ライフサイエンスコーパス: central

1 in the central millimeter), and 3 (FS in the central 3 mm) with each other and with best-corrected VA

2 easured at the fovea and averaged across the central 3-mm horizontal segment.

3 e function of RIM-binding proteins (RBPs) as central active-zone scaffolding molecules.

4 We assessed overall and central adiposity in 1,006 children in early childhood (

5 male population, observed effect of baseline central adiposity on future periodontitis progression is

6 An anatomical atlas of the central adult fly brain was recently described [12]; how

7 in peril everywhere, but forest elephants in Central Africa have sustained alarming losses in the las

8 he diversity of HIV-1 CRF01_AE originated in Central Africa in the mid-1970s, was introduced into Tha

9 With nearly 50% of forest elephants in Central Africa thought to reside in Gabon [1], their los

10 in eastern Africa, 17% (6-29) in western and central Africa, 11% (5-18) in Latin America and the Cari

11 ia score (items 1-7), as assessed by blinded central AIMS video raters.

12 ugh arc volcanism has been advocated for the Central America margin while at other locations mass bal

13 abasin difference is primarily driven by the Central American Gap Winds (CAGW), which intensify (weak

14 ent with model simulations of the impacts of Central American Seaway closure a strengthened AMOC with

15 The presence of the hormone oxytocin in the central amygdala makes a mother rat willing to put her l

16 distinct behavioral modules and suggest that central amygdala neurons instruct predatory hunting acro

17 However, how the central amygdala participates in such a learning process

18 Participants had blinded central analyses of baseline and 24 h CTs, with dIVH def

19 to hard drusen, whereas fragmentation of the central and basal contents was seen frequently in larger

20 In animal studies, central and blood borne inflammatory cytokines that can

21 references from PubMed-MEDLINE, Embase, and CENTRAL and did also a new search spanning the period Ja

22 epigenetic profiling of human resting naive, central and effector memory T cells using ChIP-Seq and f

23 xplored the functional reorganization of the central and peripheral EVC following visual field defect

24 kes imposed by the relative positions of the central and peripheral stalks affects c-subunit stepping

25 en and women], geographical region [western, central, and eastern China], urbanity [urban vs rural],

26 stal coronary pressure and flow velocity and central aortic pressure were recorded with sensor wires.

27 n Australia (9%), the Middle East (14%), and central Asia (16%) and decline in many African savannas

28 present a 320 year Hg deposition history for Central Asia, based on a continuous high-resolution ice-

29 cal region covering the southwestern part of Central Asia.

30 del of feeding in Caenorhabditis elegans Our central assumption is that food intake serves a dual to

31 s, and no low-lying acceptor orbitals on the central atom.

32 ue turnover or following injury represents a central biological problem.

33 Randomisation was done with a central block randomisation process.

34 ogic method was developed to further advance central BP measurement.

35 stage for understanding and controlling the central branch point of this pharmacologically important

36 rms are distributed along the peripheral and central branches of their bifurcated axons.

37 es positively with physical proximity to the central business district and to other physically attrac

38 We conclude that the GR in adipocytes exerts central but diverging roles in the regulation of metabol

39 xin binding to its glycan receptor Neu5Ac is central, but, due to the ubiquity of Neu5Ac, how typhoid

40 ation with CRIP1a, but that a phosphorylated central C-terminal peptide competed for association with

41 pecies (Neotoma fuscipes and N. macrotis) in central California, USA.

42 This cage differs in that the central cavity is phenyl-linked rather than having the p

43 presence of a 27-mer DNA duplex containing a central CC mismatch.

44 (ventromedial, ventro-lateral, centromedial, central, centrolateral, dorsomedial, dorsolateral) ident

45 he carboxyl terminus of each protomer in the central channel of the hexamer and hinders the interacti

46 lfate blocked chloride transport through the central channel.

47 ocks on the strand that is excluded from the central channel.

48 ruitment domain next to Rrp6 and the exosome central channel.

49 The central circadian pacemaker (Suprachiasmatic Nuclei, SCN

50 Despite being recognized as a central clinical issue for RDEB, wound healing impairmen

51 hrane Central Register of Controlled Trials (CENTRAL), Cochrane Database of Systematic Reviews, Web o

52 ols for characterizing early-born neurons in central complex function.

53 ion for investigating the development of the central complex, and tools for characterizing early-born

54 Columnar neurons of the central complex, generated by the type II lineages DM1-4

55 nucleus of the hypothalamus is an important central component of hypothalamic-pituitary-adrenal axis

56 Our study highlights forensic services as a central component of the mental health system, which has

57 effective parameters were optimized using a central composite design.

58 Randomisation was completed by a central computer, and participants were allocated to tre

59 A central concern is how consideration of model difference

60 join their effort to care for children-is a central contributor to children's well-being and sociali

61 146, F147, and Y150 cluster at the predicted central core of the trimeric interface and are important

62 tism (RA), and topographic astigmatism (TA), central corneal thickness (CCT) and endothelial cell den

63 Blocking HFD-induced cell proliferation by central delivery of the antimitotic drug arabinofuranosy

64 RCA1 and CRISP2 DMRs were identified as most central disease-associated DNA methylation biomarkers.

65 g the reversible ring closure/opening of the central dithienylethene via irradiation with UV/visible

66 We show here that while the central DNA binding domain is essential for anchoring at

67 hich are powerful sources of radiation whose central engine is located in the core of the host galaxy

68 that might be considered representative for Central Europe and the greater Alpine region.

69 though this period has been well explored in central Europe using ancient nuclear DNA [1, 2], its gen

70 ing a high level of productivity across many Central European mountain forests under future climate c

71 ted with the trait) between the northern and central European parts of the cline.

72 e to striatal-like projection neurons in the central extended amygdala.

73 Integrin-mediated adhesion is a central feature of cellular adhesion, locomotion, and en

74 A central feature of HSV pathogenesis is the ability to pe

75 ead and eyes as quickly as possible from the central fixation point to a specified target located 20

76 der naturally occurring extremes have become central for improved predictions of future reef form and

77 y species of raptors have two foveae, a deep central fovea and a shallower temporal fovea.

78 s sufficient cone structure remaining in the central fovea of BCM patients to consider AAV-mediated g

79 robabilities of CP-visible, new-onset GA and central GA after 1 to 5 years.

80 1) The central gate residue Glu(130) (Glu(90) in Chlamydomonas

81 A central goal in biochemistry is to explain the causes of

82 mTOR complex I (mTORC1) is a central growth regulator that senses amino acids through

83 ates at risk for jaundice at Queen Elizabeth Central Hospital in Blantyre, Malawi.

84 structure, where the two Cas2 domains form a central hub (twofold axis of symmetry) flanked by two Ca

85 The central importance of oxygen, energetics, and redox home

86 eomic characterization of blood plasma is of central importance to clinical proteomics and particular

87 rease in widespread extreme rain events over central India during 1950-2015.

88 r of extreme rain events is on the rise over central India.

89 This demonstrates a central integration mechanism is sufficient to evoke pai

90 The interactions between the central ion and the bath spins suppress the flip-flop ra

91 ast tumour tissue in a microarray, done in a central laboratory by technicians unaware of treatment a

92 three color patches, middle color patch CLC (central lateral color patch), and two anterior color pat

93 n the Gaussian distribution predicted by the central limit theorem.

94 involved all three CaM domains including the central linker and both lobes.

95 key bi-functional switch that underlies the central logic of PCP signaling during morphogenesis, and

96 The BCVA and central macular thickness were recorded at baseline and

97 w explores and discusses current evidence on central mechanisms underlying exercised-induced pain and

98 nduced pain have been developed and point to central mechanisms underlying this phenomena, such as in

99 diet-induced obesity by both peripheral and central mechanisms.

100 CD4(+) T cells are central mediators of autoimmune pathology; however, defi

101 TH1/TH17 central memory (TH1/TH17CM) cells were selectively incre

102 T cells, and reduced naive and effector and central memory CD8+ T cells.

103 b DosR latency antigen specific, regulatory, central memory response is therefore a novel functional

104 scle pathology is related to deregulation of central metabolic pathways, which may identify potential

105 ften leads to growth inhibition and perturbs central metabolism and this burden varies with the prote

106 rences 67 B vitamins play essential roles in central metabolism.

107 tty acids via the de novo synthesis of PA, a central metabolite for membrane phospholipid biosynthesi

108 d the stronger electronic effect between the central metal and anion in the complex.

109 By varying the central metal ion of the polypyridyl complexes (Os, Ru,

110 of areas 1 (complete atrophy), 2 (FS in the central millimeter), and 3 (FS in the central 3 mm) with

111 Alpha-synuclein (alpha-SYN) is a central molecule in Parkinson's disease pathogenesis.

112 nsthoracic echocardiography showed mild (1+) central MR in 1 patient, and no residual MR in the remai

113 um tuberculosis (Mtb) growth, or progress to central necrosis and cavitation, facilitating pathogen g

114 The mechanisms by which WNV enters the central nervous system (CNS) and host-factors that are i

115 Tumors residing in the central nervous system (CNS) compromise the blood-brain

116 understanding of immune surveillance of the central nervous system (CNS) have repeatedly provoked di

117 Central nervous system (CNS) infection and neurological

118 is a prevalent health issue that can lead to central nervous system (CNS) inflammation with long-term

119 Microglial cells are phagocytes in the central nervous system (CNS) that become activated in pa

120 D1) selectively affects motor neurons in the central nervous system (CNS), causing the adult-onset de

121 Notably, the first new central nervous system (CNS)-targeted oligonucleotide-ba

122 quired for hyperpolarizing inhibition in the central nervous system (CNS).

123 roximately 30% of the cells in the mammalian central nervous system (CNS).

124 findings, presence of microcephaly or other central nervous system abnormalities, and timing of infe

125 ng blood from the extracellular fluid in the central nervous system and thus presents an essential ob

126 e myeloid leukemia, soft-tissue sarcoma, and central nervous system cancer.

127 tion pathways between gut microbiota and the central nervous system could include autonomic, neuroend

128 mplicated in neuron-glia interactions during central nervous system development and in hair follicle

129 and connected with human metabolic diseases, central nervous system diseases, and neoplasms.

130 4A gene have been described in patients with central nervous system hypomyelination.

131 ments, with a focus on preventing congenital central nervous system malformations.

132 ligible if they had symptomatic or untreated central nervous system metastases, had received anticanc

133 These cytokines regulate central nervous system neurons to induce sleep.

134 motor activity levels when injected into the central nervous system of mice.

135 xamined multiple sclerosis lesions and other central nervous system pathologies with prominent myelin

136 control over gastrointestinal functions, the central nervous system provides extrinsic neural inputs

137 Here we show that primary cells from the rat central nervous system respond differently to photo-toxi

138 ce an acquired demyelinating syndrome of the central nervous system will have a monophasic disease co

139 t GEBR-32a is rapidly distributed within the central nervous system with a very favourable brain/bloo

140 e most common, though 1 case did involve the central nervous system with few symptoms.

141 ll lymphatic vessels, including those in the central nervous system, and Schlemm's canal.

142 In the central nervous system, apoE is produced primarily by as

143 istinguishes several cell types from the rat central nervous system, largely based on the relative pr

144 put, originated from different levels of the central nervous system, to the different compartments.

145 erapy thus has potential in the treatment of central nervous system-related pathologies, such as Alzh

146 has multiple roles in the development of the central nervous system.

147 -related oligodendroglial protein in the rat central nervous system.

148 ia are the intrinsic immune sentinels of the central nervous system.

149 ral irregularity of neuronal activity in the central nervous system.

150 k of capacity of this agent to penetrate the central nervous system.

151 elements following early development of the central nervous system.

152 d interleukin-8 in the respiratory tract and central nervous system.

153 While central neural circuits regulating thirst have been well

154 review key findings that have elucidated the central neuroendocrine mechanism of sleep during sicknes

155 k topology the spike train statistics of the central node can be tuned to have a certain firing rate

156 and that the transcription factor OLIG2 is a central node in the affected pathway.

157 We focus on the spiking statistics of the central node, which fires in response to a noisy input a

158 itative analysis of glial cell insertions at central nodes of Ranvier.

159 n and spinal cord and is the major source of central noradrenaline.

160 ng and regenerating muscle fibers, increased central nuclei, elevated creatine kinase activity and en

161 k between Type III-A CRISPR-Cas immunity and central nucleic acid metabolism.

162 e direct topography involving bed nucleus vs central nucleus divisions; (2) CRF content of the CEA-DA

163 dy, we retrogradely transported dye from the central nucleus of the amygdala (CeA) to identify CeA-pr

164 In the adjusted model, central obesity (OR = 1.88, 95%CI = 1.18, 3.01) and cons

165 ral obesity (OR = 1.77, 95%CI = 1.11, 2.81), central obesity (OR = 2.09, 95%CI = 1.46,3.01) and consu

166 95% confidence interval [CI]: 3.69-9.55) and central obesity (OR = 3.45, 95% CI: 2.27-5.23) were stro

167 The prevalence of general obesity, central obesity, and hypertension among the children was

168 ion of bioaccumulated copper occurred in the central older region of ammonium-grown colonies.

169 ion with beta-arrestin 1, and phosphorylated central or distal C-terminal peptides competed for assoc

170 of CB1R protein complexes demonstrated that central or distal C-terminal peptides competed for the C

171 visual field defects specifically affecting central or peripheral vision.

172 r obesity (OR: 1.57; 95% CI: 1.15, 2.13) and central overweight or obesity (OR: 1.73; 95% CI: 1.19, 2

173 model that enables anomalous warm SST in the central Pacific.

174 re decreases the optimum interactions of the central part of Tm with the C-terminal region of TnI.

175 Intestinal inflammation is the central pathological feature of colitis and the inflamma

176 Randomisation was done via a central patient screening and randomisation system with

177 ude that motoneurons provide feedback to the central pattern generator (CPG) during drug-induced loco

178 with the lack of biophysical evidence for a central pattern generator, and recent experimental evide

179 ry bursts with properties similar to in vivo central pattern generators.

180 anic solutions; the aqueous sample forms the central phase and is encompassed by two free liquid memb

181 Arginine methylation on histones is a central player in epigenetics and in gene activation and

182 d substrate unfolding by threading through a central pore.

183 Despite its central position in human physiology, the in vivo oligom

184 in druggable CATH functional families occupy central positions in a human protein functional network,

185 tudies suggest that peripheral tumors elicit central pro-inflammatory cytokine production, in turn le

186 on test sets is close to the result using a central processing unit.

187 nuclear Mpp6 exosome bound to RNA shows the central region of Mpp6 bound to the exosome core, positi

188 re of the skyrmion core, identifying a 25 nm central region of uniform magnetization followed by a la

189 of MEDLINE (PubMed), EMBASE (OVID), Cochrane Central Register of Controlled Trials (CENTRAL), Cochran

190 n PubMed, PsycINFO, EMBASE, and the Cochrane Central Register of Controlled Trials (from database inc

191 systematic literature search on the Cochrane Central Register of Controlled Trials, MEDLINE, and Emba

192 Systematic review The Cochrane Central Register of Controlled Trials, Prospero, Medline

193 dividuals recorded in the Danish Cytogenetic Central Register with a 22q11.2 deletion or duplication

194 emergence of ZBP1 as a pathogen sensor and a central regulator of cell death and inflammatory respons

195 target of rapamycin complex 1 (mTORC1) is a central regulator of cell growth that responds to divers

196 nal thioredoxin-binding domain, along with a central regulatory region that links the two.

197 The results indicate that AtBAG7 plays a central regulatory role in the heat-induced UPR pathway.

198 sis thaliana) COP1/SPA ubiquitin ligase is a central repressor that suppresses light signaling in dar

199 the internal medicine (IM) examination is a central requirement of the American Board of Internal Me

200 anish Civil Registration System, Psychiatric Central Research Register, and Register of Causes of Dea

201 The Zebrafish Model Organism Database is the central resource for zebrafish (Danio rerio) genetic, ge

202 We revealed that the central retinal lesions either do not impair motion dete

203 in the resection cavity, assessed by blinded central review of brain MRI scans by the study neuroradi

204 obtained during surgery, analysed by masked central review of local histopathology reports.

205 uation Criteria in Solid Tumors version 1.1 (central review), assessed in prespecified subgroups base

206 to show connectivity deficits of the brain's central rich club (RC) system relative to both control s

207 nts at positions 5,5' remain coplanar to the central rings.

208 The hedgehog (Hh) signaling pathway plays a central role during embryonic development, and its aberr

209 nvolved in ciliary functions, confirming the central role for primary cilia in Hh signaling.

210 ving receptors for axon guidance cues play a central role in controlling growth cone behaviour.

211 The intestine plays a central role in digestion, nutrient absorption and metab

212 es, mediated in Arabidopsis by MET1, plays a central role in epigenetic inheritance, we examined geno

213 ithin and between brain regions and serves a central role in establishing complex and adaptive cognit

214 s an attractive therapeutic target given its central role in formation of sebum, a key factor in acne

215 rvous system control of inflammation plays a central role in hypertension.

216 (PMd) and primary motor (M1) cortices play a central role in mapping sensation to movement.

217 Uncoupling protein 1 (UCP1) plays a central role in nonshivering thermogenesis in brown fat;

218 Direct band-gap semiconductors play the central role in optoelectronics.

219 Its central role in regulating glycolysis in human sarcomas

220 The amygdala may, therefore, play a central role in RL.

221 port) is a multiprotein complex that plays a central role in the coordination of synthesis, processin

222 ction as the cellular power plant and play a central role in the early stages of programmed cell deat

223 rbing multinucleated osteoclasts that play a central role in the maintenance and repair of our bones

224 e exon-1 region of mutant huntingtin plays a central role in the pathogenesis of Huntington's disease

225 Ohr also appeared to play a central role in the peroxynitrite response, because the

226 s essential to brain development and plays a central role in the response to brain injury.

227 to a load-bearing network, thereby playing a central role in wall mechanics and growth, but this view

228 The central role of protein kinases in controlling disease p

229 or raft partitioning of TMDs and support the central role of rafts in membrane traffic.

230 include the Gata2 transcription factor play central roles in hematopoietic fate establishment.

231 Lipids play central roles in metabolism and cell signaling, and thus

232 ltrated neutrophils and macrophages and play central roles in wound healing.

233 A total of 362 patients with central RVO or hemi-RVO were enrolled between September

234 y was negatively associated with overall RT (central, S3, T3, I3, and N3 sectors, P = .004-.024) and

235 Central sensitization and network hyperexcitability of t

236 However, mechanisms by which central serotonin action leads to fat loss remain unknow

237 ch can be distinguished from the findings of central serous chorioretinopathy.

238 that M. sexta's sensitization occurs through central signal amplification.

239 an Cu(I) equiv added, with binding by twelve central sites dominating.

240 sensory input may prevent BTP and targeting central sites may be required for pain relief once BTP h

241 The central six-component triage system is divided into an u

242 te V1-ATPase, the mechanical property of the central stalk is a key determinant of the rate of ATP tu

243 R is independent of RAD51, which encodes the central strand exchange protein in yeast required for co

244 dummy, and the patients, investigators, and central study staff were masked to treatment allocation.

245 Other outcomes included visual acuity, central subfield retinal thickness, and number of anti-V

246 asmic chaperones Skp and SurA, and BamA, the central subunit of the BAM complex, on the folding kinet

247 these sounds show significant differences in central sulcus (CS) morphology, particularly in the infe

248 and physiological reactivity among the most central symptoms in the networks in terms of the extent

249 The method yielded central systolic, diastolic, and pulse pressure bias and

250 e capillary gas chromatography (PCGC) is the central technique used for the purification of volatile

251 n to symptoms of weight gain and dyspnea are central tenets of patient education in heart failure (HF

252 Broadband tunability is a central theme in contemporary nanophotonics and metamate

253 The involvement of central theta-band and occipital alpha-band effects are

254 of inflammatory cytokines in peripheral and central tissues.

255 change at charged solid-liquid interfaces is central to a broad range of chemical and transport pheno

256 aptic plasticity in the nucleus accumbens is central to age-related changes in voluntary running.

257 Central to all of these functions is their ability to ch

258 Matrix metalloproteinases (MMPs) are central to cancer development and metastasis.

259 Central to CD8(+) T cell-mediated immunity is the recogn

260 ighlighting the key areas of ethical tension central to evaluating physician-assisted suicide and eut

261 As p53 is central to hematopoietic stem cell functions, its aberra

262 that (1) analogical comparison processes are central to human cognition; and (2) intuitive physical k

263 endothelium to sites of tissue infection is central to inflammation, but also promotes chronic infla

264 tors (NMDARs) are glycoproteins in the brain central to learning and memory.

265 The entry of calcium into mitochondria is central to metabolism, inter-organelle communication, an

266 Anhedonia is central to multiple psychiatric disorders and causes sub

267 Reexperiencing symptoms were central to other symptoms in the acute phase, with intru

268 Mu opioid receptors (MORs) are central to pain control, drug reward, and addictive beha

269 ules between membranes, and this property is central to PITP-mediated regulation of lipid signaling.

270 ear or behavioral responses is thought to be central to PTSD symptomatology, but its role in predicti

271 Lignocellulose degradation is central to the carbon cycle and renewable biotechnologie

272 ontypeable Haemophilus influenzae (NTHI) are central to the chronicity, recurrence, and resistance to

273 Halting global biodiversity loss is central to the Convention on Biological Diversity and Un

274 Species abundance distributions (SAD) are central to the description of diversity and have played

275 Central to the development of these robots is the fabric

276 plasticity in regions of the brain that were central to the emergence of speech functions in humans.

277 architecture varies across space and time is central to the evolution of genomes in response to natur

278 However, issues central to the future of health and health care in the U

279 ul waiting (tincture of time) appeared to be central to the healing process.

280 ements, so-called super-enhancers (SEs), are central to the maintenance of cancer cell identity and p

281 Central to the method is the introduction of nanopores i

282 that this post-translational modification is central to the rewiring of plants for photoautotrophic g

283 oxygen reduction and evolution reactions are central to the stability of rechargeable metal-air batte

284 y based on non-invasive diffusion imaging is central to the study of human brain connectivity.

285 Central to this problem is the mechanism by which a brai

286 Central to this regulation is Aurora B kinase, which pho

287 Improving the quality of healthcare remains central to UK and international policy, practice and res

288 This is central to understanding geometric control of genetic pr

289 Reconstructing the lineage of cells is central to understanding how the wide diversity of cell

290 se as immunotherapeutics that can circumvent central tolerance and limit graft-versus-host disease.

291 Leaf dry mass per unit leaf area (LMA) is a central trait in ecology, but its anatomical and composi

292 ed harvesting of polymetallic nodules in the Central Tropical Pacific will generate plumes of suspend

293 akes fixations, not individual items, as its central unit.

294 common complication among patients requiring central venous access as part of their medical care.

295 Central venous access device (CVAD)-related thrombosis (

296 Selection of central venous catheter insertion site in ICU patients c

297 est correlation with mean deviation of the 4 central VF points (rho = -0.420; P < .001).

298 itecture, function, and development of mouse central visual pathways.

299 t links four double-helical layers; we use a central weaving oligonucleotide containing a sequence of

300 Randomisation was via a central web-based data capture system (mixed blocks of 3