ライフサイエンスコーパス: cellular reprogramming

1 iptional networks throughout development and cellular reprogramming.

2 and describe how pioneer factors may enable cellular reprogramming.

3 NA methylation and hydroxymethylation during cellular reprogramming.

4 ific chromatin factor provides a barrier for cellular reprogramming.

5 eful tool to study the mechanisms underlying cellular reprogramming.

6 properties of stem cells and the process of cellular reprogramming.

7 properties of stem cells and the process of cellular reprogramming.

8 esponse to pathogen attack involves dramatic cellular reprogramming.

9 source of insulin(+) cells after undergoing cellular reprogramming.

10 dicates DNA methylation changes induced upon cellular reprogramming.

11 types and 134 tissues, defining an atlas of cellular reprogramming.

12 new insights into the mechanisms underlying cellular reprogramming.

13 quences of inactivating Rb in the context of cellular reprogramming.

14 that the PpCSP genes function redundantly in cellular reprogramming.

15 sive environment for cell fate change during cellular reprogramming.

16 nsect cells will be the method of choice for cellular reprogramming.

17 e therefore unavailable for purification and cellular reprogramming.

18 s provide a global view of barriers to human cellular reprogramming.

19 ons, cardiomyocytes or beta-cells, and after cellular reprogramming.

20 eash cellular plasticity and favor oncogenic cellular reprogramming.

21 t the Hippo pathway constitutes a barrier to cellular reprogramming.

22 ize their importance in ESC pluripotency and cellular reprogramming.

23 nd RBMXL1, that impede gene induction during cellular reprogramming.

24 and sequence of molecular events inherent to cellular reprogramming.

25 he absence of complex soluble chemistries or cellular reprogramming.

26 t undergoes dynamic DNA demethylation during cellular reprogramming.

27 Emerging evidence increasingly points to cellular reprogramming, a process during which fully dif

28 lethal gene interactions and oncogene-driven cellular reprogramming ('addiction'), giving rise to new

29 s shared mechanisms in stress adaptation and cellular reprogramming and address the therapeutic impli

30 duced during differentiation and reversed in cellular reprogramming and cancer.

31 Recent innovations in cellular reprogramming and differentiation techniques ha

32 lects how these target sites are used during cellular reprogramming and early mouse development.

33 lls overcomes an early epigenetic barrier in cellular reprogramming and facilitates the generation of

34 foundation for elucidating the mechanisms of cellular reprogramming and for studying the safety and e

35 including, synthetic and structural biology, cellular reprogramming and functional pharmaceutical scr

36 Lin28, a key factor for cellular reprogramming and generation of induced pluripo

37 We use cellular reprogramming and genome engineering to functio

38 ction and provide an unexpected link between cellular reprogramming and host-pathogen interaction.

39 ce, which highlight innovative approaches to cellular reprogramming and how this revolutionary techni

40 emphasis on understanding the mechanisms of cellular reprogramming and its potential applications in

41 n to consider classical observations such as cellular reprogramming and multilineage locus priming.

42 , a previously unrecognized role of Jmjd3 in cellular reprogramming and provide molecular insight int

43 genous CX45 expression significantly blocked cellular reprogramming and reduced the efficiency.

44 r supports the crucial role played by p53 in cellular reprogramming and suggests an alternative metho

45 wn that pioneer factors are also crucial for cellular reprogramming and that they are implicated in t

46 adult stem cells and pluripotent stem cells, cellular reprogramming and tissue engineering are in pro

47 tylation in other cell states such as during cellular reprogramming and to quantify non-histone prote

48 he potential oncogenicity that may arise via cellular reprogramming, and could represent a valuable i

49 linking Sox proteins with stem cell biology, cellular reprogramming, and disease with an emphasis on

50 ractions at silent genes during development, cellular reprogramming, and steroid hormone induction.

51 using a recently demonstrated microRNA-based cellular reprogramming approach, human fibroblasts from

52 Transcriptional mechanisms underlying this cellular reprogramming are still poorly understood.

53 ggest a fundamentally different function for cellular reprogramming as a means of 'chromosome therapy

54 e model for tissue regeneration, implicating cellular reprogramming as an essential element.

55 transient loss of cell polarity to the total cellular reprogramming, as found by transcriptional anal

56 It is now clear that the extensive cellular reprogramming associated with defence will redu

57 To analyze cellular reprogramming at the single-cell level, mass cy

58 ng the use of transcription factors (TFs) in cellular reprogramming, based on a device commonly used

59 s process, we systematically dissected human cellular reprogramming by combining a genome-wide RNAi s

60 1.The ubiquitin-proteasome system regulates cellular reprogramming by degradation of key pluripotenc

61 ings indicate that culture conditions during cellular reprogramming can strongly influence the epigen

62 indings that establish the essential role of cellular reprogramming during neoplastic transformation

63 y which GATA3 functions as a pioneer TF in a cellular reprogramming event relevant to breast cancer,

64 Application of the principles of cellular reprogramming for the treatment of cancer, howe

65 trate for the first time that HMGA1 enhances cellular reprogramming from a somatic cell to a fully pl

66 Cellular reprogramming from somatic cells to induced plu

67 e diverse functions in embryonic stem cells, cellular reprogramming, growth, and oncogenesis.

68 Cellular reprogramming has been recently intensively stu

69 iscuss how progress in stem cell biology and cellular reprogramming has enabled exciting new strategi

70 d more restricted cell fates, recent work in cellular reprogramming has proven that one cellular iden

71 The remarkable advances in cellular reprogramming have made it possible to generate

72 Cellular reprogramming highlights the epigenetic plastic

73 d phenotypes by epigenetic remodeling during cellular reprogramming highlights the role of epigenetic

74 uncover a sequential, two-step mechanism of cellular reprogramming in which repression of pre-existi

75 during cold response, there is a proteolytic cellular reprogramming in which the proteasome acquires

76 ls to pluripotency, a "second generation" of cellular reprogramming involves lineage-restricted trans

77 Somatic cellular reprogramming is a fast-paced and evolving fiel

78 Cellular reprogramming is a new and rapidly emerging fie

79 The theory and utility of RNA use for cellular reprogramming is explored in this review.

80 One potential mediator of long-term cellular reprogramming is heritable (epigenetic) regulat

81 Transcription factor-dependent cellular reprogramming is integral to normal development

82 ganization of the cell during the process of cellular reprogramming is valuable for stem cell researc

83 ggest that immunoediting of tumor results in cellular reprogramming may be accompanied by alterations

84 For example, therapeutic cloning and cellular reprogramming may one day provide a potentially

85 Cellular reprogramming occurred under homeostatic condit

86 (Ambystoma mexicanum) that is indicative of cellular reprogramming of differentiated cells to a germ

87 l-based regenerative therapies hold promise, cellular reprogramming of endogenous cardiac fibroblasts

88 133, 208, and 499 capable of inducing direct cellular reprogramming of fibroblasts to cardiomyocyte-l

89 In this study, we investigated whether cellular reprogramming of neural stem cells with interle

90 We also discovered that HMGA1 enhances cellular reprogramming of somatic cells to iPSCs togethe

91 Cellular reprogramming of somatic cells to patient-speci

92 ed by PGE2 and suggest a process of adaptive cellular reprogramming of the intestinal epithelium that

93 During cellular reprogramming, only a small fraction of cells b

94 n well documented as an effective method for cellular reprogramming or directed differentiation.

95 gical problems of the new century, including cellular reprogramming, organogenesis, regeneration, gen

96 Here we report a unique cellular reprogramming phenomenon, called stimulus-trigg

97 g the diverse molecular actors implicated in cellular reprogramming presents a major challenge for fu

98 This cellular reprogramming process overcomes various barrier

99 This process, which we term adaptive cellular reprogramming, promotes regeneration in one of

100 actor 4 (Klf4), one of the factors directing cellular reprogramming, recognizes the CpG dinucleotide

101 a somatic cell to a pluripotent state during cellular reprogramming requires DNA methylation to silen

102 exploration include cardiac cell therapy and cellular reprogramming targeting cell death and regenera

103 tifying the top TF candidates for a specific cellular reprogramming task.

104 Here, we present an overview of cellular reprogramming techniques used in regenerative m

105 Significant advances in cellular reprogramming technologies and hematopoietic di

106 Cellular reprogramming technologies represent an alterna

107 Cellular reprogramming technology has created new opport

108 al-mesenchymal transition and other modes of cellular reprogramming that influence the tumor microenv

109 During cellular reprogramming, the mesenchymal-to-epithelial tr

110 ogether our findings demonstrate that during cellular reprogramming, the metabolome of fibroblasts is

111 l role for ubiquitin-specific protease 26 in cellular reprogramming through polycomb-repressive compl

112 ion is driven by advances in genome editing, cellular reprogramming, tissue engineering, and informat

113 RNA or a dominant-negative construct blocks cellular reprogramming to a pluripotent state.

114 o transcriptional and epigenetic remodeling, cellular reprogramming to pluripotency is also accompani

115 In vitro studies have demonstrated that cellular reprogramming to pluripotency reverses cellular

116 Here we show that, by applying cellular reprogramming to primary CML cells, aberrant DN

117 Cellular reprogramming using chemically defined conditio

118 This study provides an example of cellular reprogramming using defined factors in an adult

119 gnaling pathways and illustrates one case of cellular reprogramming where the identity of the cell of

120 une surveillance; 2) stem cell therapies and cellular reprogramming, which seek to regenerate the dep

121 Here, we review the progress in direct cellular reprogramming, with a focus on the paradigm of

122 sis that environmental perturbations trigger cellular reprogramming, with downstream effects on cellu