ライフサイエンスコーパス: cell-matrix adhesion

1 I and their different roles in cell-cell and cell-matrix adhesion.

2 the trafficking machinery, and cell-cell and cell-matrix adhesion.

3 ls also showed defects in both cell-cell and cell-matrix adhesion.

4 ion and development as well as cell-cell and cell-matrix adhesion.

5 rane-anchored HB-EGF increases cell-cell and cell-matrix adhesion.

6 tion are frequently generated in response to cell-matrix adhesion.

7 ssion inhibits beta1-integrin expression and cell-matrix adhesion.

8 ollagen appears to play an important role in cell-matrix adhesion.

9 orient polarity in response to cell-cell and cell-matrix adhesion.

10 l reorganization in response to cell-cell or cell-matrix adhesion.

11 keletal organization, cell-cell contact, and cell-matrix adhesion.

12 al rearrangements required for cell-cell and cell-matrix adhesion.

13 enes implicated in networks of cell-cell and cell-matrix adhesion.

14 close to genes involved in intercellular and cell-matrix adhesion.

15 bited IEC migration while promoting enhanced cell-matrix adhesion.

16 vity, we were able to manipulate pre-cardiac cell-matrix adhesion.

17 tin cytoskeleton to facilitate cell-cell and cell-matrix adhesion.

18 hat plays a major role in integrin-dependent cell-matrix adhesion.

19 potentiating schwannoma's proliferation and cell-matrix adhesion.

20 1, which is required for matrix assembly and cell-matrix adhesion.

21 emble podosomes, a specialized structure for cell-matrix adhesion.

22 ing to the relative strength of cell-cell to cell-matrix adhesion.

23 sions and that they are the modular units of cell matrix adhesions.

24 d probe its mechanical properties by forming cell-matrix adhesions.

25 activated and associates with cell-cell and cell-matrix adhesions.

26 1 is an important regulator of cell-cell and cell-matrix adhesions.

27 the role of protein-tyrosine phosphatases in cell-matrix adhesions.

28 y, migfilin facilitates VASP localization to cell-matrix adhesions.

29 ells, and in the latter, they co-localize in cell-matrix adhesions.

30 PIPkin or integrins and F-actin at sites of cell-matrix adhesions.

31 ith the conversion of cell-cell adhesions to cell-matrix adhesions.

32 refore functions as an important scaffold at cell-matrix adhesions.

33 s that are thought to dissolve cell-cell and cell-matrix adhesions.

34 horylation to generate two distinct types of cell-matrix adhesions.

35 , and both have been shown to signal through cell-matrix adhesions.

36 s underlies the architecture and function of cell-matrix adhesions.

37 their microenvironment through cell-cell and cell-matrix adhesions.

38 g protein thought to reinforce cell-cell and cell-matrix adhesions.

39 recruited and/or activated in cell-cell and cell-matrix adhesions.

40 M-1) at cell-cell junctions and integrins at cell-matrix adhesions.

41 phosphorylated at Y822 in cell-cell, but not cell-matrix, adhesions.

42 nce the actin cytoskeleton and cell-cell and cell-matrix adhesion all participate in the regulation o

43 g the effects of both cell-cell adhesion and cell-matrix adhesion, along with cell growth and proteol

44 lts suggest that there is cross talk between cell matrix adhesion and growth factors in the regulatio

45 mount for dynamic cellular functions such as cell matrix adhesion and mechanotransduction.

46 ilin and filamin define a connection between cell matrix adhesions and the actin cytoskeleton and par

47 ex process that is coordinately regulated by cell-matrix adhesion and actin cytoskeleton.

48 gh a cell required coordinated modulation of cell-matrix adhesion and actomyosin contractility in the

49 ion receptors such as integrins that mediate cell-matrix adhesion and also transduce signals into cel

50 ne alpha2 chains and plays a crucial role in cell-matrix adhesion and cell differentiation.

51 the soluble Jagged1 protein caused decreased cell-matrix adhesion and cell migration defects.

52 modulation of AFAP-110 resulted in decreased cell-matrix adhesion and cell migration, defective focal

53 f galectin-3 expression, resulted in reduced cell-matrix adhesion and cell migration.

54 m1 and that the PDZ domain has a function in cell-matrix adhesion and cell migration.

55 This proposes that integrin-dependent cell-matrix adhesion and cell spreading are independentl

56 e, including small proteoglycans involved in cell-matrix adhesion and collagen fibrillogenesis.

57 t the expression of proteins associated with cell-matrix adhesion and cytoskeletal tension is regulat

58 ls, resulting in increased cell motility and cell-matrix adhesion and decreased cell-cell adhesion an

59 IP6K2 acts by enhancing cell-matrix adhesion and decreasing cell-cell adhesion.

60 Notch inhibited cells demonstrated decreased cell-matrix adhesion and enhanced lamellipodia formation

61 Reversible modulation of integrin-regulated cell-matrix adhesion and epithelial (E)-cadherin-mediate

62 We were also able to selectively restore cell-matrix adhesion and heart progenitor induction thro

63 hese data suggest that the interplay between cell-matrix adhesion and intercellular adhesion is an im

64 le 1 (ICAM-1), which is key to cell-cell and cell-matrix adhesion and leukocyte infiltration.

65 ranching that occur during oncogenesis alter cell-matrix adhesion and migration by modulating integri

66 nificance of this, demonstrating that cancer cell-matrix adhesion and outgrowth were markedly inhibit

67 in D1 and FAK, leading to enhanced survival, cell-matrix adhesion and proliferation of schwannoma.

68 lacking p38delta also displayed an increased cell-matrix adhesion and reduced cell detachment.

69 udies revealed that JAM1 knockdown decreased cell-matrix adhesion and spreading on matrix proteins th

70 t Gas6 is mitogenic and increases schwannoma cell-matrix adhesion and survival acting via Axl in schw

71 P(C) contributes to increased proliferation, cell-matrix adhesion and survival in schwannoma cells ac

72 in the cellular control of integrin-mediated cell-matrix adhesion and that loss of this interaction l

73 LC-gamma1 to the plasma membrane at sites of cell-matrix adhesion and there promoting its enzymatic a

74 nd the actin cytoskeleton to cross talk with cell-matrix adhesion and thereby define a novel pathway

75 Integrins regulate cell-cell and cell-matrix adhesion and thereby play critical roles in

76 ests the mechanism by which maspin regulates cell-matrix adhesion and tumor cell invasion does not in

77 Specifically, for sufficiently strong cell-matrix adhesion and/or sufficiently weak cell-cell

78 ced and confinement-induced EMT work through cell-matrix adhesions and cytoskeletal polarization, res

79 which affects talin and vinculin dynamics in cell-matrix adhesions and results in the formation of ta

80 kinase activity is required for turnover of cell-matrix adhesions and, in particular, the Src-depend

81 terize cell and matrix properties, including cell/matrix adhesion and mechanical and steric propertie

82 small GTPase regulating cell-cell adhesion, cell-matrix adhesion, and actin rearrangements, all proc

83 ch play critical roles in matrix deposition, cell-matrix adhesion, and actin stress fibers.

84 a key role in actin lamellipodia induction, cell-matrix adhesion, and cell anoikis.

85 lating cells, eventual loss of cell-cell and cell-matrix adhesion, and dose-dependent failure of blas

86 o increased integrin-linked kinase activity, cell-matrix adhesion, and invasion through the extracell

87 Reversible modulation of cell-cell adhesion, cell-matrix adhesion, and proteolytic activity plays a c

88 pled S1P receptors to regulate cell-cell and cell-matrix adhesion, and thereby influence cell migrati

89 Cell-cell and cell-matrix adhesion are crucial during many stages of e

90 s that regulate alterations in cell-cell and cell-matrix adhesion are deregulated to promote the earl

91 derlying schwannomas basal proliferation and cell-matrix adhesion are not understood.

92 nery to promote cell edge protrusions during cell-matrix adhesion are unclear.

93 is a novel mechanism by which cell-cell and cell-matrix adhesions are coordinated.

94 Cell-matrix adhesions are exquisite sensors of physiolog

95 sion in the cleft region and increased cleft cell-matrix adhesions are required for cleft progression

96 al tumors where alterations in cell/cell and cell/matrix adhesion are early steps in tumor disseminat

97 ing metastasis by facilitating cell-cell and cell-matrix adhesion as well as anchorage-independent ce

98 dy, we determine that CD82 expression alters cell-matrix adhesion, as well as integrin surface expres

99 ilin, a LIM-containing protein, localizes to cell-matrix adhesions, associates with actin filaments,

100 sembly of epithelial cell-cell junctions and cell-matrix adhesions at the rear of migrating cells.

101 and intercellular stresses that tend to pull cell-matrix adhesions away from the boundary.

102 rowth factor receptor and ErbB2/3, increased cell-matrix adhesion because of the overexpression of in

103 Targeted disruption of pre-cardiac cell-matrix adhesion blocked heart progenitor induction.

104 During cell-matrix adhesion, both tyrosine and serine/threonine

105 version of epithelial cell-cell adhesions to cell-matrix adhesions, but the mechanisms of cleft forma

106 TGFbeta promotes cell-matrix adhesion by inducing the synthesis of extrac

107 r distinction between cell-cell adhesion and cell-matrix adhesion by showing that type IV collagen is

108 lobal regulator of endothelial cell-cell and cell-matrix adhesions, CD151 is needed for the optimal f

109 gical functions, such as cell-cell adhesion, cell-matrix adhesion, cell proliferation, motility and d

110 anize the ECM and regulate its engagement by cell-matrix adhesion complexes (CMACs) are therefore ess

111 Cell-matrix adhesion complexes (CMACs) play fundamental

112 Because signaling from cell-cell and cell-matrix adhesion complexes regulates cell proliferat

113 cytolinkers and components of cell-cell and cell-matrix adhesion complexes, i.e., desmosomes and hem

114 co-clustering of beta1 integrins and tTG at cell-matrix adhesion contacts.

115 ted cell-cell adhesion and integrin-mediated cell-matrix adhesion coordinate to affect the physical a

116 Many of these are involved in cell-matrix adhesions, cytoskeleton, and transcriptional

117 , and genetic alterations that perturb local cell-matrix adhesion drove cell translocation.

118 n unexpected role of a classical cadherin in cell-matrix adhesion during cell migration.

119 tempers evoked Ca(2+) signals, and regulates cell-matrix adhesion during migration.

120 tion of the extracellular matrix and dynamic cell-matrix adhesion during reepithelialization.

121 ocess dependent on dynamic turnover of focal cell-matrix adhesions (FAs).

122 loss, namely multipolar morphology, enhanced cell-matrix adhesion, focal adhesion and, most important

123 s suggest that LOX facilitates migration and cell-matrix adhesion formation in invasive breast cancer

124 OX regulates in vitro motility/migration and cell-matrix adhesion formation.

125 somes represent a class of integrin-mediated cell-matrix adhesions formed by migrating and matrix-deg

126 nal changes in extracellular compartment and cell-matrix adhesion genes but not in cell-cell adhesion

127 Our results show that a spondin maintains cell-matrix adhesion in multiple tissues.

128 ecouple the effects of cell-cell contact and cell-matrix adhesion in TGFbeta1-induced EMT.

129 iple function of lamellipodia is to organize cell-matrix adhesions in a spatially coherent manner.

130 f the alpha2beta1 integrin from cell-cell to cell-matrix adhesions in breast epithelial cells.

131 n was not required for vinculin functions in cell-matrix adhesions, including integrin-induced cell s

132 nd glycoproteins implicated in cell-cell and cell-matrix adhesion interactions, cell migration, and t

133 e regulation of the F-actin cytoskeleton and cell-matrix adhesions, involve previously unrecognized c

134 ant model shows that integrin beta1-mediated cell-matrix adhesion is a major determinant of the mural

135 odel of cancer invasion, where cell-cell and cell-matrix adhesion is accounted for through non-local

136 Weakening of cell-matrix adhesion is blocked significantly (p < 0.01)

137 Cell-matrix adhesion is essential for building animals,

138 Cell-matrix adhesion is essential for the development an

139 Loss of cell-matrix adhesion is often associated with acute epit

140 many mammalian cell types, integrin-mediated cell-matrix adhesion is required for the G1-S transition

141 migfilin, a recently identified component of cell-matrix adhesions, is a biphasic regulator of cell m

142 oA acts on both actomyosin contractility and cell-matrix adhesion, it suggests a role for such proces

143 zed that LPS increases integrin function and cell-matrix adhesion, leading to impaired enterocyte mig

144 vidence that a balance between cell-cell and cell-matrix adhesion may be critical for the normal deve

145 he effects of increased beta1,6 branching on cell-matrix adhesion-mediated phenotypes, human fibrosar

146 ated that these compounds strongly inhibited cell-matrix adhesion, migration, and invasion of U87-MG

147 Mechanistically, the tension sensing cell-matrix adhesion molecule, vinculin, and the Rho/ROC

148 IP can function as a HP/HS-binding cell-cell/cell-matrix adhesion molecule.

149 ve survey of the complement of cell-cell and cell-matrix adhesion molecules in this organism.

150 erization triggered by specific cell-cell or cell-matrix adhesion molecules propelled invasive cell m

151 otein family serves to connect cell-cell and cell-matrix adhesion molecules to the intermediate filam

152 ted proteolytic activity, cell signaling, or cell-matrix adhesion necessary for cell migration during

153 utants, we establish which components of the cell-matrix adhesion network are coordinated through dir

154 Examples include cell-cell and cell-matrix adhesions, nucleoprotein bodies, and cell si

155 in this setting by modulating cell-cell and cell-matrix adhesion of endothelial cells.

156 (P10-P5', amino acids 330-345) alone induced cell-matrix adhesion of mammary carcinoma cells and corn

157 by the MEK1/ERK module promotes and sustains cell-matrix adhesion of untransformed cells.

158 ion, actomyosin contractility, cell-cell and cell-matrix adhesions on cleft progression, and it was u

159 vealed that fibrillar fibronectin can induce cell-matrix adhesions on cultured human salivary epithel

160 Although many cells generally require cell-matrix adhesion, our results demonstrate that CRKL

161 barrier dysfunction and suggest that common cell-matrix-adhesion pathways are involved in the progre

162 hereby KiSS-1 regulates events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reo

163 Cell-cell and cell-matrix adhesions play essential roles in the functi

164 Integrin-mediated cell-matrix adhesion plays an important role in control

165 n MIG-2-null colon cancer cells strengthened cell-matrix adhesion, promoted focal adhesion formation,

166 Migfilin interacts with the cell-matrix adhesion protein Mig-2 (mitogen inducible ge

167 gulation of genes encoding for cell-cell and cell-matrix adhesion proteins, and in the upregulation o

168 reflect the traditional view of integrins as cell-matrix adhesion proteins.

169 cells of the blistered skin, suggesting that cell-matrix adhesion provided by laminin 5 plays a role

170 dation of the surrounding ECM accompanied by cell-matrix adhesion pulls the cells into the surroundin

171 An important role of cell matrix adhesion receptors is to mediate transmembra

172 ion of E-cadherin would affect expression of cell matrix adhesion receptors.

173 s with increased expression of cell-cell and cell-matrix adhesion receptors.

174 , PCOLN3; the metalloprotease PRSM1; and the cell matrix-adhesion regulator, CMAR.

175 eves its distinct functions at cell-cell and cell-matrix adhesions remains unanswered.

176 ntrolled by signal-mediated cytoskeletal and cell matrix adhesion remodeling.

177 While increased mechanical loading at cell-matrix adhesions results in focal adhesion growth,

178 TK) with key roles in integrating growth and cell matrix adhesion signals, and FAK is a major driver

179 composition of the extracellular matrix and cell-matrix adhesion sites provides cells with a means o

180 a1 integrin nor tensin localize to fibrillar cell-matrix adhesion sites.

181 critical for maintaining the composition of cell-matrix adhesion sites; in the absence of fibronecti

182 d locally, rapidly, and correctly as diverse cell-matrix adhesion sites?

183 analyses of cell motion, membrane dynamics, cell-matrix adhesion status and F-actin organization, th

184 strength, epithelial cell mitosis rate, and cell-matrix adhesion strength.

185 Cell-matrix adhesion strongly influences developmental s

186 These findings, perturbed and up-regulated cell-matrix adhesion, suggest possible mechanisms for th

187 pe adhesion system (cadherin/nectin) and the cell-matrix adhesion system (integrin/CD155) by virtue o

188 somes and are thought to be more involved in cell-matrix adhesion than invadopodia [2-4].

189 Cooperative cell-cell and cell-matrix adhesions that sculpt the emerging tissue ar

190 Hemidesmosomes (HDs) are epithelial-specific cell-matrix adhesions that stably anchor the intracellul

191 nabled and enhanced by altered cell-cell and cell-matrix adhesion, the cancerous mass can invade the

192 anied by fibronectin deposition and stronger cell-matrix adhesion, the transition to leader-cell phen

193 other matrices and integrins are involved in cell-matrix adhesion, this model system gives us a limit

194 reas activation of the IGF-IR kinase reduces cell-matrix adhesion through a PI-3K-dependent, but ROCK

195 iate divalent cation-dependent cell-cell and cell-matrix adhesion through tightly regulated interacti

196 action couples with actin polymerization and cell-matrix adhesion to regulate cell protrusions and re

197 mbrane skeleton and that links cell-cell and cell-matrix adhesion to the development of cell polarity

198 Shc orchestrates signals from cell-cell and cell-matrix adhesions to elicit flow-induced inflammator

199 These results indicate that the loss of cell matrix adhesion triggers protein kinase C activatio

200 own, although an alteration in cell-cell and cell-matrix adhesion versus an autoimmune process has be

201 The impact of cAMP on cell-matrix adhesion was followed by immunostaining of f

202 When cell-matrix adhesion was reduced (in poly(2-hydroxyethyl

203 Both the increase and decrease in cell-matrix adhesion were blocked by disrupting intracel

204 Thus, we have characterized an endothelial cell matrix adhesion, which shows complex cytoskeletal i

205 tion of forces from intercellular tension to cell-matrix adhesions, which break down the cadherin jun

206 Mig-2 recruits migfilin to cell-matrix adhesions, while the interaction with filami

207 t low-dose, disrupts the integrity of TJ and cell-matrix adhesions, with indicators of cellular stres