ライフサイエンスコーパス: cerebellar granule neuron

1 scription of a set of long neuronal genes in cerebellar granule neurons.

2 evealed to be enriched in the developing rat cerebellar granule neurons.

3 e mitochondrial dysfunction and apoptosis in cerebellar granule neurons.

4 muscarinic receptor in transfected cells and cerebellar granule neurons.

5 however, it does attenuate MAG inhibition of cerebellar granule neurons.

6 toxicity model using primary cultures of rat cerebellar granule neurons.

7 s of bafilomycin and chloroquine on cultured cerebellar granule neurons.

8 , and deep cerebellar nuclei, in addition to cerebellar granule neurons.

9 d induces apoptosis in cultured cortical and cerebellar granule neurons.

10 beta1 subunits promote neurite extension in cerebellar granule neurons.

11 ell as endogenous expression of this gene in cerebellar granule neurons.

12 elieved to arise from immature precursors of cerebellar granule neurons.

13 optosis in both transfected HEK293 cells and cerebellar granule neurons.

14 ted the apoptotic effect of BimEL in primary cerebellar granule neurons.

15 for normal expression of the GABRA6 gene in cerebellar granule neurons.

16 cultured neonatal hippocampal and postnatal cerebellar granule neurons.

17 ish VFDNFVLK-mediated process extension from cerebellar granule neurons.

18 nal program directing the differentiation of cerebellar granule neurons.

19 s induced by oxidative stress using cultured cerebellar granule neurons.

20 ndent expression of the Shh gene in cultured cerebellar granule neurons.

21 ic Ca(2+) current density in hippocampal and cerebellar granule neurons.

22 v4 currents in various cell types, including cerebellar granule neurons.

23 found but indirect effect on the survival of cerebellar granule neurons.

24 bition of neurite outgrowth from primary rat cerebellar granule neurons.

25 high transcriptional activity in postmitotic cerebellar granule neurons.

26 rophic factors, are critical for survival of cerebellar granule neurons.

27 use cortical neurons Neuro2A and primary rat cerebellar granule neurons.

28 n native receptors on inhibitory synapses of cerebellar granule neurons.

29 d D) were detected by immunoblot analysis in cerebellar granule neurons.

30 hippocampal pyramidal neurons or to damaged cerebellar granule neurons.

31 n regulating neuronal survival using primary cerebellar granule neurons.

32 r axon formation, and tested its function in cerebellar granule neurons.

33 A subtype of glutamate receptors (NMDARs) in cerebellar granule neurons.

34 IGF-I to promote survival of primary murine cerebellar granule neurons.

35 subtype to synaptic receptor populations in cerebellar granule neurons.

36 echanisms involved in the apoptotic death of cerebellar granule neurons.

37 brain, we studied IRP expression in cultured cerebellar granule neurons.

38 dent increase in calcium channel currents in cerebellar granule neurons.

39 a novel target of ethanol in the developing cerebellar granule neurons.

40 ange in spontaneous IPSC (sIPSC) kinetics in cerebellar granule neurons.

41 ng mock action potentials on voltage-clamped cerebellar granule neurons.

42 o native receptors in inhibitory synapses of cerebellar granule neurons.

43 ine oxidase and NADH is toxic to cultures of cerebellar granule neurons.

44 ant failed to inhibit axon growth in primary cerebellar granule neurons.

45 ays a key role in the postnatal migration of cerebellar granule neurons.

46 unction in primary cultures of postnatal rat cerebellar granule neurons.

47 S and delta types, and by using cultured rat cerebellar granule neurones.

48 ined with K+ withdrawal-induced apoptosis in cerebellar granule neurons, a model for activity-depende

49 bited L1-CAM-dependent neurite elongation in cerebellar granule neurons, a pathway previously shown t

50 onatal lethality and massive degeneration of cerebellar granule neurons, a phenotype that is dose dep

51 Withdrawal of neuronal activity in cerebellar granule neurons activated GSK3beta in the nuc

52 in red grapes and blueberries, protects the cerebellar granule neurons against ethanol-induced cell

53 We found that JAZ protects cerebellar granule neurons against potassium deprivation

54 at is expressed at high levels in migrating, cerebellar granule neurons, along with Astn1, at develop

55 rowth in primary cultures of hippocampal and cerebellar granule neurons, an effect abolished by treat

56 tivity of MEF2s during apoptosis of cultured cerebellar granule neurons, an established in vitro mode

57 led a previously unidentified progenitor for cerebellar granule neurons and a cell of origin for medu

58 illness accompanied by massive apoptosis of cerebellar granule neurons and accumulation of an aggreg

59 nts with concomitant KCNK3 surface losses in cerebellar granule neurons and cell lines.

60 sion promotes the death of otherwise healthy cerebellar granule neurons and cortical neurons in cultu

61 rane proteoglycan, inhibits axon growth from cerebellar granule neurons and dorsal root ganglia (DRG)

62 vitro model system based on purified target cerebellar granule neurons and explants of afferents, po

63 e the survival and/or differentiation of rat cerebellar granule neurons and human retinoblastoma cell

64 -induced toxicity in primary cultures of rat cerebellar granule neurons and in rat pheochromocytoma (

65 ptor (GABRA6) is preferentially expressed in cerebellar granule neurons and is part of an intrinsic p

66 ited IGF-I-induced activation of MAPK in rat cerebellar granule neurons and NG-108 neuronal cells.

67 BDNF in the anti-apoptotic effect of NMDA in cerebellar granule neurons and suggest that the NMDA-BDN

68 t delta subunit-containing GABA(A)Rs of both cerebellar granule neurons and thalamic relay neurons of

69 ptors (GABA(A)Rs) are a prominent feature of cerebellar granule neurons and thalamic relay neurons.

70 s to define the pool of myosins in migrating cerebellar granule neurons and type-1 neocortical astroc

71 sis was confirmed in pure populations of rat cerebellar granule neurons and was blocked by HA1004, an

72 arachidonic acid resembled that observed in cerebellar granule neurons and was fully reversible.

73 ospecific, killing primary cortical neurons, cerebellar granule neurons, and differentiated PC-12 cel

74 ive pathway, including inner-ear hair cells, cerebellar granule neurons, and the pontine nuclei.

75 treatment reduced caspase-3-like activity in cerebellar granule neurons, and the time course and conc

76 olog CPP32 is processed and activated during cerebellar granule neuron apoptosis.

77 Primary cerebellar granule neurons are an established in vitro m

78 Cerebellar granule neurons are highly susceptible to inj

79 Cerebellar granule neurons are the most abundant neurons

80 Using primary cerebellar granule neuron as a model, our investigation

81 We used rat cerebellar granule neurons as a model cell system for in

82 we performed whole-cell recordings from rat cerebellar granule neurons at different times during dev

83 gment of ADNP, potentiated axon outgrowth in cerebellar granule neurons by activating the sequential

84 entiates N and L calcium channel currents in cerebellar granule neurons by an unknown mechanism.

85 rs (MORs) were immobilized on the surface of cerebellar granule neurons by avidin-mediated cross-link

86 IGF-I signaling via AKT promotes survival of cerebellar granule neurons by blocking the FKHRL1-depend

87 th factor-1 (IGF-1) promotes the survival of cerebellar granule neurons by enhancing calcium influx t

88 d that clone 17a transcripts were induced in cerebellar granule neurons by glutamate or 6-hydroxydopa

89 eflect the in vivo innervation of developing cerebellar granule neurons by glutamatergic afferents.

90 gest that mastoparan initiates cell death in cerebellar granule neurons by inducing Ca2+ release from

91 vents oxidative stress-induced cell death in cerebellar granule neurons by specific regulation of the

92 onic mouse, it is shown that activation of a cerebellar granule neuron can give rise to a rapid inwar

93 e, and constitutively active forms of Akt in cerebellar granule neurons causes, respectively, no chan

94 In the present paper, we show that in rat cerebellar granule neurons, CB1 cannabinoid receptor ant

95 ifferentiated PC12 cells or KCl from primary cerebellar granule neurons (CGCs).

96 of PrP(A117V) and wild-type peptides in rat cerebellar granule neuron (CGN) cultures.

97 Cerebellar granule neuron (CGN) survival depends on acti

98 ike protein-6 DPP6-S to the gamma of native [cerebellar granule neuron (CGN)] and reconstituted Kv4.2

99 oxide synthase (nNOS) can protect developing cerebellar granule neurons (CGN) against alcohol-induced

100 biquitin-like Modifier (SUMO) pathway in rat cerebellar granule neurons (CGN) and that SUMOylation of

101 using primary cultures of mesencephalic and cerebellar granule neurons (CGN) and/or glia demonstrate

102 In primary cultures of rat cerebellar granule neurons (CGN), brevetoxins produce ac

103 is of DIC and OGC in primary cultures of rat cerebellar granule neurons (CGNs) and cerebellar astrocy

104 idence of the neuroprotective role of LFG in cerebellar granule neurons (CGNs) and PCs in an organoty

105 s of glutamate induces apoptosis of cultured cerebellar granule neurons (CGNs) and that CGNs do not r

106 on of peroxynitrite to the damage induced in cerebellar granule neurons (CGNs) by treatment with the

107 Neuronal activity promotes the survival of cerebellar granule neurons (CGNs) during the postnatal d

108 eurotoxicity of domoic acid (DomA), by using cerebellar granule neurons (CGNs) from mice lacking the

109 nstitutive process, we exposed postnatal rat cerebellar granule neurons (CGNs) maintained in culture

110 romatin accessibility and gene expression in cerebellar granule neurons (CGNs) of the developing mous

111 Here, we show that cerebellar granule neurons (CGNs) or neuroblastoma cells

112 Cerebellar granule neurons (CGNs) possess a standing out

113 In cerebellar granule neurons (CGNs) primed to undergo apop

114 in B (ToxB) induces apoptosis in primary rat cerebellar granule neurons (CGNs) principally via inhibi

115 Here, we demonstrate in primary rat cerebellar granule neurons (CGNs) that oxidative or nitr

116 Cerebellar granule neurons (CGNs) undergo apoptosis when

117 beta1 promotes neurite outgrowth of cultured cerebellar granule neurons (CGNs) via homophilic adhesio

118 wed that beta1 promotes neurite outgrowth in cerebellar granule neurons (CGNs) via homophilic cell ad

119 types, dorsal root ganglion neurons (DRGNs), cerebellar granule neurons (CGNs), and hippocampal neuro

120 growth and growth cone formation in cultured cerebellar granule neurons (CGNs), dorsal root ganglions

121 s of H(2)O(2) on the viability of post-natal cerebellar granule neurons (CGNs), the nature of the cel

122 The ability of neurons, such as cerebellar granule neurons (CGNs), to fire action potent

123 occupancy of target promoters in developing cerebellar granule neurons (CGNs).

124 ns throughout the postmitotic development of cerebellar granule neurons (CGNs).

125 o the cytoplasm in brain tissue and cultured cerebellar granule neurons (CGNs).

126 euronal cell line (SH-SY5Y) and cultured rat cerebellar granule neurons (CGNs).

127 RhoA, Rac1, and Cdc42, induces apoptosis of cerebellar granule neurons (CGNs).

128 ed to dendrite formation in developing mouse cerebellar granule neurons (CGNs).

129 ed manner during dendritogenesis in maturing cerebellar granule neurons (CGNs).

130 led this gene expression component of PCD in cerebellar granule neurons challenged separately by pota

131 )PrP in a neuronal setting, we have utilized cerebellar granule neurons cultured from Tg(L9R-3AV) mic

132 Cerebellar granule neurons cultured in medium containing

133 Rat cerebellar granule neurons cultured in medium supplement

134 itor continuously the respiration of primary cerebellar granule neuron cultures while simultaneously

135 Cerebellar granule neurons depend on insulin-like growth

136 the intrinsic initiator caspase-9 in primary cerebellar granule neurons deprived of serum and depolar

137 F interaction may play a key role in in vivo cerebellar granule neuron development, as well as in the

138 Cultured cerebellar granule neurons die by apoptosis when switche

139 ting this technique, primary cultures of rat cerebellar granule neurons display a concentration-depen

140 , we demonstrate that postnatal cortical and cerebellar granule neurons exclusively express an altern

141 alterations in [Ca(2+)](i) in fluo-3-loaded cerebellar granule neurons exposed to domoate, and ascer

142 Cerebellar granule neurons express the IL-16 receptor CD

143 s resistant to GSK3beta inhibition protected cerebellar granule neurons from either GSK3beta activati

144 ganglion neurons derived from adult mice or cerebellar granule neurons from postnatal rodents cultur

145 S6, GABA(B)R, and GIRK channel subunits, and cerebellar granule neurons from RGS6(-/-) mice showed a

146 ant AMPARs and on GluA2-containing AMPARs in cerebellar granule neurons from stargazer mice transfect

147 urification of early embryonic precursors of cerebellar granule neurons from the rhombic lip, the dor

148 We have examined the behavior of cerebellar granule neurons from these neonatal knockouts

149 detected in mutant TBP aggregates in primary cerebellar granule neurons from transgenic SCA17 mice.

150 ega-agatoxin IVA, and nimodipine to cultured cerebellar granule neurons from wild-type mice inhibited

151 We found that cerebellar granule neuron germinal zone exit is regulate

152 at the inactivation kinetics of the I(SA) in cerebellar granule neurons has voltage dependence that i

153 lpha 6 subunit of GABAA receptors, unique in cerebellar granule neurons, has been shown to increase d

154 In vitro studies of sympathetic and cerebellar granule neurons have demonstrated that the su

155 nal cell death in cortical, hippocampal, and cerebellar granule neurons in a Bax-dependent manner.

156 ow that Dp5 and other BH3-only proteins kill cerebellar granule neurons in a Bax-dependent manner.

157 ively active GPCRs were overexpressed in rat cerebellar granule neurons in culture, the transfected n

158 ease the expression of R-type current in rat cerebellar granule neurons in culture.

159 l dynamics during apoptosis in rat and mouse cerebellar granule neurons in culture.

160 ghly branched dendrites during maturation of cerebellar granule neurons in dissociated cultures and i

161 For example, cerebellar granule neurons in staggerer and lurcher muta

162 Death of cerebellar granule neurons in Tg(DeltaCR) mice is not ac

163 ant astrotactin peptide blocked migration of cerebellar granule neurons in vitro along astroglial fib

164 ts of the Id2 D box enhance axonal growth in cerebellar granule neurons in vitro and in the context o

165 Cerebellar granule neurons in vitro specifically arrest

166 ied brevican inhibits neurite outgrowth from cerebellar granule neurons in vitro, an activity that re

167 diated inhibition of axon outgrowth from rat cerebellar granule neurons in vitro.

168 endogenous FOXO proteins in hippocampal and cerebellar granule neurons, including in the rat cerebel

169 r to neonatal rat forebrain astrocytes or to cerebellar granule neurons increased NF-kappaB/DNA bindi

170 s, that chronic IL-6 treatment of developing cerebellar granule neurons increases the membrane and cu

171 We report that in cultured cerebellar granule neurons induced to die by low potassi

172 ectin-1 ectodomain, and promoted survival of cerebellar granule neurons induced to undergo apoptosis.

173 KCl withdrawal-induced apoptosis in cerebellar granule neurons is associated with aberrant c

174 human neuronal cell line SH-SY5Y and in rat cerebellar granule neurons is directly sensitive to chan

175 In addition, axonal outgrowth from cerebellar granule neurons is increased on or in CM from

176 -deficient postnatal dorsal root ganglion or cerebellar granule neurons is inhibited by myelin and by

177 levation of intracellular cAMP levels in rat cerebellar granule neurons leads to phosphorylation and

178 Calcium influx into cerebellar granule neurons led to activation of p38 mito

179 n factor RU49 as a definitive marker for the cerebellar granule neuron lineage.

180 In cultured cerebellar granule neurons, low neuronal activity trigge

181 ral GABAA receptor subunit mRNAs increase as cerebellar granule neurons migrate to their adult positi

182 In rat cerebellar granule neurons, mRNA and protein levels of t

183 ed responses were inhibited by DTT whilst in cerebellar granule neurones, NMDA-activated currents wer

184 In cerebellar granule neurons of neonatal rats micromolar c

185 significantly increased and cotranscribed in cerebellar granule neurons of the GIFN/STAT2-/- mice.

186 It is generally believed that cerebellar granule neurons originate exclusively from gr

187 uces GDNF-mediated survival in a transfected cerebellar granule neuron paradigm.

188 use mutant weaver exhibits a massive loss of cerebellar granule neurons postnatally.

189 A failure in the control of proliferation of cerebellar granule neuron precursor cells (GCPs), locate

190 in response to Shh stimulation in NIH3T3 and cerebellar granule neuron precursor cells in a p53-indep

191 During development, proliferation of cerebellar granule neuron precursors (CGNP), candidate c

192 We further show that cerebellar granule neuron precursors (CGNP), which are b

193 hedgehog (Shh)-induced neuroproliferation in cerebellar granule neuron precursors (CGNP).

194 iquitin ligase Huwe1 has been inactivated in cerebellar granule neuron precursors (CGNPs) and radial

195 Cerebellar granule neuron precursors (CGNPs) depend on s

196 Smoothened, is required for proliferation of cerebellar granule neuron precursors (CGNPs) during deve

197 ssion of the proto-oncogene Nmyc in cultured cerebellar granule neuron precursors (CGNPs) in the abse

198 Postnatal proliferation of cerebellar granule neuron precursors (CGNPs), proposed c

199 nt entails rapid peri-natal proliferation of cerebellar granule neuron precursors (CGNPs), proposed c

200 Cerebellar granule neuron precursors (CGNPs), proposed c

201 In primary cerebellar granule neuron precursors (CGNPs), proposed S

202 In proliferating cerebellar granule neuron precursors (CGNPs), Sonic hedg

203 Shh) and GC signaling in proliferating mouse cerebellar granule neuron precursors (CGNPs).

204 arise from the uncontrolled proliferation of cerebellar granule neuron precursors (GNP).

205 Cerebellar granule neuron precursors (GNPs) can give ris

206 edgehog (Shh) regulates the proliferation of cerebellar granule neuron precursors (GNPs) in part via

207 Hedgehog (Shh) is an efficacious mitogen for cerebellar granule neuron precursors (GNPs), and mutatio

208 t to originate from abnormally proliferating cerebellar granule neuron precursors (GNPs).

209 itutively active form of Smoothened in mouse cerebellar granule neuron precursors (ND2:SmoA1 mice).

210 tain compounds to block the proliferation of cerebellar granule neuron precursors expressing an oncog

211 genes were derepressed, whereas Brg-deleted cerebellar granule neuron precursors failed to respond t

212 ools in cerebellar germinal zones, including cerebellar granule neuron precursors in the external gra

213 ave recently found that the proliferation of cerebellar granule neuron precursors is significantly re

214 expression of N-Myc or cyclin D1 in primary cerebellar granule neuron precursors isolated from Ink4c

215 In particular, we found that in cerebellar granule neuron precursors, the N-myc transcri

216 thways cooperate to promote proliferation of cerebellar granule neuron precursors.

217 N-myc), which is essential for expansion of cerebellar granule neuron precursors.

218 ctions to regulate cell cycle progression in cerebellar granule neuron precursors.

219 The type of inhibition exhibited by Zn2+ on cerebellar granule neurones, previously grown in high K+

220 In cerebellar granule neurons primed to undergo apoptosis,

221 required for the regulated proliferation of cerebellar granule neuron progenitors (CGNP) and for the

222 ellar hypoplasia, decreased proliferation of cerebellar granule neuron progenitors (CGNP), and Purkin

223 erates alongside differentiation to regulate cerebellar granule neuron progenitors (CGNPs) and to pre

224 Cerebellar granule neuron progenitors (CGNPs) express As

225 Atr deletion in cerebellar granule neuron progenitors (CGNPs) induced pr

226 proliferation and induce differentiation of cerebellar granule neuron progenitors (GNPs) and primary

227 y testing and functional target screening in cerebellar granule neuron progenitors (GNPs) reveal that

228 Some are thought to originate from cerebellar granule neuron progenitors (GNPs) that fail t

229 ate the proliferation and differentiation of cerebellar granule neuron progenitors (GNPs).

230 Genetic inactivation of Chd7 in cerebellar granule neuron progenitors leads to cerebella

231 In cultured cerebellar granule neurons, reduction of extracellular K

232 , myelin-associated glycoprotein addition to cerebellar granule neurons resulted in a reduction in th

233 e, we report that gene-profiling analyses in cerebellar granule neurons reveal that the large majorit

234 s (GABACs) in nucleated patches excised from cerebellar granule neurons revealed that GABACs kinetics

235 ubiquitin-conjugating enzyme UBC13 in rodent cerebellar granule neurons robustly increases the number

236 . show that the leading process of migrating cerebellar granule neurons senses repulsive Slit molecul

237 mice to walk across irregularly spaced pegs, cerebellar granule neurons show a rapid and transient in

238 ure NT-3, whereas membrane depolarization in cerebellar granule neurons stimulated endogenous proNT-3

239 sslinking protein as an entry point into the cerebellar granule neuron system in combination with sup

240 uclear translocation of FOXO1 in primary rat cerebellar granule neurons that are deprived of neuronal

241 om wasp venom, induces apoptosis in cultured cerebellar granule neurons that can be blocked by choler

242 ng TREK-2S and TREK-2L were also observed in cerebellar granule neurons that express TREK-2 mRNA.

243 ne 17a in in vitro models of apoptosis using cerebellar granule neurons that were subjected to potass

244 GluN2C-containing NMDA receptors (NMDARs) in cerebellar granule neurons, that when expressed on the s

245 In mouse cerebellar granule neurons the effects of neuregulin-1 (

246 In cultured primary cerebellar granule neurons, the electrophoretic mobility

247 arly high expression in somatic motoneurons, cerebellar granule neurons, the locus ceruleus, and raph

248 Cerebellar granule neurons, the most abundant class of C

249 ction potential firing, by studying cultured cerebellar granule neurons treated with siRNA targeted a

250 Cerebellar granule neurons undergo apoptosis when switch

251 A similar ROS burst in cerebellar granule neurons undergoing apoptosis was also

252 In cerebellar granule neurons undergoing apoptosis, inhibit

253 Furthermore, in cultured cerebellar granule neurons undergoing apoptosis, NIL-16

254 d the localization of Bax to mitochondria in cerebellar granule neurons undergoing apoptosis.

255 rowth factor (NGF) and was also expressed in cerebellar granule neurons undergoing terminal different

256 Primary cultured rat cerebellar granule neurons underwent apoptosis when swit

257 hole-cell recordings were made from cultured cerebellar granule neurons using perforated patch clamp

258 n of presynaptic vesicle cycling in cultured cerebellar granule neurons.Using FM dyes to label the po

259 Using cultures of cerebellar granule neurons, we show that expression of T

260 ptured ganglioside-binding proteins from rat cerebellar granule neurons were identified by quantitati

261 3 (D3-Fc) of NG2 inhibited axon growth from cerebellar granule neurons when the proteins were substr

262 HDAC3 induces death of otherwise healthy rat cerebellar granule neurons, whereas shRNA-mediated suppr

263 ta receptors is shared by GABAA receptors on cerebellar granule neurones, which are known to express

264 alternative strategy, tested on rat neonatal cerebellar granule neurons, which involves a 48-hour pre

265 In addition, cerebellar granule neurons with an RNAi-mediated knockdo

266 Preincubation of cerebellar granule neurons with nNOS inhibitor exacerbat

267 ats may be toxic, we transfected primary rat cerebellar granule neurons with polyglutamine-green fluo

268 These lines produced strong labeling in cerebellar granule neurons, with additional expression i

269 In cultured cerebellar granule neurones, Zn2+ inhibited responses to