intracellular pH.

204 of cell membrane potential, ion homeostasis, cell volume, mitochondrial ATP production, mitochondrial

205 In normal erythrocytes, it is involved in cell volume modification.

206 ated with a reduction in both Hb content and cell volume: normal cells are likely to be removed by th

207 Inaccuracy in the estimation of cell volume (nuo) is the major source of error in the ca

208 volume, starch content, and amount of starch/cell volume obey lognormal distributions.

209 h hypertonic solutions to a minimum relative cell volume of 0.84+/-0.01 (n=8) in 3min.

210 f zeolite ZSM-25, which has the largest unit-cell volume of all known zeolites (91,554 cubic angstrom

211 f GRP antagonist RC-3940-II on viability and cell volume of BPH-1 human prostate epithelial cells and

212 The cell volume of calcein AM-loaded keratocytes and myofibr

213 2), a complex material with a primitive unit cell volume of ~6858 A(3) and ~285 atoms per primitive u

214 Adipocyte cell volume on histology was 25-fold higher in 14- to 16

215 d the first detailed study of the effects of cell volume on neuronal dynamics.

216 Necrosis is depicted by a gain in cell volume (oncosis), swelling of organelles, plasma me

217 ease/decrease in membrane, redistribution of cell volume, or both.

218 le- and multicell level, finding that single-cell volumes oscillate with a timescale of 4 h and an am

219 acute and persistent increase in hepatocyte cell volume, proliferation, and transcription of genes t

220 olume-to-surface ratio (r=0.78, P<0.001) and cell volume (r=0.75, P<0.001).

221 f Na(+)/K(+)-ATPase functioning, where below cell volume rapidly increases as a function of the remai

222 of the energy supply exists, below which the cell volume rapidly increases.

223 ace area, yet they maintain the same nuclear/cell volume ratio as wild-type cells.

224 facilitate maintenance of a constant nuclear/cell volume ratio in the face of altered membrane prolif

225 The calibration accounts for matrix:cell volume ratio, high- and low-affinity binding, activ

226 the result of hemodilution or true red blood cell volume (RBCV) deficit.

227 After the post-ET assessment, red blood cell volume (RBCV) was re-established at the pre-ET leve

228 We show that cell volume reaches the same maximal level irrespective

229 aptive gene expression program that leads to cell volume recovery or apoptosis under persistent stres

230 on led to persistent blebbing and attenuated cell volume recovery.

231 on of EAG2 in cells at interphase results in cell volume reduction and mitotic-like morphology.

232 membrane impermeable solute results in total cell volume reduction with no plasmolysis, whereas a sho

233 y a factor of 100, despite a contracted unit cell volume reflecting a positive chemical pressure effe

234 lated anion channels (VRACs) are crucial for cell volume regulation and have many other important rol

235 ion ([Cl(-)](i)) plays a fundamental role in cell volume regulation and neuronal response to GABA.

236 tation embryos first in a novel mechanism of cell volume regulation and second as a major methyl dono

237 mammalian brain, with implications for both cell volume regulation and/or GABAergic signaling.

238 Collectively, our data identify cell volume regulation as a basic conserved homeostatic

239 udy, we evaluated the effects of normalizing cell volume regulation by adding glycine, an organic osm

240 Octanoate significantly attenuated cell volume regulation in hypotonic solutions, consisten

241 Cell volume regulation is a primitive response to altera

242 semble of ion transport proteins involved in cell volume regulation is well established, the molecula

243 Its contribution to cell volume regulation might include interactions with a

244 Cell volume regulation was measured using a video-imagin

245 In eukaryotes, they are implicated in cell volume regulation, acidification, and cell cycle.

246 is translocation, which has a direct role in cell volume regulation, occurs within 30 s and is depend

247 ed cell-biological, like fluid secretion and cell volume regulation, whereas cation channels have his

248 ions including endocytosis, drug efflux, and cell volume regulation.

249 nhibition and a loss of bumetanide-sensitive cell volume regulation.

250 across channels that have a relevant role in cell volume regulation.

251 ell migration in confinement that depends on cell-volume regulation via water permeation.

252 l changes due to cytoskeletal modulation and cell-volume regulation.

253 ked increased biochemical association of the cell volume regulator Src with MLCK and with the endocyt

254 y 10 to 160 pg of brevetoxin per cell, while cell volume remained stable.

255 Volume changes deviating from original cell volume represent a major challenge for cellular hom

256 l structures of 1 and 2 with equivalent unit cell volumes require an additional pressure of ca. 1 GPa

257 f each model and the significant decrease in cell volume resulting from administration of the cytotox

258 ell fate: a approximately 2-fold increase in cell volume results in a 4- to 5-fold decrease in the pr

259 parameter ratio with minimal change in unit cell volume, reveals the existence of a three-stage cati

260 tein and body weight (rho(G)=-0.51, P=0.03), cell volume (rho(G)=-0.73, P=0.04), serum triglycerides

261 nstrate that an impedance-based microfluidic cell volume sensor can be used to study the roles of aqu

262 e relationship between transcript number and cell volume sets the biological stochasticity of living

263 d temperature worsened the ATP depletion and cell volume shrinkage.

264 r related cubic structure of comparable unit cell volume (space group Pa3, a = 22.4310(15) A, V = 112

265 nto the sink provided by the large granulosa cell volume, such that by 20 min the cGMP concentration

266 entry into S phase at inappropriately small cell volumes, suggesting that JAG can override a cell si

267 sed on an increased ratio of surface area to cell volume synthesis [6, 7].

268 Patients with ATTR had a higher total cell volume than did healthy subjects (mean, 53 mL/m(2)

269 ns in sodium intracellular concentration and cell volume that must be maintained within narrow ranges

270 DETA-NO resulted in a 12% to 16% decrease in cell volume that was abolished by the soluble guanylyl c

271 erned by osmotically driven changes in guard cell volume, the role of membrane water channels (aquapo

272 contractility and (2) through regulation of cell volume through ion transport.

273 hannel, is responsible for rapid response of cell volume to changes in plasma tonicity.

274 transcription rate increases in parallel to cell volume to compensate it by keeping the actual mRNA

275 Here, we use rapid perturbation of cell volume to modulate the concentration of weakly boun

276 etic method, we show that small increases in cell volume to reduce the hemoglobin concentration can r

277 te the stationary population distribution of cell volumes to extrinsic biological noise present in gr

278 hanges in ion concentrations, glutamate, and cell volume together with exchange of matter between cel

279 se fluorescence microscopy to acquire single cell volume trajectories for a large population of Sacch

280 tion of nanomaterial suspensions in a packed cell volume tube, and is validated against gold-standard

281 Mean ASM cell volume (V(C)), the number of ASM cells per length o

282 ation (15.2%, 5.8%, and 19.0% for half-time, cell volume [V(o)], and hydraulic conductivity [L(p)], r

283 larger, due to a significant contribution of cell volume variability.

284 dinal, and parallel increase in histological cell volume, volume-to-surface ratio, and tauic between

285 Cell volume was measured in low-passage human SC cells u

286 Cell volume was measured using a video-imaging method.

287 Cell volume was measured with the use of calcein AM fluo

288 Cell volume was monitored by electronic cell sorting.

289 1; P = .001), but in patients with AL, total cell volume was normal (mean, 47 mL/m(2) +/- 17 vs 45 mL

290 ive oxygen species generation or a change in cell volume was not necessary for NLRP3 activation.

291 Using an independent measurement of cell volume, we find cell density to be approximately 1.

292 of the regenerated myocyte mass and myocyte cell volume were greater in animals injected with hCSCs

293 ECV and total cell volume were measured in the heart.

294 uniqueness of steady-state solutions of the cell volume were validated, and contributions of individ

295 Histological cardiomyocyte diameters and cell volumes were higher in mice treated with L-NAME com

296 water efflux and a concomitant reduction in cell volume, which is countered by the accumulation of o

297 AL; however, ATTR is associated with higher cell volume, which suggests concomitant cell hypertrophy

298 mutant that has undergone a 70% reduction in cell volume with respect to wild type.

299 growth, and decoupling of DNA synthesis from cell volume, with a concomitant increase in cell size he

300 This allows the recovery of the cell volume without increasing intracellular ionic stren