ライフサイエンスコーパス: cellular function

1 cellular adhesive processes and differential cellular function.

2 the synthesis of polyprenol diphosphates and cellular function.

3 rs to osmotic stress is an important part of cellular function.

4 nsures its timely bioavailability for proper cellular function.

5 by the cytoskeleton is an important part of cellular function.

6 gh to trigger tissue regeneration or restore cellular function.

7 ll metabolic reprogramming and its effect on cellular function.

8 Proper cell size is essential for cellular function.

9 Signaling networks are key regulators of cellular function.

10 them more susceptible to deficits in normal cellular function.

11 cient gene knockdown without impeding normal cellular function.

12 NA secondary structure, is critical to their cellular function.

13 ts of PARylation on host gene expression and cellular function.

14 ieve the degree of processivity required for cellular function.

15 cal for its role in regulating signaling and cellular function.

16 ucing the biological machinery essential for cellular function.

17 external events, is a fundamental aspect of cellular function.

18 that long non-coding RNAs (lncRNAs) modulate cellular function.

19 teins that perform more than one independent cellular function.

20 ellular redox buffer which can impair proper cellular function.

21 modulator receptors to modulate synaptic and cellular function.

22 racellular thiols is important for revealing cellular function.

23 itical determinant of the proteome and hence cellular function.

24 e their diverse roles in gene regulation and cellular function.

25 e PMN-MPs and MPO as important regulators of cellular function.

26 sine kinase activity is essential for normal cellular function.

27 parasitism of Arabidopsis to ensure optimal cellular function.

28 cording is a powerful technique for studying cellular function.

29 th proteins that serve as hubs for essential cellular functions.

30 spatial regulation of lipid biosynthesis for cellular functions.

31 eic acids (ssNAs) are ubiquitous in many key cellular functions.

32 isy) process with important implications for cellular functions.

33 on between organelles and impact fundamental cellular functions.

34 ct genome organization and potentially alter cellular functions.

35 but also underlies a wide range of positive cellular functions.

36 s (m(6)A/m) of messenger RNA mediate diverse cellular functions.

37 polymers that are required for a variety of cellular functions.

38 biology has been the programmable control of cellular functions.

39 l of biological molecules can greatly impact cellular functions.

40 e, and it has thus been proposed to play key cellular functions.

41 nein is involved in a multitude of essential cellular functions.

42 ll-to-cell communication to regulate several cellular functions.

43 comparable effects on canonical pathways and cellular functions.

44 ade at mitochondria and the ER has separable cellular functions.

45 le in determining the observed impairment of cellular functions.

46 gene expression, and participates in diverse cellular functions.

47 d may also have a potential risk of altering cellular functions.

48 canonical pathways, upstream regulators and cellular functions.

49 The P2X7 receptor (P2X7R) regulates many cellular functions.

50 ERRFI1) is an adaptor protein with multiple cellular functions.

51 e within the cytoplasm is important for many cellular functions.

52 velop tools for the directed manipulation of cellular functions.

53 lc26A uptake systems participate in multiple cellular functions.

54 embly of signaling complexes are crucial for cellular functions.

55 (Ca(2+)) is a universal regulator of various cellular functions.

56 diate redox signaling necessary for numerous cellular functions.

57 pathway and its role in DNA repair and other cellular functions.

58 re- and post-Golgi membranes serve different cellular functions.

59 sphorylation in KF network rearrangement and cellular functions.

60 an proteome play important roles in numerous cellular functions.

61 probably not appropriate, given its critical cellular functions.

62 e substrates and better elucidation of their cellular functions.

63 teins has emerged as a key regulator of many cellular functions.

64 short RNAs that regulate gene expression and cellular functions.

65 ganism transcriptional activity and specific cellular functions.

66 scaffolding protein to gain insight into its cellular functions.

67 role in maintaining chromatin integrity and cellular functions.

68 o acid biosynthesis and catabolism and other cellular functions.

69 l method to identify molecules that regulate cellular functions.

70 the interplay between their organization and cellular functions.

71 ughput and multiplex screening of samples or cellular functions.

72 nase (PI3K) signaling pathway regulates many cellular functions.

73 ganelle that plays crucial roles in numerous cellular functions.

74 of small GTPases that perform a plethora of cellular functions.

75 and transcription factor, regulating several cellular functions.

76 opBP1) are two proteins performing essential cellular functions.

77 ains, consequently better compartmentalizing cellular functions.

78 (XBP1) plays an important role in EC and SMC cellular functions.

79 er cells during mitosis as well as for other cellular functions.

80 nt LSDs disrupt multiple lysosomal and other cellular functions.

81 mpartments specialized to carry out specific cellular functions.

82 e factor for Rab-GTPases to regulate diverse cellular functions.

83 cells (VSMCs), which contribute to important cellular functions.

84 understood how FACT is fine-tuned for normal cellular functions.

85 ical consequences for membrane integrity and cellular functions.

86 ing of RPA to DNA is necessary for different cellular functions.

87 eukaryotic cells to control a wide array of cellular functions.

88 acterial second messenger regulating various cellular functions.

89 he cell and is involved in a large number of cellular functions.

90 anelle contacts have a vital role in diverse cellular functions.

91 to visualize molecular signals or manipulate cellular functions.

92 ets, suggesting that this isoform has unique cellular functions.

93 d within 53 communities representing central cellular functions.

94 o targeted genome regulation for engineering cellular functions.

95 effector proteins into host cells to affect cellular functions.

96 ng genes is a major mechanism of controlling cellular functions.

97 rs, and hence has been implicated in various cellular functions.

98 PCNA has far-reaching impacts on a myriad of cellular functions.

99 linked with their regulatory mechanisms and cellular functions.

100 - epsilon - is thought to fulfill conserved cellular functions.

101 branching, and linkage site encode different cellular functions.

102 wn to have essential roles in many different cellular functions.

103 reduction, and dependence upon the host for cellular functioning.

104 set of genomic regions required for specific cellular function [1, 3, 4].

105 They are critical in diverse cellular functions, acting as scaffolds for protein recr

106 al sclerosis (ALS)-linked mutations, but the cellular functions affected upon inclusion formation are

107 other 109 such genes potentially involved in cellular functions also happening at early stages of dev

108 Both cellular function and clinical adaptability was demonstr

109 ically disordered proteins are important for cellular function and common in all organisms.

110 iple putative ZIKV cell entry receptors, and cellular function and differentiation were preserved.

111 t gaps in our understanding of APC-dependent cellular function and dysfunction.

112 ent neutral cysteine proteases that modulate cellular function and have been implicated in various in

113 at occurring in exercising muscle to sustain cellular function and identifies nerve terminals as crit

114 OP2 acts as a high-order regulator balancing cellular function and inflammation with broad implicatio

115 Understanding the cellular function and metabolism of bis(monoacylglycero)

116 , and biochemical cues correlate to observed cellular function and phenotype development is examined.

117 ar reprogramming, with downstream effects on cellular function and phenotypes.

118 gest that replication in macrophages affects cellular function and plays an important role in pathoge

119 both types of interaction are important for cellular function and regulation of SH2 domain-containin

120 te analysis provides valuable information on cellular function and response to external stimuli.

121 rved during aging but also profoundly affect cellular function and stress resistance, thereby contrib

122 te the essential nature of mCa(2+) efflux in cellular function and suggest that augmenting mCa(2+) ef

123 of gene expression in cancer, impacting both cellular function and the composition of the surrounding

124 nteractions are essential for the control of cellular functions and are critical for regulation of th

125 at provide compartmentalization for distinct cellular functions and are likely responsible for the re

126 including Erk, Jnk and p38 regulate diverse cellular functions and are thought to be controlled by i

127 nerate toxic by-products that interfere with cellular functions and cell viability when exposed to li

128 key for diverse aspects of gene expression, cellular functions and development, and its disruption c

129 of the chaotic behavior in the robustness of cellular functions and diseases, for example, in the con

130 e apparent that AMPK regulates several other cellular functions and has specific roles in cardiovascu

131 n, intracellular trafficking, and many other cellular functions and have been shown to be modified du

132 ained UPR activation has negative effects on cellular functions and may worsen disease symptoms.

133 ium, highlighting the modulation of discrete cellular functions and metabolic pathways.

134 us in meldonium vs. control, and a number of cellular functions and pathways strongly associated with

135 ource for exploring Myst2 and Niam essential cellular functions and should contribute to deeper under

136 Although mitochondria are critical for cellular functions and survival in the nervous system, a

137 tions are part of many diverse and essential cellular functions and yet most of them remain to be dis

138 amics must be precisely regulated for normal cellular function, and disruptions in lipid homeostasis

139 Diverse in structure, cellular function, and fitness roles, TA systems are def

140 These processes are central to cellular function, and the molecular details of the inte

141 nvironment to epigenetic gene regulation and cellular function, and their actions may be relevant to

142 ffects of chilling on membrane potential and cellular function, and these perturbations are tightly a

143 gulatory non-coding RNAs with a diversity of cellular functions, and are frequently dysregulated in c

144 Here we review the regulation of CDK9, its cellular functions, and common core structures used to t

145 pe (NE) is critical for numerous fundamental cellular functions, and mutations in several NE constitu

146 g to its catalytic product in regulating its cellular functions, and suggest a model for how this int

147 ts of soluble extracellular signals on these cellular functions are fairly well understood, but relat

148 RBM25 in global splicing regulation and its cellular functions are unknown.

149 rrents remain poorly characterised and their cellular functions are unknown.

150 GTPase protein levels, and thereby, controls cellular functions as diverse as memory and cell motilit

151 GapR activity is critical for cellular function, as loss of GapR causes severe, pleiot

152 ur results show the RhoG plays a role in the cellular functions associated with CDR formation, includ

153 Because of their central cellular function, bacterial chaperones might be potenti

154 ellular communication on gene expression and cellular function between premalignant (dysplastic) epit

155 ntracellular messenger that controls diverse cellular functions but can become toxic and cause cell d

156 rphologies that are intimately tied to their cellular function, but how organelles are shaped is poor

157 zed by progressive loss of physiological and cellular functions, but the molecular basis of this decl

158 entakisphosphate (IP5) regulate a variety of cellular functions, but their role in vascular biology r

159 NAs) are emerging as important regulators of cellular functions, but their roles in oligodendrocyte m

160 Dysregulation of these cellular functions by increased lipid intake plays a sig

161 ndividual Cle proteins have adopted discrete cellular functions by interfering with chemotaxis and by

162 esides its genetic roles, the genome affects cellular functions by nongenetic means through its physi

163 theory is how many gene response programs or cellular functions can be robustly encoded by dynamic co

164 , proteins, saccharides, amino acids...) and cellular functions (cell cycle, respiration, metabolism,

165 aled that ssUVR modulated genes with diverse cellular functions changed in a dose-dependent manner.

166 n is causally inhibiting autophagic flux and cellular functions could not, up to the present, be dete

167 deliver active mediators to locally modulate cellular function during inflammation.

168 s) and found drastic differences in multiple cellular functions during interphase, including cell mig

169 ales as they play an essential role for many cellular functions during protein-protein interactions a

170 insic kinase domain, enabling it to modulate cellular functions either by conducting ions through the

171 a class of molecules that modulate numerous cellular functions essential for normal development.

172 Here, we identify an additional cellular function for the Nus factor complex in Escheric

173 e of red-to-near-infrared light to stimulate cellular functions for physiological or clinical benefit

174 ed to generate or regulate proteins with key cellular functions; for example, during development or s

175 Proteins have evolved to perform diverse cellular functions, from serving as reaction catalysts t

176 the lipids of the membrane is important for cellular function, however, tools enabling the interroga

177 horylation events to regulate a diversity of cellular functions; however, the extended substrate spec

178 controls gene expression and contributes to cellular function in flowering plants.

179 OS and appraise their potential influence on cellular function in plants.

180 r the first time the direct measurement of a cellular function in real time and on orbit.

181 are centrally involved in the modulation of cellular function in response to low oxygen conditions.

182 evels these molecules also have a beneficial cellular function in the form of cell signaling and redo

183 h miR-204 and modulating FZD4 expression and cellular function in the Wnt-signaling-driven tumor prog

184 ransduce signals to regulate a wide array of cellular functions in eukaryotes.

185 oteins (TMBs) serve a multitude of essential cellular functions in Gram-negative bacteria, mitochondr

186 ntioxidants represent a sensitive measure of cellular functions in health and numerous diseases, the

187 olumes and long-term in vitro assessments of cellular functions in microfluidic bioreactors and organ

188 grin-dependent adhesion, as well as in other cellular functions in neutrophils, is poorly understood.

189 tor protein 1 (Rap1) performs multiple vital cellular functions in the budding yeast Saccharomyces ce

190 related and oncogenic canonical pathways and cellular functions in the respective cell populations.

191 CANCE STATEMENT Ca(2+) entry serves critical cellular functions in virtually every cell type, and app

192 y of cells and the reconstruction of partial cellular functions in vitro from purified or engineered

193 entially regulates genes involved in diverse cellular functions including cell cycle, proliferation,

194 1R1A regulates genes associated with various cellular functions including cell junction, adhesion and

195 important biological factor regulating many cellular functions including cell motility, intercellula

196 family of adaptor proteins regulate diverse cellular functions including cell proliferation, metabol

197 1 mutation was found to dysregulate multiple cellular functions including DNA damage response, telome

198 nicotine and e-cigarette derived nicotine on cellular functions including profibrotic response and ot

199 embrane-less organelle involved in different cellular functions including ribosomal biogenesis.

200 Mce systems that contribute to a variety of cellular functions including sterol uptake and cell enve

201 Proteins are the primary effectors of cellular function, including cellular metabolism, struct

202 n is linked to the role of lysosomes in many cellular functions, including autophagosome degradation,

203 keletal polymers that participate in diverse cellular functions, including cell division, intracellul

204 long been associated with affecting several cellular functions, including cell proliferation, differ

205 or hundreds of molecules involved in diverse cellular functions, including development, bioelectric s

206 acellular signals at the origin of essential cellular functions, including differentiation, prolifera

207 a substantial role in the regulation of many cellular functions, including exo- and endocytosis.

208 ocess that is essential for a broad range of cellular functions, including genome maintenance, protei

209 mulates gene expression required for various cellular functions, including metabolisms and proliferat

210 Ps) that have the capacity to affect various cellular functions, including motor-mediated transport.

211 s signaling cascades that drive a variety of cellular functions, including neuronal migration and axo

212 Protein ubiquitination regulates key cellular functions, including protein homeostasis and si

213 ve organelles that play an important role in cellular functions, including reactive oxygen species (R

214 e cellular messenger cAMP regulates multiple cellular functions, including signaling in cilia and fla

215 IGFBP-1 can affect cellular functions independently of IGF binding through

216 mily of multipass membrane proteins, but its cellular function is currently unknown.

217 ave received much attention, how RTA impacts cellular function is less well understood.

218 t mechanism by which these receptors control cellular function is poorly understood.

219 ne major mechanism by which oxygen regulates cellular function is through the hypoxia-inducible facto

220 l pathways that implicate diseases and vital cellular functions is a fundamental problem in biomedici

221 with small molecules to specifically perturb cellular functions is commonly referred to as chemical b

222 netic mutation, the temporal coordination of cellular functions is lost, reducing organismal health a

223 heir genomes into proteins that perform many cellular functions-is highly conserved throughout natura

224 agy has a fundamental role in many essential cellular functions, it is not surprising that autophagic

225 mmon DNA damage response (DDR) that sustains cellular function, maintains genomic integrity, and supp

226 actors (TFs) to DNA controls most aspects of cellular function, making the understanding of their bin

227 binding channel of AGO3 and consequently its cellular function, may be modulated by accessory protein

228 ablished relationship between morphology and cellular function, morphological profiling has become in

229 also poses a challenge to the maintenance of cellular functions necessary for viral replication if co

230 owever, a more surprising result is that the cellular function of CP in cells appears to require bind

231 We further investigated the cellular function of miR-150 in our lung injury models.

232 l Charcot-Marie-Tooth (CMT) disease, but the cellular function of MORC2 is poorly understood.

233 nto lipid biosynthesis may not be a cardinal cellular function of SERINC5.

234 biomedical research, capable of probing the cellular functions of a vast range of substrates, whilst

235 However, additional cellular functions of AMOTL2 besides YAP inhibition are

236 Many cellular functions of CARMILs require the interaction wi

237 vel, cancerous phenotypes are the outcome of cellular functions of critical genes, regulatory interac

238 es have been associated with autism, but the cellular functions of different neuroligins and their mo

239 Despite the many cellular functions of dynein, DHC-1 is a strong negative

240 The cellular functions of LepA (also termed EF4) and BipA (a

241 art disease in humans, yet the molecular and cellular functions of the protein remain unknown.

242 Here we focus on the cellular functions of the three class II PI3K isoforms,

243 ue that the EGFR allows HCMV to regulate the cellular functions of these replication-restricted cells

244 Cellular functions of Vpr are tied to its interaction wi

245 uch as chorea acanthocytosis (ChAc), but the cellular functions of Vps13 proteins are not well define

246 In 48 tissues with known tissue-specific cellular functions, OhmNet provides more accurate predic

247 agnetic fields can activate mechanosensitive cellular functions or physically destruct cancer cells.

248 to the impact of DNA variation (genotype) on cellular function (phenotype).

249 is involved in many disparate and essential cellular functions, preventing easy interpretation of at

250 tates and to identify compounds that improve cellular function regardless of whether the compound act

251 rapeutics, yet prediction of tissue-specific cellular function remains a critical challenge for biome

252 They localize in the ER membranes, but their cellular function remains unclear.

253 The normal cellular function requires communication between mitocho

254 A system-wide understanding of cellular function requires knowledge of all functional i

255 srupt genes or regulatory regions, impacting cellular function, so for many experiments it is importa

256 er, wild-type huntingtin (HTT) has important cellular functions, so the ideal strategy would selectiv

257 at includes eight members and is involved in cellular functions such as adhesion, migration, and diff

258 f integrin activity is paramount for dynamic cellular functions such as cell matrix adhesion and mech

259 understanding Scribble-beta-PIX-coordinated cellular functions such as directional cell migration.

260 and at the same time regulate many important cellular functions such as migration, differentiation, a

261 the cell, which is vital for a multitude of cellular functions such as migration, division, contract

262 f guanine-quartets that can disrupt critical cellular functions such as replication and transcription

263 roteins and has been implicated in essential cellular functions such as signaling and gene expression

264 components but also are involved in various cellular functions such as signaling and protein sorting

265 ubule networks required for a broad range of cellular functions such as spindle assembly or cell pola

266 ide oxidoreductase that performs an array of cellular functions, such as cellular signaling and respo

267 -1 (MSI1) exerts essential roles in multiple cellular functions, such as maintenance of self-renewal

268 GRK2 contributes to the modulation of basic cellular functions-such as cell proliferation, survival,

269 OhmNet provides more accurate predictions of cellular function than alternative approaches, and also

270 in parallel with the substantial changes in cellular function that accompany immune cell activation.

271 an opportunity for probing and manipulating cellular functions that cannot be addressed by conventio

272 ring-driven approaches to the programming of cellular functions that could yield transformative techn

273 by SMAD has the potential to affect numerous cellular functions that involve RNA.

274 stem lies in not only the great diversity of cellular functions that it can generate but also the abi

275 as a critical regulatory mechanism of vital cellular functions that maintain overall brain health.

276 ho family GTPases are critical regulators of cellular functions that play important roles in cancer p

277 to understanding protein binding motifs and cellular function, that is, an interactome.

278 to perturb biological membranes and disrupt cellular function; these include a highly lipophilic ele

279 olutionarily constrained proteins within the cellular functions they interact with and that (ii) desp

280 As (miRs) mediate higher order regulation of cellular function through coordinated modulation of mRNA

281 l layer of regulation of gene expression and cellular function through the selective splicing and exp

282 overy of small-molecule effectors of various cellular functions through screens of compound libraries

283 a large family of ligands that regulate key cellular functions through their receptors, plexins.

284 e hierarchy in order to effectively transfer cellular functions to a functionally uncharacterized tis

285 ausal chains from risk genes to proteins and cellular functions to endophenotypes, cognitive impairme

286 Although viruses require cellular functions to replicate, their absolute dependen

287 How the pathogen modulates cellular functions to support its growth is poorly under

288 To preserve cellular function, transcription of proteasome subunit g

289 identify VHL as an E3 ligase with important cellular functions under both normoxic and hypoxic condi

290 integrated with cells and supplementing the cellular functions under oxidative stress.

291 could contribute to a progressive decline in cellular function, understanding the mechanisms that det

292 ated surrogates at r(2) >/= 0.8) could alter cellular function, we assessed their location overlap wi

293 To further address the role for EZH2 in Treg cellular function, we have now generated mice that lack

294 ausing mutations strongly affect hippocalcin cellular functions which suggest a central role for pert

295 e been shown to serve a variety of important cellular functions, which include signalling, compartmen

296 stems centers on providing adequate iron for cellular function while limiting iron toxicity.

297 the impact of the nanoreactors on improving cellular functions with a potential to serve as artifici

298 ce activated cell sorting (FACS) and control cellular functions with light sensitive proteins (Optoge

299 the mechanism involved in estrogen-mediated cellular function within the oviduct remains unclear.

300 Moonlighting proteins (MPs) show multiple cellular functions within a single polypeptide chain.