ライフサイエンスコーパス: centric

1 of liberal bias in the field seems American-centric.

2 olarized by stress even when the material is centric.

3 eb resources is protein-centric, and not PPI-centric.

4 which is peptide-centric instead of protein-centric.

5 n countries and quantitative studies were UK centric.

6 gen resource that enables infectious disease-centric access, analysis and visualization of host-patho

7 Using a high-probe-density, gene-centric aCGH microarray, we present evidence of small-sc

8 Cytolytic T cell-centric active specific and adoptive immunotherapeutic a

9 COL17A1 in HFSCs orchestrates the stem cell-centric aging program of the epithelial mini-organ.

10 Gene-centric analyses in 8335 subjects of European ancestry a

11 Gene-centric analyses offer a promising avenue for efficient

12 at couldn't be recovered by traditional gene-centric analyses.

13 ion (LO) is by definition a process, process-centric analysis and visualization of this important pha

14 ome-wide association study (GWAS) and a gene-centric analysis in subjects of European ancestry and Af

15 ion would be hidden from a conventional gene-centric analysis of gene expression.

16 Splice-junction centric analysis of RNA-Seq data provides advantages in

17 Subsequent peptide-centric analysis, through proteolytic digestion of C9 an

18 e evaluation of the network-centric and gene-centric analytic methods showed that mlDNA substantially

19 s extensive associations to existing species-centric anatomical ontologies, allowing integration of m

20 n cascades are described taking intervention-centric and client-centric perspectives to look at suppl

21 ular, there is ongoing dissent between motor-centric and cognitive accounts whether premotor cortex o

22 ification of Diseases, Ninth Revision (ICD9)-centric and disease name centric views of disease inform

23 and download expression data from both gene-centric and experiment-centric perspectives.

24 ment of variant associations) to obtain gene-centric and gene set association results corrected for g

25 Comparative evaluation of the network-centric and gene-centric analytic methods showed that ml

26 ly localized to the root stele, suggesting a centric and gradual release of its diterpene products in

27 y will eventually require an even less brain-centric and mechanistic cognitive neuroscience that focu

28 rsupial genome that harbors large amounts of centric and pericentric heterochromatin.

29 anization that we show is OFF-dominated, OFF-centric and runs orthogonal to ocular dominance columns.

30 nt algorithms for cardiac arrest are rescuer centric and vary little from patient to patient.

31 The most sensitive species were mainly centrics and araphid diatoms (in this study, Thalassiosi

32 tific psychology, 2) considerably less brain-centric, and 3) nosologically more skeptical and less do

33 ion genetics "follows" genes, is replication-centric, and is concerned with vertically consistent gen

34 n provided in these web resources is protein-centric, and not PPI-centric.

35 CARD is ontologically structured, model centric, and spans the breadth of AMR drug classes and r

36 ding of HBc interactions is therefore capsid-centric, and this view has been limited by the resolutio

37 matics resources and provides automated gene-centric annotations, (b) drugBase, a database of drug-ta

38 her host-centric (pro-tolerance) or pathogen-centric (anti-virulence).

39 or example, we demonstrated that the context-centric approach can be used to identify potential molec

40 pared to single SNP-based analysis, the gene-centric approach has greater power, especially when ther

41 e-scale meta-analysis involving a dense gene-centric approach has uncovered additional loci and varia

42 The results show that a shape-based, ligand-centric approach is more consistent than, and often supe

43 However, this species-centric approach neglects the often dramatic changes in

44 ent than, and often superior to, the protein-centric approach taken by docking.

45 In other words, the RNA ligand-centric approach taken here overcomes a problematic mole

46 The splice-junction centric approach that this software enables will provide

47 from network neighbors' and (iii) a context-centric approach to 'find context-associated hub genes',

48 mplementary network methods: (i) a phenotype-centric approach to 'find new members for a pathway'; (i

49 find new members for a pathway'; (ii) a gene-centric approach to 'infer functions from network neighb

50 h these examples, we demonstrate that a gene-centric approach to comparing metabolic networks allows

51 In this paper, we present a graph-centric approach to improving metagenome-guided peptide

52 A structure-centric approach to support discovery of antiparasitic c

53 ial to the promotion of a successful patient-centric approach to surgical care.

54 In this article, we present a gene-centric approach via entropy statistics for a genomewide

55 We discuss the feasibility of the peptide-centric approach which was tested on several quantitativ

56 NPs become available, our entropy-based gene-centric approach would provide a robust and computationa

57 mon characteristics to evaluate a drug (drug-centric approach) and optimal treatment based on curated

58 drug combinations for each patient (patient-centric approach).

59 Complementary to this, a gene-centric approach, such as the 50K IBC HumanCVD chip, whi

60 in WFS1 cause Wolfram syndrome; using a gene-centric approach, we show that variation in WFS1 also pr

61 ical mechanisms, rather than a strictly gene-centric approach, will provide grounds for a different a

62 virtual screening is the shape-based, ligand-centric approach.

63 Indeed, network-centric approaches have proven to be helpful for finding

64 Unlike gene-centric approaches, pathway-based methods provide a syst

65 SNP data utilizing a 50K cardiovascular gene-centric array (ITMAT-Broad-CARe [IBC] array).

66 dization with a custom high-resolution miRNA-centric array and/or whole-genome sequence data to ident

67 00 single nucleotide polymorphism (SNP) gene-centric array having dense coverage of over 2,000 candid

68 Using a vascular gene-centric array in 23,634 EA and 6657 AA participants from

69 single nucleotide polymorphisms from a gene-centric array in approximately 5000 individuals (Cardioc

70 d additional BP loci, we used a bespoke gene-centric array to genotype an independent discovery sampl

71 difiers of SCD severity, we performed a gene-centric association study in 1514 African American parti

72 We conducted a systematic, gene-centric association study using 518 LD-tagging single nu

73 Altogether, our data reveal an emergent Kap-centric barrier mechanism that may underlie mechanistic

74 genes involved in key keratinocyte and skin-centric biological processes.

75 y that are invisible to contemporary haploid-centric cell biological, proteomic, and functional genom

76 t the primer terminus opposite cytosine, DNA centric changes lead to a clash between O8 of 8-oxoG and

77 Here we present HiChIP, a protein-centric chromatin conformation method.

78 Glio (Avastin in Glioblastoma; NCT00943826), CENTRIC (Cilengitide, Temozolomide, and Radiation Therap

79 dietary carotenoids such as beta-carotene by centric cleavage via the enzyme BCO1.

80 Telomere-centric CNR following recursive WGD in plants is also im

81 e manufacture employs a unique optical fiber-centric coaxial design approach that yields a lightweigh

82 changes exist by using a high density, gene-centric Comparative Genomic Hybridizations (CGH) array o

83 s requires a deep-sequencing, geographically centric, comparative pathogenomics strategy.

84 We describe a need for an endocrine-centric component for overall health assessments and pro

85 failure of accepted experimental and native-centric computational approaches to adequately describe

86 ld also be directed to improve other patient-centric concerns, such as functional capacity and qualit

87 This growing body of useful, gene-centric content is the result of the work of thousands o

88 tablish a continuum under a mechanism of Kap-centric control.

89 latively low-cost per sample and broad, gene-centric coverage of CpGs across the human genome, Illumi

90 tes, dominated by an English-language, Anglo-centric culture.

91 Furthermore, the Th17-centric cytokines IL-17, IL-6, IL-23, and IL-12 were sig

92 mportant but not yet standard to combine RNA-centric data and analysis tools with other types of expe

93 nderlying operons; (ii) an integrated operon-centric data resource that provides not only operons for

94 An equivalent 2-DE-centric data structure would similarly have to include a

95 the assay library used for targeted, peptide-centric, data analysis.

96 Therefore, we aimed to develop a molecule-centric database featuring CKD-related experiments from

97 ped the PlantSEED, an integrated, metabolism-centric database to support subsystems-based annotation

98 we have developed EuSplice--a unique splice-centric database which provides reliable splice signal a

99 iated transcription-independent mitochondria-centric death cascade rescued a significant fraction of

100 itask approach, which explicitly models gene-centric dependencies across multiple and distinct genomi

101 We demonstrate that accounting for the gene-centric dependencies enables leveraging information from

102 In addition, the gene-centric design makes it possible to add several importan

103 The phylo-centric design of BorreliaBase is a novel model for inte

104 We implemented an exon-centric design of high-resolution aCGH to detect single-

105 e of iron than the comparably sized, oceanic centric diatom Thalassiosira oceanica.

106 The CCM(s) present in the marine-centric diatom, Thalassiosira pseudonana, were studied i

107 of low Fe acclimation are largely unknown in centric diatoms.

108 A gene-centric disease association study of 24,832 putative fun

109 erapeutic role for autophagy in this nucleus-centric disease.

110 tomic-scale control of inversion-preserving (centric) displacements.

111 e ExAC browser provides gene- and transcript-centric displays of variation, a critical view for clini

112 TCR binding was highly peptide centric, dominated by two residues of the complementarit

113 The Omegaven trial is a multi-centric, double-blind, randomized, placebo- controlled t

114 veloping methods that are protein expression-centric (e.g. isotope coded affinity tag, isobaric tag f

115 ected with high predictive value in amygdala-centric emotion circuits at a surprisingly young age.

116 To facilitate this process of patient centric evidence-based care multidisciplinary Heart Team

117 e that has partially rejected orthodox, gene-centric evolutionary theory.

118 Our findings highlight how gene-centric experiments (such as systematic knock-out or sil

119 have historically been managed in a prostate centric fashion.

120 cellular dynamics in which a single nucleoid-centric focus of DrSSB is observed within 1 h of irradia

121 ant attention because of a prevailing energy-centric focus on the role of glucose as substrate for ox

122 on of nonnative stabilization against native-centric forces is conceptualized as frustration.

123 This has involved migrating from an entry-centric format to one that is gene-centered.

124 Our hope is that such trust-centric frameworks provide a sustainable solution that r

125 nd from previous work, we constructed an RHO-centric functional map, allowing pleiotropic and epistat

126 s great promise for contributing to a domain-centric functional understanding of genomes in the next

127 The parental complements share the same centric fusions relative to the presumed macropodid ance

128 Here we present a domain-centric Gene Ontology (dcGO) perspective.

129 This framework incorporates three function-centric gene-set analysis strategies: a meta-analysis of

130 trates that IRF4 adopts either SPIB- or BATF-centric genome-wide distributions in related states of p

131 orts specific to non-overlapping, gene-model-centric genomic loci.

132 theory which calls for the departure of gene-centric genomic research.

133 Genome-wide and large-scale gene-centric genotyping studies that involve tens of thousand

134 es has demonstrated the potential for domain-centric GO enrichment analysis to yield functional insig

135 Because the native-centric Go model simulations do not explicitly include s

136 Domain-centric GO, 'dcGO', provides associations between ontolo

137 as been improved and provides a single, gene-centric graph summarizing the available cell-cycle exper

138 Edge-centric graph-theoretic analysis showed that highly sele

139 e loci on the homolog by relocation near the centric heterochromatin (trans-inactivation).

140 block that causes the locus to interact with centric heterochromatin.

141 ion between CG content and the distance from centric heterochromatin.

142 The use of gene-centric high-density array comparative genomic hybridiza

143 I study (n=5592) was genotyped with the gene-centric HumanCVD BeadChip (Illumina).

144 th the pleiotropic responsibility of LMW PAH-centric hydroxylation, and its epistatic functional cont

145 We have developed comprehensive protein-centric ID mapping services providing mappings for 90 ID

146 Fixation was centric in 30 eyes (81%), paracentric in 3 eyes (8%), an

147 in 2010, end-of-life care was more hospital-centric in Belgium, Canada, England, Germany, and Norway

148 somatic variants that drive cancer are 'gene-centric' in that they consider only somatic variants wit

149 We estimated the expected gene-centric information capture for whole-genome chips using

150 riptions of the trait with a variety of gene-centric information sources.

151 quantitative proteomic data which is peptide-centric instead of protein-centric.

152 Thus, highly focused peptide-centric interactions associated with suboptimal TCR-pMHC

153 A cell type-centric interface allows the identification of genes exp

154 A gene-centric interface returns haematopoietic expression patt

155 This article argues that the gene-centric interpretations of evolution, and more particula

156 These IkappaBdelta-centric "kappaBsomes" are distinct from the 2:2 complexe

157 eld of anxiety disorders is largely receptor-centric, leaving intracellular pathways largely unexplor

158 ains in EHR/EMR, HIE and other collaboration-centric life sciences domains have taught us, the core c

159 for Alzheimer's disease (AD) posits a neuron-centric, linear cascade initiated by Abeta and leading t

160 genomics in clinical context so that patient-centric longitudinal clinical, genomic, and molecular ph

161 This review takes a virus-centric look at the coronavirus replication transcriptio

162 n for each protein is organised in a residue-centric manner and each residue is linked to the relevan

163 e remodeling take place in a target membrane-centric manner, progressing from punctate dimples, to th

164 zed by the TCR CDR1 and CDR2 loops in an MHC-centric manner.

165 This study highlights the role of gene-centric matchmaking tools to establish causal links to g

166 Using a gene-centric "matchmaking" system, we were able to identify a

167 ric stress cannot induce a polar response in centric materials; piezoelectricity is, for example, pos

168 r impact on type 2 diabetes using a European-centric meta-analysis comprising 37,293 case and 125,686

169 Here, we use genome-centric metagenomics to recover 17 draft genomes of anam

170 e present oncodomain hotspots, a new 'domain-centric' method for identifying clusters of somatic muta

171 y using plant-centric rather than atmosphere-centric metrics from Earth system models (ESMs).

172 This trigger-loop-centric model can explain many properties of transcripti

173 imulating the master equation of this native-centric model for the benchmark villin subdomain, with o

174 argument will be presented that the mutation-centric model of cancer suggests unrealistic solutions t

175 that the intermediates predicted by a native-centric model of cotranslational folding account for the

176 These data challenge an amygdalo-centric model of emotional modulation and suggest that n

177 g yeast that is incompatible with this Wpl1p-centric model.

178 Contrary to origin-centric models of segregation, which predict distinct dy

179 ll studies reported to date, challenges gene-centric models of tumorigenesis.

180 ng simulations as well as simplified, native-centric models.

181 rphism in microRNA target sites (poly-miRTS)-centric multistage meta-analysis for lumbar spine (LS)-,

182 The application of this time-centric network reconstruction method in each case produ

183 seases that are the focal points in the race-centric networks and of particular clinical importance.

184 Integrative gene network and a novel CNV-centric Node Network (CNN) analysis method highlighted A

185 the function of signalling pathways, module-centric optimisation algorithms, whose aim is to identif

186 We classified outcomes as patient-centric or not patient-centric using a prespecified defi

187 This chromosome-centric organization has important implications for cell

188 previous works, our study reveals a pathway-centric organization of 3D-nucleome, whereby, functional

189 Functional status is a key patient-centric outcome, but there are little data on whether fu

190 o make recommendations for measuring patient-centric outcomes in interventions for motor improvement

191 Patient-centric outcomes that provide insight into the relative

192 Patient-centric outcomes-such as adverse events (n = 19; 15%), t

193 to quantify tracheostomy effects on patient-centric outcomes.

194 The atmosphere-centric Palmer Drought Severity Index predicts future in

195 erosing pancreatitis) and 2 (idiopathic duct centric pancreatitis).

196 Because of the stream-centric paradigm, memory requirements are minimized (oft

197 s that connect acentric chromosomes to their centric partners.

198 pothesis, we developed and applied a residue-centric patient presentation score to 9,176 cancer patie

199 spindle microtubules in a unique chromosome-centric pattern, in the vicinity of overlapping microtub

200 e BRCA1 in replication-linked maintenance of centric/pericentric heterochromatin and suggest a novel

201 al and functional experiments from a network-centric perspective by showing that global properties of

202 n risk taking became apparent: the procedure-centric perspective described how surgeons viewed their

203 viewed their colleagues whereas the surgeon-centric perspective described how surgeons viewed themse

204 It is from a lipid-centric perspective that we discuss the larger question

205 profiles, common artifacts for CLIP and RNA-centric perspectives on RBP activity.

206 ribed taking intervention-centric and client-centric perspectives to look at supply, demand, and effi

207 n data from both gene-centric and experiment-centric perspectives.

208 In this review, polymer-centric photonic and phononic crystals and metamaterials

209 i function has been described from a protein-centric point of view, but we now appreciate that concep

210 Organism-centric portals containing dynamically generated data ar

211 studies in rodents (90 days) to derive gene-centric predictors of chronic toxicity and carcinogenici

212 ishes between therapies that are either host-centric (pro-tolerance) or pathogen-centric (anti-virule

213 native mass spectrometry and (glyco)peptide-centric proteomics.

214 eport that catalytically similar single-atom-centric Pt sites are formed by binding to sodium ions th

215 etrieve significant peptides lost in protein-centric quantification for further downstream analysis.

216 We show that peptide-centric quantification has several advantages over prote

217 sion, providing excellent accuracy for MS(1)-centric quantification.

218 ctrometry (LC-MS(E)), for absolute "ribosome-centric" quantification of r-proteins in Escherichia col

219 Within three cluster-centric radii, the fraction of gas-rich galaxies decline

220 at this reduction is captured by using plant-centric rather than atmosphere-centric metrics from Eart

221 This virus-centric re-examination concludes that viruses can indeed

222 nctional classifier called InterPro2GO, gene-centric read assembly, principal coordinate analysis of

223 Although the meeting was kidney-centric, reflecting the expertise present, these recomme

224 )-containing heterochromatin is located near centric regions of chromosomes and regulates DNA-mediate

225 Centric regions of eukaryotic genomes are packaged into

226 ar level due to repetitious sequences within centric regions.

227 s were present between premature contacts in centric relation (PCCR), clinical attachment loss, and a

228 ce Integration Center (PATRIC) is a genomics-centric relational database and bioinformatics resource

229 ntences (and their documents) conveying gene-centric relationships of interest to a scientist.

230 t, factorbook is a transcription factor (TF)-centric repository of all ENCODE ChIP-seq datasets on TF

231 nvenient tool for users to access known gene-centric resources, as well as a mechanism to discover ne

232 Our results reveal an important metabolism-centric role of USP13, which may lead to potential thera

233 Implementation of a lean-focused, patient-centric rounding structure stressing essential processes

234 lysis plan, meta-analyses, and weighted gene-centric scores.

235 d for discovery proteomics based on spectrum-centric scoring can be adapted to large-scale DIA experi

236 riments that have been analyzed with peptide-centric scoring strategies, and we provide guidance on t

237 dent acquisition (DIA) combined with peptide-centric scoring, as exemplified by the technique SWATH-M

238 Ferret successfully retrieved relevant gene-centric sentences from PubMed records.

239 udy (n = 224), was genotyped with a 50K gene-centric single-nucleotide polymorphism (SNP) array.

240 ation results for blood pressure using exome-centric single-variant and gene-based tests identified 3

241 Centric-skewing correlates with a bias towards class I b

242 f QuickSNP is the option to select only gene-centric SNPs from a chromosomal region in an automated f

243 s such as high-resolution displays and human-centric soft electronics.

244 e such analyses, we have developed biologist-centric software (myFX) that contains computational meth

245 were used to develop and implement a patient-centric standardized rounding process, which we hypothes

246 m has thus far been addressed from a protein-centric standpoint; however, protein-coding regions only

247 chromosome 9p21 for association using a gene-centric statistical test.

248 ates with the novel aggregation method, cell-centric statistics (CCS).

249 e so-called one-node search and related gene-centric strategies that incorporate implicit links to pr

250 drug action, thus offering a unique pathway-centric strategy for drug discovery.

251 We used data from a socio-centric study of sexual behaviour in Malawi to quantify

252 A new cardiovascular gene-centric subgenome single nucleotide polymorphism array i

253 ring common pathways are merged into pathway-centric supermodules and a Cytoscape plug-in (MetaDCNExp

254 response exhibit breaking of the macroscopic centric symmetry through inhomogeneity induced by the hi

255 Further, components from these nucleotide-centric systems have been utilized in several other syst

256 ficant results in GWAS display a highly gene-centric tendency.

257 ng for effective number of SNPs using a gene-centric test, six SNPs (rs7875153, rs7848524, rs4446809,

258 contain more than 1.4 million words of gene-centric text with extensive citations back to the primar

259 rom those found in classical, model organism-centric textbooks.

260 An alternative to disease-centric therapeutic approaches is that of 'geroscience',

261 current as well as unexplored EC metabolism-centric therapeutic avenues are discussed.

262 and computational tools for evaluating water-centric thermodynamics are reviewed.

263 re we present PECAN, a library-free, peptide-centric tool that robustly and accurately detects peptid

264 lar dynamics simulations as well as fragment-centric topographical mapping of binding interfaces, we

265 This p53-centric transcriptional network and its associated pheno

266 m (ES) cell pluripotency is governed by OCT4-centric transcriptional networks.

267 has been a big obstacle, mitigating a leptin-centric treatment of obesity.

268 led the ADAPTABLE (Aspirin Dosing: A Patient-centric Trial Assessing the Benefits and Long-term Effec

269 d outcomes as patient-centric or not patient-centric using a prespecified definition.

270 fy common and rare psoriasis-associated gene-centric variation.

271 A pathway-centric view acknowledges the heterogeneity between geno

272 In this study we take a protein-centric view and explore the ancestral origins of protei

273 In this review, we provide a virus-centric view and novel insights into HPV-positive head a

274 mostly been ignored, resulting in a protein-centric view of assembly that is unable to explain adequ

275 These results challenge a Z-ring-centric view of bacterial cytokinesis and identify cell

276 ock, with a focus on (a) an emerging network-centric view of clock architecture, (b) mechanistic insi

277 in IDRs and refine the traditional structure-centric view of disease mutations.

278 ing of plastid integration and favors a host-centric view of endosymbiosis.

279 icals offer the opportunity to adopt a chemo-centric view of human health that does not require detai

280 A mean-centric view of populations, whereby a change in the mea

281 These findings suggest that the HDL-centric view of RCT may need revision.

282 matically generates an uninterrupted species-centric view of sequence conservation and enables the di

283 ecent findings, however, challenge the actin-centric view of the motility of critical secretory organ

284 tive group functioning, they adopt a Western-centric view of the relationship of the individual to th

285 oxidative theory of aging beyond a cellular-centric view to include extracellular matrix and the cri

286 This prevailing macrophage-centric view, however, does not explain emerging aspects

287 re hard to explain with a traditional driver-centric view.

288 ith sequence, probably due to a more pathway-centric view: 80% domain sequence identity is required f

289 This ''protein-centric" view is increasingly challenged by evidence for

290 oxicity are moving beyond a simplistic 'foci-centric' view of DM1 pathogenesis as a spliceopathy due

291 argue against a purely 'transcription factor-centric' view of transcription initiation, suggesting th

292 nth Revision (ICD9)-centric and disease name centric views of disease information.

293 Current FG-centric views reason that selective Kap translocation is

294 ot be clearly observed with traditional gene-centric visualization tools.

295 ism, and each has been interpreted in autism-centric ways (psychoanalytic interpretations of pronoun

296 present the results of our analysis in a TF-centric web repository Factorbook and will continually u

297 The platform provides either a target-centric workflow to identify diseases that may be associ

298 ociated with a specific target, or a disease-centric workflow to identify targets that may be associa

299 transition between these target- and disease-centric workflows.

300 ure development includes providing a variant-centric XML archive and a web page for details of SCV su