ライフサイエンスコーパス: ceruloplasmin

1 protein carriers (albumin, transcuprein, and ceruloplasmin).

2 activities of paraoxonase, arylesterase, and ceruloplasmin.

3 dentity to the serum multicopper ferroxidase ceruloplasmin.

4 potentials of C. cinereus laccase and human ceruloplasmin.

5 .007) between expression levels of c-jun and ceruloplasmin.

6 d hypercholesterolemia, as well as low serum ceruloplasmin.

7 cted with cDNAs encoding wild-type or mutant ceruloplasmin.

8 te protease inhibitor, apolipoprotein E, and ceruloplasmin.

9 apoTF] and catalytic oxidation of 6-OHDA by ceruloplasmin.

10 parenchyma in association with absent serum ceruloplasmin.

11 th the determination of the concentration of ceruloplasmin.

12 f multinuclear copper oxidases that includes ceruloplasmin.

13 ed band revealed identity to the ferroxidase ceruloplasmin.

14 cedure) and peroxide-oxidized forms of human ceruloplasmin.

15 east, homologous to the human plasma protein ceruloplasmin.

16 e plasma levels of ferritin, transferrin and ceruloplasmin.

17 ge of other proteins, including human plasma ceruloplasmin.

18 ltammetric peak increased in the presence of ceruloplasmin.

19 vity could not be fully explained by Heph or ceruloplasmin.

20 where it delivers copper to the ferroxidase ceruloplasmin.

21 We now show evidence that ceruloplasmin, a copper-containing acute phase reactant,

22 Ceruloplasmin, a Cu-containing ferroxidase, is found at

23 f metal ions is not known; however, purified ceruloplasmin, a plasma protein containing 7 coppers, ox

24 Nitrated ceruloplasmin, a significant biomarker for cardiovascula

25 number of key differences relative to human ceruloplasmin: a lower copper content and a lack of a ty

26 As further evidence for a role of ceruloplasmin, activation of U937 cells with zymosan ind

27 th dialysis groups had low plasma copper and ceruloplasmin activities.

28 as liver (67)Cu retention, serum copper, and ceruloplasmin activity increase.

29 and hemodialysis subjects had low ratios of ceruloplasmin activity to immunoreactive protein, and lo

30 Ceruloplasmin activity, benzylamine oxidase, and superox

31 Plasma copper, ceruloplasmin activity, ceruloplasmin concentration, and

32 Plasma copper, ceruloplasmin activity, ceruloplasmin protein, plasma ma

33 luding age of onset, clinical manifestation, ceruloplasmin activity, hepatic copper levels, and the p

34 oxide levels, paraoxonase, arylesterase, and ceruloplasmin activity, prolidase level, and total sulfh

35 Apart from the ferroxidase ceruloplasmin, all are involved in myelin homeostasis; 1

36 We now show that ceruloplasmin also increases LDL oxidation by vascular c

37 An increase in serum ceruloplasmin, an estrogen-responsive liver protein, was

38 a distinct group of patients with low serum ceruloplasmin and basal ganglia symptoms identified a se

39 liver, is required for copper metallation of ceruloplasmin and biliary copper excretion.

40 ns, a situation that usually elevates plasma ceruloplasmin and copper values.

41 was a significant correlation between plasma ceruloplasmin and disease severity (Pearson product mome

42 aracteristics of those found in domain II of ceruloplasmin and fungal laccase.

43 The mammalian ferroxidases ceruloplasmin and hephaestin are homologs of Fet3p.

44 Its functional homologs, e.g. ceruloplasmin and hephaestin, could play a similar role

45 Fet3p is a ferroxidase that, like ceruloplasmin and hephaestin, couples the oxidation of 4

46 tive, and quantitative detection of nitrated ceruloplasmin and hold a great promise for point-of-care

47 EPA+GLA had a significant reduction in BALF ceruloplasmin and IL-8 during the study as compared with

48 motif, which is repeated six times in human ceruloplasmin and is conserved in the homologous protein

49 nal iron overload resulting from knockout of ceruloplasmin and its homologue hephaestin exhibit retin

50 ase domain and compare it with that of human ceruloplasmin and other multicopper oxidases that are de

51 network for biosynthetic incorporation into ceruloplasmin and sequesters excess copper to endocytic

52 es are oxidized in peroxide-oxidized chicken ceruloplasmin and that none of the type 1 copper sites d

53 e channels was examined by cotransfection of ceruloplasmin and the chloride channel.

54 Conventional WD testing utilizing serum ceruloplasmin and/or serum copper levels are less sensit

55 and VCAM), parietal epithelial cells (e.g., ceruloplasmin), and podocytes (e.g., nephrin and prepron

56 platelet-activating factor acetylhydrolase, ceruloplasmin, and apoJ in HDL occur during acute influe

57 Plasma copper, ceruloplasmin, and cholesterol are relatively insensitiv

58 ve and significant decline in plasma copper, ceruloplasmin, and Cu/Zn superoxide dismutase activity i

59 of the iron-regulating proteins transferrin, ceruloplasmin, and ferritin are present in glaucoma.

60 ed increased mRNA expression of transferrin, ceruloplasmin, and ferritin heavy and light chains.

61 the iron, had high levels of ferroportin 1, ceruloplasmin, and hephaestin mRNA.

62 he mRNAs in question encode 15-lipoxygenase, ceruloplasmin, and histones.

63 Serum copper, ceruloplasmin, and manganese levels were normal, but her

64 beta-hydroxylase, amyloid precursor protein, ceruloplasmin, and other proteins required for normal br

65 on, the ratio of enzymatic to immunoreactive ceruloplasmin, and plasma copper, independently of chrom

66 uid (BALF) for measurement of total protein, ceruloplasmin, and transferrin, total neutrophil count,

67 transferrin receptor, increased ferritin and ceruloplasmin, and unchanged ferroportin were observed i

68 Ceruloplasmin antioxidant function is mainly related to

69 increased in heart failure (HF), can affect ceruloplasmin antioxidant function through amino acid mo

70 Consistently, the ceruloplasmin AP-1 site was specifically recognized by c

71 Copper in milk ceruloplasmin appears to be particularly available for a

72 onship between the two-domain MCOs and human ceruloplasmin appears to extend not only to the 3D struc

73 nding consistent with early work identifying ceruloplasmin as a ferroxidase and with recent findings

74 corporated into both secreted and GPI-linked ceruloplasmin as a late event in the secretory pathway.

75 Additionally, peripheral infusion of ceruloplasmin attenuated neurodegeneration and nigral ir

76 , FeOxII, ceruloplasmin, nitrotyrosine-bound ceruloplasmin, B-type natriuretic peptide, norepinephrin

77 Ceruloplasmin, B-type natriuretic peptide, norepinephrin

78 ores than plasma concentrations of copper or ceruloplasmin because the enzyme activities are sensitiv

79 intracellular copper and reduces plasma non-ceruloplasmin-bound copper (NCC) by forming tripartite c

80 s with IFN-gamma increased the production of ceruloplasmin by at least 20-fold.

81 t to previous cell-free experiments in which ceruloplasmin by itself (in PBS) oxidizes LDL, under the

82 odel postulates repression of translation of ceruloplasmin by mRNA binding proteins.

83 studies revealed synthesis and secretion of ceruloplasmin by these cells.

84 Thus, one of the additional Type 1 sites in ceruloplasmin cannot be catalytically relevant in the fo

85 ipase A2 group VI, fatty acid 2-hydroxylase, ceruloplasmin, chromosome 19 open reading frame 12 and A

86 ase response proteins: alpha2-macroglobulin, ceruloplasmin, complement components, lipocalin-2, metal

87 Plasma copper, ceruloplasmin concentration and activity, and urinary co

88 Plasma copper, ceruloplasmin activity, ceruloplasmin concentration, and erythrocyte superoxide

89 Plasma copper, ceruloplasmin concentration, and urinary copper increase

90 with Wilson's disease, such as reduced serum ceruloplasmin concentrations.

91 y, we have determined that peroxide-oxidized ceruloplasmin contains one permanently reduced Type 1 si

92 presence of chloride and hydrogen peroxide, ceruloplasmin converted myeloperoxidase to Compound II a

93 ysteine by thiol/disulfide exchange, whereas ceruloplasmin converts cysteine to cystine by copper-dep

94 ytic cleavage or removal of one of the seven ceruloplasmin copper atoms inhibited activity.

95 ein product in the retina and the liver, and ceruloplasmin could be identified in the retina by immun

96 To determine whether the ferroxidase ceruloplasmin (Cp) and its homolog hephaestin (Heph) are

97 ntified in mice deficient in the ferroxidase ceruloplasmin (Cp) and its homologue hephaestin (Heph) (

98 QTLs) from the same BC population identified ceruloplasmin (Cp) as a positional eQTL in macrophages b

99 Ceruloplasmin (Cp) decreases nitric oxide bioavailabilit

100 Individuals with hereditary ceruloplasmin (Cp) deficiency have profound iron accumul

101 Ceruloplasmin (Cp) expression is increased locally as a

102 lex by RNA affinity chromatography using the ceruloplasmin (Cp) GAIT element as ligand.

103 aceruloplasminemia by disrupting the murine ceruloplasmin (Cp) gene.

104 A role of the copper protein ceruloplasmin (Cp) in iron metabolism is suggested by it

105 Fet3p is functionally homologous to ceruloplasmin (Cp) in that both are ferroxidases.

106 A role for ceruloplasmin (Cp) in vertebrate iron metabolism is sugg

107 Ceruloplasmin (Cp) is a copper-containing ferroxidase th

108 Ceruloplasmin (Cp) is a Cu-containing plasma protein tho

109 Ceruloplasmin (Cp) is a glycoprotein secreted by the liv

110 Human ceruloplasmin (CP) is a multicopper oxidase essential fo

111 Ceruloplasmin (CP) is also induced by hypoxia and inflam

112 Ceruloplasmin (Cp) is an acute-phase protein with ferrox

113 Activated Inhibitor of Translation (GAIT) of ceruloplasmin (Cp) mRNA by a genetic screen for Cp 3'-UT

114 . those derived from CCL22, CXCL13, CCR4 and ceruloplasmin (Cp) mRNAs) have substantially different a

115 We used Hephaestin (Heph) and Ceruloplasmin (Cp) single or double (Heph/Cp) knockout (

116 cing of gamma interferon (IFN-gamma)-induced ceruloplasmin (Cp) synthesis in monocytes.

117 s the liver-derived, multicopper ferroxidase ceruloplasmin (Cp) that is important for iron release fr

118 escence; we show that hBMVEC express soluble ceruloplasmin (Cp) transcript as well.

119 Ceruloplasmin (Cp) was measured by both oxidase activity

120 rophage iron efflux, focusing on the role of ceruloplasmin (Cp), a copper protein with a potent ferro

121 Ceruloplasmin (Cp), a ferroxidase present in the cerebro

122 in GAIT complex that silences translation of ceruloplasmin (Cp), a protein linked to the inflammatory

123 We have shown previously that human ceruloplasmin (Cp), a serum protein containing seven Cu

124 We here show that ceruloplasmin (Cp), an acute phase reactant with importa

125 issues express either Heph or its homologue, ceruloplasmin (Cp), but the retina expresses both.

126 In the case of ceruloplasmin (Cp), induced synthesis of the protein by

127 -acid glycoprotein (AAG), transferrin (TF), ceruloplasmin (CP), neutrophil gelatinase-associated lip

128 utside the cell, a multi-copper ferroxidase, ceruloplasmin (Cp), oxidizes ferrous to ferric ion.

129 Ceruloplasmin (CP), the major plasma anti-oxidant and co

130 are modulators of copper incorporation into ceruloplasmin (CP).

131 disease due to mutations in the ferroxidase ceruloplasmin (Cp).

132 n of central nervous system tissue utilizing ceruloplasmin cRNA probes reveals abundant ceruloplasmin

133 ge significantly during copper depletion but ceruloplasmin decreased during copper repletion.

134 Our results demonstrate that ceruloplasmin decreases the bioavailability of iron in u

135 hese tissues was equivalent in wild-type and ceruloplasmin-deficient mice.

136 Plasma copper and ceruloplasmin did not change significantly during copper

137 loss of the copper-containing plasma enzyme ceruloplasmin disrupt mammalian iron homeostasis.

138 ite reductase domain 2, laccase domain 3 and ceruloplasmin domains 2, 4 and 6.

139 e chain reaction demonstrated high levels of ceruloplasmin expression in retina and liver, but minima

140 In situ hybridization identified ceruloplasmin expression in the inner nuclear and gangli

141 e results demonstrate abundant cell-specific ceruloplasmin expression within the central nervous syst

142 In Fet3p, as in ceruloplasmin, Fe(II) is oxidized to Fe(III) at the type

143 We found a approximately 80% loss of ceruloplasmin ferroxidase activity in the substantia nig

144 Val, Leu or Phe in the axial position) as in ceruloplasmin, Fet3p, fungal laccases and some plantacya

145 steine oxidation, and immunoprecipitation of ceruloplasmin from human plasma did not inhibit the capa

146 the expression of the ATP7B target protein, ceruloplasmin, from PN to Bergmann glia, where ATP7A (Me

147 Despite the need for copper in ceruloplasmin function, this protein plays no essential

148 n of systemic tissues revealed cell-specific ceruloplasmin gene expression in hepatocytes, the spleni

149 g ceruloplasmin cRNA probes reveals abundant ceruloplasmin gene expression in specific populations of

150 , these data reveal that glial cell-specific ceruloplasmin gene expression is essential for iron home

151 In the central nervous system, abundant ceruloplasmin gene expression was detected in specific p

152 elucidate the pathogenesis of this disease, ceruloplasmin gene expression was examined in human brai

153 A locus on the ceruloplasmin gene on chromosome 3 was significantly ass

154 in phlebotomized mice with a deletion of the ceruloplasmin gene.

155 inherited loss-of-function mutations in the ceruloplasmin gene.

156 condary to loss-of-function mutations in the ceruloplasmin gene.

157 h patients reveal inherited mutations in the ceruloplasmin gene.

158 ted with specific inherited mutations in the ceruloplasmin gene.

159 toms identified a series of mutations in the ceruloplasmin gene.

160 association with inherited mutations of the ceruloplasmin gene.

161 Chicken ceruloplasmin has been previously reported to display a

162 In one approach, ceruloplasmin has been shown to exhibit oxidant activity

163 ome chemical or spectroscopic differences in ceruloplasmin have been reported depending on the method

164 Saccharomyces cerevisiae Fet3p and human ceruloplasmin (hCp) are members of this family that exhi

165 mologous human plasma copper-binding protein ceruloplasmin (hCp) has been solved, and the A domains o

166 ce-associated macrophage protein 1 (Nramp1), ceruloplasmin, hephaestin, and glyceraldehyde 3-phosphat

167 pcidin-resistant Fpn; hepcidin knockout; and ceruloplasmin/hephaestin double knockout).

168 Ceruloplasmin/Hephaestin double-knockout (DKO) mice with

169 l gene, Heph, encoding a transmembrane-bound ceruloplasmin homologue that is mutant in the sla mouse

170 n the ferroxidase reaction catalyzed by this ceruloplasmin homologue.

171 lpha1-antichymotrypsin, alpha-fetal protein, ceruloplasmin, IGF binding protein 1, transferrin, apoli

172 ependent on the logarithmic concentration of ceruloplasmin in blood.

173 her, these data reveal no essential role for ceruloplasmin in copper metabolism and suggest a previou

174 To elucidate the role of ceruloplasmin in copper metabolism, the kinetics of copp

175 ion as an essential ferroxidase, the role of ceruloplasmin in copper transport and metabolism remains

176 r revealed a critical physiological role for ceruloplasmin in determining the rate of iron efflux fro

177 ngs reveal an essential physiologic role for ceruloplasmin in determining the rate of iron efflux fro

178 The possible role of ceruloplasmin in inhibiting reaction oxygen species in t

179 To elucidate the role of ceruloplasmin in iron homeostasis, we created an animal

180 al role for astrocyte-specific expression of ceruloplasmin in iron metabolism and neuronal survival i

181 The concentrations of copper and ceruloplasmin in milk vary with lactational stage.

182 We have studied the copper sites of chicken ceruloplasmin in order to probe the origin of these diff

183 Consistent with a role for ceruloplasmin in PD etiopathogenesis, ceruloplasmin knoc

184 This may indicate that the resting form of ceruloplasmin in plasma under aerobic conditions is a fo

185 n-related proteins ferritin, hephaestin, and ceruloplasmin in relation to oxidative damage in the bra

186 antibodies was the presence of a fragment of ceruloplasmin in serum, which was eliminated in purified

187 the upregulation of alpha2-macroglobulin and ceruloplasmin in the diabetic retina, but not in the cer

188 n protein delivers copper to the ferroxidase ceruloplasmin in the liver, it is likely that the Wilson

189 yloid A, LPS-binding protein, fibrinogen, or ceruloplasmin; in contrast, C3H/HeJ mice, which carry a

190 hese animals, hepatocyte copper intended for ceruloplasmin incorporation is trafficked into a compart

191 In metal ion-free medium, human ceruloplasmin increased bovine aortic SMC- and EC-mediat

192 mparison of the structures of fVIII, fV, and ceruloplasmin indicates that the location of bound metal

193 Ceruloplasmin induction in monocytic cells was agonist s

194 highly specific polyclonal antibody to human ceruloplasmin inhibits LDL oxidation by at least 65%.

195 Collectively, our results indicate that ceruloplasmin inhibits myeloperoxidase by reducing Compo

196 Ceruloplasmin is a 132-kDa glycoprotein abundant in huma

197 Ceruloplasmin is a multicopper oxidase essential for nor

198 Ceruloplasmin is a serum ferroxidase that contains great

199 Ceruloplasmin is an abundant serum glycoprotein containi

200 Ceruloplasmin is an iron-export ferroxidase that is abun

201 Ceruloplasmin is present in these fluids and may also be

202 Although ceruloplasmin is synthesized primarily by the liver in a

203 Ceruloplasmin is unique among the multicopper oxidases i

204 oxidized 75% of the ascorbate in plasma from ceruloplasmin knock-out mice, but there was no significa

205 le for ceruloplasmin in PD etiopathogenesis, ceruloplasmin knockout mice developed parkinsonism that

206 onal studies done in sla, Heph-knockout, and ceruloplasmin-knockout mice proved that cytosolic FOX ac

207 isease severity (r =.30; p =.012) and plasma ceruloplasmin levels (r =.48; p =.00067).

208 s confirmed lower serum transferrin (Tf) and ceruloplasmin levels in ACLF and ACLF-MOF, compared to p

209 ApoJ and ceruloplasmin levels in HDL peaked 3 days after infectio

210 d neurologic deficits should have copper and ceruloplasmin levels measured as part of their diagnosti

211 Paired ceruloplasmin levels were available in six patients and

212 Zn superoxide dismutase, cytochrome oxidase, ceruloplasmin, lysyl oxidase, and dopamine beta-hydroxyl

213 son and/or Menkes proteins provide copper to ceruloplasmin made in the RPE.

214 Monocytic cell-derived ceruloplasmin may contribute to defense responses via it

215 indings show, in principle, that intravenous ceruloplasmin may have therapeutic potential in PD.

216 studies to show that human albumin, but not ceruloplasmin, mediates the conversion of homocysteine t

217 ss in which copper bound to albumin, but not ceruloplasmin, mediates the reaction.

218 Parallel changes occur in ceruloplasmin messenger RNA expression in the mammary gl

219 e functional role of each copper site within ceruloplasmin, metabolic studies indicate that achieving

220 The maximal response was at 100-300 microg ceruloplasmin/ml, a level at or below the unevoked physi

221 The mechanism by which ceruloplasmin mobilizes iron from cell stores has been c

222 cultures confirmed that astrocytes expressed ceruloplasmin mRNA and biosynthetic studies revealed syn

223 This complex binds the 3'UTR of ceruloplasmin mRNA and blocks its translation.

224 ctivation of U937 cells with zymosan induces ceruloplasmin mRNA and ceruloplasmin protein synthesis a

225 eotides targeted to different regions of the ceruloplasmin mRNA block LDL oxidation by up to 95%.

226 rotein binds to and shuts off translation of ceruloplasmin mRNA.

227 IFN-gamma also increased ceruloplasmin mRNA.

228 Ferritin and ceruloplasmin mRNAs were significantly increased in the

229 d activity of serum FeOxI is associated with ceruloplasmin nitration and reduced survival in patients

230 atched controls (n=35), serum FeOxI, FeOxII, ceruloplasmin, nitrotyrosine-bound ceruloplasmin, B-type

231 Meta-analyses show that nonbound ceruloplasmin (non-Cp) copper (also known as free or lab

232 We assessed levels of copper, ceruloplasmin, non-Cp copper, iron, transferrin, ferriti

233 Neither ceruloplasmin nor O2. alone increased LDL oxidation, but

234 he current experiments (in RPMI 1640 medium) ceruloplasmin only oxidizes LDL in the presence of cells

235 n of ClC-4 doubled copper incorporation into ceruloplasmin (P = 0.011), whereas identical overexpress

236 nemia, the biosynthesis of a missense mutant ceruloplasmin (P177R) occurring in an affected patient w

237 stent with a mechanism in which cell-derived ceruloplasmin participates in oxidation of LDL by U937 m

238 The synthesis of holoceruloplasmin but not ceruloplasmin peptide was markedly diminished in CuR 41.

239 Ceruloplasmin plays a role in this second phase.

240 so show that cellular factors in addition to ceruloplasmin, possibly active oxygen species and/or lip

241 el that stimulates copper incorporation into ceruloplasmin, probably by improving the efficiency of t

242 Together, these results suggest that the ceruloplasmin promoter activity is significantly enhance

243 Ceruloplasmin promoter activity was significantly activa

244 oplasmin promoter to be critical for optimal ceruloplasmin promoter activity.

245 nude mice carrying SKOV3.ip1 xenografts, the ceruloplasmin promoter demonstrated significantly higher

246 We found that the ceruloplasmin promoter drove up to 30-fold higher lucife

247 ed an activator protein-1 (AP-1) site in the ceruloplasmin promoter to be critical for optimal cerulo

248 Total ceruloplasmin protein is related to copper status but re

249 with zymosan induces ceruloplasmin mRNA and ceruloplasmin protein synthesis after a 5-6 h lag that i

250 Plasma copper, ceruloplasmin activity, ceruloplasmin protein, plasma malondialdehyde, benzylami

251 protein, and low ratios of plasma copper to ceruloplasmin protein.

252 and inversely related to nitrotyrosine-bound ceruloplasmin (r, -0.305; P=0.003).

253 Ceruloplasmin rapidly reduced Compound I, the Fe(V) redo

254 ation of serum samples and isolated purified ceruloplasmin reduced FeOxI activity while increasing ce

255 In conclusion, ceruloplasmin-related indexes in kidney dialysis patient

256 The gene for ceruloplasmin-related iron transport protein hephaestin

257 ribution among copper sites in the different ceruloplasmins relative to other multicopper oxidases.

258 Ceruloplasmin remained elevated throughout the time cour

259 Ceruloplasmin secreted by IFN-gamma-stimulated U937 cell

260 and/or zinc-containing serum glycoproteins, ceruloplasmin, serum amyloid P-component, and amyloid pr

261 We propose that ceruloplasmin should provide a protective shield against

262 nalysis using these clones detected a 3.7-kb ceruloplasmin-specific transcript in multiple murine tis

263 sis and RNAse protection studies demonstrate ceruloplasmin-specific transcripts in multiple regions o

264 nd, superoxide dismutase effectively blocked ceruloplasmin-stimulated oxidation by both cell types.

265 itical role for cellular superoxide (O2.) in ceruloplasmin-stimulated oxidation.

266 mpletely reconstituted the oxidation rate of ceruloplasmin-stimulated SMC.

267 These results are the first to show that ceruloplasmin stimulates EC- and SMC-mediated oxidation

268 Exogenous addition of purified human ceruloplasmin stimulates U937 cell oxidation of LDL to n

269 s has been verified by showing inhibition of ceruloplasmin synthesis and by the ability of exogenous

270 human brain, and biosynthetic studies reveal ceruloplasmin synthesis and secretion in these same regi

271 e show that IFN-gamma is a potent inducer of ceruloplasmin synthesis by monocytic cells.

272 l type specific, as IFN-gamma did not induce ceruloplasmin synthesis in endothelial or smooth muscle

273 In human ceruloplasmin the reduction potential is further increas

274 etry were taken as evidence that, similar to ceruloplasmin, the enzyme likely contains multiple type

275 In an homologous structure, ceruloplasmin, the residue equivalent to Arg593, is in a

276 in synthesis and by the ability of exogenous ceruloplasmin to overcome the inhibition.

277 , are essential and act synergistically with ceruloplasmin to oxidize LDL.

278 suggests a critical role for this region in ceruloplasmin trafficking and indicates that substitutio

279 provide copper for important enzymes such as ceruloplasmin, tyrosinase, and peptidylglycine monooxyge

280 estigated the relationship between FeOxI and ceruloplasmin tyrosine and cysteine modification and exp

281 Both ceruloplasmin tyrosine nitration and cysteine thiol oxid

282 smin reduced FeOxI activity while increasing ceruloplasmin tyrosine nitration and cysteine thiol oxid

283 n; flavonoid(-)-epicatechin, which prevented ceruloplasmin tyrosine nitration but not cysteine oxidat

284 times higher than (64)Cu-albumin and (64)Cu-ceruloplasmin uptake, respectively.

285 ge in expression restores copper delivery to ceruloplasmin via ATP7A.

286 In contrast, ceruloplasmin was a highly efficient catalyst for the ox

287 Ceruloplasmin was a potent inhibitor of purified myelope

288 Ceruloplasmin was an ineffective catalyst of homocystein

289 Ceruloplasmin was expressed in the retina, and was induc

290 Quantitative detection of nitrated ceruloplasmin was realized by recording the fluorescence

291 Ceruloplasmin was the predominant protein associated wit

292 ositol (GPI)-linked wild-type or P177R human ceruloplasmin were examined by pulse-chase metabolic lab

293 in this disease, cDNA clones encoding murine ceruloplasmin were isolated and characterized.

294 In addition, ferroportin and ceruloplasmin were markedly decreased within the epithel

295 Plasma copper and ceruloplasmin were not affected by diet.

296 case, T. ferrooxidans rusticyanin, and human ceruloplasmin), which lie in a reduction potential range

297 BeWo cells also synthesized a form of ceruloplasmin whose structure differed from that of the

298 sensor displays rapid responses for nitrated ceruloplasmin with the concentration as low as 1 ng/mL.

299 sminemia can result from retention of mutant ceruloplasmin within the early secretory pathway.