ライフサイエンスコーパス: centrally acting

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1 monstrate that galantamine, a reversible and centrally acting AChE inhibitor approved for treatment o

2 tor, and it was less toxic than huperzine, a centrally acting AChE inhibitor.

3 plied to all anticonvulsant trials and other centrally acting agents and nonpsychotropic drugs.

4 is the prototype for the development of new centrally acting agents targeting specifically I1imidazo

5 iuretics, alpha-blockers, beta-blockers, and centrally acting agents), for a mean of 3.4 years.

6 omimetic actions can be reversed by a potent centrally acting alpha2 adrenergic receptor (AR) agonist

7 (via 48 h transdermal administration of the centrally acting alpha2-adrenergic receptor agonist, clo

8 The increased basal BP was attenuated by the centrally acting alpha2a agonist guanfacine, suggesting

9 m circuitry and that cannabinoids are indeed centrally acting analgesics with a new mechanism of acti

10 ve injury (neuropathic pain) is resistant to centrally acting analgesics, whereas inflammatory pain r

11 o lever-press for cocaine hydrochloride (the centrally acting and abused form of the drug).

12 ed that rilmenidine, a well tolerated, safe, centrally acting anti-hypertensive drug, could induce au

13 I(1)-imidazoline receptor with moxonidine, a centrally acting antihypertensive, increased by greater

14 Likewise, systemic injections of the centrally acting beta-adrenoceptor antagonist propranolo

15 While centrally acting cannabinoid agonists are known to produ

16 Centrally acting cannabinoids are well known for their a

17 s marketing and clinical withdrawal of other centrally acting CB1 antagonists; however, the design st

18 precluded clinical use of first-generation, centrally acting CB1 receptor blockers.

19 this effect is generally inhibitory, we used centrally acting cholinergic agonists to augment central

20 irst of all on the cell cycle machinery with centrally acting cyclin-dependent kinases (CDKs) and the

21 reatment algorithms using various classes of centrally acting drugs, including antidepressants and an

22 findings suggest that clozapine, and related centrally acting drugs, might be highly effective for re

23 The present study showed that leptin, a centrally acting hormone secreted by adipocytes, rescued

24 This centrally acting IL-1beta has recently been shown to imp

25 suggest a potential neuroprotective role for centrally acting L-type calcium channel blockers of the

26 matory pathway is of interest for the use of centrally acting muscarinic cholinergic enhancers as ant

27 The centrally acting muscarinic cholinergic receptor agonist

28 ide, has led to the discovery of the potent, centrally acting muscle relaxant (E)-2-(4,6-difluoro-1-i

29 antiinflammatory and analgesic agent without centrally acting muscle relaxant activity.

30 s rats produced by systemic injection of the centrally acting N-methyl-D-aspartate (NMDA) receptor io

31 up-regulation in the dorsal root ganglion of centrally acting neuromodulators and simultaneously in t

32 Pretreatment with the centrally acting nicotinic antagonist, mecamylamine (1 m

33 differential contribution of peripherally or centrally acting NMU system.

34 Pain treatment with centrally acting opiates is limited by tolerance.

35 nation of a peripherally acting NSAID with a centrally acting opioid drug is found to be more effecti

36 be less pronounced for peripherally than for centrally acting opioids, which provides a promising per

37 developed; one such agent, tapentadol, is a centrally acting oral analgesic that possesses a combine

38 forming a glucogenic function, asprosin is a centrally acting orexigenic hormone that is a potential

39 Sibutramine, a centrally acting reuptake inhibitor of monoamines, and o

40 this study was to test whether moxonidine, a centrally acting sympathoinhibitory agent, can lead to a

41 Metabolically stable and centrally acting thyrotropin-releasing hormone (TRH) ana

42 earlier is applied to provide an overview of centrally acting treatment strategies, both psychologica

43 refore, our design afforded a novel lead for centrally acting TRH analogues.

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