ライフサイエンスコーパス: ceramide kinase

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1 lipase A2 (cPLA2alpha) or down-regulation of ceramide kinase.

2 phosphorylation, is completely inactive with ceramide kinase.

3 ed during phagocytosis through activation of ceramide kinase.

4 es not serve as substrate for the neutrophil ceramide kinase.

5 agocytic index in association with increased ceramide kinase activation and translocation to lipid ra

6 Ceramide kinase activation occurs in a time-dependent fa

7 Our method is useful for assaying ceramide kinase activity both in vitro and in cultured c

8 Current assays for ceramide kinase activity employ [(32)P]ATP, with separat

9 Ceramide kinase and its product ceramide 1-phosphate hav

10 tudy identifies previously unknown roles for ceramide kinase and its product, C-1-P, in AA release an

11 Recently, we demonstrated that ceramide kinase, and its product, ceramide 1-phosphate (

12 This new ceramide kinase assay is more specific than the commonly

13 that ceramide 1-phosphate (C1P) produced by ceramide kinase (CERK) is a negative regulator of LPS-in

14 We now report that ceramide kinase (Cerk) is required for mammary tumor rec

15 We characterized the first ceramide kinase (CERK) mutant in any organism.

16 1-phosphate is formed by a calcium-dependent ceramide kinase, found predominately in the neutrophil p

17 raction of Bwa with CDase and the Drosophila ceramide kinase gene (DCERK).

18 Down-regulation of ceramide kinase had no effect on AA release induced by e

19 We studied whether human ceramide kinase (hCERK) activity and ceramide 1-phosphat

20 C1P produced by ceramide kinase is an activator of group IVA cytosolic p

21 Recombinant ceramide kinase is highly active and ceramide is the onl

22 w that the sphingolipid biosynthetic enzyme, ceramide kinase, is a novel regulator of PLC signaling a

23 Thus ceramide kinase-mediated maintenance of ceramide level i

24 ceramide kinase specifically down-regulated ceramide kinase mRNA and activity with a concomitant dec

25 increase in ceramide, resulting from lack of ceramide kinase, perturbs the membrane microenvironment

26 labeled lipid in organic solvent extracts of ceramide kinase reactions.

27 RNA interference targeted to ceramide kinase specifically down-regulated ceramide kin

28 A mutation in ceramide kinase specifically leads to proteolysis of NOR

29 veloped a fluorescent plate reader assay for ceramide kinase that uses commercially available C6-NBD

30 Collectively, these results indicate that ceramide kinase, via the formation of C-1-P, is an upstr

31 Human ceramide kinase was recently cloned and characterized.

32 the production of C-1-P in mammalian cells, ceramide kinase, was activated in response to IL-1beta a

33 Using recombinant ceramide kinase, we have now developed a rapid and speci

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