ライフサイエンスコーパス: centrocyte

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1 , proliferating germinal center centroblasts/centrocytes.

2 lls, CD5(+) B cells, and GC centroblasts and centrocytes.

3 , essentially as nonproliferative CXCR4(neg) centrocytes.

4 ated into a population with the phenotype of centrocytes after stimulation with CD40 ligand (CD40L) a

5 Nevertheless, a subset of centrocytes and B cells in the subepithelium showed nucl

6 t murine Aicda(-/-) GC B cells accumulate as centrocytes and inefficiently generate plasma cells.

7 als for differentiation of centroblasts into centrocytes and resistance to B cell receptor-mediated a

8 we propose that the selection probability of centrocytes and the recycling probability of selected ce

9 GC founder cells, 0% of centroblasts, 13% of centrocytes, and 9% of memory B cells.

10 centroblasts, it extends to all isotypes in centrocytes, and it is extinct in memory B cells.

11 in ex vivo isolated tonsillar centroblasts, centrocytes, and memory B cells.

12 mRNA was only found in tonsil naive B cells, centrocytes, and to a lesser extent in centroblasts.

13 Annexin V, comprised mostly (93%) of CD77(-) centrocytes, and were enriched for CD69(+) cells.

14 es and the recycling probability of selected centrocytes are not constant but vary during the GC reac

15 It has been proposed that centrocytes are selected in the light zone on the basis

16 Germinal center centroblasts and centrocytes as well as tonsillar memory B cells express

17 w that the frequent recycling of Ag-selected centrocytes back into centroblasts can lead to efficient

18 Upon further culture, the centrocytes differentiated to memory B cells, a process

19 gest that Bcl-x rather than Bcl-2 may rescue centrocytes during selection in the germinal center.

20 Centroblasts differentiated to centrocytes during the culture period of 3 days as demon

21 Purified B-cell fractions enriched for centrocytes express high amounts of Bcl-x and relatively

22 transit (naive B cells --> centroblasts --> centrocytes --> memory B cells) by gene expression profi

23 blasts give rise to smaller nonproliferating centrocytes in the light zone that compete for binding a

24 henotypic characteristics of germinal center centrocytes, including a low level of surface Ig, a lack

25 GC dissociation, followed by the release of centrocytes into the periphery, is advantageous for gene

26 nterfollicular neoplastic B cells were small centrocyte-like cells with lower grade cytology and lowe

27 ation, the BCL1 3B3 cells differentiate into centrocyte-like cells, whereas the BCL1 5B1b cells blast

28 IRTA1 in marginal zone B cells and IRTA2 in centrocytes, marginal zone B cells, and immunoblasts.

29 the transition between DZ centroblast and LZ centrocyte phenotypes occurred independently of position

30 large numbers even when most of the selected centrocytes recycle back into centroblasts.

31 as follicle-center B cells (centroblasts and centrocytes) show weaker expression.

32 with focal germinal centers (GCs) containing centrocytes staining strongly for bcl-2 protein, whereas

33 he germinal center B-cell-like subclass; the centrocyte subtype had a superior prognosis compared wit

34 subtype had a complex genotype, whereas the centrocyte subtype had high TP53 mutation and insertion/

35 ement with the observed therapeutic outcome, centrocyte subtypes were estimated as being less resista

36 Centroblasts produce non-proliferating centrocytes that are thought to migrate to the light zon

37 o be a specialized niche comprised mostly of centrocytes that may be in transition between activation

38 on by AG490 prevented the transition from GC centrocytes to preplasmablast, suggesting that STAT3 is

39 Centroblasts then mature into centrocytes to undergo clonal selection.

40 The transition of centroblast to centrocyte was enhanced by BCR stimulation and IL-4.

41 sed in positive regulatory domain 1-positive centrocytes, which are negative for all the B cell trans

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