ライフサイエンスコーパス: cell-matrix interaction

1 gh multiple mechanisms, including effects on cell matrix interaction.

2 anisms for its role in tissue remodeling and cell-matrix interaction.

3 uggest a role of PS1 in cell adhesion and/or cell-matrix interaction.

4 t of its phosphorylation is regulated by the cell-matrix interaction.

5 ss after liver injury, involves considerable cell-matrix interaction.

6 duced by anticancer agents via disruption of cell-matrix interaction.

7 d other genes involved in axon outgrowth and cell matrix interactions.

8 help to dissect the role of this protein in cell-matrix interactions.

9 es a physiologically relevant model to study cell-matrix interactions.

10 ent that leads to dysregulated cell-cell and cell-matrix interactions.

11 ese features suggest a role in cell-cell, or cell-matrix interactions.

12 genetic programs and orchestrated cell-cell/cell-matrix interactions.

13 ating physiologically relevant cell-cell and cell-matrix interactions.

14 FAK was due to ECM remodeling and increased cell-matrix interactions.

15 me depends on the magnitude of cell-cell and cell-matrix interactions.

16 cellular sensing as well as in cell-cell and cell-matrix interactions.

17 cell movements depend on both cell-cell and cell-matrix interactions.

18 ly significant functions in cell-cell and/or cell-matrix interactions.

19 ar differentiation through its modulation of cell-matrix interactions.

20 , which is required for normal cell-cell and cell-matrix interactions.

21 ial cells, events that require regulation of cell-matrix interactions.

22 and subsequent impact on potential aberrant cell-matrix interactions.

23 tumor metastasis, leading to alterations in cell-matrix interactions.

24 ers of three major gene families involved in cell-matrix interactions.

25 rombospondin 2 (TSP2) regulates a variety of cell-matrix interactions.

26 mbrane proteins, which mediate cell-cell and cell-matrix interactions.

27 are dependent on dysregulated cell-cell and cell-matrix interactions.

28 does not depend on its ability to stabilize cell-matrix interactions.

29 oteinase expression, cell proliferation, and cell-matrix interactions.

30 CAM has been shown to modulate cell-cell and cell-matrix interactions.

31 t it may play an important role in cell-cell/cell-matrix interactions.

32 ne-spanning molecule that may play a role in cell-matrix interactions.

33 predicted to be involved in cell-cell and/or cell-matrix interactions.

34 to have suppressing effects on cell-cell and cell-matrix interactions.

35 believed to play key roles in cell-cell and cell-matrix interactions.

36 th the integrity of extracellular matrix and cell-matrix interactions.

37 nsformation of adjacent keratinocytes and on cell-matrix interactions.

38 oducts, has been implicated in cell-cell and cell-matrix interactions.

39 pillary morphogenesis involves cell-cell and cell-matrix interactions.

40 licating these proteins in the regulation of cell-matrix interactions.

41 or the beta3C integrin subunit in modulating cell-matrix interactions.

42 ember of the proteoglycan family involved in cell-matrix interactions.

43 kine not previously known to be regulated by cell-matrix interactions.

44 esis has been a long-standing model to study cell-matrix interactions.

45 nd development, including mammary epithelial cell-matrix interactions.

46 ptors appear to have functional roles in the cell-matrix interactions.

47 by exogenous mitogens and both cell-cell and cell-matrix interactions.

48 that early and late amelogenesis depend upon cell-matrix interactions.

49 sion-related genes, disrupting cell-cell and cell-matrix interactions.

50 n domains capable of mediating cell-cell and cell-matrix interactions.

51 time of cuticle secretion and remodeling of cell-matrix interactions.

52 une system functioning through cell-cell and cell-matrix interactions.

53 ar differentiation through its modulation of cell-matrix interactions.

54 of uPA overexpression on cell migration and cell-matrix interactions.

55 sion molecules that direct key cell-cell and cell-matrix interactions.

56 as key regulators of cellular functions and cell-matrix interactions.

57 the cells it carries, promoting advantageous cell-matrix interactions.

58 of adherens junctions, tight junctions, and cell-matrix interactions.

59 lly isotropic matrix via locally reinforcing cell-matrix interactions.

60 cell proliferation, and altered cell-cell or cell-matrix interactions.

61 in growth factor signaling and cell-cell and cell-matrix interactions.

62 matrix proteins and interference with renal cell-matrix interactions.

63 s in cell spreading and the tension state of cell-matrix interactions.

64 aminin at the cell surface, affecting normal cell-matrix interactions.

65 elial integrity when cells are denied proper cell-matrix interactions.

66 rane, particularly at sites of cell-cell and cell-matrix interactions.

67 nced proliferation and altered cell-cell and cell-matrix interactions.

68 result of competition between cell-cell and cell-matrix interactions.

69 sion/growth-regulatory galectins within cell-cell/matrix interactions.

70 reduced motility and altered cell - cell and cell - matrix interactions.

71 ation of most cells is strictly dependent on cell-matrix interactions, a phenomenon called anchorage

72 athogenic viral strains alters cell-cell and cell-matrix interactions, affecting extracellular matrix

73 of how context, in particular cell-cell and cell-matrix interactions, affects endothelial cell respo

74 ell survival signals caused by disruption of cell--matrix interactions and contributes to anoikis res

75 MAGP-2 interacts with Jagged-1 that controls cell-matrix interaction and cell motility, two key facto

76 Cell-cell and cell-matrix interaction and cell spreading are reduced w

77 ation, lineage determination, cell adhesion, cell-matrix interaction and cytoskeleton remodeling.

78 kinase (ILK) has been implicated in podocyte cell-matrix interaction and is induced in proteinuria.

79 in the development of colitis by modulating cell-matrix interaction and wound healing.

80 a variety of biological processes including cell-matrix interactions and activation of chemokines, e

81 ndins (TSPs) are extracellular regulators of cell-matrix interactions and cell phenotype.

82 serine/threonine kinase that is important in cell-matrix interactions and cell signaling.

83 es (ECMs), providing new pathways to explore cell-matrix interactions and direct cell fate under phys

84 cell morphology, cell-cell interactions, and cell-matrix interactions and eventually result in the fo

85 dhesion receptors mediate both cell-cell and cell-matrix interactions and have been shown to play vit

86 ein that has been implicated in cell-cell or cell-matrix interactions and in the proteolysis of molec

87 etween tumor and normal tissue will decrease cell-matrix interactions and inhibit matrix cross-linkin

88 and myocardial dysfunction, but the role of cell-matrix interactions and integrins in this process h

89 nctions, including maintenance of epithelial cell-matrix interactions and intestinal homeostasis.

90 that matrix glycation interferes with normal cell-matrix interactions and intracellular signaling tha

91 paran sulfate proteoglycan that can regulate cell-matrix interactions and is enriched in focal adhesi

92 he inhibition of the AGE-RAGE axis to resume cell-matrix interactions and maintain tissue integrity.

93 ole of the newly deposited matrix protein in cell-matrix interactions and remodeling.

94 e other transglutaminases, it is involved in cell-matrix interactions and serves as an adhesion co-re

95 xL, Bak, and Bax) or mediators of epithelial cell-matrix interactions and survival (e.g., alpha5beta1

96 imulates the localization of ERK to sites of cell-matrix interactions and that this is mediated by th

97 the immediate microenvironment (cell-cell or cell-matrix interactions) and the extended tumour microe

98 defy anoikis, cell death caused by a lack of cell-matrix interaction, and grow in an anchorage-indepe

99 a membrane protein involved in cell-cell and cell-matrix interactions, and 3' sequences from the huma

100 t a variety of stimuli, including cytokines, cell-matrix interactions, and challenge with foreign mat

101 breast epithelial-endothelial cell-cell and cell-matrix interactions, and examined the expression of

102 al alterations in keratinocyte cell-cell and cell-matrix interactions, and extensive remodeling of th

103 MMP-9 promotes neuronal death by disrupting cell-matrix interactions, and MMP-9 knockout mice have r

104 onclude that TSP2 plays an important role in cell-matrix interactions, and that a deficiency in the p

105 motifs indicative of a role in cell-cell or cell-matrix interactions, and the PKD2 encodes a protein

106 on, cytoskeleton organization, cell-cell and cell-matrix interactions, apoptosis, cell cycle, and oxi

107 he engagement of the alphavbeta3 integrin in cell-matrix interactions appears to coordinate an intens

108 ffects of MMAC1 on motility, cell - cell and cell - matrix interactions are due to its tumor suppress

109 's effects on cell motility, cell - cell and cell - matrix interactions are thought to be due to its

110 The less well organized sites of cell-matrix interaction are sufficient for translocating

111 zation of cells into tissues, and defects in cell-matrix interactions are an important element in man

112 For example, cell-cell and cell-matrix interactions are crucial for leukocyte homin

113 or cells (LEPC) that incorporate the in vivo cell-matrix interactions are essential to enhance LEPC e

114 Cell-matrix interactions are frequently mediated by the

115 Cell-matrix interactions are made possible by integrins,

116 Cell-cell and cell-matrix interactions are of utmost importance in the

117 CM), yet the pathogenic mechanisms involving cell-matrix interactions are poorly understood.

118 These results show that alterations in cell-matrix interactions are sufficient to initiate and

119 Although it is known that cell/matrix interactions are essential for directional m

120 alloproteinase ADAM9 modulates cell-cell and cell-matrix interactions as well as ectodomain shedding

121 ystic kidney disease (ADPKD), is involved in cell-matrix interactions as well as in ciliary signaling

122 potential novel regulators of cell-cell and cell-matrix interactions, as well as of matrix degradati

123 ossesses multifaceted roles in modulation of cell-matrix interactions, as well as tumor growth and me

124 factor in preventing CD44- and HA-dependent cell-matrix interactions at the inflammatory site.

125 The role of integrin/cell matrix interactions between the RPE and the basemen

126 d in a wide range of cell-cell signaling and cell-matrix interactions, both in vitro and in vivo in i

127 in epithelial cells is generated not only by cell-matrix interaction but also by cell-cell interactio

128 differentiation is likely to involve altered cell-matrix interactions but the mechanism is not known.

129 Embryogenesis is guided by cell-cell and cell-matrix interactions, but it is unclear how these ph

130 er, our results suggest that Tmem2 regulates cell-matrix interactions by affecting both ECM organizat

131 an Arg-Gly-Asp (RGD) motif needed to mediate cell-matrix interactions by binding to cell-surface inte

132 pe and function in response to cell-cell and cell-matrix interactions by guiding cytoskeletal structu

133 ural plasticity by altering cell-cell and/or cell-matrix interactions by increasing intermolecular sp

134 l migration, and show that PAI-1 can control cell-matrix interactions by regulating the accessibility

135 is enriched for genes with defined roles in cell-matrix interactions, cell motility, and endocytosis

136 (MMP1, MMP3, TIMP1, uPA, and PAI-1); and 4) cell-matrix interactions (Col1alpha1, Col1alpha2, and in

137 rface association of activated MMP-2, on the cell-matrix interactions controlled by collagen-specific

138 acellular motifs indicative of cell-cell and cell-matrix interactions, coupled through multiple trans

139 Each of these steps is regulated by cell-matrix interactions, cytokine and growth factor sec

140 ILK is involved in cell-matrix interactions, cytoskeletal organization, and

141 ariety of processes, including cell-cell and cell-matrix interactions, cytoskeletal remodeling, prote

142 hyaluronan is of low affinity, and effective cell/matrix interaction depends on multiple interactions

143 es: not only proliferation but cell-cell and cell-matrix interactions, DNA repair, invasion and motil

144 a indicate that GRIP1 is required for normal cell-matrix interactions during early embryonic developm

145 AI and further highlights the importance of cell-matrix interactions during enamel formation.

146 t participates in a variety of cell-cell and cell-matrix interactions during fertilization and develo

147 that the invasive GBM cells rely heavily on cell-matrix interactions during invasion and remodeling.

148 impact of transmembrane protein 2 (tmem2) on cell-matrix interactions during muscle morphogenesis in

149 n important role in modulating cell-cell and cell-matrix interactions during nervous tissue histogene

150 ry rather than structural role in modulating cell-matrix interactions during normal development and r

151 dulatory proteins are important effectors of cell-matrix interactions during tissue remodeling and re

152 Our recent efforts have focused on the tumor cell-matrix interactions essential to tumor cell activat

153 vidence that Nck directs the polarization of cell-matrix interactions for efficient migration in thre

154 to overcome difficulties in tracking stromal cell-matrix interactions for several days in live mice.

155 ithelial cells are dependent on cell-cell or cell-matrix interactions for survival and undergo apopto

156 lycan that co-operates with integrins during cell-matrix interactions for the assembly of focal adhes

157 ion to the well-recognized, force-regulated, cell-matrix interactions, forces also tune the interacti

158 s achieved, in part, via protection of renal cell-matrix interactions from damage by a variety of RCS

159 teases in intact tissues where cell-cell and cell-matrix interactions had been maintained.

160 ventricular myocytes, yet the importance of cell-matrix interactions has not been extensively examin

161 ar protein with a primary role in modulating cell-matrix interactions, has been implicated in tissue

162 Cell-matrix interactions have critical roles in regenera

163 mal tubule epithelial cell and cell-cell and cell-matrix interactions important for this repair funct

164 rful model system to study integrin-mediated cell-matrix interaction in an in vivo context, as it is

165 that IGF signaling is masked by signals from cell-matrix interaction in anchorage-dependent condition

166 We provide evidence that decorin modulates cell-matrix interaction in this context by stimulating c

167 cell fate is contextual and is modulated by cell-matrix interactions in a cell type-specific manner.

168 (alpha and beta), is involved in regulating cell-matrix interactions in a variety of tissues, includ

169 rins and laminins are important mediators of cell-matrix interactions in both vertebrates and inverte

170 odel that can be used to address the role of cell-matrix interactions in cartilage homeostasis and os

171 ortant role for collagen XVIII/endostatin in cell-matrix interactions in certain tissues that may be

172 These studies underscore the importance of cell-matrix interactions in controlling cardiac gene exp

173 To address the role of cell-matrix interactions in gland development, pellets c

174 ts on cell growth, apoptosis, cell-cell, and cell-matrix interactions in immortalized human thyroid c

175 proteases, and structural proteins influence cell-matrix interactions in the context of left ventricu

176 beta signaling that influences cell-cell and cell-matrix interactions in the developing nervous syste

177 the Hep II domain of fibronectin could alter cell-matrix interactions in the TM and provides an inter

178 lts suggest that TGFBIp may modulate scleral cell-matrix interactions in vivo, thereby affecting scle

179 ly regulated genes include those involved in cell-matrix interactions including proline 4-hydroxylase

180 receptor c-met results in the regulation of cell-matrix interactions, including the MAPK-dependent s

181 Presumably an intact cell-matrix interaction inhibits caspase activation and

182 axillin-dependent ERK activation at sites of cell-matrix interaction is critical for HGF-stimulated e

183 dation, a minimal network model of a dynamic cell-matrix interaction is proposed.

184 ch regulated interplay between cell-cell and cell-matrix interactions is likely to have wide relevanc

185 ecreted protein that regulates cell-cell and cell-matrix interactions, leading to alterations in cell

186 nges from dendritic to stellate/bipolar, and cell-matrix interactions mature from punctate to focal a

187 gest that Jagged regulation of cell-cell and cell-matrix interactions may contribute to the control o

188 Recent studies show that cell-matrix interactions mediated by integrins can trans

189 faces, these fibrous materials recapitulated cell-matrix interactions observed with collagen matrices

190 tivity and dysregulates the cell-cell and/or cell-matrix interactions of infected cytotrophoblasts an

191 and motility as well as affect cell-cell and cell-matrix interactions of malignant human glioma cells

192 as the regulatory influence of cell-cell and cell-matrix interactions on signaling outcomes.

193 ing of ITGB6 resulting in either compromised cell-matrix interaction or compromised ITGB6 activation

194 d in known proteins involved in cell-cell or cell-matrix interactions, PKD2 has homology to PKD1 and

195 Cell-cell and cell-matrix interactions play a critical role in tissue

196 membrane matrix integrity, composition, and cell-matrix interactions play an important role in ancho

197 Cell-cell and cell-matrix interactions play important regulatory roles

198 Integrin-mediated cell-matrix interactions play important roles in regulat

199 Many factors, including cell-matrix interactions, play a role in the development

200 Cdc42 deficiency leads to a defect in global cell-matrix interactions reflected by a decrease in coll

201 Cell-matrix interactions regulate chondrocyte differenti

202 derstanding the molecular mechanisms whereby cell-matrix interactions regulate liver regeneration may

203 glycoprotein implicated in intercellular and cell matrix interactions, regulation of the complement s

204 sustain oncogenic signals in the absence of cell-matrix interactions remains poorly understood.

205 h of which would be predicted to compete for cell-matrix interactions, resulted in a dose-dependent r

206 ing septation may cause loss of cell-cell or cell-matrix interactions, resulting in apoptosis (anoiki

207 ely activated RhoA protein that disrupts the cell-matrix interaction results in dephosphorylation of

208 array analysis were involved in cell-cell or cell-matrix interaction, Rho signaling, calcium homeosta

209 inds calcium and collagens, and can modulate cell-matrix interactions, so altering cell shape, growth

210 lation of ICAP-1alpha phosphorylation by the cell-matrix interaction suggests an important role of IC

211 The defect is associated with an altered cell-matrix interaction that is evident by morphologic c

212 These effects are opposite to cell-matrix interactions that are strengthened by proton

213 To explore the signals from cell-matrix interactions that control orientation of cel

214 ment of physiological cell-cell contacts and cell-matrix interactions that lessen their dependence on

215 Langerin may have an unanticipated role in cell-matrix interactions that modulate LC development, l

216 GF) is a matricellular protein that mediates cell-matrix interaction through various subtypes of inte

217 single-cell migration with matrix fibers and cell-matrix interactions through contact guidance and ma

218 In these cells, cell-matrix interactions through integrins are required

219 rlooked is mechanical force, which regulates cell-matrix interactions through intracellular focal adh

220 ovium, plays a central role in cell-cell and cell-matrix interactions through ligation of cell surfac

221 s have the potential to be key modulators of cell-matrix interactions through the activities of their

222 ignaling by growth factors and cell-cell and cell-matrix interactions to prevent apoptosis, senescenc

223 l pathways that transmit signals from proper cell-matrix interactions to promote cell survival.

224 ents, we studied formation and maturation of cell-matrix interactions under conditions in which we co

225 Relevance of matrix viscoplasticity to cell-matrix interactions was established through a quant

226 de-binding protein involved in cell-cell and cell-matrix interactions, was recently shown to be a tum

227 To acquire information on this cell-matrix interaction, we developed a technique for co

228 ar mechanisms responsible for these abnormal cell-matrix interactions, we compared the levels of matr

229 e regulation of the paracellular pathway and cell-matrix interactions, we studied whether protein com

230 However, several mediators of cell-matrix interaction were reduced in the Tgfbr2(derma

231 Cell-cell and cell-matrix interactions were quantified and correlated

232 tein, polycystin-1, involved in cell-cell or cell-matrix interactions, whereas the PKD2 gene product,

233 e embryonic heart, and suggest that specific cell-matrix interactions which facilitate cell migration

234 tated by a precise sequence of cell-cell and cell-matrix interactions, which are mediated in part thr

235 unctions that involve numerous cell-cell and cell-matrix interactions, which ultimately mediate the h

236 ithin the integrin-based adhesome that links cell-matrix interactions with the tissue-specific functi

237 1 is an important regulator of cell-cell and cell-matrix interactions, with important roles in nerve

238 l the cell type, organization, and cell-cell/cell-matrix interactions within these systems.

239 d rich in cysteine) is a protein involved in cell matrix interactions, wound repair, and cell migrati