ライフサイエンスコーパス: cementum

1 determine whether this material was bone or cementum.

2 ritical in preventing abnormal resorption of cementum.

3 predictably stimulate formation of acellular cementum.

4 maged calcified tissue confirmed that it was cementum.

5 is a 14 kDa polypeptide sequestered in tooth cementum.

6 surfaces were planed in order to remove root cementum.

7 e root, differentiate and secrete dentin and cementum.

8 rade III CEPs appeared completely covered by cementum.

9 (PP(i)) and a severe deficiency in acellular cementum.

10 P < 0.01), and a sharp reduction in cellular cementum.

11 ing alveolar bone, periodontal ligament, and cementum.

12 (PM2) mesial roots including removal of root cementum.

13 in Hyp mouse molars, focusing on dentin and cementum.

14 t between the periodontal ligament (PDL) and cementum.

15 ar bone (0.7 +/- 0.1 to 0.9 +/- 0.2 GPa) and cementum (0.6 +/- 0.1 to 0.8 +/- 0.3 GPa) was observed u

16 n = 66; dentin, 0.9 +/- 9.2 mV, n = 59; and cementum, -0.8 +/- 8.2 mV, n = 42, with a positive sing

17 ), including new bone (2.33 mm vs. 0.23 mm), cementum (1.74 mm vs. 0.23 mm), and associated periodont

18 n = 46; dentin, -8.1 +/- 7.4 mV, n = 45; and cementum, -14.3 +/- 8.0 mV, n = 34.

19 Cementum, a mineralized tissue lining the tooth root sur

20 Proper formation of cementum, a mineralized tissue lining the tooth root sur

21 Cementum, alveolar bone, and the PDL of periostin-null m

22 However, hardness of cementum and alveolar bone at any given age were signifi

23 re we investigated the histologic changes of cementum and alveolar bone in a pycnodysostosis patient,

24 he histologic and ultrastructural changes of cementum and alveolar bone might be affected by CTSK mut

25 sed localization of DMP1 in vivo in cellular cementum and alveolar bone of mice treated with a single

26 specialised connective tissue that connects cementum and alveolar bone to maintain and support teeth

27 tion, loss of attachment, and destruction of cementum and alveolar bone.

28 eruption rate is due to a lack of acellular cementum and associated defective periodontal attachment

29 nt contained dentin with overlying acellular cementum and associated periodontal ligament tissue.

30 Cementum and bone mineralization is regulated by factors

31 the specialized matrices of enamel, dentin, cementum and bone.

32 ination of the primary teeth revealed normal cementum and dentin structure.

33 f plaque, calculus, and perhaps contaminated cementum and dentin.

34 sence of a narrow pouch-like opening between cementum and enamel in 15 of 16 teeth (93.8%).

35 n associated with the formation of acellular cementum and it has been found to stimulate periodontal

36 There is little potential for new cementum and new bone formation.

37 in the formation of gingival pockets between cementum and periodontal epithelium, a hallmark of perio

38 lity of EGR to induce formation of acellular cementum and promote significant anaplasis of the suppor

39 mage to tooth structure (enamel, dentin, and cementum), and alteration in tooth sensitivity.

40 including formation of periodontal ligament, cementum, and alveolar bone.

41 g apparatus, including periodontal ligament, cementum, and alveolar bone.

42 failed to rescue the defects in the dentin, cementum, and alveolar bones in the Dmp1-KO mice.

43 ssues--including periodontal ligament (PDL), cementum, and bone--are a major cause of tooth loss in a

44 vivo with ultrastructure of dentin, enamel, cementum, and bone.

45 l regeneration, i.e., formation of new bone, cementum, and connective tissue attachment.

46 The permselectivity of human enamel, cementum, and dentin sections was examined, in a microwe

47 n, detailed through histology with new bone, cementum, and inserting fibers.

48 Instead of generating new bone, cementum, and inserting periodontal ligament fibers, CTG

49 the formation and mineralization of dentin, cementum, and jaw bones.

50 ed stimulation of osteogenesis, regenerative cementum, and new attachment formation.

51 alveolar bone, the periodontal ligament, the cementum, and oral mucosa.

52 ar roots with thin dentin, lack of acellular cementum, and osteoid accumulation in alveolar bone.

53 ERS cells are attached to the surface of the cementum, and others separate to become the epithelial r

54 econstruct periodontal tissues such as bone, cementum, and periodontal ligament cells (PDL).

55 After 5 mos, analysis showed alveolar bone, cementum, and periodontal ligament formation in all trea

56 New alveolar bone, cementum, and periodontal ligament were consistently obs

57 In this model, regeneration (new bone, cementum, and periodontal ligament) of 71% of the origin

58 enhancing the regeneration of alveolar bone, cementum, and periodontal ligament.

59 red by formation of tissues resembling bone, cementum, and possibly dentin.

60 s denuded of its periodontal ligament (PDL), cementum, and superficial dentin through a bony window c

61 tory mechanisms of root resorption repair by cementum at the proteomic and transcriptomic levels.

62 ic force microscopy analysis showed that the cementum became significantly thickened, softened, and f

63 nt of periodontal regeneration including new cementum, bone and connective tissue, and area measureme

64 h and graft, and no histological evidence of cementum, bone, or periodontal ligament (PDL) and, there

65 ens analyzed histologically demonstrated new cementum, bone, periodontal ligament, and connective tis

66 MPf only developed significantly greater new cementum compared with controls.

67 oth is made of an enamel-covered crown and a cementum-covered root.

68 Cementum-covered roots of 20 extracted human premolars w

69 cted teeth and evaluated for the presence of cementum covering these areas by stereomicroscopy, light

70 t their absence is associated with increased cementum defects in amelogenin-knockout (KO) mice.

71 180 and LRAP mRNA expression correlated with cementum defects observed in the amelogenin-null mice.

72 The cementum defects were characterized by an increased pres

73 imbalance as the etiology of HPP-associated cementum defects.

74 ickness ( P = 0.00007) and a 23% increase in cementum density ( P = 0.009) compared to age-matched he

75 (-/-) mouse molar and incisor roots, and the cementum deposited appeared hypomineralized.

76 ralization were unaffected, whereas cellular cementum deposition increased although it displayed dela

77 of erupted molars and incisors but excessive cementum deposition with increased numbers of Ibsp- and

78 Cementum-derived attachment protein (CAP) is a collageno

79 Cementum-derived growth factor (CGF) is a 14 kDa polypep

80 HERS cells also participate in the cementum development and may differentiate into cementoc

81 gene of the Hyp mouse resulted in defective cementum development.

82 Nonsignificant changes in acellular cementum did not appear to affect periodontal attachment

83 ded thinner BSP-positive staining within the cementum, discontinuous mineralization, and a globular a

84 s are involved in the formation of acellular cementum during development of the periodontal attachmen

85 to be involved in the formation of acellular cementum during tooth development, suggesting that these

86 oglycans were identified at PDL-bone and PDL-cementum entheses using alcian blue stain.

87 New cementum formation (CF) presented better results for SRP

88 defect fill (DF) in G1 and higher BD and new cementum formation (NCF) in both groups.

89 DF), newly formed bone density (BD), and new cementum formation (NCF) were histometrically assessed.

90 in designing methods for enhancing bone and cementum formation adjacent to root surfaces.

91 al tissues, and thus events and modifiers of cementum formation and mineralization need to be determi

92 In Phospho1(-/-) mice, acellular cementum formation and mineralization were unaffected, w

93 y defects, impairing new bone formation, new cementum formation and new attachment.

94 hat differentially induced genes may mediate cementum formation and resorption.

95 , this bound peptide significantly increased cementum formation compared with that attained in contro

96 intramembranous bone formation and enhanced cementum formation during periodontal wound healing.

97 Mean new cementum formation experimental sites 1.36 mm (71% of in

98 acellular phosphate concentration may affect cementum formation have not been elucidated.

99 hogenetic protein-2 (BMP-2)-induced bone and cementum formation in a previously established rat model

100 he effect of sustained PDGF gene transfer on cementum formation in an ex vivo ectopic biomineralizati

101 Cementum formation is deemed to be instrumental for the

102 r cementum, further revealing that acellular cementum formation is not substantially regulated by PHO

103 evealed a significant reduction in acellular cementum formation on Bsp (-/-) mouse molar and incisor

104 of ankylosis; however, a marked increase in cementum formation on the root surfaces of fully develop

105 No significant new cementum formation or ankylosis was noted.

106 lial rest cells contribute to the control of cementum formation via epithelial-mesenchymal interactio

107 New cementum formation was greatest in the BMP acid conditio

108 Minimal new bone and cementum formation was observed.

109 tachment, new epithelial attachment, and new cementum formation).

110 helium and connective tissue attachment, new cementum formation, and new bone formation were evaluate

111 BSP plays a non-redundant role in acellular cementum formation, likely involved in initiating minera

112 MP-2/ACS supported significantly greater new cementum formation.

113 or identification of new bone, ankylosis and cementum formation.

114 steoblasts and cementoblasts during cellular cementum formation.

115 The amount of new cementum formed for the rhPDGF-BB/equine group (4.8 +/-

116 mineralization of alveolar bone and cellular cementum, further revealing that acellular cementum form

117 dontium, where similar tissues like bone and cementum grow at different rates.

118 Removal of the detached cementum in combination with bone grafting using a minim

119 hether the cementocyte is a dynamic actor in cementum in comparable fashion with the osteocyte in the

120 logy revealed dramatically expanded cervical cementum in GACI teeth, including cementocyte-like cells

121 s, including bone, periodontal ligament, and cementum in human interproximal intrabony defects and mo

122 a pouch-like opening between the enamel and cementum in mandibular molars with Grade III CEPs.

123 iograph showed an apparent separation of the cementum in the area of the pocket.

124 and furcation defects, but the length of new cementum in the interproximal intrabony defects was grea

125 tal ligament stem cells (PDLSCs) and forming cementum in vivo.

126 Through its importance to cementum integrity, BSP is essential for periodontal fun

127 Cementum is a critical mineralized tissue; however, cont

128 ructurally/functionally competent tooth root cementum is a critical step for the successful restorati

129 Cementum is a key component of a functional periodontal

130 dontal support including bone, ligament, and cementum is a major goal of therapy.

131 Cementum is a mineralized tissue covering the tooth root

132 canalicular system of both alveolar bone and cementum is abnormal, with irregular lacunar walls and f

133 The cementum is also defective, as characterized by irregula

134 Restoration of functional cementum is considered a criterion for successful regene

135 Further, the presence of healthy cementum is considered to be an important criterion for

136 However, regenerating lost cementum is difficult and often incomplete.

137 humans and mice reveal that the formation of cementum is sensitive to intra- and extracellular phosph

138 st when the outermost layer of the tusk, the cementum, is used.

139 l tissue breakdown, with a lack of acellular cementum leading to periodontal ligament detachment, ext

140 flammation and may have produced cementum or cementum-like matrix on the titanium surface adjacent to

141 root lineage and led to formation of ectopic cementum-like structures.

142 he callus region; and 5) newly formed dental cementum-like tissue (NFC).

143 necting the adjacent bone to a thin layer of cementum-like tissue observed on the root surface.

144 Furthermore, HERS cells were able to form cementum-like tissue when transplanted into immunocompro

145 We propose that defective alveolar bone and cementum may account for the periodontal breakdown and i

146 docrine signals and actively directing local cementum metabolism.

147 NB), density of newly formed bone (DNB), new cementum (NC), and extension of remaining defect (ERD) w

148 ea (NBA), area of bone trabeculae (ABT), new cementum (NC), and extension of remaining defect were hi

149 n addition to the histologic findings of new cementum, new bone, a new periodontal ligament, and a ne

150 s notch showed evidence of regeneration (new cementum, new bone, and new periodontal ligament) in 3 s

151 o analyze the surface features of enamel and cementum of feline teeth affected with advanced FORL.

152 dy, we characterized the dentin, enamel, and cementum of Sox2-Cre-mediated Fam20C KO mice.

153 ent and gingival collagen fibers to both the cementum of the root surface and alveolar bone.

154 L) is the connective tissue that anchors the cementum of the teeth to the alveolar bone.

155 BSP and OCN genes, confirming its nature as cementum or bone.

156 lt in any inflammation and may have produced cementum or cementum-like matrix on the titanium surface

157 oronally advanced flap with EMD revealed new cementum, organizing PDL fibers and islands of condensin

158 the tissues necessary for regeneration: new cementum, organizing PDL fibers, and islands of condensi

159 ce with regard to the presence or absence of cementum over the enamel projection within the furcation

160 beta-TCP showed evidence of regeneration of cementum, PDL with inserting connective tissue fibers, a

161 iodontal attachment apparatus, including new cementum, PDL, and bone coronal to the root notch in fou

162 Structural defects in cementum-PDL interfaces in Bsp (-/-) mice caused PDL det

163 ts, PDLSCs showed the capacity to generate a cementum/PDL-like structure and contribute to periodonta

164 em cells that have the potential to generate cementum/PDL-like tissue in vivo.

165 aratus, including the acellular and cellular cementum, periodontal ligament (PDL), and alveolar bone,

166 ) has been shown to promote formation of new cementum, periodontal ligament (PDL), and bone and to si

167 gival recession defects in restoring missing cementum, periodontal ligament (PDL), and supporting alv

168 nce of the periodontal attachment apparatus (cementum, periodontal ligament [PDL], and bone).

169 The results revealed new cementum, periodontal ligament with Sharpey's fibers, an

170 Qualitatively, new cementum, periodontal ligament with Sharpey's fibers, an

171 dontal regeneration (e.g., formation of root cementum, periodontal ligament, and alveolar bone).

172 s to evaluate regeneration of alveolar bone, cementum, periodontal ligament, and associated root reso

173 anisms by which it promotes the formation of cementum, periodontal ligament, and bone are not well un

174 in order for the host cells to stimulate new cementum, periodontal ligament, and bone.

175 ted in intense 3H-MISO retention in cellular cementum, periodontal ligament, osteocytes, and, occasio

176 papilla, odontoblasts, dentine matrix, pulp, cementum, periodontal ligaments, chondrocytes in Meckel'

177 generation, multipotential differentiation, cementum/periodontal-ligament-like tissue regeneration,

178 In support of our hypothesis, a cementum phenotype was detected using a combination of i

179 al phosphate levels; thus, we hypothesized a cementum phenotype, likely of decreased formation, would

180 nhibited mineralization of tissue-engineered cementum possibly due to the observed downregulation of

181 The clinical significance of these cementum pouches has yet to be determined but bacterial

182 ration 0.8+/-0.6 and 1.5+/-0.8 mm, and total cementum regeneration 2.0+/-1.3 and 1.6+/-1.7 mm for GTR

183 evaluate space provision, alveolar bone, and cementum regeneration following use of a bioabsorbable,

184 Limited cementum regeneration was observed for PGA-TMC/rhBMP-2 a

185 d 2) limited and similar amounts of bone and cementum regeneration were observed for both the GTR+DBM

186 There was limited, if any, appreciable cementum regeneration.

187 or cellular lacunae or featured evidence of cementum remodeling.

188 mentocyte-like cells and unusual patterns of cementum resorption and repair.

189 control lesions with 2.78 and 2.57 mm of new cementum respectively.

190 Twenty dentin/cementum root slabs were prepared for each thickness of

191 In many cases, dramatic amounts of new cementum, Sharpey's fibers, periodontal ligament, and bo

192 In many cases, dramatic amounts of new cementum, Sharpey's fibers, periodontal ligament, and bo

193 g formation of the apically located cellular cementum, some cementoblasts become embedded in the ceme

194 many resorptive lesions were noted along the cementum surface, with evidence of isolated cemental rep

195 evere enamel defects, very thin dentin, less cementum than normal, and overall hypomineralization in

196 In general, more cells attached to cementum than to calculus.

197 BSP is present in cementum, the hard tissue covering the tooth root that a

198 subjects revealed 4-fold increased cervical cementum thickness ( P = 0.00007) and a 23% increase in

199 e molars revealed 4-fold increased acellular cementum thickness ( P = 0.002) and 5-fold increased cem

200 function mouse models suggest that increased cementum thickness may be caused by decreased extracellu

201 ty was correlated significantly with incisor cementum thickness.

202 th and to eliminate periodontal ligament and cementum to expose the tooth dentin.

203 Despite the significance of cementum to general oral health, the mechanisms controll

204 etermine if it does, we selected sperm whale cementum to provide large anisotropic substrates resembl

205 The sensitivity of cementum to reduced PPi levels in both human and mouse t

206 thickness ( P = 0.002) and 5-fold increased cementum volume ( P = 0.002), with no changes in enamel

207 No new cementum was formed along the root surface in the above

208 No new cementum was found in furcations.

209 interpreted to be root planing marks on the cementum, we were able to demonstrate that complete peri

210 y significant increases in the amount of new cementum were observed in groups BG and BO/BG when compa

211 Bone, periodontal ligament, and cementum were removed as completely as possible with han

212 ars, and both periodontal ligament (PDL) and cementum were removed.

213 d significant increases in the amount of new cementum when compared to open flap debridement in a can

214 P1) is highly expressed in alveolar bone and cementum, which are important components of the periodon

215 Additionally, in the smaller lesions, new cementum width at the level of the notch was twice as gr

216 The cementum width was slightly greater in the wider (4 and

217 mbined 1 and 2 mm defects, the height of new cementum with EMD plus graft was 3.88 mm versus 2.03 mm

218 mbined 1 and 2 mm defects, the height of new cementum with enamel matrix protein treatment was 45% gr