ライフサイエンスコーパス: cetrorelix

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1 nd 14 after the initiation of treatment with cetrorelix.

2 ale rats are also decreased by high doses of Cetrorelix.

3 ts were rapidly and completely suppressed by cetrorelix.

4 ed for at least 72 h after administration of Cetrorelix.

5 eatment with a low-dose depot formulation of Cetrorelix (20-24 microg per kg per day) on the pituitar

6 Cetrorelix, a GnRHR1 antagonist, inhibited the expressio

7 Chronic administration of cetrorelix also decreased the level of membrane receptor

8 treatment of female rats with large doses of Cetrorelix, an antagonist of luteinizing hormone-releasi

9 red the effects of chronic administration of cetrorelix and triptorelin on the LHRH-R mRNA level and

10 on, revealed that a single s.c. injection of cetrorelix at a dose of 100 microg per rat significantly

11 ere investigated after a single injection of Cetrorelix at a dose of 100 microg per rat.

12 in the mRNA expression after treatment with Cetrorelix, but not always Decapeptyl, paralleled those

13 To determine whether the treatment with Cetrorelix can affect the concentration of measurable LH

14 Prolonged treatment for 10 days with a Cetrorelix depot formulation releasing 100 microg/day de

15 Continuous perfusion of the cells with 50 nM cetrorelix did not cause any significant changes, but pr

16 Thus, the treatment with low doses of Cetrorelix did not seriously impair gonadal functions.

17 The results suggest that Cetrorelix in low doses induces only a partial pituitary

18 inuous exposure of pituitary cells to 100 nM Cetrorelix in the superfusion system, which is devoid of

19 tigated the direct effect of LHRH antagonist cetrorelix in vitro on the expression of the pituitary L

20 udies demonstrate that prolonged exposure to Cetrorelix in vivo, but not in vitro, down-regulates the

21 sults confirm that LHRH antagonists, such as cetrorelix, inhibit the gene expression of pituitary LHR

22 at pituitaries after therapy with antagonist cetrorelix is associated with an increase in receptor co

23 Cl)2,D-Pal(3)3,D-Cit6,D-Ala10]LH-R H (SB-75; Cetrorelix) is a modern, potent antagonistic analog of L

24 one deprivation is indicated, lower doses of Cetrorelix may suffice.

25 After (5 h) a single injection of 100 microg Cetrorelix, no significant decrease occurred in the mRNA

26 The inhibitory effect of Cetrorelix on serum LH, pituitary LHRH-R mRNA, and LHRH-

27 investigate the effects of LH-RH antagonist cetrorelix on the binding characteristics and subcellula

28 e mechanisms, we investigated the effects of Cetrorelix on the mRNA expression of pituitary LH-RH-R a

29 ats were reduced after 10-day treatment with Cetrorelix or 100 microg/day Decapeptyl.

30 5 microg/day) for 30 days or LHRH antagonist Cetrorelix pamoate (100 microg/day) for 30 days and dail

31 Cetrorelix pamoate reduced serum LH in female rats and d

32 cate that administration of LH-RH antagonist Cetrorelix produces a marked down-regulation of pituitar

33 ter administration of a depot formulation of cetrorelix, releasing 100 microg of peptide daily, the e

34 receptor concentration was found 3-6 h after Cetrorelix treatment and a recovery in receptor number b

35 In normal female rats, cetrorelix treatment suppressed the LHRH-R mRNA level by

36 In contrast, 2-6 h after cetrorelix treatment, the concentration of binding sites

37 regulation of LH-RH binding sites induced by Cetrorelix was accompanied by serum LH and testosterone

38 ors at 1, 3, and 6 h after administration of Cetrorelix were approximately 28%, 14%, and 10%, respect

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