ライフサイエンスコーパス: cerberus

1 ccurately describe the function of mammalian Cerberus.

2 4 (caAlk4), induced both cardiac markers and Cerberus.

3 nal repressor Hex while Dkk-1 did not induce Cerberus.

4 ls (Vg1, Xnr1-2) can induce ectopic XHex and cerberus.

5 al injection of XHex mRNA can induce ectopic cerberus.

6 sc, Xeomes, Xapod, Xchordin, Mix1, Xlim1 and Cerberus.

7 /bone morphogenetic protein (BMP) antagonist Cerberus-1 (Cer1) in embryonic stem cell cultures orches

8 However, Cerberus, a secreted protein that also induces an ectopi

9 In addition, Cerberus alone blocks signaling by Activin- and Nodal-li

10 Cerberus alone was found sufficient to initiate cardioge

11 dorsoanterior endoderm, which expressed both cerberus and a subset of the genes expressed by the prec

12 effect of morpholino-medicated knockdown of Cerberus and Hex, which is required for Dkk1-induced car

13 Nodal extracellularly, the Nodal antagonists Cerberus and Lefty are permissive for ADMP activity.

14 expression of the anterior endodermal marker Cerberus and other mesendodermal genes downstream of Wnt

15 s inhibits expression of the anterior marker Cerberus and results in anterior truncations.

16 Members of the protein family comprising Cerberus and the putative tumour suppressor Dan have not

17 amily that includes the head-inducing factor Cerberus and the tumor suppressor DAN.

18 e expression of the organizer genes chordin, cerberus and Xnr3, but they were not necessary for the e

19 nteriorly expressed genes including Chordin, Cerberus, and Blimp1.

20 rganizer factors, including goosecoid, Xnot, Cerberus, and chordin, are severely reduced.

21 provide support for the model that Gremlin, Cerberus, and DAN block BMP signaling by binding BMPs, p

22 Therefore, we propose that Gremlin, Cerberus, and DAN control diverse processes in growth an

23 es downstream of the BMP antagonists noggin, cerberus, and gremlin since ectodermal explants expressi

24 igands are limited, and include follistatin, Cerberus, and Lefty.

25 ion of mesodermal marker genes such as Xbra, Cerberus, and Otx2, which are subsequently down-regulate

26 ll as the anterior endodermal genes Xhex and cerberus, and the organizer specific gene, Xlim1, are do

27 In Xenopus, XHex and cerberus are early marker genes of the anterior endomeso

28 Surprisingly, although no known targets of Cerberus are expressed asymmetrically on the right side

29 Using XHex and cerberus as markers we have examined the signals underly

30 Thus, our findings expand the roles of Cerberus as TGF-beta family signaling inhibitor, provide

31 porter gene assays, we discovered that human Cerberus bound and inhibited the TGF-beta family ligands

32 resses mCer1 which, like its Xenopus homolog cerberus, can induce markers of cardiac specification an

33 Chick Cerberus (cCer) was found to be expressed in the left he

34 tion of the organizer genes Goosecoid (Gsc), Cerberus (Cer), and Chordin (Chd).

35 odal inhibitors Lefty2 (Lefty) and truncated Cerberus (Cerb-S) and by pharmacological interference us

36 N-terminal region, and support the idea that Cerberus could have regulatory activities beyond direct

37 eir activity is modulated by a member of the Cerberus/Dan family of BMP antagonists, Protein Related

38 characterization of 51-B6, a novel member of Cerberus/Dan family of secreted BMP inhibitors, which we

39 secreted protein encoded by a member of the Cerberus/Dan gene family, mediates the Sonic hedgehog (S

40 ated by Caronte (Car), a novel member of the Cerberus/Dan gene family, which induces targets by antag

41 The carboxy-terminal fragment of Cerberus, designated Cer-S, provides a specific secreted

42 Since the specific knockdown of Cerberus did not abrogate heart induction by the Wnt ant

43 The expression of cerberus during gastrulation is activated by earlier nod

44 The gene cerberus encodes a secreted protein that is expressed in

45 Microsurgical ablation of the cerberus-expressing endoderm decreased the incidence of

46 In Xenopus, the cerberus-expressing endoderm is required for heart, but

47 entral misexpression of XHex induced ectopic cerberus expression and conferred anterior signalling pr

48 ssion of the Wnt target gene snail2 restores cerberus expression and rescues the eye defects caused b

49 ordin are important for maintaining XHex and cerberus expression.

50 alling components blocks endogenous XHex and cerberus expression.

51 C cofactors and antagonists of the Lefty and Cerberus families of proteins, allowing precise control

52 It is thought that the Cerberus Fossae fissures on Mars were the source of both

53 Our work shows that Cerberus Fossae provided the waters that carved Marte Va

54 n be induced by Vg1), a second inhibition by Cerberus from the underlying hypoblast, and finally a la

55 g that previous studies, which analyzed frog Cerberus function, may not accurately describe the funct

56 The Xenopus cerberus gene encodes a secreted factor that is expresse

57 stine knot-containing factors including dan, cerberus, gremlin, prdc, and caronte.

58 lls expressing homologues of the AVE markers cerberus, Hex and Hesx1.

59 7, Chordin, Lim1, Hnf3beta, Otx2, Goosecoid, Cerberus, Hex, Dickkopf1, and Crescent are all already e

60 determine the molecular activities of human Cerberus in TGF-beta family signaling.

61 oderm depends on Nodal-mediated induction of Cerberus in underlying endoderm, and that this pathway f

62 Finally, although misexpression of cerberus induced ectopic heads, it was unable to induce

63 The underlying reason is that Cerberus is a complex, multifunctional protein: It binds

64 Cerberus is a key regulator of vertebrate embryogenesis.

65 sequence homology between frog and mammalian Cerberus is low, suggesting that previous studies, which

66 We propose that, in Xenopus, cerberus is redundant to other bone morphogenetic protei

67 sses Hex and the putative head-inducing gene cerberus, is proposed to be equivalent to the mouse ante

68 ctivin B, BMP-6, and BMP-7, but not the frog Cerberus ligand BMP-2.

69 expression of anterior markers such as Hex, Cerberus-like and Lhx1.

70 Microinjection of cerberus mRNA into Xenopus embryos induces ectopic heads

71 uced expression of Siamois, XTwin, Xnr3, and Cerberus mRNAs in a protein synthesis independent manner

72 and the overexpression of Wnt8, Siamois, and Cerberus mRNAs.

73 -autonomously, thus supporting the idea that Cerberus or another diffusible factor is an essential me

74 ve secreted protein that is 48% identical to cerberus over a 110-amino acid region.

75 esoderm, as indicated by their inhibition by Cerberus overexpression.

76 es in Athabasca Valles and its distal basin, Cerberus Palus, are actually composed of this lava.

77 Protein related to DAN and cerberus (PRDC) is a secreted protein with a cystine kno

78 the structure of protein related to Dan and Cerberus (PRDC), a more potent BMP antagonist within the

79 onists, including protein related to DAN and cerberus (PRDC), have an unpaired cysteine that is thoug

80 BMP antagonists, Protein Related to Dan and Cerberus (PRDC).

81 us organizer: deep endoderm, which expressed cerberus; prechordal mesoderm, which showed overlapping

82 Here we show that the cerberus protein functions as a multivalent growth-facto

83 y, morpholino-mediated specific knockdown of Cerberus reduced both endogenous cardiomyogenesis and ec

84 Here we describe the existence of a cerberus-related gene, Cerr1, in the mouse.

85 Strikingly, the molecular function of Cerberus remains poorly understood.

86 ganizer genes, including chordin, noggin and cerberus, required the activity of both the Wnt pathway

87 ist and Snail2 negatively regulate levels of cerberus RNA, which encodes a Nodal, bone morphogenic pr

88 iously identified in imagery and topography (Cerberus Rupes and Valles Marineris).

89 Cerberus's anti-Nodal activity inhibits NF-kappaB activi

90 njection of RNA encoding the nodal inhibitor Cerberus-short (CerS).

91 which mesoderm induction has been blocked by Cerberus-short, a reagent that specifically inhibits Nod

92 Injection of a Nodal antagonist, Cerberus-short, reduced the severity of head and axial d

93 Notably, full-length Cerberus successfully blocked ligand binding to type II

94 In addition, full-length Cerberus suppressed breast cancer cell migration but the

95 Unlike the effect of misexpressing cerberus, these signals could not neuralise overlying ec

96 Downstream of Wnt, the head inducer Cerberus was identified as an effector that mediates ADA

97 undant cDNA enriched in Spemann's organizer, cerberus, was isolated by differential screening.

98 s induced strongly by siamois, moderately by cerberus, weakly by Wnt8 and noggin, and not by chordin

99 molecules such as Chordin, Noggin, Xnr6 and Cerberus were not re-expressed in these embryos.

100 from that of the multifunctional antagonist cerberus, which completely abolishes mesoderm induction

101 n unforeseen role for the DAN family protein Cerberus within presumptive foregut endoderm as essentia

102 ed dorsoanterior endodermal markers, such as cerberus, Xhex-1 and Frzb, in animal cap ectoderm.