ライフサイエンスコーパス: centrally

1 Adelta-fibers (peripherally) and HT neurons (centrally).

2 ogical suspicion of metaplasia was confirmed centrally.

3 cases, migraine attacks are thought to begin centrally.

4 d through a secure website and were reviewed centrally.

5 line and annual lens photographs were graded centrally.

6 zation induced by tissue damage was mediated centrally.

7 All other data were analyzed centrally.

8 outer rim of viable cells but necrotic cells centrally.

9 cases of new-onset diabetes were adjudicated centrally.

10 Randomization was done centrally.

11 that controls gut functions peripherally and centrally.

12 Enrolled patients were randomly assigned centrally 1:1 to a maximum of six 3-week cycles of gemci

13 a maximum of six cycles and were randomised centrally (1:1) through a minimisation approach to recei

14 Randomisation was done centrally (1:1:1) by a computerised system using an inte

15 ths before screening) were randomly assigned centrally (1:1:1:1), via interactive response technology

16 Patients were randomly assigned centrally (1:1:1:1:1:1), via an interactive response tec

17 The GEM TCR docks centrally above CD1b, whereby the conserved TCR alpha-ch

18 r sporadic ALS were randomly assigned (1:1), centrally according to a computer-generated allocation s

19 is the prototype for the development of new centrally acting agents targeting specifically I1imidazo

20 precluded clinical use of first-generation, centrally acting CB1 receptor blockers.

21 findings suggest that clozapine, and related centrally acting drugs, might be highly effective for re

22 forming a glucogenic function, asprosin is a centrally acting orexigenic hormone that is a potential

23 earlier is applied to provide an overview of centrally acting treatment strategies, both psychologica

24 tently, systemic treatment with donepezil, a centrally active acetylcholinesterase inhibitor, prevent

25 orts have been focused on the development of centrally active COMT inhibitors, which can be valuable

26 Here, we report a set of centrally active DAGL inhibitors and a structurally rela

27 ely metabolized in rats, but MDC is the only centrally active metabolite that could contribute to ove

28 to compounds which were orally bioavailable, centrally active, and which demonstrated robust lowering

29 (SR141716A), otenabant, and taranabant, are centrally active, with a high level of psychiatric side

30 Interventions: The final diagnosis was centrally adjudicated by 2 independent cardiologists usi

31 The final diagnosis was centrally adjudicated by 2 independent cardiologists usi

32 The final diagnosis was centrally adjudicated by 2 independent cardiologists usi

33 Lung cancer diagnoses were centrally adjudicated by pathology review.

34 Of the 298 participants who met centrally adjudicated entry criteria, no differences bet

35 (aHR) and 95% confidence intervals (CI) for centrally adjudicated incident HF and mortality during 1

36 Primary efficacy outcome was a composite of centrally adjudicated recurrent DVT, fatal or nonfatal p

37 Major bleeding events were centrally adjudicated.

38 eted by genetic ablation or by peripheral or centrally administered anti-miR-155 inhibitor in SOD1 mi

39 rs, we explored the antidiabetic efficacy of centrally administered FGF1, which, unlike other FGF pep

40 The effects of systemic or centrally administered orexin receptor (OXR) antagonists

41 mly assigned 1:1 using a computer-generated, centrally administered procedure, stratified by clinical

42 y assigned (1:1) using a computer-generated, centrally administered procedure, stratified by trial ce

43 d that rats fed a high-fat diet or that were centrally administered thapsigargin displayed hypothalam

44 However, centrally aligned nuclei observed in muscle fibers sugge

45 Participants were centrally allocated by the study statistician to vaccine

46 Randomization was computerized and centrally allocated, with patients, health care professi

47 on began at the juxtaparanodes and continued centrally along the first internode.

48 agreement between Pittsburgh compound B and centrally analysed cerebrospinal fluid, a minority of su

49 Randomisation was computer generated centrally and allocated by telephone call or fax.

50 e allocation sequence was computer-generated centrally and concealed to all personnel.

51 Mutant Nrp2 islets aggregated centrally and failed to disperse radially.

52 andomisation, stratified by centre, was done centrally and independently, with allocation with serial

53 otubules and membranous organelles clustered centrally and neurofilaments displaced to the periphery.

54 atory cytokine interleukin-27 is upregulated centrally and peripherally after intracerebral hemorrhag

55 into the pathological alterations occurring centrally and peripherally in PD.

56 Thus, MDP scaffolds delivered centrally and peripherally within whole dental pulp tiss

57 mals with functional TLR4 when administrated centrally and peripherally.

58 nter, indicating that cone loss predominates centrally and rod loss increases peripherally.

59 Patients were randomised centrally and stratified by hospital according to a pre-

60 Randomisation was done centrally and stratified by previous trastuzumab treatme

61 ar layer (ONL) (nasally), and inner segment (centrally and temporally) were found in patients with ON

62 The randomisation was done centrally, and sites learned of the assignment only afte

63 ations were marketed, of which 34 (27%) were centrally approved and 90 (73%) were unapproved; metform

64 f FDC sales volumes (2011-2012) arising from centrally approved and unapproved formulations and from

65 We also determined the proportions of centrally approved and unapproved formulations marketed

66 Atypical responses were identified by using centrally assessed irRC data in patients with >/= 28 wee

67 89 (24%, 95% CI 20-29) of 370 patients had a centrally assessed objective response, and as of Sept 1,

68 combined positive score of 10% or more had a centrally assessed objective response.

69 The primary end point was centrally assessed PFS.

70 2 (PET2) and 4 (PET4) induction cycles, and centrally assessed using international harmonization pro

71 Visual fields showed sensitivity losses centrally associated with defects on OCT.

72 Intrusive memories and reactivity are centrally associated with other symptoms in the acute ph

73 The MPOD peaked centrally at 0.25 degrees of retinal eccentricity (mean

74 Targeting the receptor with a new centrally available antagonist, JNJ-47965567, suppressed

75 ileptic mice with systemic injections of the centrally available, potent, and specific P2X7 receptor

76 ner usually associated with slow-exchanging, centrally bound agents.

77 eral stimuli when the task requires focusing centrally but reduced filtering of central stimuli when

78 MRCP and ERCP images were read centrally by 3 radiologists and 2 endoscopists, respecti

79 Patients were randomly assigned (1:1) centrally by an interactive voice and web response syste

80 e 2, patients were randomly assigned (1:1:1) centrally by an interactive voice response system to dul

81 Patients were randomly assigned (1:1), centrally by an interactive voice response system, to re

82 Participants were randomly assigned (1:1) centrally by an interactive voice response system, to re

83 sured using standard audiometry and reviewed centrally by audiologists masked to allocation using Ame

84 PET-CT was reported centrally by experts at 5 national core laboratories.

85 A reminder/recall notification conducted centrally by health departments in collaboration with pr

86 Specimens were tested centrally by LBC, the AHPV test, and the HC2 test, and w

87 tereoscopic fundus photographs were assessed centrally by masked graders for the development of late

88 Of 29 new neurological events adjudicated centrally by masked reviewers, no strokes were identifie

89 Feeding and satiety are coordinated centrally by melanocortin-4 receptors (MC4R) in neurons

90 s open-label, but TCD examinations were read centrally by observers masked to treatment assignment an

91 to end of treatment (48 weeks), as assessed centrally by two independent pathologists.

92 andom allocation sequence computer generated centrally by WHO).

93 for potential antiobesity agents that target centrally coexpressed Y1 and Y5 receptors to suppress ap

94 We enrolled 326 centrally confirmed cases of AIS and 115 stroke-free con

95 AURA2), patients aged at least 18 years with centrally confirmed EGFR Thr790Met-positive mutations, l

96 ear group survived longer in the subset with centrally confirmed GIST and without macroscopic metasta

97 l were men and women (aged >/=18 years) with centrally confirmed HER2-positive advanced breast cancer

98 articipants were aged 18 years or older with centrally confirmed HER2-positive stage II-III operable

99 al (PFS), was evaluated in 183 patients with centrally confirmed non-GCB DLBCL who received one or mo

100 nto two parallel substudies according to the centrally confirmed pretreatment T790M mutation status o

101 tients who provided consent, 341 (85.9%) had centrally confirmed, localized GISTs with mutation analy

102 findings reveal that microneme secretion is centrally controlled by protein kinase G and that this p

103 onserved region of the vertebrate brain that centrally controls responses to environmental stressors.

104 and the dual-topology arrangement includes a centrally coordinated cation, most likely Na(+).

105 structure can exhibit is in part due to the centrally coordinated octahedra bond flexibility, which

106 are built from individuals whose work is not centrally coordinated.

107 Reactome pathways are centrally curated with periodic input from selected doma

108 unction is disrupted along nerves containing centrally derived myelin, demonstrating that, although p

109 tions to peripheral myelinating glial cells, centrally derived oligodendrocyte progenitor cells (OPCs

110 cal and electrophysiological features of the centrally directed part of the rat AN projecting from th

111 radients from which we infer the presence of centrally driven winds in typical quiescent galaxies tha

112 conclude that the pharmacodynamic effect is centrally driven.

113 ents, acute stroke-related headache might be centrally driven.

114 Glucose is an aldosic monosaccharide that is centrally entrenched in the processes of photosynthesis

115 Responses were centrally evaluated by PERCIST 1.0 in 93 patients.

116 g a sponsor-generated randomisation sequence centrally executed by an interactive voice response or i

117 Randomisation was centrally executed using an interactive voice or web res

118 The centrally expressed melanocortin-3 and -4 receptors (MC3

119 Here, we present an IC-FPOP flow system that centrally focuses the cells, ensuring consistent radiati

120 equipment at both study visits, were graded centrally for early and late AMD on the basis of drusen

121 s Patients with metastatic UBC were screened centrally for HER1/HER2 overexpression.

122 Photographs were graded centrally for retinopathy severity and macular edema usi

123 zumab 15 mg/kg every 21 days and were tested centrally for the pretreatment T790M resistance mutation

124 We did the randomisation with a centrally generated, computerised allocation sequence wi

125 nd stereoscopic fundus photographs that were centrally graded for development of late AMD (central ge

126 Randomisation codes were obtained from a centrally held list via an interactive web response syst

127 for shuttling a single Ag or Cu atom into a centrally hollow, rod-shaped Au24 nanoparticle, forming

128 Centrally, IB4(+) , but not CTB(+) , projection areas we

129 Randomisation was centrally implemented using an interactive voice respons

130 Disruptions in fear-extinction learning are centrally implicated in a range of stress-related disord

131 m mitogen-activated protein kinases that are centrally implicated in renal fibrogenesis and inflammat

132 one amyloid-beta (Abeta) peptides, which are centrally implicated in the pathogenesis of Alzheimer's

133 onic charge transfer with an electrode, is a centrally important challenge in the field of bioelectro

134 oaden understanding of how mutations in this centrally important core subunit of complex I affect its

135 ts to the metastability of reflectins as the centrally important design principle governing biophoton

136 of layered materials in a polymer matrix is centrally important for many engineering and manufacturi

137 -17A) (also known as IL-17) has emerged as a centrally important mediator of immune defense against b

138 has led to our modern understanding of this centrally important process.

139 We propose that TRIP13 plays centrally important roles in the sequence of events lead

140 n test classification, and randomly assigned centrally in a 1:1 ratio to receive erlotinib (150 mg/da

141 The peeling progresses centrally in association with iris movement and aqueous

142 Randomisation was done centrally in blocks of 12, and stratified by trial centr

143 Randomisation was computer-generated centrally in blocks of four, stratified by site.

144 Randomisation was done centrally in each country.

145 ates the acute effects of estrogens produced centrally in response to social stimuli.

146 ensure that appropriate signals are carried centrally in scotopic conditions when sensitivity rather

147 nociceptive mediators both peripherally and centrally in sickle mice correlative to the antinocicept

148 e is that the methylammonium ions do not sit centrally in the A-site cavity, but disordered around tw

149 n adherent hemocyte subset that participates centrally in the anti-digenean defense response.

150 Are sensory estimates formed centrally in the brain and then shared between perceptua

151 The ECS is also involved centrally in the manifestation of stress, and endocannab

152 They are positioned centrally in the neurovascular unit between endothelial

153 In Finland, uveal melanomas are treated centrally in the Ocular Oncology Service, Helsinki Unive

154 ROCK, that localizes diffusely, rather than centrally, in epithelial cell apices.

155 ore than 150 clinical variables were curated centrally, including demographics, laboratory values, me

156 Pathologic specimens were evaluated centrally, including Ki-67 index and hormone immunolabel

157 ase 2 expression is observed associated with centrally injected MDP scaffolds at early time points, i

158 The PI3K/PDK1/Akt signaling axis is centrally involved in cellular homeostasis and controls

159 Histone H2B monoubiquitination (H2Bub1) is centrally involved in gene regulation.

160 tRNAs (and their nucleolytic fragments) are centrally involved in stress signalling and adaptive tra

161 rleukin-18 (IL-18) is a pleiotropic cytokine centrally involved in the cytokine cascade with complex

162 Hypoxia inducible factors (HIFs) are centrally involved in the modulation of cellular functio

163 s provide evidence that immune molecules are centrally involved in the orchestration of cardiac tissu

164 ands perform complex functions, and they are centrally involved in the pathogenesis of acne vulgaris.

165 Endothelial cells (ECs) are centrally involved in the pathogenesis of organ injury i

166 utant inhibits constriction, suggesting that centrally localized apical ROCK/myosin activity promotes

167 The photopsias from neovascular AMD are more centrally located (83%), quick and repetitive (79%), see

168 es beta1-integrin activity, the formation of centrally located active beta1-integrin- and tensin-rich

169 membrane, whereas F0F1-ATP synthase is more centrally located at the cristae membrane.

170 Eight centrally located BRC repeats in BRCA2 mediate binding a

171 In addition, the centrally located chiral (S)-BINOL motif of the [3]rotax

172 The root meristem has a centrally located group of mitotically quiescent cells,

173 1 protein sequence and found a single domain centrally located in RPM-1 that is sufficient for bindin

174 limbs showed more regenerating myocytes with centrally located nuclei.

175 HLA class I peptides with centrally located oligosaccharides have been shown to be

176 piece hydrophobic acrylic intraocular with a centrally located opaque annular mask measuring 3.23 mm

177 a middle domain, a C-terminal domain, and a centrally located open cavity.

178 ctomy may be required in locally advanced or centrally located pancreatic neoplasms to achieve comple

179 Our evidence suggests that PrP's centrally located proline and lysine residues act as con

180 constantly recruited to and released from a centrally located replisome, providing, to our knowledge

181 2.3, 95% confidence interval [CI] 1.4-3.8), centrally located tumor (HR 2.5, 95% CI 1.2-5.2), tumor

182 haride features a folded conformation with a centrally located turn-type structure stabilized by arom

183 ce was 10 nucleotides in length, contained a centrally located UUGA core element, and had a preferred

184 carboxylic acids the double bonds are mainly centrally located with mainly trans-configuration.

185 g in challenging scenarios where tumors are: centrally located, > 5 cm in diameter, lacking tissue di

186 fluid concentrations of amyloid-beta42; (ii) centrally measured cerebrospinal fluid amyloid-beta42 us

187 and (iii) cerebrospinal fluid amyloid-beta42 centrally measured using an antibody-independent mass sp

188 Centrally Mediated Abdominal Pain Syndrome (CAPS), forme

189 d-brain barrier to reverse morphine-induced, centrally mediated analgesia when given intravenously.

190 In vivo studies with 5 demonstrate centrally mediated antinociception, significantly reduce

191 e results suggest that acute sepsis disrupts centrally mediated osmoregulatory reflexes through diffe

192 nergy balance through enhanced and prolonged centrally mediated reduction of food intake.

193 P448Lneo(-) muscles showed reduced levels of centrally nucleated myofibers, reduced variance, increas

194 One hot spot, located centrally on chromosome 1, behaved similarly in male and

195 A TRAV1-2(-) TCR docks more centrally on MR1, thereby adopting a markedly different

196 ane, including finite-sized channels located centrally or acentrally, stiffness of the hypothesized c

197 We randomly assigned women who had a centrally or medially located primary tumor, irrespectiv

198 otentiate anesthetic duration when delivered centrally or peripherally.

199 demonstrates how an endogenous CBE network, centrally orchestrated by SF1, could remodel the genomic

200 Response was assessed centrally per irRC and RECIST v1.1.

201 ing interphase and positive signaling by the centrally placed nucleus at mitotic entry [2-4]: the cel

202 sitive to HCN4 immunostaining, supplied by a centrally placed thick-walled arteriole.

203 led a network dominated by highly connected, centrally positioned master sequences.

204 involving a polarized actin cytoskeleton and centrally positioned myosin, with cell-scale order that

205 TUBB2B tubulinopathies show in the majority, centrally predominant polymicrogyria-like cortical dyspl

206 ng, followed by an episodic memory test with centrally presented retrieval cues.

207 tial orienting and a nonspatial feature of a centrally presented stimulus in nonprimate species.

208 's classic endogenous cuing task, in which a centrally presented, spatially informative cue is follow

209 ls currently used in these vehicles, CNG and centrally produced LNG increase emissions by 0-3% and 2-

210 e to Shh, and Gnaz mutant intestines contain centrally projected enteric axons.

211 ated stress-induced behaviors, including the centrally projecting Edinger-Westphal nucleus, the hippo

212 cation sequence with a block size of four to centrally randomise patients aged 18-80 years with a non

213 e enrolled from hospitals worldwide and were centrally randomised (1:1) to chemotherapy (type selecte

214 Patients were centrally randomised (1:1) to receive either oral masiti

215 -breast irradiation of 50 Gy in 5 weeks were centrally randomised (1:1) with a minimisation algorithm

216 lled trials (3325 patients); all trials were centrally randomised and open label, with overall surviv

217 treated with breast-conserving surgery were centrally randomised to either whole-breast irradiation

218 s trial, patients at least 61 years old were centrally randomized (1:1) to receive either a single in

219 tastatic spread, with PSA </= 50 ng/mL, were centrally randomized 1:1 to either RT or RT plus AS star

220 Participants were centrally randomized into intervention (22,600 ppm fluor

221 Participants were centrally randomized to undergo either UT-DSAEK or DSAEK

222 518 were assessed for eligibility, 433 were centrally randomized, and 419 were analyzed as randomize

223 Within 90 days of cystectomy, patients were centrally randomly assigned (1:1) by minimisation to eit

224 Patients were centrally randomly assigned in a 1:1 ratio to either AHT

225 Overall, a total of 340 patients were centrally randomly assigned to receive VTD or VCD.

226 an mass were measured using standardized and centrally read abdominal CT scans and whole-body dual-en

227 zed histologic outcomes were evaluated using centrally read biopsies.

228 in lipase (LPL) in astrocytes is required to centrally regulate energy homeostasis.

229 The brain's serotonergic system centrally regulates several physiological processes and

230 between perceptual and motor pathways or is centrally represented sensory activity decoded independe

231 a small number of genes within each Tamp are centrally responsible for each Tamp's fitness effects.

232 ad significantly thinner cortex in typically centrally-responsive primary visual cortex - the region

233 AUS images were centrally reviewed and classified as normal or suspiciou

234 on screening for relevant abnormalities were centrally reviewed and were informative in 542 cases (88

235 ysis was performed by using patient data and centrally reviewed baseline PET-CT scans for 185 patient

236 t, 5-year IFFS was 79% versus 73%; among 336 centrally reviewed high-risk patients, it was 77% versus

237 or clinicopathological parameters, including centrally reviewed histological grade, hormone receptors

238 Either the GG assay or centrally reviewed Ki67 significantly improves clinicopa

239 -to-treat population as assessed by blinded, centrally reviewed MRI or CT.

240 pulation and the proportion of patients with centrally reviewed overall response per Response Evaluat

241 rnational Group (BIG) 1-98 trial and who had centrally reviewed pathology data were included (N = 2,9

242 6 to August 2013, 588 prospectively treated, centrally reviewed patients with stage III FHWT were tre

243 od, Barrington et al present the analyses of centrally reviewed positron emission tomography-computed

244 The primary endpoint was centrally reviewed progression-free survival.

245 istered, and 23 patients with tumors who met centrally reviewed radiographic criteria registered.

246 ients were enrolled and imaging studies were centrally reviewed to assess for bilateral renal lesions

247 Best response to chemotherapy was centrally reviewed with a response rate (complete, parti

248 Images were centrally reviewed with the use of a 5-point scale for P

249 tomography scans and pathology reports were centrally reviewed, and information was collected regard

250 e, and at least 1 month after treatment were centrally reviewed.

251 Histologic features were centrally scored according to Banff guidelines, includin

252 e primary outcome measure was improvement in centrally scored liver histology defined as a decrease i

253 Randomisation was done centrally, stratified by centre and patient type (with v

254 us axis of basic and acidic residues running centrally through the membrane arm connects the ubiquino

255 We randomly assigned patients (1:1:1) centrally to afatinib 40 mg orally once per day, afatini

256 Long-chain fatty acids (FAs) act centrally to decrease food intake and hepatic glucose pr

257 Patients were randomly assigned 1:1 centrally to either the docetaxel, prednisone, and custi

258 infer that it forms a parallel dimer folded centrally to enable contact between the N and C termini.

259 e synapse, T cell receptors (TCRs) clustered centrally to form the central supramolecular activation

260 It progressed centrally to higher stages, manifesting a spectrum of di

261 temic vascular and renal effects, AngII acts centrally to modulate the activities of neuroendocrine a

262 otensin II (AngII) and aldosterone cooperate centrally to produce a robust sodium appetite.

263 palms or soles) were randomly assigned (1:1) centrally to receive surgery with either a 1 cm or 3 cm

264 ose; block sizes of four; computer-generated centrally) to receive either oral eliglustat or imigluce

265 ibility, we created transgenic mice that are centrally tolerant to these immunodominant epitopes.

266 trast to T cells, offspring B cells were not centrally tolerized and retained their ability to respon

267 eshwork becomes established without invading centrally toward the gut epithelium has not been address

268 A retrospective analysis was performed of centrally tracked outcomes from index PCI procedures ent

269 Proportions of centrally unapproved formulations after 1 May 2002 did n

270 Metformin excepted, substantial numbers of centrally unapproved formulations for NSAID, anti-depres

271 MD was read centrally using a quantitative method (Cumulus) and its

272 Illumina MiSeq platforms and processed data centrally using a semi-automated bioinformatics pipeline

273 ype and status of brain metastases, was done centrally using a validated number generating system imp

274 Randomisation occurred centrally using an interactive voice response system and

275 ock randomisation (block size five) was done centrally using an interactive web response system, stra

276 Computer-generated randomisation was done centrally using block sizes of four and six, and only th

277 tation analysis for KIT and PDGFRA performed centrally using conventional sequencing.

278 Summary-level results were meta-analyzed centrally using inverse-variance weighting.

279 Patients were randomly assigned (1:1) centrally using permuted blocks (block size 8) to receiv

280 or group B (chemotherapy plus bevacizumab), centrally, using permuted blocks sizes and stratified by

281 Randomisation was carried out centrally, using the eClinicalOS electronic data capture

282 CVD was defined as the occurrence of centrally validated myocardial infarction, stroke, invas

283 vanced disease) were randomly assigned (1:1) centrally via an interactive response system to etirinot

284 rrently with chemotherapy), then implemented centrally via an interactive voice and web-response syst

285 rrently with chemotherapy), then implemented centrally via an interactive voice and web-response syst

286 Randomisation was done centrally via an interactive web response system using b

287 allocation at the investigator site was done centrally via internet with stratification for chemother

288 This suggests that efficient coding applies centrally, where it extends to higher-order sensory feat

289 on signaling via MyD88 when it is delivered centrally, whereas this response is mediated via the TRI

290 Observers fixated centrally, while flash stimuli at perceptual threshold a

291 Randomisation was done centrally with an interactive voice or web-based respons

292 The randomisation was done centrally with an interactive voice or web-based respons

293 Randomisation was done centrally with an interactive voice or web-response syst

294 Randomisation was done centrally with an interactive voice response system and

295 Randomisation was done centrally with an interactive voice response system.

296 Randomisation was done centrally with an interactive voice response system; pat

297 andomisation, with permuted blocks, was done centrally with an interactive web response system.

298 uterised double-blind randomisation was done centrally with permuted blocks.

299 at are defined by a dominant epitope located centrally within a narrow variant pool.

300 checkpoint for the system appeared to occur centrally within the bone marrow during the final stage