ライフサイエンスコーパス: central region

1 r flexible and tightly anchored to the rigid central region.

2 n the far periphery and decreased toward the central region.

3 grow from the edge of the droplet toward the central region.

4 lving several unexpected triples formed at a central region.

5 uth Central region to 100% in the West North Central region.

6 as the disorder and flexibility in the ING4 central region.

7 cular depressions, often with pores in their central region.

8 se of recombination complexes to/from the SC central region.

9 th deletions of conserved amino acids in the central region.

10 e, with minimal effect on the N-terminus and central region.

11 uenced by the bubble passage compared to the central region.

12 r relative order are highly conserved in the central region.

13 oA-I while the other five mAbs recognize the central region.

14 a cluster of electrodes located in a fronto-central region.

15 eactive to each protein are found within its central region.

16 nd 96 (1.5%) for disease of 6581 in the East Central region.

17 the northwest and 457 of 6082 (7.5%) in the central region.

18 ative diagnostic MR criterion of FCD2 in the central region.

19 istal ends, and a maximum loss of 39% in the central region.

20 ly foci form along synaptonemal complex (SC) central regions.

21 ssures in the South, Mediterranean, and some central regions.

22 ns a disproportionate share of topologically central regions.

23 al (high-frequency) areas terminated in more central regions.

24 uter parts, indicating ongoing growth of the central regions.

25 peared to gain dominance across northern and central regions.

26 gion (2.18, 1.44-3.28) and 41% higher in the central region (1.41, 0.99-2.01) than in the eastern reg

27 ) with automated static perimetry within the central regions (+/-15 degrees ) examined with SD OCT.

28 Here we show that the central region (213 residues) of chicken INCENP is not a

29 Deletion of the central region ((676)I-W(760)) of AgAPN2tb eliminated it

30 a combination of three attributes of the SC central region: a CO-promoting activity that functions l

31 is weakly associated with the membrane and a central region acting as a sensor of the lipid propertie

32 ransfer of stem cells between the border and central regions, all Lgr5(+) cells are endowed with long

33 ross-links with Raptor were clustered in the central region (amino acid residues 56-72) we call RCR (

34 B pathway by forming a stable complex with a central region (amino acids 150-272) of the inhibitor of

35 ings) with histologically proven FCD2 of the central region and 44 control subjects on the basis of a

36 es is governed by two regions that flank the central region and are structurally more variable.

37 s, and type 2 BMLs, which encompass both the central region and either the medial or the lateral comp

38 facilities in the Federal Capital Territory, central region and in Kano, northwest Nigeria.

39 oboration for cooperative assembly of the SC central region and indicates that SYP-1 preferentially a

40 ctional, with more growth contributed by the central region and less growth at either end.

41 hered state, whereas the largely hydrophobic central region and part of the carboxy (C)-terminal hydr

42 at contain residues 17-23 (LVFFAED) from the central region and residues 30-36 (AIIGLMV) from the C-t

43 vestigation of two key regions of Abeta: the central region and the C-terminal region.

44 tutions induce structural instability in the central region and the overlapping ends of Tm, respectiv

45 llel pairs of C(3)G homodimers that span the central region and thus for assembly of complete TFs, wh

46 cture comprising both highly inter-connected central regions and sparsely connected peripheral region

47 were phase coupled to theta oscillations in central regions and to alpha oscillations in right parie

48 dynamically coupled hydration changes of the central region, and conformational changes of Glu(in) an

49 ded by multiple genes that share a conserved central region, and epitope mapping revealed T-cell epit

50 e Aalpha and Bbeta chains extending from the central region, and the short gamma chain "tail" extendi

51 tern region of China than in the eastern and central regions, and injury was a main cause of death in

52 That is, these mutations in the central region appeared to destroy the communication bet

53 r N-terminal conserved domain and the 4E-BP1 central region are closely located, we found that peptid

54 Several different deletions spanning the central region as well as three disease-associated point

55 and bottom interfaces of the films while the central regions behave similarly to the bulk with a clea

56 pate in pore formation, the role of the YopD central region between amino acids 150-227 remains unkno

57 urfaces; cavitation is localized in a narrow central region between the dimers, where an apolar amino

58 The protein is localized by a central region between the N-terminal COBL domain and th

59 nd its regulators INCENP and TD60, whereas a central region binds MCAK, Kif2a, and microtubules, sugg

60 owever, preferentially be found today in the central regions ('bulges') of galaxies, because they for

61 ure has already formed in the N-terminal and central regions but not in the C-terminal region.

62 abolish the barrier to transcription in the central region by decreasing the local wrapping rate.

63 ranscriptional activation domain of ZLD to a central region characterized by low complexity.

64 end of lower endothelial cell density in the central region compared with the peripheral region.

65 Here, we identify a novel role for a central region component of the SC, SYP-4, in negatively

66 We find that SYP-2, a SC central region component, is a potential target for MPK-

67 e X similarly to paired chromosomes, but the central region component, SYP-1, is not loaded on the X

68 tinin-4-binding site on eNOS was mapped to a central region comprising the calmodulin-binding domain,

69 Abs to juxtamembrane and central region constructs were both DR4 associated.

70 single-stranded DNA oligomers composed of a central region containing (SNS)6 or (ANi)5 covalently at

71 (Pol) I and RNA Pol II in yeast through its central region containing conserved NusG N-terminal homo

72 The central region contains five domains and is important fo

73 At all ages we observed SEPs over central regions contralateral to the stimulated hand.

74 nsory afferent traffic as well as input from central regions controlling sympathetic nerve activity,

75 pectedly, the increased proliferation in the central region corresponded to a trend of lower endothel

76 ism is cardiac muscle troponin T (cTnT), the central region (CR) and the T2 region of which differ si

77 cifically the hydrophobic domain (HD) or the central region (CR).

78 emonstrate that Rictor contains two distinct central regions critical for mTORC2 function.

79 teraction with APC, CD28 is recruited to the central region (cSMAC) of the immunological synapse.

80 rminal domain favoring alpha(t), whereas the central region demonstrated a preference for Palphabeta.

81 e data indicate that activin residues in the central region determine its specificity toward type I r

82 Further deletion of the conserved central region diminished binding to tropomyosin.

83 d and coastal subpopulations, separated by a central region dominated by A. coluzzii.

84 model, where the numerator originates from a central region driving the neuron and the denominator or

85 YP-1, a major structural component of the SC central region, during meiosis in Caenorhabditis elegans

86 in the N-terminal leader and throughout the central region encoding the AIP signal.

87 receptive field structure: an OFF-dominated central region flanked by ON-dominated subfields.

88 als that the D-loop is ordered and acts as a central region for hydrophobic and electrostatic interac

89 The central region forms a flexible domain with two antipara

90 euronal projections within a collagen-filled central region, generating 3D neural networks with struc

91 The central region (harboring nucleoporin-binding sites) reg

92 r compensates for mismatches, pairing to the central region has been known to function only at rare s

93 quitin ligase activity that is mediated by a central region homologous to mammalian U-box domains.

94 outh-Central region to 607 in the East North-Central region in 2002 (93.2% higher; P < .001).

95 e II fibrocytes in the spiral prominence and central region in the cochlear lateral wall.

96 We identified a conserved central region in the SidE proteins that was sufficient

97 osing gradients are matched, cells home to a central region in which the signals from multiple chemok

98 sory integration was evident in central/post-central regions in both hemispheres as well as midline s

99 apy (ART) clinics in the southwest and north central regions in Nigeria.

100 persistent activation in medial frontal and central regions in patients.

101 Region A, the central region including the foveal center, had normal O

102 In particular, while the central region including the H3-H3' interface retains a

103 Neurodegeneration within central regions involved in odour perception may contrib

104 imarily at dendritic tips but also from more central regions, involves adhesion to the keratinocyte,

105 Previous studies have shown that its central region is essential for function even though its

106 By contrast, cell proliferation in the central region is minimally affected by MAPK1 deletion.

107 ghly extended, we show that flexibility in a central region is required for GCC185's ability to funct

108 the present pattern of a seismically active central region linked to more aseismic areas in the nort

109 y with the N-terminal EC domain, whereas the central region makes contacts to both the N-terminal and

110 In addition, the central region mediated binding to phosphatidylinositol

111 ults further highlight the importance of the central region near binding site S(2) in the selectivity

112 First, the central region of (CAG)(8) is more solvent-exposed than

113 tial feature of UL36 is the existence in its central region of a stalk capable of connecting capsid a

114 inhibited by specific antibodies against the central region of Abeta and by naturally occurring p3 pe

115 containing residues 17-23 (LVFFAED) from the central region of Abeta and residues 30-36 (AIIGLMV) fro

116 ot previously observed for the amyloidogenic central region of Abeta.

117 We identified the central region of Abeta42 as the most critical region fo

118 e we report that two of these located in the central region of Acm1 constitute a pseudosubstrate sequ

119 e ubiquitination, these same elements in the central region of Acm1 prevent ubiquitination.

120 rafts are identified histochemically in the central region of adhered platelets where fibrin and myo

121 In contrast, point mutations in the central region of alpha-synuclein, referred to as nonamy

122 ion and map two LC8-binding sites within the central region of Ana2, Ana2M (residues 156-251).

123 (vii) Certain mutations in the central region of ATase appeared to dramatically improve

124 Thus, cytotoxic immune synapses include a central region of bidirectional vesicular traffic, which

125 The central region of both Las17 and WASP is rich in proline

126 Chandler from the central region of Chile were evaluated.

127 also analyzed the replication dynamics of a central region of chromosome 1 in procyclic forms.

128 ure of the proton transport mechanism in the central region of ClC-ec1 at a molecular level.

129 e used to study proton transport through the central region of ClC-ec1, a widely studied ClC transpor

130 Simultaneously, a central region of complete outer-fluid displacement grow

131 opy on several constructs, one including the central region of CSP, which is rich in NANP amino acid

132 uch that the far medial LPMR projects to the central region of DCS (projection area of AGm) and the c

133 The central region of dorsocentral telencephalon (DC(core) )

134 duced Smo signaling, whereas deletion of the central region of EC2 renders Smo fully active, suggesti

135 we show that 14-3-3 proteins interact with a central region of Exo1 and negatively regulate Exo1 dama

136 pts, and increased H3K4 dimethylation in the central region of FLC.

137 , Ca(V)2-containing organelles reside in the central region of growth cones, but are absent from dist

138 tion complexes of positions (+)7/(+)8 to the central region of h28, (+)4/(+)5 to rpS15(S19p), and (-)

139 The sirtuin proteins contain a central region of high sequence conservation that is req

140 A segment of the central region of Hsl1 (residues 611-950), composed of t

141 The central region of INCENP has been proposed to comprise a

142 tion) was calculated electronically within a central region of interest.

143 ted with the source or a location within the central region of its host galaxy.

144 Rab6 binding occurred through the central region of LidA and followed a stoichiometry for

145 ulates a second-site interaction between the central region of MDM2 and MDMX, and thus increases MDMX

146 nuclear Mpp6 exosome bound to RNA shows the central region of Mpp6 bound to the exosome core, positi

147 Antibodies to the polymorphic central region of MSPDBL2 were associated with reduced r

148 We present genetic data implicating the central region of mu1 in altering the cell attachment pr

149 acetylcholine receptors are clustered in the central region of muscle before and independently of inn

150 nt Wnt pathway, may guide motor axons to the central region of muscle fibers for synapse formation in

151 sing site was mapped to aspartate-135 in the central region of MyD88.

152 as well as on the serine- and arginine-rich central region of N, which binds nsp3.

153 omain to the reported consensus motif in the central region of ORF45.

154 ition, we determined a critical role for the central region of Pan1 in endocytosis and viability.

155 PDLP5 was found to localize at the central region of PD channels and associate with PD pit

156 Although flexibility is decreased in the central region of phospho-PAGE4, the polypeptide chain r

157 The central region of Pirh2 harbors a RING finger domain tha

158 ent with these results, the integrity of the central region of pny pnf SAMs can be partially restored

159 s have unacceptable eradication rates in the central region of Portugal and cannot be used, according

160 ated with failure of these treatments in the central region of Portugal.

161 alysis and site-directed mutations, that the central region of PP1c beta confers the isoform-specific

162 The central region of PrgI forms an alpha-helical hairpin, w

163 Mutations within the central region of prion protein (PrP) have been shown to

164 pendent on residues in the largely invariant central region of Pro1.

165 complexes with N-GDS, Akt complexes with the central region of RalGDS through an intermediary, JIP1.

166 HEG1 binds to a central region of Rasip1 and deletion of this domain eli

167 ystal structure of Sus1 and Cdc31 bound to a central region of Sac3 (the CID domain) that is crucial

168 rometry, methionine residues in the Met-rich central region of SspB were shown to be oxidized by H(2)

169 (71-98), were synthesized with Ala-d3 in the central region of the alpha-helix.

170 + MACR concentrations are reported over the central region of the Amazon basin during the wet season

171 ructure of mammal species cooccurring in the central region of the Atlantic Forest.

172 a(2+) signals did not fully propagate to the central region of the cell.

173 r hand, it was elevated significantly in the central region of the cell.

174 x treated and control cells showed up in the central region of the cells and were related to lipid pe

175 ter (low bond length alternation) around the central region of the chain.

176 late around epithelial tubes residing in the central region of the developing pancreas (associated wi

177 s and C terminus of gB and especially in the central region of the ectodomain reduced cell fusion act

178 nt between genotype A and D was found in the central region of the endemic areas, where three SFTSV g

179 hed by the N-acetylglucosamine moiety in the central region of the enzyme binding cleft.

180 oss of chondrocytes and growth arrest in the central region of the epiphyses.

181 Thus, protein interactions with the central region of the fatty acyl chain optimize GCAP1 bi

182 utations are localized in the N-terminal and central region of the gene, leading to nonsense-mediated

183 oma galaxy clusters, which together form the central region of the Great Wall--the largest local stru

184 In solution, the central region of the H3 segment is positioned close to

185 ize to peripheral arms but do not occupy the central region of the hexamers.

186 The central region of the human retina, the fovea, provides

187 ith Abs to an epitope located in the 831-862 central region of the IA-2 tyrosine phosphatase domain.

188 this study to assess 2 types of BMLs in the central region of the knee (type 1 BMLs, which are relat

189 The central region of the LacI N-subdomain monomer-monomer i

190 f magnitude more weakly than that across the central region of the layers.

191 ole in controlling cell proliferation in the central region of the lens epithelium.

192 Multipolar Purkinje cells are located in the central region of the lobe, with large, multipolar, spin

193 rast, we observed robust GATA-3 binding to a central region of the locus where DNase hypersensitivity

194 The central region of the MapA protein had similarity to pas

195 trategy for the key cyclization to forge the central region of the molecule, ring C.

196 nned residues 282 to 291 (GLSSKSPYSS) in the central region of the molecule.

197 ntramolecularly with each other and with the central region of the molecule; in fibrin, the alphaC-do

198 ect sarcolemmal sites often localized to the central region of the muscle fibers.

199 of the viral N-RNA complex suggests that the central region of the N protein interacts with the viral

200 In murine polyomavirus, the central region of the origin contains four copies (P1 to

201 observed between MCV OBDs when bound to the central region of the origin.

202 HLA-B*35:08(LPEP) similarly, straddling the central region of the peptide but making limited contact

203 A phylogenetically conserved central region of the protein is critical for wild-type

204 no acid substitutions, pinpointed to a small central region of the protein that is required to trigge

205 tary structural techniques, we show that the central region of the protein, encompassing amino acids

206 on of HCPro involved in this function in the central region of the protein.

207 unexpected features, including a disordered central region of the PulG helical stem, and highly flex

208 , the region of highest visual acuity in the central region of the retina.

209 t in the periphery and was infrequent in the central region of the retina.

210 slocation to become more concentrated in the central region of the RPE cells.

211 ilizing the SC in pachytene by switching the central region of the SC from a more dynamic to a less d

212 span a gap between cohesin complexes and the central region of the SC, consistent with their essentia

213 how these SYP proteins are organized in the central region of the SC.

214 Here, we show that the conserved central region of the second variable loop (V2) of gp120

215 oluene or single base pair mismatches in the central region of the sense strand (9-12 nt), significan

216 modulate the toxic activity displayed by the central region of the SidE protein.

217 y inducing conformational changes within the central region of the stalk, which, in turn, promote fus

218 elial cell entry, on a prominent loop in the central region of the structure.

219 Here we report that the central region of the supernova remnant SNR 0509-67.5 (t

220 ulates the redistribution of CARD11 from the central region of the synapse to a distal region.

221 3, and SYP-4) have been proposed to form the central region of the synaptonemal complex (SC) thereby

222 In early pachytene Vilya localizes along the central region of the synaptonemal complex and to discre

223 were involved in these interactions, but the central region of this protein, which contains a repetit

224 The central region of Tim23, which enters the intermembrane

225 show that the structural instability in the central region of Tm modifies cardiac contractile functi

226 hesis that the structural instability in the central region of Tm modulates the function of the overl

227 The S229E-induced instability in the central region of Tm(DM) altered the overlapping ends of

228 the cryo-electron microscopy structure of a central region of TPX2 bound to the MT surface.

229 ta3 at the C terminus and alphaVbeta5 at the central region of tropoelastin.

230 ed trial, we included primary schools in the central region of Uganda that taught year-5 children (ag

231 re of the skyrmion core, identifying a 25 nm central region of uniform magnetization followed by a la

232 These phenotypes require the central region of USP8, containing three extended Arg-X-

233 The central region of vIRF4 is required for its interaction

234 i (STEC) sampled from 104 dairy units in the central region of Zambia and compared these with isolate

235 dium and commercial-sized dairy farms in the central region of Zambia and its relationship to antibio

236 HF), a potentially deadly disease endemic to central regions of Argentina.

237 The central regions of blue counter-rotators show younger st

238 s a larger involvement of the N-terminal and central regions of CaM in this interaction.

239 In contrast, central regions of carcinomas exhibit elevated tissue fl

240 ation of new material occurred mainly in the central regions of cells and was significantly lower in

241 ryon deficiency is typically observed in the central regions of clusters ( approximately 0.5 the viri

242 salt bridges composed of the N-terminal and central regions of each tau monomer, with the C-terminal

243 ejecting large amounts of cold gas from the central regions of galaxies, thereby strongly affecting

244 dary ossification centers do not form in the central regions of Has2 mutant growth plates owing to a

245 Well-defined RNA structures in the central regions of HCV genomes appear to facilitate pers

246 Spinal and central regions of interest (ROI) included the bilateral

247 d during senescence, preferentially from the central regions of lamina-associated domains (LADs), whi

248 n of the centered site type help explain why central regions of many miRNAs are evolutionarily conser

249 In comparison with the central regions of primary PTCs, the invasive fronts ove

250 e different velocities of myosin V motors in central regions of S2 cells, suggesting regional control

251 utic delivery to otherwise poorly accessible central regions of solid tumors.

252 region of origin (northern, northeastern or central regions of Thailand).

253 taples are located in the flattened, stacked central regions of the cisternae, the soluble aggregates

254 surprisingly well tolerated in the seed and central regions of the guide strand and increase the sil

255 mponents of the dense, high refractive index central regions of the lens and generally have high solu

256 .198 Hz were stronger in the peripheral than central regions of the malignant tumours; however, no su

257 re found to interact with the N-terminal and central regions of the monomeric protein although with d

258 rial myoctes and were detected more often in central regions of the non-junctional SR compared to nor

259 the nasal, temporal, inferior, superior, and central regions of the posterior pole in 83%, 75%, 67%,

260 e initial Kruppel (Kr) expression pattern in central regions of the precellular embryo.

261 the C- to the N-terminal end and hydrophobic central regions of the protein relative to human aS.

262 al biophysical properties of residues within central regions of the putative TM helices.

263 Surprisingly, Muller glia in central regions of the retina express Pax2, and levels o

264 specifically localize to the peripheral and central regions of the SAM were examined in Arabidopsis

265 t tumor vessel maturation in RB initiates in central regions of the tumor and radiates toward the per

266 Some auras propagated from peripheral to central regions of the visual field-these typically foll

267 cells in the invasive areas, but not in the central regions of these tumors.

268 helial outgrowths of the dorsal otocyst, the central regions of which fuse and resorb to leave three

269 (vi) Certain point mutations in the central region or an internal deletion removing most of

270 uth of the country versus 3.91% in the north central region [P < 0.01]).

271 were drawn on the T1WI image in the tumours' central regions, peripheral regions and neighbouring tis

272 artial depletion of the synaptonemal complex central region proteins attenuates crossover interferenc

273 domains: an N-terminal BTB/POZ domain and a central region recruiting CtBP and NuRD complexes.

274 P with a deletion of residues 105-125 in the central region (referred to as DeltaCR PrP) provide impo

275 lected sequence changes in the p55 domain, a central region required for binding of the toxin to host

276 e-function analysis of Mrc1 also uncovered a central region required for proper mediator function and

277 We identified a central region (residues 85 to 221) in the Guanarito vir

278 of intermolecular disulfide bonds within the central region (residues 91-115) of the morbillivirus H-

279 ing several different point mutations in the central region that cause familial prion diseases in hum

280 ular interaction between the RING domain and central region that regulates MDMX nuclear import.

281 They contain a unique, 80-kDa central region that shares no homology with other protei

282 trial hurricanes: cyclonic circulation, warm central region (the eye) surrounded by a ring of high cl

283 This central region therefore becomes more compact and more n

284 taroline ranged from 96.7% in the West South Central region to 100% in the West North Central region.

285 y region, ranging from 314 in the East South-Central region to 607 in the East North-Central region i

286 elical coiled-coil regions, which bridge the central region to each distal region, were also well pro

287 Therefore, the ability of the YopD central region to facilitate optimal effector protein de

288 ucleus: this was heaviest laterally, and the central region was generally zebrin negative.

289 ly, SidJ did not suppress toxicity when this central region was produced in yeast.

290 When the orientation of the central region was reversed with respect to these flanki

291 In 1 region (Central Region) we surveyed the same 100 randomly select

292 lar specialist, and living in the East North Central region were associated with greater rates of pre

293 pecimen geometry so that stresses within the central region were concentrated and homogenous while mi

294 ECs and an increase in distensibility in the central regions when measured using small indentations.

295 moderately cross-linked bundles, but in the central region, where tethering loses its effect, featur

296 on in the dense environment of the cluster's central regions, where second-generation stars form.

297 e (alpha(t)GTPgammaS) in comparison with the central region, whereas an opposite pattern was observed

298 st was climatically unstable relative to the central region, which served as a large climatic refugiu

299 h a preferential distribution of body fat in central regions, which does not, however, seem to influe

300 volume-spanning gels at low density, whereas central regions with higher average valence gel at highe