ライフサイエンスコーパス: cellular effect

1 ivities as well as those that impede optimal cellular effects.

2 PTX in vivo likely stem from their distinct cellular effects.

3 ccurring phytochemicals with weak estrogenic cellular effects.

4 ng oxidized lipoproteins and mediating their cellular effects.

5 N and Bcl-2 were involved in miR-21-mediated cellular effects.

6 means by which diverse stimuli mediate their cellular effects.

7 d through activation of PERK to induce their cellular effects.

8 is not known whether gJ mediates additional cellular effects.

9 to DNA damage, mutagenesis and other harmful cellular effects.

10 causes the GC disruption, leading to various cellular effects.

11 nantiomer of D-e-Cer, failed to induce these cellular effects.

12 usions with similar morphology but different cellular effects.

13 s interaction proved insufficient to mediate cellular effects.

14 on TGFbeta because of its known pleiotropic cellular effects.

15 tivation of protein kinases leads to diverse cellular effects.

16 PRA and PRB, respectively), each with unique cellular effects.

17 n of alphaT3-1 cells indicating long-lasting cellular effects.

18 riptional regulation downstream of DEK1 with cellular effects.

19 ately determines the extent of IGF-dependent cellular effects.

20 effects can produce significantly different cellular effects.

21 prime candidate for mediating some of Rac's cellular effects.

22 ents, suggesting that it may have additional cellular effects.

23 toma gene product] that mediate its distinct cellular effects.

24 e report on the mechanism of NDF/HRG-induced cellular effects.

25 the mechanisms by which ceramide induces its cellular effects.

26 s associated with WGD, focusing primarily on cellular effects.

27 nd the responses they elicit, may have broad cellular effects.

28 ulators RCC1 and RanGAP mediates many of its cellular effects.

29 nsic differences between fragments and their cellular effects.

30 y downstream effector proteins to elicit its cellular effects.

31 n alter the presentation to target cells and cellular effects.

32 our metastasis suppressor which has multiple cellular effects.

33 KC isoforms alpha and beta mediate different cellular effects.

34 ich biological amphiphiles can produce their cellular effects.

35 y these signaling factors wield such diverse cellular effects.

36 ide are important bioactive lipids with many cellular effects.

37 ethionine aminopeptidases (MetAPs) for their cellular effects.

38 of suppression of POX/PRODH in MYC-mediated cellular effects.

39 ders, suggesting that they may induce common cellular effects.

40 Inhibition of PI3K had similar adverse cellular effects.

41 Typically, the cellular effect accompanies an induction of mesodermal c

42 rming growth factor-beta (TGF-beta)-mediated cellular effects and examined the signaling pathway invo

43 ovide a mechanistic explanation for both the cellular effects and in vivo phenotypic abnormalities in

44 nterest to determine whether TC10 has unique cellular effects and interacts with the same targets as

45 ng has potential for elucidating the complex cellular effects and mechanisms of action of novel targe

46 In this study we examined the cellular effects and molecular mechanism of the arrestin

47 fine-tuners of a range of pathophysiological cellular effects and molecular signaling pathways involv

48 characteristics of mutant TDP-43 to aberrant cellular effects and patient phenotype.

49 uced calcium responses to mediate downstream cellular effects and providing evidence for TRPA1 functi

50 ated TLR3 can engage Src to trigger multiple cellular effects and reveal a possible link between inna

51 epidermis as a model system to elucidate the cellular effects and signaling feedback sequelae of mTOR

52 oteins that interact with PAK to mediate its cellular effects and to couple it to upstream receptors

53 All these cellular effects appear to depend on the G-quadruplex bi

54 These cellular effects are accompanied by alterations of the a

55 This study suggests that some MYC-induced cellular effects are due to MYC regulation of proline me

56 These cellular effects are in line with the recently reported

57 interacting with a receptor whose downstream cellular effects are mediated by the cta G(alpha)protein

58 ich secretory phospholipase A2 (PLA2) exerts cellular effects are not fully understood.

59 ecretory phospholipases A(2) (PLA(2)s) exert cellular effects are not fully understood.

60 The DNA damage pathways underlying these cellular effects are not well understood.

61 ranslational regulation of HuR and resulting cellular effects are poorly understood.

62 We show that the first observable cellular effects are the formation of membrane distortio

63 s of growth/guidance stimulate such negative cellular effects as F-actin disassembly/repulsion.

64 rall structure of Vpr is essential for these cellular effects, as N- and C-terminal deletions affecte

65 At least 1 of the cellular effects associated with HIV inhibition is inter

66 enzyme and its human counterpart, and their cellular effects at different stages of the Trypanosoma

67 ranslational modification, with differential cellular effects based on phosphorylation at specific se

68 ta, and IFN-omega, induce somewhat different cellular effects but act through a common receptor compl

69 gy, similar gene sequence, and exert similar cellular effects, but the replication of the virus outsi

70 Progesterone can exert cellular effects by acting on membrane receptors or by a

71 nsmitters, light, and odorants mediate their cellular effects by activating heterotrimeric guanine nu

72 rigenesis, is thought to mediate its diverse cellular effects by altering the expression of specific

73 It is thought that estrogen exerts its cellular effects by regulating the expression of specifi

74 60 nm, well below that of 5-15 microm, where cellular effects by sarcoplasmic/endoplasmic reticulum c

75 ctivity within seconds, indicating that some cellular effects can occur via membrane delimited events

76 ctivity within seconds, indicating that some cellular effects can occur via membrane delimited events

77 s how this new assay, targeted to downstream cellular effects, can uncover unique ligand efficacies l

78 o its extracellular (EC) domain, whereas its cellular effects depend on activation of its cytoplasmic

79 Rapamycin and FK506 have unique cellular effects despite the fact that they bind to the

80 Additional cellular effects due to inhibition of Aurora kinases inc

81 y characterising transcriptional changes and cellular effects following modulation of p63 expression,

82 PAHAs and PABAs exhibit strikingly different cellular effects from SAHA and have the potential for us

83 After documenting the in vitro cellular effects, halofuginone (intraperitoneum injectio

84 of membrane-associated AMPs as well as their cellular effects have been extensively documented; howev

85 wide variety of structural, functional, and cellular effects have been identified in reproductive tr

86 Individual Ox-PL responsible for specific cellular effects have been identified.

87 This unique combination of cellular effects in conjunction with acute channel block

88 these different mutations may have variable cellular effects in neurons and/or oligodendrocytes.

89 s mammalian erythropoiesis, exhibits diverse cellular effects in non-hematopoietic tissues.

90 c patients and to functionally analyze their cellular effects in the mitochondrial compartment.

91 integrating and spatially restricting their cellular effects in time and space.

92 heterodimer with RXR, mediates a variety of cellular effects including adipocyte-differentiation.

93 -kinase/Akt/mTOR pathway causing pleiotropic cellular effects including an mTOR-dependent loss in ins

94 mplex (GC), which is associated with various cellular effects, including anoikis.

95 ic subtypes of meningioma and exerts diverse cellular effects, including DR5 up-regulation, modulatio

96 active phospholipid, induces a wide range of cellular effects, including gene expression, cytoskeleta

97 th cytosolic RNA degradation and pleiotropic cellular effects, including growth inhibition and apopto

98 myelogenous leukemia (CML) and has multiple cellular effects, including the induction of autophagy a

99 We also demonstrate that these cellular effects, increased rate of oxidative metabolism

100 esting a link between biochemical events and cellular effects induced by CD38.

101 Amongst the cellular effects induced by cholinergic modulation are a

102 ule cells, the heterogeneous distribution of cellular effects induced by ectopic En expression sugges

103 and we have explored potential links between cellular effects induced by rapamycin and p53.

104 ise mechanism by which FGF19 regulates these cellular effects is poorly understood.

105 ription of genes involved in a wide range of cellular effects known to increase the aggressive nature

106 These cellular effects may predispose individuals with a histo

107 different G proteins may result in specific cellular effects mediated by AT2 stimulation.

108 Among the multiple cellular effects mediated by lysophosphatidic acid (LPA)

109 n physiologically counteracts several of the cellular effects mediated by the activation of beta-adre

110 NAs in H(2)O(2)-mediated gene regulation and cellular effects, miR-21 expression was down-regulated b

111 O (a nitrosating agent) and NO have distinct cellular effects; NO more effectively interacts with glo

112 on regulator, itself is a growth factor with cellular effects not dependent on IGFs.

113 The first cellular effect observed with continuous exposure to 50

114 K inhibitors 8a and 8b that recapitulate the cellular effects observed by short hairpin ribonucleic a

115 However, none of the cellular effects observed using ICMT inhibitors were as

116 To determine the cellular effect of disrupting ERK5 signaling from CCR7,

117 Induction of HO and iNOS may reflect the cellular effect of diverse cytokines elaborated in the r

118 We used 401 to test the cellular effect of mTOR inhibition without the complicat

119 in human ovarian carcinoma, we examined the cellular effect of oncogenic RAS on the expression statu

120 Thus, this cellular effect of PEP-19 does not depend simply on bind

121 cell technologies to identify a significant cellular effect of rare penetrant NRXN1 mutations in hum

122 SOCS-3 induction is the first cellular effect of resistin that is independent of insul

123 ding proteins whose occupancy determines the cellular effect of stimulation.

124 t this concentration could also abolish this cellular effect of TCDD.

125 A more detailed analysis of the cellular effect of these PI3K/mTOR dual inhibitors demon

126 The phase II Lessons From Antagonizing the Cellular Effect of Thrombin-Coronary Artery Disease (LAN

127 w data help resolve the roles of the diverse cellular effects of 2ME2 including microtubule disruptio

128 stic information that clarifies the multiple cellular effects of 2ME2, and the identification of prom

129 one gamma-H2AX by 4NQO may contribute to the cellular effects of 4NQO, including its selective activi

130 p a quantitative trait locus influencing the cellular effects of 5-fluorouracil to chromosome 9q13-q2

131 e pool of tagged heterozygotes to assess the cellular effects of 78 compounds in Saccharomyces cerevi

132 Cellular effects of a Nedd8-activating enzyme (NAE) inhi

133 work provides a greater understanding of the cellular effects of a non-JAK2V617F, MPN-associated JAK2

134 l of these cyclodepsipeptides, we probed the cellular effects of a novel and representative family me

135 eview summarizes recent studies highlighting cellular effects of adiponectin and its role in human li

136 ase, mechanisms underlying the molecular and cellular effects of alcohol, the application of new and

137 us reports that Golgi fragmentation mediates cellular effects of alphaSNAP knockdown, we found that e

138 regulation and to examine the molecular and cellular effects of altered expression of specific gene

139 Previous studies on the cellular effects of altered levels of two of these rRNAs

140 We show that these off-target cellular effects of AM251 are mediated by proteasomal de

141 Because little is known about the direct cellular effects of Ang II on human cardiac fibroblasts,

142 gned to the multidomain APC protein, but the cellular effects of APC expression and how they relate t

143 This study provides new perspectives on the cellular effects of APC that might lead to a deeper unde

144 ation R61T is able to rescue the deleterious cellular effects of ApoE4 by preventing the formation of

145 ity that this enzyme may mediate some of the cellular effects of araC.

146 Together, these results suggest that cellular effects of biguanides depend on their metal-bin

147 We examined the detailed molecular and cellular effects of blockade of IL-17 signaling in human

148 ating evidence has demonstrated that the net cellular effects of cAMP are also regulated by EPAC.

149 Thus, we suggest that at least some of the cellular effects of carotenoids are mediated through the

150 In subsequent analyses of the cellular effects of CD56(140kD) overexpression in the de

151 chain ceramide analogs, widely used to study cellular effects of ceramide, have biological effects th

152 The cellular effects of chelerythrine are not due to either

153 DNA lesions near a DSB and that the indirect cellular effects of cisplatin treatment are not signific

154 protein-dependent signaling pathway mediates cellular effects of CMV infection of SMCs.

155 signaling is required for the behavioral and cellular effects of cocaine.

156 In contrast, the cellular effects of congener 21a, which inhibited Clk1 o

157 s suggest that stress-induced changes in the cellular effects of CRF in the DRN translate to changes

158 lity as antiparasitic agents, we compare the cellular effects of curcumin and the enone linker lead c

159 de serves as a second messenger in mediating cellular effects of cytokines and stress.

160 These in vivo results demonstrate that the cellular effects of DNA damage depend on the development

161 two quantitative trait loci influencing the cellular effects of docetaxel to chromosomes 5q11-21 (LO

162 by thymic presenting cells and to study the cellular effects of EBV infection, the present work util

163 tatin 5 (1), which attenuated the downstream cellular effects of elastase in an epithelial lung airwa

164 In this study we addressed the molecular and cellular effects of elevated and suppressed levels of ci

165 The cellular effects of estrogen in vitro together with the

166 d provide mechanistic insight into the rapid cellular effects of estrogen on brain function.

167 However, the subsequent cellular effects of Et743 are not fully understood.

168 stand the interrelationship of the different cellular effects of ExoS, functional analyses were perfo

169 tation appeared to have little impact on the cellular effects of ExoS.

170 heterotrimeric G proteins in modulating the cellular effects of extracellular nucleotides.

171 Although other cellular effects of EZH2 inhibition may contribute to th

172 Herein, we focus on the cellular effects of G(o) signaling in the gamma lobe mus

173 the properties of GABAergic neurons and the cellular effects of GABA have not been described in Dros

174 We have previously used LCLs to examine the cellular effects of genetic variants that modulate the e

175 These cellular effects of GIT1 require its intact ARF GAP acti

176 protein kinases (MAPKs) mediate many of the cellular effects of growth factors, cytokines and stress

177 The immunologic and cellular effects of herpesvirus infections contribute to

178 Together, these distinct cellular effects of Hh signaling in neural progenitor ce

179 s pombe as a model system to investigate the cellular effects of HIV-1 vpr gene expression.

180 omyopathy and are not fully explained by the cellular effects of hyperglycemia alone.

181 A limited number of studies show the cellular effects of hypertonic saline and no studies, to

182 Most of the cellular effects of hypoxia are mediated by O2-labile hy

183 targets and function of TRMT1 to uncover the cellular effects of ID-causing TRMT1 mutations.

184 To determine the cellular effects of induced, oxidative DNA damage, we es

185 ol studies have focused on the molecular and cellular effects of inositol depletion without consideri

186 onstitute a novel mechanism for the distinct cellular effects of insulin and IGF-1, the former being

187 Therefore, cellular effects of intrabacterial ammonia generation un

188 ng nurse cells of the fly ovary to study the cellular effects of intracellular IIS components on lipi

189 Taken together with previous work on the cellular effects of LAR, the present results are consist

190 y susceptible to lead toxicity; however, the cellular effects of lead on neuronal development are not

191 ciative learning, and reproduces many of the cellular effects of learning, such as the reduction of p

192 enosine 5'-phosphate (PAP), in mediating the cellular effects of lithium.

193 Many of the cellular effects of LPA and S1P are attributable to modi

194 )/Edg-4, and lpa(3)/lp(A3)/Edg-7 mediate the cellular effects of LPA.

195 ctivity of the autonomic nervous system, the cellular effects of MC4Rs on parasympathetic and sympath

196 The cellular effects of mitochondria- or surface-selective a

197 quitous second messenger responsible for the cellular effects of multiple hormones and neurotransmitt

198 The cellular effects of n-alkanols and general anesthetics o

199 ne beta subunit, sGC mediates the widespread cellular effects of nitric oxide (NO).

200 However, the relationship between the cellular effects of norepinephrine and the impact of nor

201 noporation mediates and enhances the diverse cellular effects of nsPEF.

202 hat inhibition of PAK may be involved in the cellular effects of OSU-03012 in these cells.

203 Here we have examined the cellular effects of overexpression of SIRT1, the closest

204 y to different tumors, and the molecular and cellular effects of PD-1 blockade.

205 We have also investigated the cellular effects of peroxynitrite in HaCaT cells, a huma

206 ese results help reconcile seemingly opposed cellular effects of Pfn1, provide new insights into the

207 The network and cellular effects of PGE2 and TTX treatments reversed wit

208 s, is a principal determinant of the diverse cellular effects of PGE2.

209 Here, we characterize the biochemical and cellular effects of PIAs.

210 signaling mechanisms underlying the observed cellular effects of PLK1 involve direct PLK1-dependent p

211 Our data suggest that the cellular effects of progerin are transduced, at least in

212 pression, and provides a novel mechanism for cellular effects of PTEN.

213 effectors have been described to mediate the cellular effects of Rap1 in a context-dependent manner.

214 kinase inhibitor in intact cells or that the cellular effects of rapamycin are not mediated through g

215 It has been assumed that the cellular effects of reactive tetrahydroisoquinolines res

216 ors are widely expressed in neurons, but the cellular effects of receptor activation are unclear.

217 190-deficient cells, we demonstrate that the cellular effects of Rnd expression are mediated by p190.

218 alance between the desirable and undesirable cellular effects of ROS.

219 Although these cellular effects of roscovitine are thought to be caused

220 We show that the pathway responsible for the cellular effects of S-nitrosothiols is specific for S-ni

221 e signaling mechanisms mediating the diverse cellular effects of S1P remain to be determined.

222 Notably, these cellular effects of small t are dependent on its interac

223 S1P(1-5)) have been shown to mediate various cellular effects of sphingosine 1-phosphate (S1P).

224 The cellular effects of SR1848 treatment are recapitulated a

225 Drugs that mirror the cellular effects of starvation mimics are considered pro

226 cades and could be involved in mediating the cellular effects of such signals.

227 Here, we report that the cellular effects of TcdA can be substantially enhanced v

228 ys the antibody-dependent enhancement of the cellular effects of TcdA.

229 y rodent neuronal culture model to study the cellular effects of TDP-43 dysfunction in hippocampal an

230 ors represent a common mechanism involved in cellular effects of tea polyphenols.

231 signaling proteins involved in mediating the cellular effects of TGF-beta(1).

232 mportance of ARF binding to the toxicity and cellular effects of the ADP-ribosylating bacterial toxin

233 rol CHO cells in a manner reminiscent of the cellular effects of the APP "Swedish mutation." The incr

234 In addition, cellular effects of the best dual inhibitors were determ

235 th TUBB4A reflect the selective and specific cellular effects of the causative mutations.

236 To distinguish the cellular effects of the different 5-HT2AR agonists, we d

237 ng that FAK might participate in some of the cellular effects of the growth factors in modulating cel

238 nt study, we investigated the functional and cellular effects of the neuropeptide thyrotropin-releasi

239 In this study, we investigated the cellular effects of the unmodified and acetyl mini-chape

240 rcaptopurine and other purine analogues, the cellular effects of these compounds remain relatively un

241 The cellular effects of these compounds were characterized i

242 vitro As a further proof-of-concept test for cellular effects of these compounds, we performed proxim

243 cer therapeutics, but little is known of the cellular effects of these inhibitors on tumor vessels.

244 thin mammalian intracardiac ganglia, but the cellular effects of these neuropeptides remain poorly un

245 jective of the Lessons From Antagonizing the Cellular Effects of Thrombin-Acute Coronary Syndromes (L

246 ibits pedestal formation, revealing that the cellular effects of Tir and Map must be co-ordinately re

247 unknown mechanism by which IP may limit the cellular effects of TP.

248 We present a study of the cellular effects of TUBB4A mutations responsible for H-A

249 ion, but they can respond to and mediate the cellular effects of type I IFNs.

250 evaluated the expression, localization, and cellular effects of Us5/gJ.

251 id sequence, ultrastructural morphology, and cellular effects of VacA are unrelated to those of any o

252 Immune cellular effects of vasoactive intestinal peptide (VIP)

253 rtance of tumor phenotype in determining the cellular effects of VEGF and PDGF inhibitors on tumor ve

254 dies of viral latency, reactivation, and the cellular effects of viral infection will provide clues f

255 This study compared the cellular effects of XL880 and XL184 with those of an RTK

256 ed glycation end products (AGEs) exert their cellular effects on cells by interacting with specific c

257 s in a brain focal ischemia model and direct cellular effects on human umbilical vein endothelial cel

258 en suggested that molecules with significant cellular effects on retinoblastoma protein (pRb) or its

259 explore the structural, conformational, and cellular effects on the B-Raf kinase domain upon binding

260 We examined the cellular effects on tumor vasculature of a novel DNA oli

261 Investigations into the cellular effects produced by fostriecin treatment reveal

262 Cellular effects produced by mutant SOD1, including impa

263 sights into mechanisms for these contrasting cellular effects, protease activated receptor 3 (PAR3) a

264 TauNHCl has diverse cellular effects ranging from inhibiting the production

265 among telomeres, their regulation and their cellular effects remain elusive.

266 ccal enterotoxin B, which mimics some of the cellular effects seen in patients with severe bacterial

267 yglutamine proteins may determine subsequent cellular effects such as nuclear localization and cellul

268 in their sequences, signaling partners, and cellular effects such as oncogenic transformation and cy

269 ay also be involved in growth-factor-induced cellular effects such as the modulation of cell adhesion

270 -8, possibly involved in regulating numerous cellular effects, such as effects on cell growth or cell

271 e can promote cancer progression by a direct cellular effect that is independent of its effect on the

272 ides are easily inactivated and have diverse cellular effects that are distinct from antimicrobial ac

273 that some tyrosine kinase inhibitors produce cellular effects that are mechanistically different from

274 also provides a rare example of TLR-mediated cellular effects that do not require gene induction and

275 ddition, angiotensin II also has a number of cellular effects that may contribute to disease pathogen

276 ) family of lipid mediators, elicits diverse cellular effects that range from mitogenesis to the prev

277 he molecular mechanisms in propofol-mediated cellular effect, the expression of programmed cell death

278 IL-6 exerts its cellular effects through a cell-surface receptor which a

279 Furthermore, glucose exerts many of its cellular effects through lipid mediators.

280 reasing evidence reveals that ROS have wider cellular effects through their role in many signal trans

281 oltage-gated calcium channels has widespread cellular effects upon a host of physiological processes

282 ription polymerase chain reaction to examine cellular effects upon compound addition.

283 rrhythmogenic consequences, we simulated the cellular effects using a new AP model, which reproduced

284 d with numerous receptors that mediate their cellular effects via activation of G(q)-type G proteins,

285 w phosphorylation of a protein might achieve cellular effects via direct impacts on the protein's agg

286 he relationship between Hsp90 inhibition and cellular effects, we developed a method that measures dr

287 ical activities that might account for these cellular effects, we found that monodansylcadaverine (MD

288 rstand how PC inhibits BCP and CPPD-mediated cellular effects, we have investigated the mechanism by

289 These cellular effects were associated with a significant decr

290 ns was investigated in this study, and their cellular effects were compared with those caused by the

291 entiation and G0 arrest, where the doses for cellular effects were consistent with the transcriptiona

292 MiR-21-mediated cellular effects were further confirmed in vivo in ballo

293 Moreover, cellular effects were observed at 1-Chl concentrations s

294 These cellular effects were preceded by fragmentation of the G

295 These cellular effects were, in part, explained by the effect

296 study reveals the behavioral impact of this cellular effect, whereby the level of GIRK3 expression i

297 o studies showed that EMD stimulates various cellular effects, which could potentially enhance wound

298 o fractionate EMD and associate its specific cellular effects with different molecular weight fractio

299 ew mechanisms by which mutant p53 exerts its cellular effects, with a particular focus on the burgeon

300 nction of cholinergic modulation to specific cellular effects within these regions.