ライフサイエンスコーパス: central nervous system

1 ral irregularity of neuronal activity in the central nervous system.

2 s and can result in damage to the developing central nervous system.

3 of encephalitogenic effector T cells in the central nervous system.

4 tinic acetylcholine receptors present in the central nervous system.

5 most severe congenital malformations of the central nervous system.

6 degenerative and autoimmune diseases of the central nervous system.

7 elements following early development of the central nervous system.

8 ng the effects of metabolic disorders on the central nervous system.

9 imination of virally transduced cells in the central nervous system.

10 d did not require microglial function in the central nervous system.

11 excitatory neurotransmission throughout the central nervous system.

12 coupled receptor abundantly expressed in the central nervous system.

13 al role for this inflammatory protein in the central nervous system.

14 ith other neurodegenerative disorders of the central nervous system.

15 ct neighbouring cell types of the Drosophila central nervous system.

16 and relay signals from the periphery to the central nervous system.

17 environment that surrounds every cell of the central nervous system.

18 tanding issue in patterning of the embryonic central nervous system.

19 table diseases such as those that affect the central nervous system.

20 tebrates and a predominant expression in the central nervous system.

21 subunit with the greatest importance in the central nervous system.

22 for studies of neurological pathways in the central nervous system.

23 ent bleeding in joints, soft tissue, and the central nervous system.

24 ce induces inflammatory demyelination in the central nervous system.

25 rmation is delivered to and perceived by the central nervous system.

26 d interleukin-8 in the respiratory tract and central nervous system.

27 an often-fatal demyelinating disease of the central nervous system.

28 of sensorimotor function after injury to the central nervous system.

29 ressed by many developing neurons within the central nervous system.

30 lus timecourse is first reconstituted in the central nervous system.

31 ged in maintaining neuron-neuron adhesion in central nervous system.

32 cious sensations from visceral organs to the central nervous system.

33 us system infection and severe spread to the central nervous system.

34 and along neuroanatomical tracts within the central nervous system.

35 associated with obesity are expressed in the central nervous system.

36 s are fundamental synaptic organizers in the central nervous system.

37 o initiation of an autoimmune process in the central nervous system.

38 eptor (IGF-1R) controls this response in the central nervous system.

39 has multiple roles in the development of the central nervous system.

40 -related oligodendroglial protein in the rat central nervous system.

41 ia are the intrinsic immune sentinels of the central nervous system.

42 l that exhibits high viral burden within the central nervous system.

43 1 and serotonin interact at the level of the central nervous system.

44 uronal damage and BACE1 up-regulation in the central nervous system.

45 ly disseminating to colonize the purine-poor central nervous system.

46 er propensity for metastasis to bone and the central nervous system.

47 lerosis (MS) is an autoimmune disease of the central nervous system.

48 o define the role of O-GlcNAc cycling in the central nervous system.

49 k of capacity of this agent to penetrate the central nervous system.

50 rain, leading to suboptimal treatment in the central nervous system.

51 restrict the genetic ablation of Lpd to the central nervous system.

52 Aside from occipital skull defects, central nervous system abnormalities are uncommon.

53 cells, leading to a more severe spectrum of central nervous system abnormalities than is typically s

54 findings, presence of microcephaly or other central nervous system abnormalities, and timing of infe

55 xpressed in homologous regions including the central nervous system and adrenal glands.

56 mediate excitatory neurotransmission in the central nervous system and are critically involved in br

57 Motor neurons are the output neurons of the central nervous system and are responsible for controlli

58 ttention due to its pleiotropic roles in the central nervous system and implications in various brain

59 preventing inflammatory tissue damage in the central nervous system and none directly promotes repair

60 he 2016 WHO classification of tumours of the central nervous system and on scientific developments si

61 t in primary DLBCL that occurred outside the central nervous system and ophthalmic regions (46.0 mont

62 lmic DLBCL than in DLBCL located outside the central nervous system and ophthalmic regions.

63 icroglia are the resident macrophages of the central nervous system and play complex roles in the mil

64 al physiology of lymphatic drainage from the central nervous system and potential aberrations in neur

65 on quantitative trait loci in tissues of the central nervous system and relevant to transcriptional r

66 Central nervous system and spinal abnormalities are also

67 ng blood from the extracellular fluid in the central nervous system and thus presents an essential ob

68 ommon vascular anomalies that develop in the central nervous system and, more rarely, the retina.

69 MeHg as a neurotoxin impacts on the human central nervous systems and especially on the developing

70 in the mouse, reducing dissemination to the central nervous system, and decreasing reactivation of c

71 catecholamine neurotransmitters of the human central nervous system, and is involved in many behavior

72 i malformation, medication use, tumor of the central nervous system, and no diagnosis.

73 ll lymphatic vessels, including those in the central nervous system, and Schlemm's canal.

74 ce expressing biologically active C3a in the central nervous system, and their respective wild-type c

75 lora to modulate ongoing inflammation in the central nervous system, and we also discuss the potentia

76 In the central nervous system, apoE is produced primarily by as

77 ne, typically classified as a disease of the central nervous system, appeared to be most genetically

78 he neurotoxic effects of cannabis use on the central nervous system as a result of how it affects ret

79 Demyelination of central nervous system axons, associated with traumatic

80 tal abnormalities during gestation, with the central nervous system being one of the most affected or

81 s on adipocytes and through signaling in the central nervous system by dampening sympathetic outflow

82 It also plays significant roles in the central nervous system by modulating neurotransmission.

83 Ultrasonography of the central nervous system can reveal inflammatory changes a

84 acute myeloid leukemia (1.9 [1.5-2.4]); and central nervous system cancer (1.8 [1.2-2.8]) experience

85 e myeloid leukemia, soft-tissue sarcoma, and central nervous system cancer.

86 ced liver injury (DILI): antimicrobials; and central nervous system, cardiovascular and oncology ther

87 the high incidence of severe defects in the central nervous system caused by human cytomegalovirus (

88 are an abundant and evolutionarily conserved central nervous system cell type.

89 and revealed involvement of a wide range of central nervous system cell types (eg, neurons, endothel

90 LRP2 is expressed on the surface of many central nervous system cells including neurons and oligo

91 skeletal involvement), kidneys (81.3%), and central nervous system (CNS) (46.9%).

92 Many GJB1 mutations cause central nervous system (CNS) abnormality in males, inclu

93 ability of Salmonella to disseminate to the central nervous system (CNS) after oral infection in C57

94 flammatory environment is induced within the central nervous system (CNS) after WNV infection, leadin

95 The mechanisms by which WNV enters the central nervous system (CNS) and host-factors that are i

96 The central nervous system (CNS) and its meningeal coverings

97 rectional communication pathways between the central nervous system (CNS) and peripheral immune syste

98 on evidence of parallel degeneration of both central nervous system (CNS) and peripheral nervous syst

99 that may be associated with infection of the central nervous system (CNS) and severe neurological dis

100 Herpes simplex virus (HSV) infections of the central nervous system (CNS) are associated with signifi

101 Blood vessels in the central nervous system (CNS) are controlled by neuronal

102 Infections of the central nervous system (CNS) are often acute, with signi

103 tem, the limited capacity of regeneration of central nervous system (CNS) axons is a major obstacle f

104 Blood-central nervous system (CNS) barriers partition neural t

105 side in a unique microenvironment within the central nervous system (CNS) called the NSC niche.

106 by KSHV, we sought to determine whether the central nervous system (CNS) can be infected by KSHV in

107 Tumors residing in the central nervous system (CNS) compromise the blood-brain

108 A novel autoimmune central nervous system (CNS) disorder with glial fibrill

109 B-preferring inhibitors for the treatment of central nervous system (CNS) disorders, we sought to ide

110 ges in gene expression that occur across the central nervous system (CNS) during neurological disease

111 Unlike nonchordates, amphioxus develops its central nervous system (CNS) from a neural plate that is

112 er Katanin p60 subunit A-like 1, KATNAL1, in central nervous system (CNS) function.

113 acterisation of compounds proposed to affect central nervous system (CNS) function.

114 homogeneous, static magnetic field (SMF) on Central Nervous System (CNS) glial cells are less invest

115 The concept of immune privilege of the central nervous system (CNS) has dominated the study of

116 other tissue-resident macrophages within the central nervous system (CNS) have essential roles in neu

117 understanding of immune surveillance of the central nervous system (CNS) have repeatedly provoked di

118 Microglia play essential roles in central nervous system (CNS) homeostasis and influence d

119 of phagocytic cells, play important roles in central nervous system (CNS) homeostasis and neural plas

120 Central nervous system (CNS) infection and neurological

121 status due to inflammation are a hallmark of central nervous system (CNS) infections with neurotropic

122 is a prevalent health issue that can lead to central nervous system (CNS) inflammation with long-term

123 cells (ASC) accumulate in various models of central nervous system (CNS) inflammation, including vir

124 impairment in HIV by amplifying HIV-related central nervous system (CNS) inflammation.

125 nant unselected cohort with mainly relapsing central nervous system (CNS) inflammatory diseases.

126 Reactive astrocytes are strongly induced by central nervous system (CNS) injury and disease, but the

127 olic protection devices in reducing ischemic central nervous system (CNS) injury during SAVR.

128 rkers for neuroinflammatory responses during central nervous system (CNS) invasion by trypanosomes an

129 lymerase chain reaction (PCR) is a marker of central nervous system (CNS) involvement in congenital h

130 In acute lymphoblastic leukemia (ALL), central nervous system (CNS) involvement is a major clin

131 Viral infection of the central nervous system (CNS) is complicated by the mostl

132 elaborated by oligodendrocytes (OLs) in the central nervous system (CNS) is required for saltatory c

133 disorder where T cells attack neurons in the central nervous system (CNS) leading to demyelination an

134 was significantly associated with ocular and central nervous system (CNS) lesions and showed the stro

135 sychosis-collectively this is referred to as central nervous system (CNS) lupus.

136 Primary central nervous system (CNS) lymphoma (PCNSL) and primar

137 (MS) is an autoimmune disease targeting the central nervous system (CNS) mainly in young adults, and

138 static phenotype and tight regulation by the central nervous system (CNS) microenvironment.

139 ial fraction of the lipids incorporated into central nervous system (CNS) myelin are contributed by a

140 Furthermore, central nervous system (CNS) myelin remains an adaptive

141 ination gene, Sex-lethal (Sxl), functions in central nervous system (CNS) neurons as part of a relay

142 Damaged central nervous system (CNS) neurons have a poor ability

143 ince diagnosis is difficult with concomitant central nervous system (CNS) pathology.

144 injury-induced characteristics of the adult central nervous system (CNS) pose barriers to axonal reg

145 neuronal chemokine expression and decreased central nervous system (CNS) recruitment of T lymphocyte

146 Central nervous system (CNS) relapses are an uncommon ye

147 ssociated with the development of a manifest central nervous system (CNS) synucleinopathy (odds ratio

148 Microglial cells are phagocytes in the central nervous system (CNS) that become activated in pa

149 an inflammatory demyelinating disease of the central nervous system (CNS) that is caused by autoreact

150 NS) must signal to the motor circuits of the central nervous system (CNS) through a series of pathway

151 that nanoparticles are able to enter to the central nervous system (CNS) through regions of altered

152 lity of myelin-reactive TH17 cells to invade central nervous system (CNS) tissue and protected the mi

153 Following oral DMF administration, central nervous system (CNS) tissue is predominantly exp

154 ue to noninvasively visualize B cells in the central nervous system (CNS) to monitor MS disease progr

155 Survivors of central nervous system (CNS) tumors (SHR=4.6, 95% confid

156 ied age as the only significant predictor of central nervous system (CNS) versus PNS involvement (>50

157 ated hemangioblastomas (VHL-HB) arise in the central nervous system (CNS), and are a leading cause of

158 In the adult mammalian central nervous system (CNS), axonal damage often trigge

159 n two unrelated consanguineous kindreds with central nervous system (CNS), cardiac, renal, and digit

160 D1) selectively affects motor neurons in the central nervous system (CNS), causing the adult-onset de

161 cosylceramide and glucosylsphingosine in the central nervous system (CNS), demonstrating target engag

162 obutyric acid (GABA) immunoreactivity in the central nervous system (CNS), eyes, optic ganglia and st

163 of white-matter tracts throughout the human central nervous system (CNS), including loss of all comm

164 ple sclerosis (MS) that directly damages the central nervous system (CNS), promotes immune cell infil

165 communication is the vascularization of the central nervous system (CNS), which is driven by neurona

166 s depends on the input and plasticity of the central nervous system (CNS), which may explain the abse

167 The discovery that central nervous system (CNS)-targeted autoreactive T cel

168 Notably, the first new central nervous system (CNS)-targeted oligonucleotide-ba

169 most essential protection mechanisms in the central nervous system (CNS).

170 roximately 30% of the cells in the mammalian central nervous system (CNS).

171 utoimmune disease that targets myelin in the central nervous system (CNS).

172 contributes to the neuroinflammation in the central nervous system (CNS).

173 ility barrier for maintaining homeostasis of Central Nervous System (CNS).

174 expression is specific to astrocytes in the central nervous system (CNS).

175 al status, or dysfunction(s) of cells of the central nervous system (CNS).

176 arious parts of the meninges surrounding the central nervous system (CNS).

177 -mediated demyelinating disease of the human central nervous system (CNS).

178 iating through electrical stimulation of the central nervous system (CNS).

179 y and degenerative processes that damage the central nervous system (CNS).

180 ncement of leukocyte accumulation within the central nervous system (CNS).

181 quired for hyperpolarizing inhibition in the central nervous system (CNS).

182 gs to control autoimmune inflammation in the central nervous system (CNS).

183 (GPCRs), including those associated with the central nervous system (CNS).

184 nflammatory cell recruitment at the diseased central nervous system (CNS).

185 ecently defined demyelinating disease of the central nervous system (CNS).

186 ord is a major obstacle for tissue repair in central nervous system (CNS).

187 is generally assumed to be a function of the central nervous system (CNS).

188 her tissues, immune cell presence within the central nervous system (CNS; microglia), as well as arou

189 The Drosophila larval central nervous system comprises the central brain, vent

190 e targets for a number of cardiovascular and central nervous system conditions, but the current drugs

191 tion pathways between gut microbiota and the central nervous system could include autonomic, neuroend

192 e role of the inflammasome in peripheral and central nervous system cytokine/chemokine inflammatory r

193 Notably, infants with congenital central nervous system deformities had significantly hig

194 hway that regulates synaptic activity during central nervous system development and demonstrates a ro

195 mplicated in neuron-glia interactions during central nervous system development and in hair follicle

196 ntiated from hPSCs that may be used to model central nervous system development and serve as a potent

197 nc finger protein, ZIC2, a key regulator for central nervous system development, is a substrate of K-

198 During central nervous system development, oligodendrocytes mus

199 of midbrain dopaminergic axon growth during central nervous system development.

200 ress and future perspectives for modeling of central nervous system disease and brain development in

201 indered by the lack of objective measures of central nervous system disease burden.

202 Identification of biomarkers for central nervous system disease in MPS patients would fac

203 criminators between those three inflammatory central nervous system diseases in adults and children t

204 protein (MOG) are associated with autoimmune central nervous system diseases like acute disseminated

205 and connected with human metabolic diseases, central nervous system diseases, and neoplasms.

206 measure of neuroinflammation in a variety of central nervous system diseases.

207 licated in depression, addictions, and other central nervous system disorders and, thus, is an import

208 disease in childhood resulting in widespread central nervous system dysfunction and premature death.

209 neous condition characterized by progressive central nervous system dysfunction in association with a

210 cated that cellular processes related to the central nervous system (e.g., neurogenesis, synaptic pla

211 zapine readily enters the brain and occupies central nervous system-expressed DREADDs, whereas system

212 lamic neuropeptide hormone oxytocin is a key central nervous system factor in the regulation of food

213 Eye abnormalities were correlated with central nervous system findings, microcephaly, and the t

214 microcephaly, and 8 (33.3%) did not have any central nervous system findings.

215 mical stimulation to targeted regions of the central nervous system for extended periods.

216 ys critical roles in successive steps of the central nervous system formation during embryonic and fe

217 o how the epitranscriptome helps orchestrate central nervous system formation.

218 te-synapse interaction is crucial for normal central nervous system functioning.

219 a role of GPR17 per se as an orchestrator of central nervous system functions, they challenge the uti

220 -exertional malaise suggests exercise alters central nervous system functions.

221 orm for multilevel analysis of the mammalian central nervous system generally.

222 the role of insulin-responsive GLUT4 in the central nervous system has not been well characterized.

223 In addition, while multiple cells within the central nervous system have been involved in the develop

224 nizing physiological effects of drugs in the central nervous system have led to exploring protein-bas

225 s that underlie recovery after injury of the central nervous system have rarely been definitively est

226 study demonstrate that HE is associated with central nervous system hemichannel dysfunction, with amm

227 ing HIV-1 envelope glycoprotein 120 in their central nervous system (HIVgp120tg) mount a transient IF

228 4A gene have been described in patients with central nervous system hypomyelination.

229 lated RNA and dipeptide repeats in the mouse central nervous system increases double strand breaks an

230 Central nervous system infection of neonatal and adult r

231 RTANCE Astroviruses are an emerging cause of central nervous system infections in mammals, and astrov

232 ement responsive to steroids (CLIPPERS) is a central nervous system inflammatory syndrome predominant

233 Patients with central nervous system injuries, injury requiring medica

234 ed (LIP) ultrasound on memory impairment and central nervous system injury in a rat model of vascular

235 nd weakness from birth with variable eye and central nervous system involvement.

236 erstanding of the processes occurring in the central nervous system is crucial to the development of

237 tural and functional motif of the vertebrate central nervous system is discrete clusters of neurons o

238 Axonal regeneration in the adult mammalian central nervous system is limited in part by the non-per

239 thesis that TMEM18 itself, acting within the central nervous system, is a plausible mediator of the i

240 istinguishes several cell types from the rat central nervous system, largely based on the relative pr

241 While myelin deficit of the central nervous system leads to several severe diseases,

242 ry tract and in phrenic motor neurons of the central nervous system led us to address the individual

243 e of the small size of most terminals in the central nervous system, little is known about the regula

244 In the mammalian central nervous system, Lpd contributes to neuronal morp

245 issue of JEM, Antila et al. demonstrate that central nervous system lymphatics develop in the mouse m

246 frequent responses in patients with primary central nervous system lymphoma but was associated with

247 ments, with a focus on preventing congenital central nervous system malformations.

248 uman tissues tested, and particularly in the central nervous system, many pathways are regulated at t

249 onal modifications (PTMs) reportedly tied to central nervous system maturation, myelin stability, and

250 5 and SLC4A10 expression and function in the central nervous system may affect the regulation of syst

251 ligible if they had symptomatic or untreated central nervous system metastases, had received anticanc

252 The control of the human body sway by the central nervous system, muscles, and conscious brain is

253 the ABCD1 gene and affecting peripheral and central nervous system myelin.

254 Whereas regulation of central nervous system myelination by GPR17 is well esta

255 ctor for oligodendrocyte differentiation and central nervous system myelination.

256 inductive interactions direct cells to form central nervous system (neural plate) or sensory placode

257 In the development of the Drosophila central nervous system, neuroblasts go through two phase

258 These cytokines regulate central nervous system neurons to induce sleep.

259 kyrin-G and coregulate membrane potential in central nervous system neurons.

260 ytosine modification that is abundant in the central nervous system of mammals and which results from

261 -deficient activated T cells to the inflamed central nervous system of mice with experimental autoimm

262 motor activity levels when injected into the central nervous system of mice.

263 of acute severe VZV infection affecting the central nervous system or the lungs in unrelated, otherw

264 ligoanuric renal failure, involvement of the central nervous system, or death), and interventions (ie

265 ood counteracts age-related changes in these central nervous system parameters, although the identiti

266 xamined multiple sclerosis lesions and other central nervous system pathologies with prominent myelin

267 inhibitors are systemic toxicity and limited central nervous system permeability.

268 etylcholine receptor (nAChR) is important in central nervous system physiology and in mediating sever

269 ms through which this environment influences central nervous system physiology.

270 oposide (950 to 450 mg/m(2)) and intrathecal central nervous system prophylaxis while omitting mainte

271 In vivo labeling of central nervous system proteins with stable isotopically

272 control over gastrointestinal functions, the central nervous system provides extrinsic neural inputs

273 icroglia coordinate various functions in the central nervous system ranging from removing synaptic co

274 erapy thus has potential in the treatment of central nervous system-related pathologies, such as Alzh

275 Blood pressure (BP) is regulated at the central nervous system, renal, and vascular levels, but

276 Here we show that primary cells from the rat central nervous system respond differently to photo-toxi

277 othesized that ARV-mediated ER stress in the central nervous system resulted in chronic dysregulation

278 ly in extravascular compartments such as the central nervous system, resulting in either cerebrospina

279 Overall, our central nervous system studies in Asah1(P361R/P361R) mic

280 n is actually elevated in the late embryonic central nervous system, suggesting that CFI might play a

281 chanistic understanding of GluD signaling at central nervous system synapses.

282 (antidepressants, antipsychotics, and other central nervous system-targeted medications) are increas

283 lial cell population in the mature mammalian central nervous system that is distinct from astrocytes,

284 herapeutic intervention into diseases of the central nervous system that require the expression of la

285 During development of the central nervous system, there is a shift in the subunit

286 This suggests the ability of the central nervous system to concurrently learn operating t

287 ies have targeted different sites within the central nervous system to restore motor function followi

288 put, originated from different levels of the central nervous system, to the different compartments.

289 S) is a chronic demyelinating disease of the central nervous system traditionally characterized by an

290 Central nervous system tuberculosis (CNS TB) has a high

291 maternal age increased risk of leukemia and central nervous system tumors, older paternal age was no

292 Here we test if a mechanism in the central nervous system underlies thermal TCE.

293 es of two neuronal classes in the C. elegans central nervous system, using VGLUT-pHluorin to monitor

294 g the drug delivery of macromolecules to the central nervous system via the intrathecal route.

295 ylase 11 (HDAC11) is highly expressed in the central nervous system where it has been reported to hav

296 R1) is abundantly expressed in the mammalian central nervous system, where it regulates intracellular

297 uids where DA is at low levels, e.g., in the central nervous system, which is the usual clinical prof

298 ce an acquired demyelinating syndrome of the central nervous system will have a monophasic disease co

299 t GEBR-32a is rapidly distributed within the central nervous system with a very favourable brain/bloo

300 e most common, though 1 case did involve the central nervous system with few symptoms.