ライフサイエンスコーパス: cellular localization

1 indispensable role for parkin in TDP-43 sub-cellular localization.

2 nd the importance of PRD in its function and cellular localization.

3 group II intron RNAs, from transcription to cellular localization.

4 d, isoelectric point, expression pattern and cellular localization.

5 ional abilities are largely dependent on its cellular localization.

6 ghly conserved sequence in the CTR to affect cellular localization.

7 , and these structures are important for sub-cellular localization.

8 o perturbing macromolecular interactions and cellular localization.

9 complex formation with gH or alterations in cellular localization.

10 ested for altered ubiquitin modification and cellular localization.

11 osphorylation, and heparanase expression and cellular localization.

12 ly to share biological function, but not sub-cellular localization.

13 Myristoylation of HMGCLL1 affects its cellular localization.

14 tor (TfnR) exhibited changes in steady-state cellular localization.

15 yo1c tail, which is important for its proper cellular localization.

16 processes that are dependent on their proper cellular localization.

17 tional differences in the protein defined by cellular localization.

18 as residues in the amino domain involved in cellular localization.

19 P(C) remains elusive but may depend upon its cellular localization.

20 d the FRQ regions that are important for its cellular localization.

21 ot play a significant role in regulating its cellular localization.

22 and domain deletions also influence DNMT3B's cellular localization.

23 ted by differential degradation and distinct cellular localization.

24 e been linked to protein multimerization and cellular localization.

25 plex is critical for enzyme function and sub-cellular localization.

26 of BMPR1b expression and alterations of its cellular localization.

27 ression, phosphoregulation, dimer choice and cellular localization.

28 nized tissue types as well as details of sub-cellular localization.

29 by phosphorylation-mediated degradation and cellular localization.

30 termine the effect of inducers on SoxS-Rob's cellular localization.

31 ecificity, protein-protein interactions, and cellular localization.

32 chanisms involving phosphorylation-dependent cellular localization.

33 ally encoded HaloTag fusion protein of known cellular localization.

34 analysis was performed for WT or mutant AIRE cellular localization.

35 s, protein-protein interactions, and protein cellular localization.

36 MN plays an important role in regulating its cellular localization.

37 ell corpses, coupling DNGR-1 function to its cellular localization.

38 ologously in mammalian cells retained normal cellular localization.

39 f transmembrane proteins can determine their cellular localization.

40 matic activities and/or mediate their proper cellular localization.

41 ogy and lamination but abnormal SIK1 protein cellular localization.

42 une receptor activation, cooperation and sub-cellular localizations.

43 noelectron microscopy assessed CRF1 and CRF2 cellular localization 24 hours after the last stress.

44 Depletion of PDHK4 causes disruption of KRAS cellular localization, a reduction in KRAS activity whic

45 ity of the rare variants after assessment of cellular localization, ability to interact with GCK, and

46 tion, the ORF9 protein displays an identical cellular localization, accumulating in the trans-Golgi r

47 a to test how changes in PrP sequence and/or cellular localization affect the functional activity of

48 s through protein structure, mutagenesis and cellular localization analyses.

49 Cellular localization analysis of CT009 showed uniform m

50 though the CH domain is required for MICAL-1 cellular localization and actin-associated function, its

51 in-coupled receptors (GPCRs), as well as sub-cellular localization and activity of many other signali

52 protein-protein interactions influencing DAT cellular localization and activity, suggesting that the

53 ication by geranylgeranyl moieties for their cellular localization and activity.

54 riptional regulatory programme, in which sub-cellular localization and alternative splicing play comp

55 Tradeoffs between cellular localization and ammonium toxicity lead to sele

56 we performed experiments to determine their cellular localization and amounts.

57 Mammalian SIRTs (SIRT1-7) differ in their cellular localization and biologic functions.

58 grity of NSs is important for the stability, cellular localization and biological functions of RVFV N

59 ions of human Chk1 that regulate its protein cellular localization and checkpoint function.

60 of odor detectors, MS4As, that have similar cellular localization and chemodetection ability as ORs

61 lycosphingolipid metabolism as a function of cellular localization and chloroquine treatment.

62 Its cellular localization and contribution to the behavioral

63 The cellular localization and deposition of H2A-H2B into chr

64 mX protein activity is instead controlled by cellular localization and DNA damage induced Mdm2-mediat

65 of LRAP adaptors as key determinants of MRCK cellular localization and downstream specificities.

66 Here we studied the stability, cellular localization and enzymatic activity of the PNKD

67 rtantly, the transgenic whirlin restored the cellular localization and expression level of both USH2A

68 roaches have provided data on the diversity, cellular localization and expression patterns of differe

69 On the basis of the cellular localization and expression patterns of the can

70 However, regulation of Rho-GAP cellular localization and function is not fully understo

71 SUMOylation has been shown to regulate cellular localization and function of a variety of prote

72 d Rng9 are binding partners that dictate the cellular localization and function of Myo51.

73 that disrupting PKHD1 results in altered sub-cellular localization and function of the C2-WWW-HECT do

74 We analyzed the cellular localization and function of the N-truncated NS

75 Our results show that cellular localization and function of the Rho-GAP Rga7 a

76 Collectively, our structural, cellular localization and functional data are consistent

77 Ggamma subunits provide proper cellular localization and functional specificity to the

78 mic (gamma-CYA) actins, which have different cellular localization and functions.

79 to be conferred by specific isoforms, by sub-cellular localization and in cell-type-specific contexts

80 The cellular localization and in vitro activity of two P450

81 ere we studied the relationship between Adi3 cellular localization and its CDS activity.

82 Based upon its cellular localization and its dominant response to zinc

83 oring it to membranes, thereby affecting its cellular localization and its intracellular trafficking

84 We examined the cellular localization and potential interactions of IGFB

85 used for modifying proteins to control their cellular localization and potentially alter their biolog

86 of mutated PopZ proteins for defects in sub-cellular localization and recruitment activity.

87 The cellular localization and regulation of the AMTs suggest

88 Overall, cellular localization and RNase activity of ECP and EDN

89 r how it functions as a key regulator of the cellular localization and signaling activities of this G

90 ns that influence miRNA stability, their sub-cellular localization and target selection.

91 dendrimers and dendritic polyglycerols) for cellular localization and targeting of specific tissues

92 munoblot analyses were used to determine the cellular localization and the amount of ClC-2 expressed

93 ual nonstructural protein and examined their cellular localization and their disruption of endoplasmi

94 tational framework that employs a battery of cellular localization and topological prediction tools t

95 tt fragments have been shown to modulate Htt cellular localization and toxicity.

96 We characterized the cellular localization and trafficking of EPCR in endothe

97 al role in the regulation of mRNA stability, cellular localization and translation efficiency.

98 ult myocytes feature dramatic differences in cellular localization and translocation in mediating hyp

99 Os and intracellular proteins that may alter cellular localization and/or potency of ASOs.

100 n could regulate Myo3A biochemical activity, cellular localization, and cellular function.

101 nfocal imaging were performed for signaling, cellular localization, and coassociation studies.

102 lateral gene transfer events, alteration of cellular localization, and evolution of novel proteins b

103 ontrolling the assembly state of NMII-A, its cellular localization, and focal adhesion assembly.

104 nuum that tightly regulates Rex-2 structure, cellular localization, and function.

105 Here, we report on the interaction, cellular localization, and functional domains of these t

106 een exogenous cysteine, cellular metabolism, cellular localization, and Hg(II) coordination in aerobi

107 The aberrant cellular localization, and increased expression of the p

108 ittle is known about the expression profile, cellular localization, and physiological contribution of

109 y-based probes enable noninvasive detection, cellular localization, and proteomic identification of p

110 hich are essential for its activity, correct cellular localization, and regulation for protein glycos

111 ntermediates to regulate the protein levels, cellular localizations, and/or DNA binding of BRI1-EMS s

112 Cellular localization assay carried out by making a Musa

113 Cellular localization assay performed using transiently

114 Cellular localization, biochemistry, protein interaction

115 ore generally, network architecture reflects cellular localization, biological process, and molecular

116 nd NOD2 share striking similarities in their cellular localization, both localize to membrane ruffles

117 ved a change in CSE1L staining intensity and cellular localization by immunohistochemistry.

118 nt Seurat, a computational strategy to infer cellular localization by integrating single-cell RNA-seq

119 with a fluorescent protein and examined its cellular localization by live-cell microscopy.

120 Here, we report a dual regulation of p27 cellular localization by Ral downstream pathways, based

121 PKA and ERK1&2 kinase activities in the same cellular localization by using FRET biosensors.

122 lls and to distinguish their extra- vs intra-cellular localizations by real-time spectroscopy in ense

123 gastric cancer cells by affecting E-cadherin cellular localization, cis-dimer formation, molecular as

124 o degradation and also showed changes in sub-cellular localization compared to wild-type SIK1.

125 is initiated by exogenous signal gradients, cellular localization cues, and an intricate hierarchy o

126 Structural model predictions and cellular localization data indicate that the B. burgdorf

127 ng tissue-specific gene expression data, sub-cellular localization data, co-clustering of interacting

128 anscriptional regulation, suggesting its sub-cellular localization-dependent function.

129 ellular processes including innate immunity, cellular localization, development and differentiation,

130 n the specific conditions, interactions, and cellular localization, different conformations may be st

131 UBP27 demonstrates similar sub-cellular localization, domain structure, membrane topolo

132 ansferase 1 (CARM1) and prevents its correct cellular localization during mitosis.

133 protein components and functions at various cellular localizations during different mitotic stages t

134 ttranslational modifications, and nuclear or cellular localization, during the course of virus infect

135 c data (e.g. GO annotation, gene expression, cellular localization, etc.).

136 with Smad2, Smad3, and Smad7 expression and cellular localization examined by Western blotting.

137 usal mutations in this cohort was studied by cellular localization experiments.

138 l nucleus as expected based on the known sub-cellular localization for Dyrk1a, we found that the GFPN

139 ge is abundant in the VTA, but alpha6*-nAChR cellular localization, function, pharmacology, and roles

140 Two PDEs with distinct cellular localization have been found in OSNs: PDE1C in

141 rofile kernel SVM) to predict the native sub-cellular localization in 18 classes for eukaryotes, in s

142 ntrolled by regulating protein stability and cellular localization in cells.

143 Xs was investigated: first by expression and cellular localization in mouse and human pancreatic isle

144 efforts to understand how TDP-43 alters its cellular localization in response to proteotoxic stress,

145 ces were found for DAT kinetic parameters or cellular localization in the vehicle controls.

146 nition motif did not affect gB expression or cellular localization in transfected cells.

147 on of these transcription factors and their "cellular localization" in bronchoscopic airway biopsies

148 This signaling, related to the cellular localization inside the bone marrow niche and/o

149 (MBNL1) is a splicing factor whose improper cellular localization is a central component of myotonic

150 verexpressed gene (TOG) domain array, proper cellular localization is a requisite for full activity a

151 The prediction of protein sub-cellular localization is an important step toward elucid

152 Furthermore, we found that cellular localization is critical for the proper functio

153 onal components of cells, knowledge of their cellular localization is crucial to gaining an understan

154 Its cellular localization is dependent not only on signal tr

155 the polar chemosensory cluster and that its cellular localization is dependent on the presence of Ch

156 ed by the addition Ca(2+) ionophore and that cellular localization is dependent upon the presence of

157 e demonstrate that FOXO1 phosphorylation and cellular localization is regulated by insulin signaling

158 a(2+) sensor, is unclear with respect to its cellular localization, its Ca(2+)-dependent mobilization

159 s, inflammasomes, or cGAS, each with its own cellular localization, ligand specificity, and signal re

160 , fluorescent affinity (RFA) tag that allows cellular localization, manipulation of cellular levels,

161 6, we performed experiments to determine the cellular localization of ABCC6 in its physiological envi

162 Chamber-specificity and cellular localization of adrenergic remodeling were comp

163 d C-terminal hydrophobic motif necessary for cellular localization of ALTO.

164 has been well characterized in rodents, the cellular localization of AMPA subunits in primate basal

165 While the cellular localization of AMPA-type subunits in the basal

166 etabolism remains poorly understood, but the cellular localization of APP and its interaction with va

167 eported that copper promotes a change in the cellular localization of APP.

168 However, these mutations did not change the cellular localization of Argonaute and did not affect th

169 causing variants on Cl- channel activity and cellular localization of bestrophin-1.

170 Our findings reveal that the cellular localization of beta-TrCP1 is altered in gliobl

171 uding several rab GTPases, known to modulate cellular localization of cadherins.

172 rformed to detect mRNA expression and define cellular localization of calcitonin receptor-like recept

173 We therefore thoroughly examined the cellular localization of CB2R in the vervet monkey (Chlo

174 as therefore to explore the distribution and cellular localization of CEACAM6 using immunohistochemis

175 Together, our results show that cellular localization of Clusterin leads to divergent ef

176 Cellular localization of connexin 50 (Cx50) and connexin

177 rther analysis of the chemical structure and cellular localization of DAG in skeletal muscle revealed

178 ortance of taking the chemical structure and cellular localization of DAG into account when evaluatin

179 We investigated the spatial and cellular localization of DPP4 to evaluate an association

180 eric neurons, which depends on the level and cellular localization of dynamin, a regulatory protein t

181 investigation characterized the function and cellular localization of EmaA glycosylation.

182 Here we define the cellular localization of endogenous FMNL3, the dynamics

183 nction, relatively little is known about the cellular localization of endogenous GRKs.

184 plore these questions, we first examined the cellular localization of endogenous myomaker.

185 Cellular localization of estrogen receptor (ER) was eval

186 Cellular localization of FAM13A protein and mRNA levels

187 s demonstrate that SadB kinases regulate the cellular localization of gamma-tubulin and thereby contr

188 In this study, we report on the cellular localization of GbpC.

189 Our results define a crucial role of the cellular localization of HDAC4 in the events leading to

190 ion of SOX-9 and FGFR-3, as well as aberrant cellular localization of heparan sulfate proteoglycans,

191 In this study, we have characterized the cellular localization of human phospholipid scramblase 4

192 Expression and sub-cellular localization of IFT43 in the retina and transie

193 or cell proliferation and survival, controls cellular localization of KDM4A and consequently its asso

194 However, the cellular localization of Kv2.2 has not been fully elucid

195 SUMOylation did not affect the cellular localization of LEDGF proteins and was not nece

196 Downstream, the cellular localization of MAP kinase signaling is determi

197 Furthermore, cellular localization of miR-218-5p in human and murine

198 un proteomics has substantially resolved the cellular localization of morphine biosynthesis in opium

199 on studies on genetically modified mice, the cellular localization of mPGES-1 in the mouse brain has

200 Our data suggest that cellular localization of Mtbhsp60 upon interaction with

201 scribe our efforts to fully characterize the cellular localization of MUCL1, investigate its regulati

202 erization of these mutations showed aberrant cellular localization of mutant and endogenous ETV6, dec

203 The observed divergence in cellular localization of mutants in MDCKII cells versus

204 s-of-function mutant demonstrates how proper cellular localization of MyD88 to the Myddosome is a fea

205 alyses of replisomes, to investigate the sub-cellular localization of nascent DNA and replisomes.

206 protein, suggesting that Lgl1 regulates the cellular localization of NMII-A.

207 In contrast, the cellular localization of NT-PCG-1alpha results in a long

208 Different cellular localization of OPN is associated with its dist

209 Our observations provide insights into the cellular localization of ORF 3b that may enhance our und

210 revealed a strict correspondence between sub-cellular localization of origin domains and their conden

211 cur, or indirectly, i.e., by determining the cellular localization of p53/MDM2-interacting factors.

212 Although the amount and cellular localization of PABPCs were largely unchanged i

213 Here we show that residues 1-180 mediate the cellular localization of PakB.

214 s, relatively few studies have addressed the cellular localization of pathways for synthesis of funga

215 hat repeats 9-14, which are required for the cellular localization of PelA with PelB are also essenti

216 We examined the cellular localization of PFKFB3 and PFKFB4 and unexpecte

217 The tissue and cellular localization of PHs was determined during fruit

218 Furthermore, cellular localization of PLZF was not altered in the abs

219 SUMOylation does not affect the stability or cellular localization of PR8 NS1.

220 Cellular localization of protein expression for differen

221 Polar cellular localization of proteins is often associated wi

222 rane-bound Rac1 but dramatically changes the cellular localization of Rac1, causing polarization, whi

223 differentially, regulate the activities and cellular localization of RECQL5 and WRN, suggesting that

224 We sought to resolve the cellular localization of REEP1 and further elucidate the

225 iochemical approaches was used to refine the cellular localization of REEP1.

226 ays a key regulatory role by influencing the cellular localization of Rho GTPases and is essential fo

227 antibodies was used for data validation, and cellular localization of selected proteins was determine

228 ontrast, Vmax for [(3)H]serotonin uptake and cellular localization of SERT in mPFC and OFC were not d

229 strains lacking plrS, the production and/or cellular localization of several immune-recognized prote

230 The DNA binding activity and cellular localization of SOX9 is controlled through post

231 The cellular localization of specific Cx subtypes provides a

232 unohistochemical methods to characterize the cellular localization of SR and D-serine in the mouse an

233 AS up-regulated SSTR1; neither drug affected cellular localization of SSTRs.

234 Further studies examining the expression and cellular localization of subunit proteins and receptor p

235 of the glycosylation consensus sequence, and cellular localization of target proteins.

236 The cellular localization of the affected protein, ALMS1, ha

237 The cellular localization of the alpha(2)delta(3) subunit in

238 Expression and cellular localization of the brain water channel aquapor

239 living organelle, since the composition and cellular localization of the different constitutive cell

240 her investigation is needed to determine the cellular localization of the expression of these genes d

241 The cellular localization of the Far complex has yet to be f

242 Ras signaling activity requires correct cellular localization of the GTPase.

243 These findings support a model in which the cellular localization of the miRISC regulates the fate o

244 Proper expression and cellular localization of the mutated DbpA proteins were

245 Cellular localization of the MybA::Gfp fusion and immuno

246 However, the cellular localization of the NIF system and the involvem

247 the mouse Pramel1 gene, and to determine the cellular localization of the PRAMEL1 protein during the

248 e and that this resistance may depend on the cellular localization of the protein.

249 el single cell toolkit, we have examined the cellular localization of the proteins involved in the es

250 Cellular localization of the resulting Bsep mutants was

251 The cellular localization of the resulting green fluorescent

252 e of familial ALS, profoundly alters the sub-cellular localization of the SMN protein, preventing the

253 ed to cell-specific defects that matched the cellular localization of these receptors in the WT retin

254 brane upon expression of activated Galpha13, cellular localization of these RhoGEFs has been proposed

255 f canonical NF-kappaB, and exhibited altered cellular localization of this protein.

256 Here we examined the anatomical and cellular localization of TIP39 signaling that contribute

257 Cellular localization of TLR2, -3, and -4 was also deter

258 We report a distinct cellular localization of total STAT3 protein in Rex1(-/-

259 nantly by posttranslational modification and cellular localization of transcriptional activators.

260 nd DELM-2 does not disrupt the expression or cellular localization of TRPA-1, a TRP channel needed in

261 Accordingly, we investigated the cellular localization of US9-driven cargo in neurons and

262 KCNE4 alters the biophysical properties and cellular localization of voltage-gated potassium channel

263 While the sub-cellular localization of Wdr68 has been shown to be depe

264 We sought to characterize the cellular localization of wild type beta-arrestin-1 and a

265 The expression, regulation and cellular localization of ZmHyPRP, a gene marker of embry

266 However, while viral architecture and cellular localization often dictate the suitability of a

267 ty of PrP(Sc) to proteolysis, or altered the cellular localization or expression level of PrP(C).

268 himpanzee and orangutan displayed an altered cellular localization pattern with predominant cell surf

269 signing unique Soj conformations to distinct cellular localization patterns.

270 RNAs have highly complex and dynamic cellular localization patterns.

271 est, the N-terminal SteC domain alters Cdc24 cellular localization, preventing its nuclear accumulati

272 eceptor dysfunction despite retaining normal cellular localization, protein folding, and an ability t

273 Dependent on their cellular localization, Protein Kinase D (PKD) enzymes re

274 The cellular localization results showed that extension of t

275 cess, depending on TLRs' expression pattern, cellular localization, signaling, and deployment of infl

276 ed the hydrophobic domain, displayed diffuse cellular localization similar to that of the EGFP contro

277 , which are fundamental for controlling AQP2 cellular localization, stability, and function.

278 unique among human KIR genes in expression, cellular localization, structure, and function, yet the

279 Cellular localization studies by confocal and total inte

280 Sub-cellular localization studies clearly indicated the invo

281 More detailed cellular localization studies establish mitochondrial ta

282 f LSD1, we performed genome-wide mapping and cellular localization studies of LSD1 and its dimethylat

283 , we combined modeling, in vitro assays, and cellular localization studies to investigate the seconda

284 Cellular localization studies, however, showed a differe

285 domain organization, expression pattern, and cellular localization suggest that the zebrafish will pr

286 cal mutant signal peptides were assessed for cellular localization, surface expression, and collagen

287 anges under force stimulation as well as its cellular localization that bridges the cytoskeleton with

288 igh affinity for PG and display a pattern of cellular localization that is not influenced by depletio

289 quence alignment, ubiquitous expression, sub-cellular localization to the nucleolus and loss-of-funct

290 We show here that cyclin E1 regulates Kv2.1 cellular localization via inhibition of Cdk5 activity.

291 ette subfamily A member 1 (ABCA1), whose sub cellular localization was altered in both J774 and prima

292 Cellular localization was analyzed by immune electron mi

293 Cellular localization was determined by ImageStream flow

294 ntibiotics were added to bacteria, and their cellular localization was visualized by confocal fluores

295 Protein interactions and cellular localization were analyzed using proximity liga

296 CLM-1 and CLM-8 expression and cellular localization were assessed in murine bone marro

297 NOX5 positivity and cellular localization were studied via IHC and digital-i

298 RM1 was examined for the interaction and the cellular localization with MOCS3.

299 el regulatory mechanisms that couple protein cellular localization with the checkpoint response and c

300 Seurat will be applicable to mapping cellular localization within complex patterned tissues i