ライフサイエンスコーパス: central role

1 suggest that local inhibition often plays a central role.

2 n, in which metal-ligand cooperation plays a central role.

3 ing whether the umbrella effect is playing a central role.

4 endothelial inflammation is stated to play a central role.

5 (Figure 1 ) at the molecular level play such central roles.

6 The hedgehog (Hh) signaling pathway plays a central role during embryonic development, and its aberr

7 arily conserved from yeast to humans, play a central role during transcription initiation.

8 ins in Alzheimer's disease, which suggests a central role for alpha-synuclein toxicity in neurodegene

9 These data support a central role for ANO1 and CavL in the generation of SWs

10 B cell-deficient (microMT) mice, we reveal a central role for B cell-derived IL-4 and IL-4Ralpha in t

11 Here we demonstrate a central role for capillary endothelial cells in sensing

12 activating adaptor protein kindlin-2 plays a central role for cell adhesion and membrane protrusion b

13 rectional modulation of dyskinesia reveals a central role for CK2 in striatal physiology and indicate

14 New studies recently highlighted a central role for IFN-Is in orchestrating an immunoregula

15 and experimental analyses have identified a central role for IgE/FcepsilonRI/mast cells in promoting

16 ential expression of enhancer RNAs pointed a central role for Kruppel-like factor, MEF2C, ETS, NFY, A

17 itive energy balance, suggesting a potential central role for Lin28a in metabolism regulation.

18 Here we found a central role for major histocompatibility complex (MHC)

19 The results highlight a central role for MC1R palmitoylation in pigmentation and

20 D1b expression in TB granulomas and reveal a central role for meromycolate chains in influencing GEM-

21 Several lines of evidence support a central role for microglia in these processes.

22 In different animal models, we find a central role for mitochondrial dysfunction, and for impa

23 over the past two decades has established a central role for mTOR in regulating many fundamental cel

24 e findings support a previously unrecognized central role for MUC1-C in integrating PD-L1 activation

25 cytometry, and modular analysis suggested a central role for neutrophils and Natural Killer (NK) cel

26 ppocalcin cellular functions which suggest a central role for perturbed calcium signalling in DYT2 dy

27 f critical pertussis is characterized, and a central role for pertussis toxin (PT) is described.

28 nvolved in ciliary functions, confirming the central role for primary cilia in Hh signaling.

29 A wealth of in vitro data has demonstrated a central role for receptor ubiquitination in endocytic so

30 ORC1 pathway, and we uncover an unexpectedly central role for SLC38A9 in amino acid homeostasis.

31 tate during mucin degradation and revealed a central role for the extracellular proteases LasB and Ap

32 The discovery of the central role for the IL-23/type 17 T-cell axis in the de

33 I propose that there remains a central role for the item (or its equivalent) in a wider

34 These findings reveal a central role for the production of IL-6 by APC during in

35 ired for placental development, suggesting a central role for these microRNAs in the evolution of pla

36 pendent nucleolar stress response supports a central role for this nuclear structural protein in cell

37 suggests that organic radicals have played a central role in a gas-phase organosynthesis.

38 Hydrogels play a central role in a number of medical applications and new

39 (casp-9) is an initiator caspase and plays a central role in activating apoptotic cell death.

40 The initial Q reduction step plays a central role in activating the proton pumping machinery.

41 gnaling by Toll-like receptor 4, which has a central role in Ad pathogenesis and is known to be tight

42 g of amyloid precursor protein (APP), play a central role in AD pathogenesis.

43 Considering its central role in adaptation to nutritional stresses, we h

44 Ionic radii play a central role in all branches of chemistry, in geochemist

45 The antibody IgE plays a central role in allergic disease mechanisms.

46 forestry, and other land use (AFOLU) plays a central role in ambitious climate change mitigation effo

47 Despite their central role in amino acid sensing, it is unknown why th

48 P-TEFb (CDK9/cyclin T) plays a central role in androgen receptor (AR)-mediated transact

49 arily conserved brain structure that plays a central role in aversive processing and is hypothesised

50 SecA ATPase motor protein plays a central role in bacterial protein transport by binding s

51 The sensor-regulator hybrid SagS plays a central role in biofilm development by enabling the swit

52 surface charge, density, and porosity play a central role in biological interactions and hence accura

53 Mitochondrial calcium (mCa(2+)) has a central role in both metabolic regulation and cell death

54 ing survival in this forest but also plays a central role in buffering or exacerbating impacts of cli

55 Hypoxia plays a central role in cancer progression and resistance to the

56 Multimodality cardiovascular imaging plays a central role in caring for patients with congenital hear

57 Given its central role in cell biology, there is significant inter

58 upport an emerging view that flagella play a central role in cell division among protists that lack m

59 ial homologue of eukaryotic tubulin, plays a central role in cell division in nearly all bacteria and

60 tions involve the mitochondria, which play a central role in cellular energy production and homeostas

61 The human papillomavirus (HPV) plays a central role in cervical carcinogenesis and its oncogene

62 Electrocatalysis plays a central role in clean energy conversion, enabling a numb

63 homeostasis and immunity, play a complex but central role in condition dependence and resource costs

64 c input within the inferior olive may play a central role in control of olivo-cerebellar climbing fib

65 ving receptors for axon guidance cues play a central role in controlling growth cone behaviour.

66 cription activity of target genes and play a central role in controlling the transcription in respons

67 FICANCE STATEMENT The olfactory bulb plays a central role in converting broad, highly overlapping, se

68 Hence, our results show that the EC plays a central role in coordinating endogenous and environmenta

69 e surface of immersed charged solids plays a central role in countless natural and industrial process

70 They play a central role in Cu homeostasis by pumping Cu ions across

71 These findings demonstrate that SZT2 has a central role in dictating GATOR-dependent nutrient sensi

72 The intestine plays a central role in digestion, nutrient absorption and metab

73 ider whether vascular changes instead play a central role in disease pathogenesis, rather than repres

74 Nucleoside diphosphate kinases (NDKs) play a central role in diverse cellular processes using the can

75 Glycogen synthase kinase 3 (GSK3) plays a central role in diverse cellular processes.

76 RAD51, a multifunctional protein, plays a central role in DNA replication and homologous recombina

77 dium spiny neurons (iMSNs), because of their central role in dopamine circuitry.

78 Mitochondrial trafficking plays a central role in dorsal root ganglion (DRG) neuronal cell

79 sults provide evidence that SOX5/6/21 play a central role in driving a tumor suppressor response in b

80 oxide (NO)-cGMP bioavailability as playing a central role in each of these abnormalities.

81 Accumulation of excess glutamate plays a central role in eliciting the pathological events that f

82 Chiral ligands play a central role in enantioselective transition-metal cataly

83 The ESCRT-III core protein Shrub has a central role in endosome-to-multivesicular body membrane

84 h-factor-inducible TFs FOS/JUN (AP-1) play a central role in enhancer selection.

85 Mitochondrial flashes have a central role in ensuring that ATP levels remain constant

86 es, mediated in Arabidopsis by MET1, plays a central role in epigenetic inheritance, we examined geno

87 ithin and between brain regions and serves a central role in establishing complex and adaptive cognit

88 explain how the transcript length may play a central role in establishing ribosome recruitment and th

89 Pancreatic lipase (PL) plays a central role in fat metabolism and is a validated target

90 s an attractive therapeutic target given its central role in formation of sebum, a key factor in acne

91 Glioma stem cells (GSCs) have a central role in glioblastoma (GBM) development and chemo

92 Clearly, plastids play a central role in governing carotenogenic activity, carote

93 nication between neighboring tissues plays a central role in guiding organ morphogenesis.

94 nd factor (VWF), a multimeric protein with a central role in hemostasis, has been shown to interact w

95 c protein (BMP)-SMAD signaling pathway has a central role in hepcidin transcriptional regulation.

96 , particularly the intestinal biota, plays a central role in host physiology, and the composition and

97 the notion that alternative splicing plays a central role in human genome evolution, and possibly hum

98 rvous system control of inflammation plays a central role in hypertension.

99 Transcription factor NF-kappaB plays a central role in immunity from fruit flies to humans, and

100 se in vivo Our study shows that BRD4 plays a central role in inflammation and activation of the IRF7-

101 The gut microbiome plays a central role in inflammatory bowel diseases (IBDs) patho

102 Myeloperoxidase plays a central role in initiation and progression of vascular i

103 This assigns platelets a central role in innate immune responses and identifies t

104 are extracellular vesicles (EVs) that play a central role in intercellular signaling in mammals by tr

105 ll with the notion that these regions play a central role in language processing.

106 The liver plays a central role in lipid metabolism, and impaired response

107 Because the second messenger cGMP exerts a central role in LTP mechanisms, here we studied whether

108 receptor (FcRn) has been suggested to play a central role in maintaining high albumin plasma levels t

109 intracellular iron availability and plays a central role in maintaining iron homeostasis in Bacillus

110 Immunometabolism plays a central role in many cardiometabolic diseases.

111 Glycans play a central role in many essential biological processes.

112 are known for their elaborate behaviors and central role in many foodwebs.

113 (PMd) and primary motor (M1) cortices play a central role in mapping sensation to movement.

114 We hypothesized that ER plays a central role in mechanosensing of atherosusceptible shea

115 Amid this progress, imaging has assumed a central role in metastatic surveillance and follow-up of

116 cytoplasmic dynein-1 (dynein) motor plays a central role in microtubule organisation and cargo trans

117 In conclusion, Ohr plays a central role in modulating the levels of fatty acid hydr

118 the signature identified herein could play a central role in monitoring inflammatory disorders and th

119 REM2) is an immunomodulatory receptor with a central role in myeloid cell activation and survival.

120 The human reference genome assembly plays a central role in nearly all aspects of today's basic and

121 The t-SNARE complex plays a central role in neuronal fusion.

122 l systems, i.e. the connectome, has gained a central role in neurosciences.

123 Uncoupling protein 1 (UCP1) plays a central role in nonshivering thermogenesis in brown fat;

124 lutionarily conserved Arp2/3 complex plays a central role in nucleating the branched actin filament a

125 Direct band-gap semiconductors play the central role in optoelectronics.

126 Site-specific histone ubiquitylation plays a central role in orchestrating the response to DNA double

127 (ASE) in interspecific hybrids has played a central role in our understanding of a wide range of phe

128 e A is an essential metabolite known for its central role in over one hundred cellular metabolic reac

129 Dendritic cells (DCs) and monocytes play a central role in pathogen sensing, phagocytosis, and anti

130 including a core of common genes that play a central role in pathological inflammation.

131 those of charge, energy and momentum, have a central role in physics.

132 it of the PAR protein network, which plays a central role in polarizing a broad range of animal cell

133 Platelets play a central role in primary hemostasis by forming aggregates

134 region of the brain called the putamen has a central role in procedural memory consolidation during s

135 BRD4 plays a central role in promoting the expression of select subse

136 ligand dyad in endothelial cells (EC) has a central role in promoting vascular inflammatory response

137 ring a node with a high centrality to play a central role in propagating the dynamics of the system b

138 oral and heteromodal insular cortices have a central role in propagating these neural instructional s

139 Despite its central role in protein degradation little is known abou

140 Spatial sequestration plays a central role in protein quality control and cellular fit

141 Its central role in regulating glycolysis in human sarcomas

142 lipid antigens presented by CD1d and play a central role in regulating immunity and inflammation in

143 /AKT/GSK3beta/beta-catenin/MITF axis plays a central role in regulating melanogenesis.

144 factor ICP4 from herpes simplex virus has a central role in regulating the gene expression cascade w

145 structure of a potassium channel that has a central role in regulating the release of insulin from t

146 The nervous system plays a central role in regulating the stem cell niche in many o

147 24 h) system has a central role in regulating the timing and coordination o

148 The amygdala may, therefore, play a central role in RL.

149 ll nuclear ribonucleoprotein (snRNP) plays a central role in RNA polymerase II elongation control by

150 bacteria, the conserved protein RapZ plays a central role in RNA-mediated regulation of amino-sugar m

151 tiotemporal variations are thought to play a central role in sculpting embryonic tissues, maintaining

152 The medial prefrontal cortex, which has a central role in self-appraisal processes, is often impli

153 es prohibiting illegal drug use could have a central role in shaping health outcomes among people who

154 e tertiary structure, but nonetheless play a central role in signaling, utilizing a process known as

155 he Rho family (RhoA, Rac1, and Cdc42) play a central role in SMC functions including migration, proli

156 Chemical communication plays a central role in social, sexual and ecological interactio

157 Ceramide, which serves a central role in sphingolipid metabolism, is generated by

158 Genetics plays a central role in susceptibility to obesity and metabolic

159 traction indicated that ANO1 and CavL have a central role in SW generation, phasic contractions and t

160 rotein quality-control regulator to having a central role in systemic energy sensing and for metaboli

161 Paleolimnology played a central role in the Acid Rain debates, as it was instrum

162 Thus, adult neurogenesis plays a central role in the adaptive changes resulting from expe

163 fic S1 serine protease factor D (FD) plays a central role in the amplification of the complement alte

164 Here we show that Al toxicity plays a central role in the antibacterial action of a kaolin-ric

165 ntracellular signaling molecule that plays a central role in the biofilm life cycle.

166 IKKbeta plays a central role in the canonical NF-kB pathway, which has b

167 They have a central role in the cell multiplication decision and in

168 tein (Pgp; also known as ABCB1), which has a central role in the clearance of xenobiotics and in canc

169 port) is a multiprotein complex that plays a central role in the coordination of synthesis, processin

170 nd the pentose phosphate pathway both play a central role in the degradation of glucose in all domain

171 growing evidence that KCC2 dysfunction has a central role in the development and severity of the epil

172 rovascular injury in the distal lung plays a central role in the development of lung injury following

173 These features play a central role in the development of more severe disease c

174 Alzheimer's disease (AD), whether it plays a central role in the disease and if so how has remained u

175 le sclerosis brain and are thought to play a central role in the disease process.

176 Autophagy plays a central role in the DNA damage response (DDR) by control

177 ction as the cellular power plant and play a central role in the early stages of programmed cell deat

178 The rumen has a central role in the efficiency of digestion in ruminants

179 scriptional control of Aux/IAA genes plays a central role in the establishment of the auxin-signaling

180 llagen prolyl 4-hydroxylases (C-P4Hs) play a central role in the formation and stabilization of the t

181 Noncoding regulatory variants play a central role in the genetics of human diseases and in ev

182 Social values and concepts have played a central role in the history of mental health care.

183 Type I interferons (IFNs) play a central role in the immune defense against viral infecti

184 treatment in HDLECs was miR-155, which has a central role in the immune system and cancer.

185 Halogen chemistry plays a central role in the industrial manufacture of various im

186 Toll-like receptors play a central role in the initiation of adaptive immune respon

187 In Escherichia coli, FtsLB plays a central role in the initiation of cell division, possibl

188 re, the sodium-hydrogen exchanger may play a central role in the interplay of diabetes mellitus and h

189 s to MT regulatory proteins, not only play a central role in the intracellular transport of virus par

190 Predation plays a central role in the lives of most organisms.

191 al mitochondria through mitophagy may play a central role in the loss of mitochondrial proteostasis i

192 hat myosin light chain kinase (MLCK) plays a central role in the LPS-induced increase in TJ permeabil

193 rbing multinucleated osteoclasts that play a central role in the maintenance and repair of our bones

194 tyl coenzyme A synthase (ACS) enzyme plays a central role in the metabolism of anaerobic bacteria and

195 The 2,2'-spirobis[chromene] species plays a central role in the network of chemical reactions connec

196 tantly, we show planktivorous fish to have a central role in the North Sea food web initiating comple

197 metal-oxide-semiconductor materials plays a central role in the operation of high-speed electronic d

198 Membraneless organelles play a central role in the organization of protoplasm by concen

199 Although it has a central role in the pathogenesis of AD, knowledge of the

200 Type 2 airway inflammation plays a central role in the pathogenesis of allergen-induced ast

201 e microtubule-associated protein Tau plays a central role in the pathogenesis of Alzheimer's disease.

202 Monocytes and macrophages (MPhis) play a central role in the pathogenesis of chronic hepatitis C

203 e exon-1 region of mutant huntingtin plays a central role in the pathogenesis of Huntington's disease

204 The protein alpha-synuclein has a central role in the pathogenesis of Parkinson's disease.

205 literature that psychological trauma plays a central role in the pathogenesis of pelvic pain, one of

206 s an intrinsically disordered protein with a central role in the pathology of a number of neurodegene

207 Ohr also appeared to play a central role in the peroxynitrite response, because the

208 The lateral prefrontal cortex (LPFC) plays a central role in the prioritization of sensory input base

209 redox regulation of enzyme activity plays a central role in the rapid acclimation of chloroplast met

210 amic nucleus (STN) is hypothesized to play a central role in the rapid stopping of movement in reacti

211 in-dynein regulatory complex (N-DRC) plays a central role in the regulation of ciliary and flagellar

212 Hepatic mitochondria play a central role in the regulation of intermediary metabolis

213 s essential to brain development and plays a central role in the response to brain injury.

214 mma) production in CML patients might have a central role in the response to tyrosine kinase inhibito

215 o-electron microscopy (cryo-EM) had played a central role in the study of ribosome structure and the

216 no-acid precursor (prosystemin, PS), plays a central role in the systemic activation of defense genes

217 he covalent bond, which has since occupied a central role in the theory of making organic molecules.

218 ype 1 receptor (AT1R) is notable as it has a central role in the treatment of cardiovascular disease.

219 rus, infected cell protein 0 (ICP0), plays a central role in these processes.

220 Dehydroshikimate dehydratases (DSDs) play a central role in this process, catalyzing the conversion

221 , and the T3SS proteins YscP and YscU play a central role in this process.

222 artilage destruction and chondrocytes have a central role in this process.

223 tein acetylation, and how metabolism plays a central role in this regulation.

224 ed behaviour of populations of cells plays a central role in tissue growth and renewal.

225 and hypoxic transcriptional responses play a central role in tissue homeostasis and regulate the cell

226 x VI, extracellular loop 3 and the HD play a central role in transmitting the signal employing a uniq

227 Tumor suppressor p53 plays a central role in tumor suppression.

228 d, in particular, cholinergic neurons have a central role in updating the behavioral state as a resul

229 in-coding elements in the genome as having a central role in various biological processes.

230 Friction in ordered atomistic layers plays a central role in various nanoscale systems ranging from n

231 ontrolling the levels of CHK1, which plays a central role in viral replication.

232 to a load-bearing network, thereby playing a central role in wall mechanics and growth, but this view

233 ponsive transcription activator Zap1 plays a central role in zinc homeostasis in the budding yeast Sa

234 nal temperature gradients (LTG and ETG) play central roles in biogeographical theory, underpinning pr

235 upstream of cancer driver genes, which play central roles in cancer-associated pathways.

236 Rubisco enzymes play central roles in carbon fixation, with potential importa

237 s involving multivalent linker proteins play central roles in concentrating NPFs at endocytic sites.

238 wever, it is unclear about which miRNAs play central roles in CRC's pathogenesis and how they interac

239 Kinesin motors play central roles in establishing and maintaining the mitoti

240 dies provide evidence that WASP and WIP play central roles in establishment of a robust multivalent S

241 olution, yet their conserved histones retain central roles in gene regulation.

242 include the Gata2 transcription factor play central roles in hematopoietic fate establishment.

243 Noncoding DNA regions have central roles in human biology, evolution, and disease.

244 Long-lived human plasma cells (PCs) play central roles in immunity and autoimmunity and are enric

245 and their constituent gene products may play central roles in metabolic inflammation.

246 Lipids play central roles in metabolism and cell signaling, and thus

247 ly of the synaptonemal complex (SC) and play central roles in other meiotic processes, including homo

248 factor beta1 (TGFbeta1) protein ligand have central roles in promoting niche co-option and GBM initi

249 RNA-binding proteins play central roles in RNA regulation, including translation a

250 Primary cilia play central roles in signaling during metazoan development.

251 Individuals benefit from occupying central roles in social networks, but little is known ab

252 Considering its central roles in solution and in membrane-mediated aggre

253 Mesodiencephalic dopamine neurons play central roles in the regulation of a wide range of brain

254 ltrated neutrophils and macrophages and play central roles in wound healing.

255 Despite the central role of cAMP signaling, it is not known how cAMP

256 These results demonstrate the central role of CD44 signaling in HMWH-induced antihyper

257 nslation and provide direct evidence for the central role of cellular tRNA levels in mediating the ac

258 of chromatin, which reinforces a notion of a central role of chromatin structure in the regulation of

259 Considering the central role of dendritic cells (DCs) in immune activati

260 These findings indicate a central role of ESRP1-regulated AS for intestinal barrie

261 lation of angiogenesis by TLRs and confirm a central role of Fli1 in regulating vascular homeostasis.

262 In this review, we discuss the central role of Gal-1 in regulatory programs operating d

263 Given the central role of genetic factors in the pathogenesis of c

264 Our findings highlight the central role of genetic or epigenetic alterations on chr

265 al aspects of heterochromatin and supports a central role of HDA-1-mediated histone deacetylation in

266 9% in the bathypelagic layer, indicating the central role of heterotrophy in the dark ocean.

267 These results reveal a central role of IL-11 in fibrosis and we propose that in

268 We demonstrate the central role of immunometabolism and, in particular, mTO

269 Here, we describe the central role of inflammatory caspases and pyroptosis in

270 enetic and functional studies underscore the central role of JAK/STAT signaling in myeloproliferative

271 However, some studies have challenged the central role of ketones because medium-chain fatty acids

272 eurodegenerative diseases due in part to the central role of mitochondria in metabolism, ROS regulati

273 This study also demonstrates a central role of mTORC1 in controlling insulin processing

274 The central role of myeloid cells in driving autoimmune dise

275 icated and increasing evidence points to the central role of podocytes in the pathogenesis.

276 The central role of protein kinases in controlling disease p

277 harmacological interference to demonstrate a central role of Ptpn11 in postnatal myogenesis of mice.

278 or raft partitioning of TMDs and support the central role of rafts in membrane traffic.

279 Despite the central role of RNPs during infection, the factors dicta

280 Due to the central role of skeletal muscle in whole-body metabolism

281 iew provides an overview of evidence for the central role of subjective valuation in persuasion and s

282 ne and in complex with Rrn3, underscores the central role of subunits A43 and A14 in the regulation o

283 crown and abolished DNA uptake, suggesting a central role of the crown in natural transformation.

284 Despite the central role of the E1 enzyme in protein modification, a

285 We identified the central role of the endo-1,6-beta-glucanase in 1,6-beta-

286 This understanding is crucial given the central role of the pulvinar in current theories of inte

287 These results highlight the central role of the sgACC, default mode network, and sal

288 Our model proposes a broader and more central role of the thalamus in the genesis of multiple

289 guselkumab, and risankizumab) underscore the central role of these cytokines as predominant drivers o

290 altogether provide further evidence for the central role of transcriptional regulatory programs in s

291 Given the central role of VirD4 in type IV secretion, our study pr

292 ng bnAbs via immunizations, and the putative central roles of Tfh cells and GC in the generation of H

293 clear how phosphate could have assumed these central roles on primordial Earth, given its poor geoche

294 We stress the central role played by the strong directionality of the

295 rstanding of soil and calls attention to the central role soil plays in our environment.

296 These findings highlight the central role that heterogeneity in psychological process

297 anizations base investment decisions and the central role that stochastic financial modeling should p

298 c image of the DNA double helix embodies the central role that three-dimensional structures play in u

299 s known that the Vegfa-Notch cascade plays a central role, the transcriptional hierarchy controlling

300 tiviral or bacterial settings but also has a central role to play in DC initiation of Th2 responses.