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1 ction-deficient hERG1 mutants also prevented cellular transformation.
2 e show that several of these mutations drive cellular transformation.
3 ssion of the carcinoma variant E295K induces cellular transformation.
4 apeutic drug-induced DNA damage and enhances cellular transformation.
5 B (BRAF) recurrent V600E mutation to promote cellular transformation.
6 hanced motility is another characteristic of cellular transformation.
7 otoxic stress, resulting in a higher rate of cellular transformation.
8 naling is implicated in bone development and cellular transformation.
9 te viral latency and contribute to malignant cellular transformation.
10 APH-2 is dispensable for viral infection and cellular transformation.
11 ncreased chromosomal aberrations and induced cellular transformation.
12 BRD4 downstream oncogenes and abrogation of cellular transformation.
13 r, leading to changes in gene expression and cellular transformation.
14 ression and is required for BCR-ABL-mediated cellular transformation.
15 er cells and may be a contributing factor to cellular transformation.
16 ch for the latter protein, is sufficient for cellular transformation.
17 ts interaction with A-Raf, and thus promotes cellular transformation.
18 lation, NF-kappaB nuclear translocation, and cellular transformation.
19 metabolism are common hallmarks of malignant cellular transformation.
20 ment, cell cycle progression, apoptosis, and cellular transformation.
21 ggered by active Galphao proteins to promote cellular transformation.
22 atory networks that if disrupted can lead to cellular transformation.
23 nase activity, leading to Src-Y527F-mediated cellular transformation.
24 vity of hVPS34 is essential for Src-mediated cellular transformation.
25 ectal cancers and are an initiating event in cellular transformation.
26 572(STOP) mutant for downstream signaling or cellular transformation.
27 modifiers is modulated at specific stages of cellular transformation.
28 , let-7, and miR-155, that are implicated in cellular transformation.
29 sufficient to cause hepatocyte dysplasia and cellular transformation.
30 pathway to repair damaged DNA and to prevent cellular transformation.
31 undamental biological events associated with cellular transformation.
32 , while MWFs inhibit fibrogenesis and induce cellular transformation.
33 ments contributing to normal cell growth and cellular transformation.
34 of histone-modifying complexes in regulating cellular transformation.
35 ate that elevated tRNA synthesis can promote cellular transformation.
36 regulation of the polarity machinery during cellular transformation.
37 ir influence on protein expression vis-a-vis cellular transformation.
38 ut how a gene or pathway works in regulating cellular transformation.
39 transcription were not sufficient to promote cellular transformation.
40 ivity and regulates DNA topology to suppress cellular transformation.
41 ich requires normal gene function to prevent cellular transformation.
42 th and glandular hypertrophy associated with cellular transformation.
43 mutations, leading to genome instability and cellular transformation.
44 defined epigenetic reprogramming leading to cellular transformation.
45 ymes, alterations to DNA occur that initiate cellular transformation.
46 ooperated with the HTLV-I Tax oncoprotein in cellular transformation.
47 to play an important role in virus-mediated cellular transformation.
48 play an important role in embryogenesis and cellular transformation.
49 tes and it cooperates with Ha-ras to promote cellular transformation.
50 PTEN, overexpression of NEDD4-1 potentiated cellular transformation.
51 ins c-Ski and related SnoN in the control of cellular transformation.
52 lasts and epithelial model cells resulted in cellular transformation.
53 RK-c-Jun pathway to induce antiapoptosis and cellular transformation.
54 echanisms by which EBV infection can lead to cellular transformation.
55 have an important impact on HTLV-1-mediated cellular transformation.
56 Expression of the E295K variant also induces cellular transformation.
57 imetic S99E mutant no longer interferes with cellular transformation.
58 l interventions designed to prevent or delay cellular transformation.
59 depletion led to a decrease in LMP1-induced cellular transformation.
60 M checkpoint to allow DNA repair and prevent cellular transformation.
61 examine possible differences resulting from cellular transformation.
62 xpression of genes involved in FLT3-mediated cellular transformation.
63 ary for both efficient viral replication and cellular transformation.
64 t clinical ramifications including mediating cellular transformation.
65 sociated protein, is a putative regulator of cellular transformation.
66 a cell-type specific function for Dnmt3a in cellular transformation.
67 tential for the propagation of mutations and cellular transformation.
68 s c-Cbl-regulated EGFR degradation to induce cellular transformation.
69 s is critical for cell cycle progression and cellular transformation.
70 cal to allow time for DNA repair and prevent cellular transformation.
71 rix has long been recognized as a feature of cellular transformation.
72 -dependent inhibition of enzyme activity and cellular transformation.
73 c screen identifies genes that contribute to cellular transformation.
74 Senescence prevents cellular transformation.
75 acted as a key regulator of Bcr-Abl-mediated cellular transformation.
76 E2F1-mediated FOS induction in As2O3-induced cellular transformation.
77 e expression as well as the implications for cellular transformation.
78 antisense protein of HTLV-3 (APH-3) promoted cellular transformation.
79 ic rearrangements, some of which can lead to cellular transformation.
80 bal protein synthesis, significantly impeded cellular transformation.
81 n 3T3 cells and are also known inhibitors of cellular transformation.
82 enes that contribute to inflammation-induced cellular transformation.
83 PP2A, E7 provides these functions related to cellular transformation.
84 ate substrates, chromosomal aberrations, and cellular transformation.
85 n of RGS6, which in turn blocked Ras-induced cellular transformation.
86 the DNA-damage-induced G2/M checkpoint, and cellular transformation.
87 organization of chromatin during EBV-driven cellular transformation.
88 down was sufficient to inhibit Ras-dependent cellular transformation.
89 lic effects differ depending on the stage of cellular transformation.
90 sor pathway is a key barrier to Ras-mediated cellular transformation.
91 I3K membrane recruitment, and PI3K-dependent cellular transformation.
92 t1 in non-transformed cells did not initiate cellular transformation.
93 ed in the absence of BRCA1 may contribute to cellular transformation.
94 IP1 ubiquitination, NF-kappaB activation and cellular transformation.
95 Because overexpression of eIF4E is linked to cellular transformation, 4E-BP is a tumor suppressor, an
96 air pathways and ROS detoxification systems, cellular transformation after apoptosis by the blebbishi
97 e cycling status of the cells independent of cellular transformation and acts in concert with the phy
98 st known function for Dlg1 in virus-mediated cellular transformation and also surprisingly expose a p
100 ceptor tyrosine kinases (RTK) contributes to cellular transformation and cancer progression by disrup
104 f the degree of dysregulation by AML1-ETO in cellular transformation and demonstrate that AML1-ETO-W6
105 We also explore the role of aneuploidy in cellular transformation and discuss the possibility of d
106 utation or oncogenic viruses is required for cellular transformation and eventually carcinogenesis.
107 Chronic inflammation in the stomach induces cellular transformation and gastric cancer primarily in
108 rms found in breast cancer may contribute to cellular transformation and genomic instability by impai
109 highlight a role for MV in the induction of cellular transformation and identify tTG and FN as essen
110 and phenformin in an Src-inducible model of cellular transformation and in mammosphere-derived breas
111 e the first evidence that MUC4 alone induces cellular transformation and indicates a novel role of MU
112 c expression of the ACTG1-MITF fusion led to cellular transformation and induced the expression of do
113 uncovered an unexpected relationship between cellular transformation and intracellular trafficking.
115 ce by oncogenic signals acts as a barrier to cellular transformation and is attained, in part, by the
122 RhoA activity has previously been linked to cellular transformation and metastatic potential of epit
124 tumor viruses is a vital step in initiating cellular transformation and represents a major shortcomi
125 in retrospective clinical analyses, inhibits cellular transformation and selectively kills breast can
126 st-line drug for treating diabetes, inhibits cellular transformation and selectively kills cancer ste
127 rmin, a standard drug for diabetes, inhibits cellular transformation and selectively kills cancer ste
128 o-inflammatory pathways are not required for cellular transformation and suggests a need for further
131 P48/TIP49 as well as MYC in MTBP function in cellular transformation and the growth of human breast c
132 rotein that has been shown to be involved in cellular transformation and to activate the phosphatidyl
133 overexpression of Ran in fibroblasts induces cellular transformation and tumor formation in mice.
134 dy, we found that the FoxM1B molecule causes cellular transformation and tumor formation in normal hu
135 rate with dysfunctional telomeres to promote cellular transformation and tumor formation in vivo.
149 rrant enzyme function in vitro and to induce cellular transformation and/or genomic instability in vi
150 ffects on growth in soft agar, a hallmark of cellular transformation, and also assessed in vivo intra
151 inhibition in human HCC cell lines decreases cellular transformation, and anti-miR-494 treatment of p
153 are pivotal to understanding the process of cellular transformation, and illustrate key targets for
154 ciency, a strong mutator phenotype, enhanced cellular transformation, and increased cancer susceptibi
161 d-type NTH1 leads to genomic instability and cellular transformation as assessed by anchorage-indepen
162 ification for transcriptional activation and cellular transformation as well as functional difference
163 cells expressing v-Src and is essential for cellular transformation, as well as for v-Src-induced tu
164 cogenes is important for distinct aspects of cellular transformation, as well as tumor growth and col
165 ulting in endogenous genomic instability and cellular transformation, as well as tumor growth in a mo
166 tion has been observed in carcinogenesis and cellular transformation associated with arsenic exposure
168 ally modified mouse models that recapitulate cellular transformation at specific developmental stages
170 ly of GTP-binding proteins, that facilitates cellular transformation brought about by an increased ra
172 hat hERG1 expression is sufficient to induce cellular transformation by a mechanism distinct from hEA
174 tem cells can evade cell death by undergoing cellular transformation by constructing "blebbishields"
177 S) family member RGS6 suppresses Ras-induced cellular transformation by facilitating Tip60-mediated d
178 denovirus E4-ORF1 protein mediates oncogenic cellular transformation by human adenovirus type 9, augm
180 1 confers a specific resistance to oncogenic cellular transformation by phosphoinositide 3-kinase (PI
181 d in certain human tumours may contribute to cellular transformation by promoting genomic instability
182 sferase 1 (Dnmt1) is essential for oncogenic cellular transformation by Ras, and Dnmt1 is overexpress
185 nd provide a rationale for the efficiency of cellular transformation by the adenoviral E1A oncoprotei
186 gh TC21 activates some pathways that mediate cellular transformation by the classical Ras proteins, t
187 l hypoacetylation of H3K18Ac associated with cellular transformation by the viral oncoprotein E1A.
190 sion levels in cancer and are able to affect cellular transformation, carcinogenesis and metastasis,
192 adopt a Xi-like conformation in response to cellular transformation, characterized by CpG hypomethyl
193 pressed in an antisense orientation, induced cellular transformation, consistent with a tumor suppres
194 , these results reveal that Bcr-Abl-mediated cellular transformation critically requires silence of t
195 on of LMP1-activated genes and LMP1-mediated cellular transformation, demonstrating an essential role
196 t into the molecular mechanisms that control cellular transformation driven by activation of protein
197 ility-associated genes at distinct phases of cellular transformation, exhibited chromosomal instabili
198 ugh genetic and epigenetic alterations drive cellular transformation, genomic plasticity, and evoluti
201 ever, the mechanism of effect of Aurora-B on cellular transformation has not been fully explored.
202 viral persistence, host immune evasion, and cellular transformation--have been ascribed to viral ncR
203 pression has been observed to correlate with cellular transformation; however, the importance to tumo
206 d gene transcription activities and promotes cellular transformation in a TOP1-dependent manner.
207 tor (HBZ) is dispensable for HTLV-1-mediated cellular transformation in cell culture, but is required
208 10gamma or p110delta is sufficient to induce cellular transformation in chicken embryo fibroblasts.
209 ic epithelial tissue types and contribute to cellular transformation in cooperation with other biolog
211 increased presence of DCLK1+ve cells promote cellular transformation in response to a second hit.
215 RIM-19 suppresses constitutive STAT3-induced cellular transformation in vitro and in vivo by down-reg
216 we show that GRIM-19 suppresses src-induced cellular transformation in vitro and in vivo by down-reg
217 EGFR CTD deletion mutants are able to induce cellular transformation in vitro and in vivo in the abse
218 ion accelerates cell proliferation, triggers cellular transformation in vitro and in vivo, and stimul
219 Ectopic expression of mutated RIT1 induces cellular transformation in vitro and in vivo, which can
220 mir-200 expression compromised KRAS-induced cellular transformation in vitro and tumor formation in
221 if (PBM) required for E4-ORF1 to induce both cellular transformation in vitro and tumorigenesis in vi
223 in soft agar is the gold-standard assay for cellular transformation in vitro, but it is unsuited for
225 ht combine to uniquely affect the process of cellular transformation (in vitro) and environmental car
226 IP) has been shown to have a crucial role in cellular transformation, in which it is vital for the su
227 rtantly demonstrate that PI3K activation and cellular transformation induced by E4-ORF1 require two s
229 GRIM-19 had no significant effect on the cellular transformation induced by other oncogenes such
230 enatal transgenic founders exhibited a gross cellular transformation into a secretory epithelium.
232 r converting our increasing understanding of cellular transformation into intelligently designed anti
233 ted T cells) upregulation has been linked to cellular transformation intrinsically, but it is unclear
234 MicroRNA profiling in isogenic models of cellular transformation involving either breast epitheli
238 he requirement of Cat-1 for this hallmark of cellular transformation is coupled to its ability to bin
242 the major metabolic changes associated with cellular transformation is enhanced nutrient utilization
245 critical cellular response that counteracts cellular transformation is oncogene-induced senescence (
246 ing knowledge of the role of large ncRNAs in cellular transformation is pointing towards their potent
249 V-1 E7 by itself is not sufficient to induce cellular transformation, it enhances the abilities of th
251 human mammary cell line, MCF10A, resulted in cellular transformation marked by epidermal growth facto
252 e that the contribution of E7 to BPV-induced cellular transformation may involve its ability to inhib
254 ostate cancer variants, respectively, induce cellular transformation most likely due to sequence-spec
255 tumor-derived HSP70 was neither required for cellular transformation nor for in vivo tumor growth.
257 ges with overactive IGF signaling to promote cellular transformation of DS fetal progenitors, reveali
258 hypothesis are the observations of increased cellular transformation of mouse embryonic cells from th
261 Here, we report efficient infection and cellular transformation of primary rat embryonic metanep
262 rect effects of oncogenic RAS(G12V)-mediated cellular transformation on the mitochondrial dynamics ma
264 as does not trigger increased proliferation, cellular transformation or EMT, and prevents MUC1 upregu
265 n attributed to MCPyV tumor antigen-mediated cellular transformation or replication, to date, no stud
267 otal role for SIRT7 in chromatin regulation, cellular transformation programs and tumour formation in
269 ioning as a tumour promoter that facilitates cellular transformation, promotes tumour growth and scul
272 mensional cell culture and that HER2-induced cellular transformation requires p62, as well as NRF2, w
274 uppressor surveillance, preventing potential cellular transformation resulting from the growth-induci
275 of mutation have exhibited the capacity for cellular transformation, several aspects of this transfo
276 ke Factor 5 (KLF5) has been shown to mediate cellular transformation signaling events downstream of o
277 och and Crabtree now show that the resulting cellular transformation stems from disruption of the nor
279 lleles are both necessary and sufficient for cellular transformation, suggesting that chemical inhibi
280 loop in the regulation of c-Myc activity and cellular transformation, supporting/suggesting a role of
281 M-Ras promotes cytoskeletal reorganization, cellular transformation, survival, and differentiation.
282 transcription-3 (STAT3) has been linked with cellular transformation, survival, proliferation, chemor
283 ic H3K9 acetylation is a better predictor of cellular transformation than are global histone acetylat
285 epigenetic control mechanisms contribute to cellular transformation, these results, together with th
286 ransformed cells and are proposed to promote cellular transformation through mechanisms such as inhib
287 ctor alpha (TGFalpha) is a potent inducer of cellular transformation, through its binding and activat
288 iple stages of oncogenesis, from the initial cellular transformation to the hierarchical organization
289 n relation to disease progression and drives cellular transformation, tumorigenesis, and metastatic p
290 hese somatic alterations, is associated with cellular transformation, tumorigenesis, cancer progressi
292 abolish E4-ORF1-induced PI3K activation and cellular transformation, we reasoned that E4-ORF1 must p
293 , a massive lymphoproliferative disorder and cellular transformation were observed in Ag-experienced
294 reported in some patients, leads to enhanced cellular transformation when compared with either mutati
295 e degree to which these substitutions induce cellular transformation when introduced into full-length
296 GTP (called 'fast-cycling' mutants) promote cellular transformation, whereas Cdc42 mutants that are
297 s were dependent on Jak1 kinase activity for cellular transformation, whereas the JAK3 kinase domain
298 GFbetaRII in CD8(+) T cell proliferation and cellular transformation, which is caused by a mechanism
299 m that underlies the ability of SKI to cause cellular transformation while unraveling a novel connect
300 al life cycle and might not be necessary for cellular transformation, yet HPV integration is frequent
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