ライフサイエンスコーパス: cellular metabolism

1 networks (GEMs) can assist in understanding cellular metabolism.

2 d various carbohydrate intermediates used in cellular metabolism.

3 a dynamic network, playing a central role in cellular metabolism.

4 or providing energy and carbon skeletons for cellular metabolism.

5 les served as the light harvester to sustain cellular metabolism.

6 y attributes, is significantly influenced by cellular metabolism.

7 onditions, suggesting its role in modulating cellular metabolism.

8 ed protein kinase (AMPKalpha), the sensor of cellular metabolism.

9 data suggest a novel role of GRP78-mediating cellular metabolism.

10 ens a new avenue for the characterization of cellular metabolism.

11 rules that govern organelle integration into cellular metabolism.

12 eraction of OTUB1 with proteins important in cellular metabolism.

13 nk the environmental signals with rhythms in cellular metabolism.

14 Mitochondria are central organelles for cellular metabolism.

15 d by a continuous energy supply derived from cellular metabolism.

16 olecules, providing clues for their roles in cellular metabolism.

17 tration states regulate different aspects of cellular metabolism.

18 y recognized as a physiological modulator of cellular metabolism.

19 s, we reveal that EVI1 overexpression alters cellular metabolism.

20 the critical connection between systemic and cellular metabolism.

21 e/threonine kinase, is a master regulator of cellular metabolism.

22 ria caused remarkable alterations in overall cellular metabolism.

23 ically showed mutations in genes involved in cellular metabolism.

24 es sustained mTORC1 activation and regulates cellular metabolism.

25 electrical signals in response to changes in cellular metabolism.

26 ions of cholesterogenic enzyme deficiency on cellular metabolism.

27 proteasome activity in CD8+ T cells affected cellular metabolism.

28 species (ROS/RNS) are natural byproducts of cellular metabolism.

29 owerful and versatile technique for studying cellular metabolism.

30 adian oscillations to integral properties of cellular metabolism.

31 these compounds readily during quenching of cellular metabolism.

32 bit PDH, highlighting SIRT4 as a guardian of cellular metabolism.

33 mitochondrial oxidative phosphorylation and cellular metabolism.

34 the metabolites was found as consequence of cellular metabolism.

35 inction, and could also potentially regulate cellular metabolism.

36 ge and often fail to take a holistic view of cellular metabolism.

37 Circadian rhythms are intimately linked to cellular metabolism.

38 onstrated that the epigenome is sensitive to cellular metabolism.

39 rtant signaling pathway to the regulation of cellular metabolism.

40 ed extensively to investigate alterations in cellular metabolism.

41 egulatory targets coupling energy storage to cellular metabolism.

42 ranscription does not restart to reestablish cellular metabolism.

43 ently sense and control vital points of core cellular metabolism.

44 at plays a central role in the regulation of cellular metabolism.

45 this energy is one of the central issues of cellular metabolism.

46 rvival of male germ cells via its effects on cellular metabolism.

47 at have profound and wide-ranging effects on cellular metabolism.

48 tochondrion is the primary energy source for cellular metabolism.

49 increasingly understood to be regulators of cellular metabolism.

50 of the apoplast has a profound influence on cellular metabolism.

51 e enzymes to form NADH is a key component of cellular metabolism.

52 ecycling, and generating molecules that fuel cellular metabolism.

53 or energy homeostasis and tightly coupled to cellular metabolism.

54 drawing a direct link between DNA repair and cellular metabolism.

55 ormation about the topology and operation of cellular metabolism.

56 ses mTORC1 activity, leading to dysregulated cellular metabolism.

57 naling cascade regulates multiple aspects of cellular metabolism.

58 er understand the burden of glycosylation on cellular metabolism.

59 ich hepatic autophagy monitors and regulates cellular metabolism.

60 monocytes and macrophages induces changes in cellular metabolism.

61 staining enzymes that are required for basic cellular metabolism.

62 r surface, uptake of serum and inhibition of cellular metabolism, accordingly.

63 Shifts in cellular metabolism affect enzymes that control epigenet

64 To ensure a faithful representation of cellular metabolism after cell sorting, we benchmarked s

65 y lymphoid tissues but necessary to regulate cellular metabolism and accumulation of CD103(+) DCs and

66 cin complex 1 (mTORC1) is a key regulator of cellular metabolism and also has fundamental roles in co

67 itochondrial membrane and is a key player in cellular metabolism and apoptosis.

68 ies, is produced at low levels during normal cellular metabolism and at higher concentrations under p

69 ther -omics data for the scientific study of cellular metabolism and bioengineering purposes.

70 , approved for type 2 diabetes therapy alter cellular metabolism and can heighten ROS production.

71 overexpression and/or aggregation may impair cellular metabolism and cause mitochondrial damage.

72 arise from rare stochastic imperfections of cellular metabolism and deficiencies in maintenance gene

73 TOR1 complex inhibits TORC1 activity to slow cellular metabolism and drive the mitotic/meiotic transi

74 etabolic sensor LKB1 is critical to maintain cellular metabolism and energy homeostasis in Tregs.

75 he unfolded protein response, autophagy, and cellular metabolism and exploit these pathways to their

76 Because of intrinsic alterations of cellular metabolism and extrinsic factors in the tumor m

77 eal a previously hidden relationship between cellular metabolism and genome evolution and provide new

78 compounds that support, or are products of, cellular metabolism and growth) is entirely controlled b

79 species, and aspartate are key regulators of cellular metabolism and growth.

80 ty by iron homeostasis is a prerequisite for cellular metabolism and growth.

81 lular signaling pathways that are central to cellular metabolism and growth.

82 NAD is essential for cellular metabolism and has a key role in various signal

83 onent of pathways involved in the control of cellular metabolism and has a role in regulating immune

84 In vivo roles for DP8 and DP9 in cellular metabolism and homeostasis were revealed via th

85 The NUDIX enzymes are involved in cellular metabolism and homeostasis, as well as mRNA pro

86 Mitochondria have various roles in cellular metabolism and homeostasis.

87 ential organelles with numerous functions in cellular metabolism and homeostasis.

88 To explore the interactions between cellular metabolism and HSV-1 infection, we performed an

89 tography tandem mass spectrometry, we mapped cellular metabolism and identified spatially defined met

90 roles of class I PI3Ks in the regulation of cellular metabolism and in immune system functions, two

91 hat miR-181 is a nonredundant determinant of cellular metabolism and is essential for supporting the

92 a pervasive model organism for investigating cellular metabolism and its regulation by signaling proc

93 e of N-acetylmannosamine, is found to endure cellular metabolism and label the surface of a mammalian

94 ntly alters several diagnostic parameters of cellular metabolism and leaf gas exchange in Arabidopsis

95 ther chemicals, as well as investigations of cellular metabolism and leveraging -omics data.

96 contribute in multiple ways to regulation of cellular metabolism and may have direct and indirect eff

97 increasing recognition of the importance of cellular metabolism and metabolic substrates for the fun

98 ng activated primarily genes associated with cellular metabolism and mitochondrial activation (e.g.,

99 a rapid autophagic flux to promptly restore cellular metabolism and mitochondrial fusion in keeping

100 K), a central stress-responsive regulator of cellular metabolism and mTOR signaling, which is known t

101 and a potential transcriptional link between cellular metabolism and muscle growth.

102 trand breaks (DSBs) are byproducts of normal cellular metabolism and obligate intermediates in antige

103 protein folding, turnover and transport, on cellular metabolism and on DNA and RNA synthesis and rep

104 , where an oxygen gradient is established by cellular metabolism and physical constraints.

105 We aimed to prospectively observe cellular metabolism and proliferation in patients with n

106 trient with pronounced regulatory effects on cellular metabolism and proliferation.

107 ferroptosis and its intimate interplay with cellular metabolism and redox machinery.

108 two cytosolic GAPCs play important roles in cellular metabolism and seed oil accumulation.

109 he lack of Pim protein kinases by regulating cellular metabolism and Sod2.

110 epair DNA damage that is generated by normal cellular metabolism and stress from the environment.

111 ajor insulin-signaling components regulating cellular metabolism and survival.

112 rotic markers and ECM assembly by modulating cellular metabolism and TGF-beta signaling.

113 channels provide a significant link between cellular metabolism and the antiviral immune response in

114 Crosstalk between cellular metabolism and the epigenome regulates epigenet

115 roles of mTOR signaling in the regulation of cellular metabolism and the pathogenesis of cancer.

116 articular the integration of complement with cellular metabolism and the potential implications in in

117 metal complexes can lead to major changes in cellular metabolism and to potent complexes with novel m

118 of lysine acylation, which is implicated in cellular metabolism and transcriptional control.

119 onths of life correspond with differences in cellular metabolism and transcriptomic profiles at birth

120 other metabolites, and thus is critical for cellular metabolism and various growth and developmental

121 na requires adequate oxygenation to maintain cellular metabolism and visual function.

122 .Sle3 lupus mice and patients present a high cellular metabolism, and a treatment combining 2-deoxy-D

123 ram that includes B-cell receptor signaling, cellular metabolism, and epigenetic regulation.

124 acquisition and assimilation, alterations in cellular metabolism, and internal S recycling.

125 glutamine are the major nutrients that fuel cellular metabolism, and the pathways utilizing these nu

126 lvement in many biological processes such as cellular metabolism, apoptosis, aging and inflammation.

127 ondria play an important role in controlling cellular metabolism, apoptosis, and innate immunity.

128 he past decades owing to its pivotal role in cellular metabolism, apoptosis, and neurotransmission.

129 receptor (Ryr2) Ca(2+) release channels and cellular metabolism are both disrupted in heart disease.

130 ecent studies have suggested that changes in cellular metabolism are important to these processes.

131 Circadian rhythms and cellular metabolism are intimately linked.

132 hese emissions and their impact on bacterial cellular metabolism are poorly understood.

133 Chromatin modification and cellular metabolism are tightly connected.

134 g free radicals, generated as by-products of cellular metabolism, are a major contributor to this dam

135 ion of ssb is a key component of both normal cellular metabolism as well as pathways responsible for

136 nown to have diverse functions in regulating cellular metabolism as well as protein synthesis.

137 ccur in several types of cancer, and altered cellular metabolism associated with IDH1 mutations prese

138 ripts related to primary cell wall and basic cellular metabolism at the base to those involved in pho

139 tocin did not affect the glutathione-related cellular metabolism before OGD, oxytocin modulated the e

140 The chromatin landscape and cellular metabolism both contribute to cell fate determi

141 er, little is known regarding how changes in cellular metabolism, both within the cancer cell and the

142 ology to make great strides in interrogating cellular metabolism but does not provide sufficient insi

143 Mitochondria are central regulators of cellular metabolism but how their function in a subset o

144 in that they spatially segregate aspects of cellular metabolism, but they do so by building not a li

145 lcNAc modification of their EGF repeats, and cellular metabolism by affecting pyrimidine synthesis an

146 Food intake is coordinated to cellular metabolism by clock gene expression with a mast

147 erve as a crucial interaction hub in primary cellular metabolism by communicating transiently between

148 However, the overabundant lysosomes derange cellular metabolism by consuming the key glycolytic enzy

149 Reprogramming of cellular metabolism by oncogenic mutations probably crea

150 rrant immune responses and that manipulating cellular metabolism can beneficially enhance or temper i

151 nylation, and exploring new avenues by which cellular metabolism can influence gene expression.

152 the relationship between exogenous cysteine, cellular metabolism, cellular localization, and Hg(II) c

153 ceptor-dependent pathway, induced changes in cellular metabolism characterized by increased fatty aci

154 Cellular metabolism converts available nutrients into us

155 This reprogramming of cellular metabolism decreases intracellular NAD(+) level

156 common lesion spontaneously generated during cellular metabolism, decreases the efficiency of human A

157 YAP appears to reprogram cellular metabolism, diverting substrates away from the

158 ide reprograming by modulation of underlying cellular metabolism during DC differentiation.

159 ave emerged for characterizing transients in cellular metabolism, dynamic metabolic flux analysis (DM

160 Cellular metabolism dynamically regulates the epigenome

161 erting nicotinamide to NAD(+), essential for cellular metabolism, energy production, and DNA repair.

162 A cytokine involved in cellular metabolism, FGF21 is a potential susceptibility

163 Remarkably, cellular metabolism fluidizes the cytoplasm, allowing la

164 pigenetic machinery require intermediates of cellular metabolism for enzymatic function.

165 nbiological carbene-transfer reactivity with cellular metabolism for small-molecule production.

166 or the differentiation of HSCs, reprogrammed cellular metabolism from mitochondrial aerobic metabolis

167 These results reveal a connection between cellular metabolism, gene regulation, and neural plastic

168 In this study, analytes central to cellular metabolism, glucose, lactate, oxygen, as well a

169 ycin (mTOR) pathway plays a critical role in cellular metabolism, growth, and proliferation and has b

170 complex 1 (mTORC1) is a master regulator of cellular metabolism, growth, and proliferation.

171 activity with c-Myc stability to coordinate cellular metabolism, growth, and proliferation.

172 nsitive intracellular processes that mediate cellular metabolism, growth, proliferation, and/or tissu

173 ell responses, it is now becoming clear that cellular metabolism has direct roles in regulating immun

174 minance of phosphorylation as a regulator of cellular metabolism has fostered the development of pept

175 However, the direct impact of autophagy on cellular metabolism has not been well studied.

176 Glucose, a chief energy source in cellular metabolism, has a significant role in cell prol

177 Defects in cellular metabolism have been widely implicated in causi

178 olves global reprogramming of transcription, cellular metabolism, hormone signalling and chromatin mo

179 een successfully used to assess and engineer cellular metabolism; however, GEMs of phototrophic metab

180 Ammonia is a ubiquitous by-product of cellular metabolism; however, the biological consequence

181 particular focus on how host, commensal, and cellular metabolism impinge upon Treg homeostasis and fu

182 In addition, it reveals cellular metabolism in diapause eggs is more active than

183 ulator of systemic metabolic homeostasis and cellular metabolism in Drosophila.

184 tion in matrix bioenergetics would influence cellular metabolism in glycolytic cells that do not requ

185 thod that allows for real-time assessment of cellular metabolism in isolated, intact long skeletal mu

186 Cellular metabolism in mammalian cells represents a chal

187 These data redefine the role of cellular metabolism in memory cell differentiation, show

188 The role of cellular metabolism in regulating cell proliferation and

189 dition to its well-known role in stimulating cellular metabolism in response to nutrients, TOR also p

190 The accuracy of these models to represent cellular metabolism in specific conditions has been impr

191 x of K(+), and thus membrane potential, with cellular metabolism in various cell types including insu

192 ses, such as HDAC3, have been shown to alter cellular metabolism in various tissues.

193 tablished miR-211 as a critical regulator of cellular metabolism in vitiligo cells.

194 b5, for a range of biochemical reactions in cellular metabolism, including for fatty acid desaturati

195 clic AMP (cAMP) is essential for controlling cellular metabolism, including glucose and lipid homeost

196 traditional media, had widespread effects on cellular metabolism, including on the metabolome, redox

197 the c-MET tyrosine kinase pathway; shifts in cellular metabolism, including up-regulation of hypoxia

198 Reprogrammed cellular metabolism is a common characteristic observed

199 Reprogramming of cellular metabolism is a hallmark feature of cancer cell

200 Altered cellular metabolism is a hallmark of cancer, and much of

201 Abnormal cellular metabolism is a hallmark of cancer, yet there i

202 Deregulated cellular metabolism is a hallmark of many cancers.

203 Deregulated cellular metabolism is a hallmark of tumors.

204 Cellular metabolism is a key regulator of cell fate, inc

205 Understanding cellular metabolism is a major challenge in current syst

206 Reprogramming of cellular metabolism is an emerging hallmark of neoplasti

207 Altered cellular metabolism is an important characteristic and d

208 It has become apparent that much of cellular metabolism is controlled by large well-folded n

209 Reprogramming of cellular metabolism is crucial for T cells responding to

210 Cellular metabolism is emerging as a key regulator of im

211 Elucidating signaling pathways that regulate cellular metabolism is essential for a better understand

212 Precise regulation of cellular metabolism is hypothesized to constitute a vita

213 unction of Bax, a pro-apoptotic regulator of cellular metabolism is implicated in neurodegenerative d

214 Cellular metabolism is increasingly recognized as a cont

215 As such, the regulation of whole-body and cellular metabolism is intimately integrated with immune

216 ics against the target, yet how it regulates cellular metabolism is not fully understood.

217 Unfortunately, such rewiring of cellular metabolism is often carried out sequentially an

218 ed, how it is regulated and coordinates with cellular metabolism is unclear.

219 ic fluxes (i.e. the rate of each reaction in cellular metabolism) is of particular interest for metab

220 ial to understanding a fundamental aspect of cellular metabolism leading to compounds that are not on

221 activation of glycolysis, and alterations in cellular metabolism may be a broadly applicable mechanis

222 oliferator-activated receptor-alpha-mediated cellular metabolism may play an important role in sepsis

223 the main interface between mitochondrial and cellular metabolisms, mediates the passage of a variety

224 most solid tumors and often lead to altered cellular metabolism, metastasis, and drug resistance.

225 the GOF activities, including alterations in cellular metabolism, might vary between the different p5

226 A prevailing view is that abnormal cellular metabolism, notably aerobic glycolysis that inc

227 ting from inflammatory responses, changes in cellular metabolism, nuclear architecture, and epigenome

228 Dysregulation of vascular stiffness and cellular metabolism occurs early in pulmonary hypertensi

229 environment due to several factors including cellular metabolism of compounds, protein-protein intera

230 rganize subcellular membranes and rewire the cellular metabolism of host cells to achieve viral repli

231 or parasite-derived LBs and PGF2alpha in the cellular metabolism of Leishmania and its evasion of the

232 rimental method of choice to investigate the cellular metabolism of microbes, cell cultures and plant

233 Visualizing cellular metabolism of nucleic acids, proteins, and lipi

234 eral decades of research investigations, the cellular metabolism of rice remains largely unclear.

235 ethers and their oxidized derivatives on the cellular metabolism of WEHI-164 and HEK-293T cell lines

236 ional glycolytic pathway and its role in the cellular metabolism ofMtbhas yet to be understood.

237 The electrical read-out of the system, cellular metabolism, oxygen consumption and morphologica

238 d OXPHOS, depleted cellular ATP, and altered cellular metabolism pathways that compromise their survi

239 with an emphasis on how disruption in normal cellular metabolism plays a role in oncogenesis.

240 Hence, cellular metabolism plays a vital role beyond simply the

241 transcription factors are key regulators of cellular metabolism, proliferation, and stress resistanc

242 of rapamycin (mTOR) is a major regulator of cellular metabolism, proliferation, and survival that is

243 cted roles of cytosine methylation in global cellular metabolism providing evidence for a 'core' m5C

244 ndrial citric acid cycle is a central hub of cellular metabolism, providing intermediates for biosynt

245 accinia virus (VACV) infection alters global cellular metabolism, providing the first metabolomic ana

246 s dominated by DO concentration (affected by cellular metabolism), rather than potential nucleation s

247 protein complexes such as those involved in cellular metabolism remains an important question.

248 espiration (maybe solely GDC), whereas basic cellular metabolism remains largely unchanged.

249 e in tumorigenesis; however, its function in cellular metabolism remains unknown.

250 Alterations of cellular metabolism represent a hallmark of cancer.

251 ate through metabolic reprogramming, whereby cellular metabolism shifts from oxidative phosphorylatio

252 d quantitative analysis of these markers for cellular metabolism show in response to doxorubicin, NAD

253 f temperature compensation as fV , M O2, and cellular metabolism significantly decreased following th

254 ry effectors of cellular function, including cellular metabolism, structural dynamics, and informatio

255 intracellular vesicles to protect the normal cellular metabolism, structure, and function of podocyte

256 transport processes, energy production, and cellular metabolism, suggesting a major change in cell p

257 Finally, changes in cellular metabolism, surface markers, and gene expressio

258 of naive T cells induces dramatic changes in cellular metabolism that are essential for cell growth,

259 ndrial respiration is a crucial component of cellular metabolism that can become dysregulated in canc

260 ation, gene regulation, and other aspects of cellular metabolism that reinforce thermostable polymera

261 ystems-biology computational method to study cellular metabolisms that are assumed to be in a steady

262 Autophagy impacts cellular metabolism, the proteome, and organelle numbers

263 ounced changes in cell cycle progression and cellular metabolism, thereby highlighting its putative r

264 process that mends DNA lesions formed during cellular metabolism; these lesions include double-strand

265 ion of cytoprotective genes, which reprogram cellular metabolism through activation of the integrated

266 hotosynthetic apparatus and other changes in cellular metabolism through extensive changes in transcr

267 tochondria and suggests that it may regulate cellular metabolism through modulating the interaction b

268 that metabolic alterations in cancer rewire cellular metabolism through unconventional pathways.

269 ute of phosphatidic acid utilization rewires cellular metabolism to adopt a triacylglycerol-rich life

270 To explore the contribution of cellular metabolism to cancer heterogeneity, we analyse

271 owever, it is largely unknown how PKM2 links cellular metabolism to chromatin regulation.

272 biology is that oncogenes actively reprogram cellular metabolism to enable tumors to survive and prol

273 ill reveal yet unexplored pathways that link cellular metabolism to epigenetic control.

274 eciated that oncogenic transformation alters cellular metabolism to facilitate cell proliferation, bu

275 randial blood glucose, an enforced change in cellular metabolism to maintain glucose homeostasis.

276 ability of cardiomyocytes, using a model for cellular metabolism to predict the levels of ATP followi

277 Viruses rely on host cellular metabolism to provide the energy and biosynthet

278 d repair mitochondrial function and to adapt cellular metabolism to stress.

279 cer cells undergo a multifaceted rewiring of cellular metabolism to support their biosynthetic needs.

280 In addition, they convey oscillations in cellular metabolism to the membrane by sensing adenine n

281 ., acetylation versus crotonylation) couples cellular metabolism to the regulation of gene expression

282 ation of stem cell, cell survival/death, and cellular metabolism under both physiological and patholo

283 nt in HIF signalling to reveal its effect on cellular metabolism under normal oxygen conditions as we

284 s caused significantly definitive changes in cellular metabolism upon exposure.

285 ed protein kinase (AMPK), a key regulator of cellular metabolism, using primary mouse and human hepat

286 of regulating gene expression, responding to cellular metabolism via chromatin modifications.

287 ecause both IDH1 and p53 are known to affect cellular metabolism, we compared the requirements for gl

288 To understand how NAMPT regulates cellular metabolism, we have shown that the treatment wi

289 d monocytes primarily use glucose to support cellular metabolism, we hypothesized that chronic monocy

290 s, e.g. genes related to cell wall and basic cellular metabolism were highly expressed in immature le

291 Metabolites are small molecules involved in cellular metabolism, which can be detected in biological

292 luoro-2-deoxy-D-glucose can be used to image cellular metabolism, which during lung inflammation main

293 an interplay between oxygen availability and cellular metabolism, which in turn has significant effec

294 luoro-2-deoxy-D-glucose can be used to image cellular metabolism, which, during lung inflammatory pro

295 face that connects nutrient choices with our cellular metabolism will be required.

296 Despite considerable research connecting cellular metabolism with differentiation decisions, the

297 a range of biological activities by linking cellular metabolism with membrane excitability.

298 nalling network integrates transcriptome and cellular metabolism with shoot-root coordination and dev

299 This leads to a functional heterogeneity of cellular metabolism within WAT that has potential impact

300 resently, agents that target angiogenesis or cellular metabolism would be reasonable therapeutic appr