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1 e been described, some of which are host and cell specific.
3 e found that the increase in Treg cells in T cell-specific A20-deficient mice was already observed in
4 eficient mice fed a high-cholesterol diet, T cell-specific ABCG1 deficiency protected against atheros
9 Akt3/+S472 in triple-negative breast cancer cells, specific ablation of Akt3/-S472 enhanced, whereas
10 ly, we have shown that villin, an epithelial cell-specific actin-binding protein functions as an anti
14 city of the kinesin-2 OSM-3/KIF17, whereas a cell-specific alpha-tubulin isotype regulates ciliary ul
19 ether, this provides proof-of-concept that a cell-specific and region-specific gene expression approa
21 ational approach for identifying effectively cell-specific and stimulation-specific promoter and enha
22 gulates mitochondrial function; however, the cell-specific and temporal role of DRP1 in AKI in vivo i
24 unohistochemically by antibodies that target cell-specific antigens in the cytosol or plasma membrane
29 ll surface glycan by taking advantage of the cell-specific aptamer, and the lectin-functionalized gol
30 tosterone (DHT)-induced PCOS with global and cell-specific AR-resistant (ARKO) mice to investigate th
32 Thus, our study defines a proviral role of B cell-specific ATM expression during chronic gammaherpesv
33 gammaherpesvirus tropism for B-1 B cells, B cell-specific ATM expression was necessary to support vi
34 In summary, we identified a novel role for B cell-specific, BAFF-dependent transmembrane activator an
35 the cost of high technical noise, including cell-specific biases in capture efficiency and library g
38 l reprogramming by introducing individual TS cell-specific 'CAG' factors (Cdx2, Arid3a and Gata3), we
39 Cardiac function significantly declined in T-cell-specific CD4-Cre(+/)(-)CD73(flox/flox) mice identic
41 d a model of specific antibody deficiency, B cell-specific CD79a-Cre x XBP1 (X-box binding protein-1)
42 Nectin-like 4 (NECL4, CADM4) is a Schwann cell-specific cell adhesion molecule that promotes axo-g
43 ional variants that precisely co-locate with cell-specific chromatin domains and pancreatic islet enh
44 -specific control module governed by a renal cell-specific chromatin structure located distal to Cyp2
45 hment of neuronal fate with the formation of cell-specific ciliary structures in Caenorhabditis elega
46 od was applied to the quantification of four cell-specific cluster of differentiation (CD) proteins u
47 A library screening, we identified an immune cell-specific, co-stimulatory receptor B7.2 (CD86) as a
50 cells (DCs) from female mice with dendritic cell-specific conditional knockout of Prdm1 (CKO mice) a
53 his research question, we have generated a T cell-specific Coronin 1a knock-out mouse (Coro1a(fl/fl)
54 RPE cells, we used two different mature RPE cell-specific Cre recombinase drivers to inactivate eith
55 or neuron apoptosis, which can be rescued by cell-specific CRE-mediated expression of wild-type FUS w
56 concentrations in the blood of sensitized T cell-specific Cyp27b1-KO mice support a lymphocyte-drive
66 nticancer functions in vivo, and mice with T cell-specific deletion of Atg5 have reduced tumour outgr
67 and regulatory (Treg) cells, and mice with T cell-specific deletion of Blimp1 (Blimp1CKO mice) sponta
70 nesulfonic acid to control mice, mice with T-cell-specific deletion of GATA3, and mice with deletion
72 on of G-protein receptor kinase 3 (GRK3) nor cell-specific deletion of GRK3/arrestin-dependent p38alp
73 we created mice harboring liver parenchymal cell-specific deletion of HOIP (Hoip(Deltahep) mice) by
74 rt here that mice with embryonic neural stem-cell-specific deletion of Llgl1 (Nestin-Cre/Llgl1(fl/fl)
75 ucosal damage, we engineered mice carrying a cell-specific deletion of Nod2 in villin and Lyz2-expres
76 Using mice with an intestinal epithelial cell-specific deletion of PPARdelta, we show that intest
77 In addition, we studied AAI in mice with a T cell-specific deletion of recombination signal-binding p
81 mice with a cardiomyocyte- or smooth muscle cell-specific deletion of the BK (CMBK or SMBK knockouts
82 stigation of mice with intestinal epithelial cell-specific deletion of the p38alpha gene, we find tha
83 equired for the acquisition of the dendritic-cell-specific demethylation and expression signature, fo
85 r genotype; however, PG shows photosynthetic cell-specific differential localization depending on the
90 xpanded minor clones and obtained epithelial cell-specific DNA/RNA for quantitative NGS analysis.
92 pirical Bayes approach to reliably model the cell-specific dropout rates and amplification bias by us
93 estigated associations in this study between cell-specific dynamic signaling pathways and drug sensit
96 ingly, mice with gastrointestinal epithelial cell-specific Egfr deletion demonstrated no differences
97 tion-induced cytidine deaminase (AID) is a B-cell-specific enzyme that targets immunoglobulin genes t
103 ranscripts were validated by qPCR to confirm cell specific expression in microdissected tissues, as w
106 its primary islet cell counterpart including cell-specific expression of beta (e.g., Pdx1) and alpha
108 ration of transgenic mice with smooth muscle cell-specific expression of either USP20 or its catalyti
110 he first in vivo genetic evidence of sensory cell-specific expression of this unusual co-receptor and
116 mproved vascular permeability of endothelial cell-specific Fli1-knockout mice by increasing the expre
117 flammatory components of SSc and endothelial cell-specific Fli1-knockout mice recapitulating SSc vasc
118 CR transgenic model of GVHD, wherein TS1 CD4 cells specific for a model minor histocompatibility Ag (
119 TRAPeS with transcriptome analysis of CD8+ T cells specific for a single epitope from Yellow Fever Vi
120 aive B cells was mirrored in a population of cells specific for an Ag to which these individuals were
121 ence of ACPAs in the absence of detectable T cells specific for citrullinated antigens: ACPAs could a
122 y HSV-specific CD8 T cells compared to CD8 T cells specific for control viruses, Epstein-Barr virus (
123 & Microbe, Moguche et al. (2017) show that T cells specific for different immunodominant vaccine anti
125 In blood samples from controls, CD4(+) T cells specific for FlaX, A4-fla2, or YidX had a T-helper
129 leukemic effects can be delivered by donor T cells specific for particular minor histocompatibility (
132 y of these mice to expand epitope-specific T cells specific for the model antigen ovalbumin expressed
134 1 phenotype; a larger proportion of CD4(+) T cells specific for these proteins in patients with CD ha
137 s the sole iron exporter in mammals, but its cell-specific function and regulation are still elusive.
141 nhancers are regulatory elements that govern cell-specific functions and harbor disease-associated se
142 uolation along the endosomal system, but the cell-specific functions of PIKfyve in vivo remain unclea
145 ated by retinoic acid gene 8 (Stra8), a germ cell-specific gene activated during meiotic commitment.
147 mouse is commonly used for conditional hair cell-specific gene deletion/reporter gene activation in
152 age differentiation with curated phenotypes, cell-specific gene functions and a multiscale model.
153 s) and associated with highly expressed germ cell-specific genes and histone retention in mature sper
155 ze the transcription factor STAT5 to control cell-specific genes at a larger scale than universal gen
158 tly regulate the expression of multiple germ cell-specific genes, including Asz1 In addition, conditi
159 ial expression analysis uncovered new immune-cell-specific genes, including novel immunoglobulin-like
163 was attenuated in islets isolated from beta-cell-specific Ghsr knockout MIP-Cre/ERT;Ghsr(f/f) mice.
167 y, deletion of endothelial (but not myeloid) cell-specific HIF1alpha doubled pulmonary fibrin deposit
168 eration during repair was attenuated in ATII cell-specific HIF1alpha knockout (SftpcCreERT2(+/-);HIF1
175 avenous infusion, for studies in either beta-cell specific insulin receptor knock-out (betaIRKO) or c
176 e receptors 1 and 2, dectin 1, and dendritic cell-specific intercellular adhesion molecule 3-grabbing
178 tin occupancy at sites in the Igh locus is B cell specific, is correlated with histone H4 lysine 20 m
179 a focus on VE-cadherin, a major endothelial cell-specific junctional protein that controls vascular
181 P on beta-cell function by the use of a beta-cell-specific knockout of the ANP receptor with guanylat
183 stochemical staining revealed stronger tumor cell-specific labeling for C3 and CFB in invasive cSCCs
185 In this study, we generated endothelial cell-specific LKB1-knockout (LKB1(endo-/-)) mice by cros
191 KO mice had decreased expression of the beta-cell-specific markers pdx1, glut2, mafA, and nkx6.1 and
192 growth parameters by analyzing expression of cell-specific markers revealed that the explant system m
194 syndromes of DNA repair deficiency or immune cell-specific maturation or functional defects that sugg
197 owever, it is not known whether there are ES cell-specific mechanisms regulating mitotic fidelity.
198 ce lifetime imaging microscopy (FLIM) to map cell-specific metabolic signatures in the kidneys of liv
204 Cre, or Cdh5-CreERT2 driver lines to develop cell-specific models of Nox2 perturbation to investigate
207 within the SVZ/RMS/OB system resulting in a cell-specific mosaic, suggesting complex EphA4 signaling
211 Abe et al. (2017) identify NLRP14 as a germ-cell-specific negative regulator of DNA sensing that may
214 were monitored in wild-type (WT) and myeloid cell-specific Nrp1 knockout (Nrp1(myel-KO)) mice fed an
216 o address this problem, we generated myeloid cell-specific Nrp1-knockout (Nrp1(myel-KO)) mice and app
217 -targeted electrophysiological recording and cell-specific optogenetic manipulation in both anestheti
219 have demonstrated that, although mice with T cell-specific overexpression of miR-27 harbor dysregulat
220 vivo, vascular smooth muscle cell/mesangial cell-specific overexpression of Nox5 in a mouse model of
222 ouse colon tissues and intestinal epithelial cell-specific p38gamma knockout (KO) attenuates colitis
224 Collectively, these findings unveil distinct cell-specific patterns of E-selectin ligand expression a
226 uced with the tamoxifen-inducible, satellite cell-specific Pax7(CreER) system in postnatal satellite
229 tion of either Hif1a or Hif2a in endothelial cell-specific Phd2 mutants demonstrated that the develop
230 proteome for normal IE function, providing a cell-specific pool of candidates for novel, important HC
231 e the reads aligned to this gene to estimate cell-specific preferences for splicing, mutation load, o
234 ressing S-della under the control of a guard-cell-specific promoter was sufficient to increase stomat
236 mmon upregulation of marginal zone B- and B1-cell-specific protein (MZB1), the expression of which id
238 reverse-phase protein arrays, the lymphocyte cell-specific protein-tyrosine kinase (LCK) as aberrantl
240 plications after hearing onset, we show that cell-specific purinergic modulation follows a precise to
243 le (SLAM) family of homotypic haematopoietic cell-specific receptors, we determined that phagocytosis
244 We used chemogenetics to extend D1-/D2-MSN cell specific regulation to cue-reinstated cocaine seeki
246 er Cdx2 regulatory elements including a stem-cell specific regulatory sequence and an element that dr
247 different populations, gene expression, and cell-specific regulatory annotation can be effectively i
248 data further indicate that ATAC-seq detects cell-specific regulatory elements for cell types compris
249 t NOTCH1 transactivates MYC via binding to B-cell-specific regulatory elements, thus implicating this
253 identify clock-relevant phosphatases, clock-cell-specific RNAi knockdowns ofDrosophilaphosphatases w
254 system, renal, and vascular levels, but the cell-specific role of Nox2 in BP regulation is unknown.
257 he aptitude to triage stimuli depends on the cells' specific sensitivities to different chemoattracta
258 e the scalability of SeqUnwinder to discover cell-specific sequence features from over one hundred th
261 the simultaneous, temporally controlled, and cell-specific silencing of multiple genes or pathways.
268 aracterized the pathogenic potential of beta cell-specific T cells, we have limited mechanistic insig
269 t sequence properties of multi-condition and cell-specific TF binding sites after controlling for une
271 s has resulted in an unmet clinical need for cell-specific therapy in the treatment of FSGS and other
273 ls or re-engineer natural materials to model cell-specific tissue-like 3D modules, which can seamless
274 rrounding normal breast tissue to identify T cells specific to each, as well as their abundance in pe
275 enic mouse system in which TCR-transgenic Th cells specific to hen egg lysozyme (HEL) are adoptively
278 of lymphocytes and proliferation of CD8(+) T cells specific to tumor-associated antigens, resulting i
279 f effector memory CD8(+) T cells (CD8(+) TEM cells) specific to three epitopes derived from the HSV-1
280 animals lacking distinct lung APC subsets or cell-specific Toll-like receptor (TLR) 4 signaling.
281 d myotube formation, we demonstrate that the cell-specific topology of syncytial nuclei is dependent
282 R targeting a peptide of the intracellular B cell-specific transcription factor BOB1 presented in the
284 to asymmetric division and activation of the cell-specific transcription factor sigma(F), a hallmark
286 ell as indirect in vivo measurements such as cell-specific transcriptional analysis of ABA metabolic
289 latory elements such as enhancers coordinate cell-specific transcriptional programmes by engaging in
290 toolset for cell-type specific profiling of cell-specific transcriptomes derived from complex biolog
291 timize parameters of FCM algorithm for human cell-specific transcriptomic data and identify robust ge
295 ns, advances in DNA sequencing indicate that cell-specific variants affect a number of phenotypes and
296 dy VDR KO, T cell-specific VDR (T-VDR) KO, B cell-specific VDR (B-VDR) KO, and vitamin D deficient mi
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