ライフサイエンスコーパス: cerebellar Purkinje cell

1 tory synapses on the somata and dendrites of cerebellar Purkinje cells.

2 udied the electrophysiological properties of cerebellar Purkinje cells.

3 of the ovary, cerebral cortical neurons, and cerebellar Purkinje cells.

4 e and show that IP6K3 is highly expressed in cerebellar Purkinje cells.

5 triking abnormalities other than the loss of cerebellar Purkinje cells.

6 e inhibition at three types of synapses onto cerebellar Purkinje cells.

7 cell counts reveal no significant absence of cerebellar Purkinje cells.

8 topoiesis, and lack of early degeneration of cerebellar Purkinje cells.

9 nd dendrites of whole-cell patch-clamped rat cerebellar Purkinje cells.

10 several cranial nerves nuclei, as well as in cerebellar Purkinje cells.

11 reveals abundant CYP2J9 mRNA and protein in cerebellar Purkinje cells.

12 neocortex and within the dendritic arbors of cerebellar Purkinje cells.

13 in dendrites of cortical pyramidal cells and cerebellar Purkinje cells.

14 ipheral locations or different modalities to cerebellar Purkinje cells.

15 eticulum vesicles in the dendritic spines of cerebellar Purkinje cells.

16 ed by long-term synaptic depression (LTD) in cerebellar Purkinje cells.

17 IP6K3 is highly concentrated in the brain in cerebellar Purkinje cells.

18 a pronounced abnormality in the location of cerebellar Purkinje cells.

19 er, and neurodegeneration, especially of the cerebellar Purkinje cells.

20 of cytoskeletal disposition and function of cerebellar Purkinje cells.

21 progressive motor deterioration, and loss of cerebellar Purkinje cells.

22 anocytes and smooth endoplasmic reticulum in cerebellar Purkinje cells.

23 nductance levels (9, 13-14, and 17-18 pS) in cerebellar Purkinje cells.

24 unique persistent and resurgent currents in cerebellar Purkinje cells.

25 progressive motor deterioration, and loss of cerebellar Purkinje cells.

26 b5 is expressed in brain capillaries, and by cerebellar Purkinje cells.

27 n were also detected in cortical neurons and cerebellar Purkinje cells.

28 progressive motor deterioration, and loss of cerebellar Purkinje cells.

29 und that ataxin-1 localizes to the nuclei of cerebellar Purkinje cells.

30 age-gated currents during somatic spiking in cerebellar Purkinje cells.

31 ing in neurons and labeled large speckles in cerebellar Purkinje cells.

32 behaviors such as thalamic relay neurons and cerebellar Purkinje cells.

33 eus (DCN) that bear considerable homology to cerebellar Purkinje cells.

34 man ataxia-telangiectasia and Atm(-/-) mouse cerebellar Purkinje cells.

35 y identified presynaptic partners, including cerebellar Purkinje cells.

36 for dendritic growth and branching of mouse cerebellar Purkinje cells.

37 ataxia and concomitant axon degeneration of cerebellar Purkinje cells.

38 t display age-dependent neurodegeneration of cerebellar Purkinje cells.

39 retinal starburst amacrine cells (SACs) and cerebellar Purkinje cells.

40 cal symptoms in mice and the degeneration of cerebellar Purkinje cells.

41 -6 is known to cause significant loss of the cerebellar Purkinje cells.

42 Polysynaptic pathways were also labeled from cerebellar Purkinje cells.

43 4-AP do not increase the inhibitory drive of cerebellar Purkinje cells.

44 ations is loss of precision of pacemaking in cerebellar Purkinje cells.

45 rallel fiber segments of the granule axon on cerebellar Purkinje cells.

46 ularly within brain motor systems, including cerebellar Purkinje cells.

47 the slow excitatory postsynaptic current in cerebellar Purkinje cells.

48 ne transporters (DATs) were all expressed in cerebellar Purkinje cells.

49 types involved in motor function, including cerebellar Purkinje cells.

50 mately yield a long-term depression (LTD) of cerebellar Purkinje cells.

51 of the sample, such as occurs when counting cerebellar Purkinje cells.

52 icroscopy to measure dendritic spines in rat cerebellar Purkinje cells.

53 holinergic neurons, dopaminergic neurons and cerebellar Purkinje cells.

54 uman Atxn1 with an expanded polyglutamine in cerebellar Purkinje cells.

55 nels that are expressed at high densities in cerebellar Purkinje cells.

56 ), is important for postnatal development of cerebellar Purkinje cells.

57 lize molecular diffusion within dendrites of cerebellar Purkinje cells.

58 tive exon results in abnormal development of cerebellar Purkinje cells.

59 Only 5-10% of cerebellar Purkinje cells, a less vulnerable population,

60 We show that, in cerebellar Purkinje cells, a single activation of the cl

61 in selected regions of the cerebral cortex, cerebellar Purkinje cells, a subset of striatal neurons,

62 hallmark of A-T is fulminant degeneration of cerebellar Purkinje cells accompanied by a progressive a

63 x has been shown to reduce the regularity of cerebellar Purkinje cell activity and to induce episodic

64 oreactive neurons appear to be innervated by cerebellar Purkinje cell afferents.

65 d to double the simple spike activity of the cerebellar Purkinje cell and eliminates complex spike ac

66 nts, including decreased firing frequency of cerebellar Purkinje cells and a decline in motor functio

67 are known to be expressed preferentially in cerebellar Purkinje cells and are involved in triggering

68 t ganglion and there was progressive loss of cerebellar Purkinje cells and atrophy of cerebellar gran

69 R)alpha, is essential for the development of cerebellar Purkinje cells and bone tissue.

70 otor coordination due to the degeneration of cerebellar Purkinje cells and brain stem neurons.

71 However, in fast-spiking GABAergic neurons (cerebellar Purkinje cells and cortical interneurons), tw

72 Cerebellar Purkinje cells and granule cells have been st

73 In contrast, in GABAergic neurons such as cerebellar Purkinje cells and hippocampal pyramidal bask

74 Cerebellar Purkinje cells and hippocampal pyramidal cell

75 elta2 receptor is predominantly expressed in cerebellar Purkinje cells and in the heterozygous Lurche

76 We found that both cerebellar Purkinje cells and inhibitory thalamic reticu

77 rize the pH-dependent activation of ASICs in cerebellar Purkinje cells and investigate how they are m

78 el subunit Kv3.3 is prominently expressed in cerebellar Purkinje cells and is known to be important f

79 t throughout the elaborate dendritic tree of cerebellar Purkinje cells and is required for normal neu

80 hat caused the degeneration of virtually all cerebellar Purkinje cells and most olivary neurons and g

81 rms alpha, gamma, and delta are expressed by cerebellar Purkinje cells and neurons in the cerebellar

82 ation revealed elevated superoxide levels in cerebellar Purkinje cells and nigral dopaminergic neuron

83 me areas where neurons did not express NeuN: cerebellar Purkinje cells and olfactory bulb mitral cell

84 orphology, number and length, is affected on cerebellar Purkinje cells and on pyramidal neurons in th

85 sulted in a marked decrease in the number of cerebellar Purkinje cells and parvalbumin-positive inter

86 Pcp2 is expressed in cerebellar Purkinje cells and retinal bipolar neurons, t

87 ganglion cells in mouse and human, including cerebellar Purkinje cells and retinal ganglion cells.

88 containing family, is present exclusively in cerebellar Purkinje cells and retinal ON bipolar cells.

89 g the activity of NMDA receptors (NMDARs) in cerebellar Purkinje cells and their possible functions.

90 P450 that is abundant in brain, localized to cerebellar Purkinje cells, and active in the biosynthesi

91 olf) is highly expressed in the striatum and cerebellar Purkinje cells, and co-localized with cortico

92 in three principal neurons of the mouse CNS: cerebellar Purkinje cells, and cortical and hippocampal

93 which receive direct inhibitory inputs from cerebellar Purkinje cells, and excitatory collaterals fr

94 riatum, CA1 subfield of the hippocampus, and cerebellar Purkinje cells, and high densities of Kv beta

95 cholinergic neurons in the basal forebrain, cerebellar Purkinje cells, and substantia gelatinosa of

96 e lysosomal-endosomal compartment, a loss of cerebellar Purkinje cells, and widespread axonal degener

97 Climbing fiber responses in cerebellar Purkinje cells are described as being invaria

98 pite lacking N-methyl-D-aspartate receptors, cerebellar Purkinje cells are highly vulnerable to ischa

99 ce are targets of oxidative damage, and that cerebellar Purkinje cells are particularly affected.

100 During locomotion, cerebellar Purkinje cells are rhythmically active, shapi

101 n stratum oriens and piriform cortex, and in cerebellar Purkinje cell areas.

102 normal mice, CAR8 is abundantly expressed in cerebellar Purkinje cells as well as in several other ce

103 Anti-PDE4D antibody distinctly labeled cerebellar Purkinje cells as well as neurons in the medi

104 cked the late phase of LTD in mouse cultured cerebellar Purkinje cells, as did deletion of the immedi

105 ating bone marrow cells with, in particular, cerebellar Purkinje cells, as well as the subsequent for

106 In the brain, there were reduced numbers of cerebellar Purkinje cells, atrophic vestibular sense org

107 Here we use recordings from visualized rat cerebellar Purkinje cell axons to localize the site of i

108 mutation alters calcium channel currents in cerebellar Purkinje cells, both because these cells are

109 , striatum, septal nuclei, substantia nigra, cerebellar Purkinje cells, brainstem and spinal motor ne

110 y dispersed synapses are activated on rodent cerebellar Purkinje cells but that it reduces presynapti

111 xamined the phosphorylation of PDE5 in mouse cerebellar Purkinje cells by immunocytochemistry and Wes

112 t conditional deletion of all neuroligins in cerebellar Purkinje cells caused loss of distal climbing

113 ermine if the properties of Ca2+ channels in cerebellar Purkinje cells change during postnatal develo

114 In cerebellar Purkinje cells, climbing fiber synapses provi

115 Although cerebellar Purkinje cell complex spikes occur at low fre

116 Loss of CCP1 in mice causes cerebellar Purkinje cell degeneration.

117 The molecular pathways controlling cerebellar Purkinje cell dendrite formation and maturati

118 ynaptic and intrinsic membrane properties of cerebellar Purkinje cell dendrites, and a 4-aminopyridin

119 croinjected into molluscan neurons or rabbit cerebellar Purkinje cell dendrites, calexcitin was highl

120 In cerebellar Purkinje cells, dendritic spikes can trigger

121 The relationship of cerebellar Purkinje cell discharge to the control of arm

122 d NBQX inhibited kainate-induced currents in cerebellar Purkinje cells, DRG neurons, and human GluR5-

123 tive, cell-autonomous and apoptotic death of cerebellar Purkinje cells during postnatal development.

124 cal, suggesting that they are coregulated in cerebellar Purkinje cells during this early compensatory

125 of plasticity in the simple-spike firing of cerebellar Purkinje cells during trial-over-trial learni

126 In particular, fz4 is expressed in cerebellar Purkinje cells, esophageal skeletal muscle, a

127 We now report that cerebellar Purkinje cells express KCa3.1 channels, as ev

128 urons that send climbing fibers to innervate cerebellar Purkinje cells for the control of motor learn

129 LTD was absent in cultured cerebellar Purkinje cells from mutant mice lacking the A

130 railed-2 (En-2) was ectopically expressed in cerebellar Purkinje cells from the late embryonic stage

131 dination caused primarily by a disruption of cerebellar Purkinje cell function.

132 armacological profile of acutely dissociated cerebellar Purkinje cell GABAARs from untreated, artific

133 terminal PDZ binding motif, were perfused in cerebellar Purkinje cells grown in culture.

134 expression of the mutant SCA1 allele within cerebellar Purkinje cells has divergent effects on the m

135 Cerebellar Purkinje cells have one of the most elaborate

136 Cerebellar Purkinje cells have two distinct action poten

137 We show here that a cerebellar Purkinje cell in a ferret can learn to respon

138 ions of a biophysically realistic model of a cerebellar Purkinje cell in a pattern recognition task s

139 lesions of the CBF and, to a lesser extent, cerebellar Purkinje cells in a dose-dependent fashion.

140 bellum of control mice, are expressed within cerebellar Purkinje cells in a mouse model of MS, chroni

141 )1.8 mRNA and protein are upregulated within cerebellar Purkinje cells in animal models of multiple s

142 We made electrophysiological recordings from cerebellar Purkinje cells in both V408A/+ mice and their

143 the structure and plasticity of synapses on cerebellar Purkinje cells in Fmr1 knockout mice, which a

144 Cerebellar Purkinje cells in GABA(A) receptor alpha1-/-

145 that results in the cell-autonomous death of cerebellar Purkinje cells in heterozygous lurcher (+/Lc)

146 Death of cerebellar Purkinje cells in lurcher animals is due to a

147 assessed the chronic toxicity of ibogaine on cerebellar Purkinje cells in male Fischer 344 rats.

148 In newborn mice sema-D is expressed by cerebellar Purkinje cells in parasagittal bands located

149 We demonstrate the presence of alpha-TTP in cerebellar Purkinje cells in patients having vitamin E d

150 showed that ibogaine causes degeneration of cerebellar Purkinje cells in rats.

151 temporally protracted heredodegeneration of cerebellar Purkinje cells in shaker mutant rats can be m

152 of the corpus callosum, and degeneration of cerebellar Purkinje cells in the NPC mouse.

153 ed in the neurons of cerebral cortex and the cerebellar purkinje cells, in a pattern similar to that

154 subunit Kv3.3 is expressed at high levels in cerebellar Purkinje cells, in auditory brainstem nuclei

155 ate the role of cartwheel cells, homologs of cerebellar Purkinje cells, in producing this inhibition.

156 and the intensity of Trio immunostaining in cerebellar Purkinje cells increase from P1 to P30.

157 receptor (mGluR) second messenger system in cerebellar Purkinje cells is constructed.

158 campus (0 vs. 3.5), subiculum (0 vs. 4), and cerebellar Purkinje cell layer (2 vs. 4) (all p < .05).

159 mEAAT1 mRNA was present predominantly in the cerebellar Purkinje cell layer and at a much lower abund

160 -II mRNA exhibits peak expression within the cerebellar Purkinje cell layer and the hippocampus, as w

161 RGS8 mRNA is highly expressed in the cerebellar Purkinje cell layer as well as in several mid

162 18.2% of wild-type L-SMase activity, but the cerebellar Purkinje cell layer, which is lost by 4 month

163 Deletion of Npc1 in mature cerebellar Purkinje cells leads to an age-dependent impa

164 that the mouse sticky mutation, which causes cerebellar Purkinje cell loss and ataxia, is a missense

165 se brains also exhibited cortical neuron and cerebellar Purkinje cell loss, astrogliosis, and decreas

166 or coordination abnormalities, prevention of cerebellar Purkinje cell loss, correction of the ultrast

167 clodextrins (HPbetaCD) significantly delayed cerebellar Purkinje cell loss, slowed progression of neu

168 wz) mutation develop adult-onset ataxia with cerebellar Purkinje cell loss.

169 These phenomena suggest that cerebellar Purkinje cells may be a uniquely vulnerable n

170 (type I) devoid of cellular organelles, and cerebellar Purkinje cells, nearly all of which accumulat

171 with ataxin-1 localized to aggregates within cerebellar Purkinje cells nuclei.

172 Furthermore, we show that cerebellar Purkinje cell number and dendritic branching

173 Inactivation of the Nfasc gene in cerebellar Purkinje cells of adult mice causes rapid los

174 rents were recorded from acutely dissociated cerebellar Purkinje cells of homozygous leaner (tgla/tgl

175 he limbic forebrain, the locus coeruleus and cerebellar Purkinje cells, or for CRF2 in any aspect of

176 omplex spike synchrony across populations of cerebellar Purkinje cells oriented in the parasagittal a

177 ing phase and the prolonged plateau phase of cerebellar Purkinje cell (PC) action potentials.

178 shed that the climbing fiber (CF) input to a cerebellar Purkinje cell (PC) can exert a controlling in

179 are characterized by loss of balance due to cerebellar Purkinje cell (PC) degeneration.

180 channel Kv1.2 alpha-subunit is expressed in cerebellar Purkinje cell (PC) dendrites where its pharma

181 post-mortem studies in ASD patients showing cerebellar Purkinje cell (PC) loss, and isolated cerebel

182 ynaptic transmission from parallel fibers to cerebellar Purkinje cells (PCs) and from climbing fibers

183 Cerebellar Purkinje cells (PCs) are predominantly affect

184 Cerebellar Purkinje cells (PCs) are primarily affected i

185 ding-bundling proteins that are expressed in cerebellar Purkinje cells (PCs) but are not detected in

186 Cerebellar Purkinje cells (PCs) express two glutamate tr

187 KEY POINTS: Cerebellar Purkinje cells (PCs) generate two types of ac

188 ional postnatal loss of P/Q-type channels in cerebellar Purkinje cells (PCs) in mice (purky) leads to

189 matic representations through the cerebellum.Cerebellar Purkinje cells (PCs) linearly encode whisker

190 Cerebellar Purkinje cells (PCs) receive GABAergic input

191 in intrinsic properties and excitability of cerebellar Purkinje cells (PCs) resulting from the leane

192 be a novel ionotropic GABA receptor in mouse cerebellar Purkinje cells (PCs) using agents reported to

193 ons, such as hippocampal pyramidal cells and cerebellar Purkinje cells (PCs), it has not been demonst

194 racterized by CT protein aggregates found in cerebellar Purkinje cells (PCs).

195 and its receptor Robo2 in self-avoidance of cerebellar Purkinje cells (PCs).

196 Brief strong depolarization of cerebellar Purkinje cells produces a slow inward cation

197 /putamen, globus pallidus, substantia nigra, cerebellar Purkinje cells, pyramidal cells of frontal co

198 sion is limited to neurons, particularly the cerebellar Purkinje cells, pyramidal cells of the hippoc

199 Cerebellar Purkinje cells receive two distinctive types

200 We find that HCN1 channels in cerebellar Purkinje cells reduce the duration of inhibit

201 Depolarization of cerebellar Purkinje cells reduced the firing rate of nea

202 expression of long-term depression (LTD) in cerebellar Purkinje cells results from the internalisati

203 Recently, the PRC theory applied to cerebellar Purkinje cells revealed that these behave as

204 tants calbindin immunostaining for surviving cerebellar Purkinje cells revealed widespread degenerati

205 nently in short-term synaptic plasticity and cerebellar Purkinje cell rhythmicity.

206 we find that deletion of HCN1 channels from cerebellar Purkinje cells selectively impairs late stage

207 Outside-out patch recordings from cerebellar Purkinje cell somas confirmed these 4-AP-sens

208 The cerebellar Purkinje cell-specific PCP-2 gene is transcri

209 ous simulations using a realistic model of a cerebellar Purkinje cell suggested that synaptic control

210 heir density in the postsynaptic membrane at cerebellar Purkinje cell synapses.

211 Cerebellar motor coordination and cerebellar Purkinje cell synaptic function require metab

212 s that trigger motor learning by controlling cerebellar Purkinje cell synaptic plasticity and dischar

213 mossy/parallel fibers and climbing fibers to cerebellar Purkinje cells that acquire a precisely timed

214 n was evident in the deep cerebellar nuclei, cerebellar Purkinje cells, the brainstem and the ventral

215 two types of action potentials generated by cerebellar Purkinje cells, the simple spikes and complex

216 lls that is essential for three processes in cerebellar Purkinje cells: the matching and maintenance

217 e growth factor-differentiated PC12 cells or cerebellar Purkinje cells to cyanide elicits rapid incre

218 which is the peak period of vulnerability of cerebellar Purkinje cells to ethanol.

219 nt throughout the soma and dendritic tree of cerebellar Purkinje cells, to be required for the mainte

220 Here, we show that brief depolarization of a cerebellar Purkinje cell triggers a slow inward current.

221 In cerebellar Purkinje cells, TRPC3 channels cause the meta

222 Brief depolarization of cerebellar Purkinje cells was found to inhibit parallel

223 Stimulation of a climbing fiber input to cerebellar Purkinje cells was shown to generate an anion

224 ng dendritic patch-clamp recordings from rat cerebellar Purkinje cells, we find that somatic depolari

225 ricted to splenic B-cells, the placenta, and cerebellar Purkinje cells where it colocalized with HNK-

226 ct reduced calcium currents, particularly in cerebellar Purkinje cells, where these channels are most

227 lled by i.c.v. injection of 192-saporin, and cerebellar Purkinje cells which are killed by OX7-sapori

228 neurones, but not in dorsal vagal nucleus or cerebellar Purkinje cells (which express other Kv3 subun

229 We have examined single NMDA channels in cerebellar Purkinje cells (which possess NR1 and 2D), de

230 , nor could we detect loss of noncholinergic cerebellar Purkinje cells, which also express p75.

231 In cerebellar Purkinje cells, which are a key component of

232 ynaptic plasticity at excitatory synapses of cerebellar Purkinje cells, which express the highest lev

233 Some of these terminals are presumably from cerebellar Purkinje cells, which were also labeled by bo