ライフサイエンスコーパス: centenarian

1 sal status, or personal or family history of centenarians.

2 mes the largest previously published GWAS on centenarians.

3 90 years and older, including estimates for centenarians.

4 ith a smaller stature in female offspring of centenarians.

5 arthroplasty are very rarely performed among centenarians.

6 ng selective accumulation of the mutation in centenarians.

7 set consisting of lifelengths of siblings of centenarians.

8 uld target the families of nonagenarians and centenarians.

9 ding for premature mortality in newborns and centenarians.

10 obability of becoming 85- to 94-year-olds or centenarians (100- to 104-year-olds) in 2010 for individ

11 r pollution, exceptional aging, and rates of centenarians: a nationwide analysis of the United States

12 study of exceptional longevity (EL) in 1055 centenarians and 1267 controls.

13 ng region variants of 53 cognitively healthy centenarians and 45 patients with Alzheimer's disease (A

14 L with 77% accuracy in an independent set of centenarians and controls.

15 Family studies of centenarians and long-lived persons have found substanti

16 the 13 bp repeat are highly prevalent among centenarians and overall number of perfect repeats in ma

17 characterized the gut microbiota in Italian centenarians and semi-supercentenarians.

18 levels in sickle cell anemia and a sample of centenarians and show that the approach is highly reprod

19 We demonstrated that centenarians and their offspring maintain longer telomer

20 rved high incidence of the C150T mutation in centenarians and twins.

21 n of rare LoFs in AD subjects as compared to centenarians, and this enrichment is more pronounced for

22 Centenarians are a model for healthy aging because they

23 Centenarians are a rapidly growing demographic group wor

24 Generally, it seems that centenarians are asymptomatic or untargeted by cancers.

25 small percentage ( approximately 15-25%) of centenarians are functionally cognitively intact.

26 Centenarians are more likely to have causes of death cer

27 Centenarians are therefore of scientific interest as a h

28 ther in silico analysis revealed that 90% of centenarians can be grouped into 19 clusters characteriz

29 Centenarian deaths increased 56% (95% CI 53.8%-57.4%) in

30 The more hypomethylated CpGs observed in the centenarian DNA compared with the neonate covered all ge

31 The centenarian DNA had a lower DNA methylation content and

32 ns, the most hypomethylated sequences in the centenarian DNA were present mainly at CpG-poor promoter

33 ch, human fibroblasts from postnatal to near centenarian donors can be efficiently converted into neu

34 were derived from three middle-aged and four centenarian donors demonstrates that while most of the c

35 Siblings of centenarians experienced a mortality advantage throughou

36 longevity, we analyzed the pedigrees of 444 centenarian families in the United States.

37 f decedents from a population-based study in centenarians found that zeaxanthin concentrations in bra

38 e bisulfite sequencing (WGBS) of newborn and centenarian genomes.

39 oad between the newborn and the nonagenarian/centenarian groups.

40 The genetics of centenarians have been extensively examined [3], but les

41 The children of centenarians have markedly reduced relative risks for ag

42 ring the aging-related health risks that the centenarians have survived and the developmental risks o

43 of exceptional longevity, usually focused on centenarians, healthy aging is not associated with known

44 However, approximately 90% of centenarians in a population-based study were functional

45 rends in place of death and associations for centenarians in England over 10 years to consider policy

46 throplasties and 7 knee arthroplasties among centenarians in this database.

47 ived individuals (LLI) (centenarians or near-centenarians) in 137 sibships and identified statistical

48 e at the end of life requires recognition of centenarians' increased likelihood to "acute" decline, n

49 vity using 308 long-lived individuals (LLI) (centenarians or near-centenarians) in 137 sibships and i

50 5- to 94-year-olds (p < 0.001) and 6.4 fewer centenarians (p < 0.001).

51 5- to 94-year-olds (p < 0.001) and 3.5 fewer centenarians (p < 0.05).

52 oon experience twice that prevalence, or one centenarian per 5000 persons.

53 samples ranging from umbilical cord blood to centenarian peripheral blood.

54 gression to evaluate factors associated with centenarians' place of death.

55 terozygous mutations in the IGF1R gene among centenarians relative to controls that are associated wi

56 n of synonymous and intronic mutations among centenarians relative to controls.

57 Centenarians represent an extreme of life expectancy.

58 n LoF burden originated both from the AD and centenarian sample.

59 e true, it would follow that most if not all centenarians should have Alzheimer's disease.

60 F1 and IGF1 receptor (IGF1R) genes of female centenarians showed overrepresentation of heterozygous m

61 that arthroplasties should not be denied to centenarians solely because of short-term postoperative

62 Numerous centenarian studies disprove this assumption given that

63 isease Centre, the Nun Study and the Georgia Centenarian Study to obtain a pool of 1110 patients, all

64 data from 3 ongoing studies: the New England Centenarian Study, the Framingham Heart Study, and scree

65 ived from genomes of appropriately consented centenarian subjects.

66 Here, in a cohort of Ashkenazi Jewish centenarians, their offspring, and offspring-matched con

67 c variations in a cohort of Ashkenazi Jewish centenarians, their offspring, and offspring-matched con

68 Centenarians thus have the potential to represent a mode

69 miology of knee and hip arthroplasties among centenarians using data from a large hospital discharge

70 with the U.S. 1900 cohort, male siblings of centenarians were at least 17 times as likely to attain

71 rtality estimates following arthroplasty for centenarians were higher than for nonagenarians (hazard

72 Centenarians were more likely to die of pneumonia (e.g.,

73 The case histories presented include a centenarian who was a model of healthy aging, a 92-year-

74 correlations thus far suggest that there are centenarians who demonstrate no evidence of neurodegener

75 There also appear to be centenarians who, despite the substantial presence of ne

76 ably because of insufficient sample sizes of centenarians, whose genomes may harbor genetic variants

77 These pedigrees included 2,092 siblings of centenarians, whose survival was compared with 1900 birt

78 lesions, a cognitively and physically intact centenarian with almost no neuropathology, and an 85-yea

79 enal disease, but there are also examples of centenarians with adequate renal function.

80 n this large population of nonagenarians and centenarians with NSTE-ACS, increasing adherence to guid

81 If this were true, most if not all centenarians would have significant disability.