ライフサイエンスコーパス: chain elongation

1 alylation in substrate selection and polySia chain elongation.

2 ur, takes place after ketosynthase-catalyzed chain elongation.

3 mplex displays increased processivity of RNA chain elongation.

4 factor EF-Tu preventing any participation in chain elongation.

5 cterized with a single ACP for each cycle of chain elongation.

6 canonical Site 2 responsible for subsequent chain elongation.

7 attenuated the UV-induced inhibition of DNA chain elongation.

8 parate gene, that catalyze discrete steps in chain elongation.

9 duction of the beta-ketothioester product of chain elongation.

10 oesters from solution onto FASs and PKSs for chain elongation.

11 synthesis by controlling the rate of peptide chain elongation.

12 s inhibition of both replicon initiation and chain elongation.

13 s were found to be equivalent substrates for chain elongation.

14 ins acting together to catalyze one round of chain elongation.

15 m thioester intermediates during siderophore chain elongation.

16 forming the uridylylated VPg primer for RNA chain elongation.

17 ACP domains in the hybrid module to catalyze chain elongation.

18 energy landscape develops late during apoMb chain elongation.

19 f the thiazoline moieties during siderophore chain elongation.

20 ion, and resulted in defects in in vitro DNA chain elongation.

21 CBV-TP were only moderate inhibitors of DNA chain elongation.

22 ccharide repeat units for ECA polysaccharide chain elongation.

23 e catalytic subunit of the polymerase during chain elongation.

24 CP1, even for the amide bond-forming step in chain elongation.

25 hing is more effective per surface unit than chain elongation.

26 porting mthPolB-catalyzed PCNA-dependent DNA chain elongation.

27 ibit protein translation by reducing peptide chain elongation.

28 l and propanol were both highly suitable for chain elongation.

29 lymerase to DNA, resulting in processive DNA chain elongation.

30 replication, whereas ts-114 is defective in chain elongation.

31 pRNA synthesis normally but is deficient in chain elongation.

32 njugation to TIF-1gamma as well as poly-SUMO chain elongation.

33 er concentrations of NTPs than did templated chain elongation.

34 y for the high processivity of EC during RNA chain elongation.

35 e transition from abortive to productive RNA chain elongation.

36 sponsible for a specific round of polyketide chain elongation.

37 ot stabilize or otherwise activate 3Dpol for chain elongation.

38 appropriate for retention of DNA during RNA chain elongation.

39 djacent to the acceptor ubiquitin facilitate chain elongation.

40 rase to the template allowing processive DNA chain elongation.

41 oxyribonucleotides or ribonucleotides during chain elongation.

42 of hydroxyurea, a drug known to inhibit DNA chain elongation.

43 ated with stimulation of the rate of peptide-chain elongation.

44 DNA replication at the level of nascent DNA chain elongation.

45 adenosine efficiently without effects on DNA chain elongation.

46 ilized ER-associated Ca2+ nor slowed peptide chain elongation.

47 anation and branching activity competed with chain elongation.

48 esis to address the polarity of maltodextrin chain elongation.

49 scopy confirmed the polarity of maltodextrin chain elongation.

50 e2S to bind the APC/C and catalyze ubiquitin chain elongation.

51 e (KS) domain within each module to catalyze chain elongation.

52 ting Met to its 2-oxo acid for glucosinolate chain elongation.

53 pore, and into the ER lumen coincident with chain elongation.

54 te (Site 2) is associated with polyubiquitin chain elongation.

55 nctive RING E3 features specifying ubiquitin chain elongation.

56 n length and linkage impact kinetic rates of chain elongation.

57 with the Cdc34 E2 Ub conjugating enzyme for chain elongation.

58 ed to accomplish twenty cycles of polyketide chain elongation.

59 ves as the acceptor for M+4 palmitoyl-CoA in chain elongation.

60 l structure is responsible for polyubiquitin chain elongation.

61 ues (K29, 48, 63R) involved in polyubiquitin chain elongation.

62 ineered to catalyze two successive rounds of chain elongation.

63 R513A mutant with a markedly reduced rate of chain elongation.

64 e synthetic direction and thus enable carbon-chain elongation.

65 rearrangements of the nascent peptide during chain elongation.

66 ediates through pathways that require carbon-chain elongation.

67 ase (KS) domain that collaborate to catalyze chain elongation.

68 V(max), reflecting a defect in polyubiquitin chain elongation.

69 O2 promoted statistically significant carbon-chain elongation across lipid classes, with the stronges

70 e (Lys-61) was shown to be essential for RNA chain elongation activity by purified enzyme; however, a

71 Our results suggest that 1) chain elongation activity is a useful and novel probe fo

72 n keto acids and alcohols by engineering the chain elongation activity of 2-isopropylmalate synthase

73 rtance of inter-module chain transfer versus chain elongation activity of some of these modules.

74 hout impairing the Ube2S-dependent ubiquitin chain elongation activity.

75 corresponding amino acids in FPPase enhanced chain-elongation activity, while similar mutations in th

76 tretches of messenger RNA and resume protein chain elongation after a "bypassed" region.

77 in a messenger sequence and resumes protein chain elongation after a "landing site" downstream of th

78 of the ubiquitination process and ubiquitin chain elongation after deneddylation.

79 in these cases, which would limit efficient chain elongation after insertion of a fluorinated monome

80 r RNA without translating and resume protein chain elongation after the bypassed region.

81 VC, suggesting that severe inhibition of DNA chain elongation and activation of the replication check

82 ich catalyzes a discrete round of polyketide chain elongation and adjusts the appropriate level of be

83 variants are characterized by pause-free RNA chain elongation and are resistant to RfaH action.

84 ule, participates in one round of polyketide chain elongation and associated chemical modifications,

85 complete cycle of polyketide or polypeptide chain elongation and associated functional group modific

86 omains necessary for each step of polyketide chain elongation and chemical modification, can be decon

87 rings revealed possible patterns of polymer chain elongation and cross-linking within the biopolymer

88 Enzymes that catalyze chain elongation and cyclopropanation are well studied,

89 Other information, such as chain elongation and desaturation, might also be derived

90 UEV domain to Rim8 interferes with ubiquitin chain elongation and directs Rim8 monoubiquitination.

91 olecules undergo iterative processes such as chain elongation and functional group manipulation, are

92 that in addition to the canonical polyketide chain elongation and functionalization encoded by type I

93 ers focus on the reduction of ethanol use in chain elongation and improve the recovery efficiency of

94 all showed reduced in vivo rates of peptide-chain elongation and increased levels of precursor 23S r

95 These size increases were largely due to chain elongation and not to alterations in the ratio of

96 nnings of substrate association upon nascent chain elongation and processivity.

97 optical tweezers that allow operations like chain elongation and shortening.

98 hus that multiple substrates can be used for chain elongation and that this process is carried out by

99 ermined by a kinetic balance between nascent chain elongation and the transmission of the RNA signal

100 is then deacylated to provide substrates for chain elongation and/or desaturation.

101 Our findings indicate that two-carbon side-chain elongation and/or m-positioning of the hydroxyl gr

102 structed from farnesyl diphosphate synthase (chain elongation) and chrysanthemyl diphosphate synthase

103 We have been investigating two mutants, cel (chain-elongation) and chol-1 (choline-requirer), which a

104 s that are believed to be defective in xylan chain elongation, and suggests that IRX10 and IRX10-L al

105 qual number of DNA adducts in inhibiting DNA chain elongation ( approximately 7-fold in CEM cells).

106 DNA and RNA chain elongation are arrested at different locations on

107 ts that the majority of two-carbon units for chain elongation are derived from beta-oxidation of [1,2

108 Peptide chain elongation as measured by polymerization of Phe-tR

109 e KS-AT-KR(0) proteins were able to catalyze chain elongation as well as the intact parent module.

110 In this study, cytotoxicity and steady-state chain elongation assays indicate that hMLH1 or hMSH6 def

111 ink inhibited DNA replication by terminating chain elongation at 1-50 nucleotides before the cross-li

112 f new replicons but also reduced the rate of chain elongation at active replication forks.

113 pentasaccharide building block suitable for chain elongation at both ends.

114 saccharide is suitably protected for further chain elongation at positions 3, 4, and 6 of the termina

115 acid production from mixed organic waste via chain elongation at this current, early stage of technol

116 to be a combination of chain fluctuation and chain elongation attributable to RNA transcription.

117 ssisted translation, the transient degree of chain elongation becomes a relevant variable expected to

118 polymerase, not only in the catalysis of RNA-chain elongation but also in the activation of the enzym

119 second dehydratase, FabZ, functions in acyl chain elongation but cannot carry out the isomerization

120 tandem UBDs inhibit efficient polyubiquitin chain elongation but have no effect on initiation of ubi

121 that are specifically involved in ubiquitin chain elongation but whose roles in proteolysis remain s

122 at PKC activation is sufficient to cause GAG chain elongation, but both PKC and ERK activation are re

123 closely related NEIL2 alone does not affect chain elongation, but combined NEIL1/2 deficiency furthe

124 form of positive winding can support nascent chain elongation, but only precatenane removal can suppo

125 lization of 3'-hydroxyl termini as sites for chain elongation by 3D, and thereby stimulates RNA synth

126 Chain elongation by another addition of the aforemention

127 consecutive adenosines dramatically impaired chain elongation by DNA pol-gamma.

128 ed, FMdC became a poor substrate for further chain elongation by DNA polymerases, resulting in a term

129 ition of O-fucose but do impair carbohydrate chain elongation by Fringe.

130 tigated the role of EXTL2 in heparan sulfate chain elongation by gene silencing and overexpression st

131 i-EF-Tu antibodies similarly inhibit peptide chain elongation by P. aeruginosa ribosomes in the in vi

132 This allows a new round of protein chain elongation by placing the next mRNA codon in the A

133 A polymerase switch then allows chain elongation by proofreading-proficient pol delta an

134 ely the ability of the proteins to block RNA chain elongation by several prokaryotic RNA polymerases

135 re, we show that the RING-E3 APC/C catalyzes chain elongation by strongly increasing the affinity of

136 Mammalian SRP slows nascent chain elongation by the ribosome during targeting in vit

137 oli and B.subtilis respectively, impeded RNA chain elongation catalyzed by T7, SP6 and E.coli RNA pol

138 onucleotide operates as a primer for in situ chain elongation catalyzed by the Taq I polymerase.

139 ns to give a mixture of geranyl diphosphate (chain elongation), chrysanthemyl diphosphate (cyclopropa

140 zation, monofunctionalization, and efficient chain-elongation coupling of OEGs further enable the inc

141 emistry of the intermediates of a polyketide chain elongation cycle catalyzed by a DH-containing modu

142 and performing the first step in the peptide chain elongation cycle.

143 Four reactions--chain elongation, cyclopropanation, branching, and cyclo

144 ed from four fundamental coupling reactions: chain elongation, cyclopropanation, branching, and cyclo

145 n of the free ubiquitin pool, we expressed a chain elongation defective ubiquitin mutant (UbK48R), wh

146 The DNA chain elongation defects were partially repaired by addi

147 uctase domain, independent of the particular chain elongation domains that were used, thereby establi

148 nvolve looping out the Pt-GG adduct to allow chain elongation downstream of the adduct.

149 nd thus can modulate the rate of polypeptide chain elongation during translation.

150 r chlorination, one-carbon truncation during chain elongation, E-double bond formation and thiazole r

151 Nascent RNA structures may regulate RNA chain elongation either directly through interaction wit

152 egard, DCS is more similar to the isoprenoid chain elongation enzyme farnesyl diphosphate synthase, w

153 roteins generated by replacing segments of a chain-elongation enzyme with corresponding sequences fro

154 belongs to a genetically distinct family of chain elongation enzymes that install E-double bonds dur

155 l products are biosynthesized via successive chain-elongation events mediated by elaborate protein as

156 he cytomegalovirus and the human polypeptide chain elongation factor 1alpha (EF-1alpha) promoters in

157 vector in which the strong human polypeptide chain elongation factor 1alpha promoter drives a bicistr

158 ination of a subset of proteins by ubiquitin chain elongation factors (E4), represented by Ufd2p in S

159 ucts, thereby permitting reinitiation of DNA chain elongation following spontaneous termination event

160 ases (AtIPMDHs) play key roles in methionine chain-elongation for the synthesis of aliphatic glucosin

161 heximide and other inhibitors of polypeptide chain elongation "freeze" ribosomes on mRNA and prevent

162 During chain elongation glycosylation reactions no column chrom

163 beta-ketoacyl moiety formed at each round of chain elongation have been studied by engineering and ch

164 Those molecules produced by chain elongation have head-to-tail (regular) carbon skel

165 olymerase delta-catalyzed PCNA-dependent DNA chain elongation; (ii) catalyzing DNA-dependent ATP hydr

166 igration by blocking hyaluronan synthesis or chain elongation impaired invasion of adjacent OSCC cell

167 n purified that specifically facilitates RNA chain elongation in a chromatin context; the properties

168 t disruption of lamin organization inhibited chain elongation in a dose-dependent fashion.

169 NA and, in UV-damaged cells, Tipin slows DNA chain elongation in active replicons.

170 Second, chain elongation in all hybrid modules tested was seriou

171 , EETs are substrates for beta-oxidation and chain elongation in endothelial cells and that there is

172 ntation of downstream products of fatty acyl chain elongation in the acylcarnitine pool during ischem

173 catalytic partners occurs in every cycle of chain elongation in the biosynthesis of fatty acids and

174 Chain shortening was accompanied by chain elongation in the synthesis of other long chain fa

175 e is limited insight into the versatility of chain elongation in view of different starting substrate

176 r completely interrupt a single round of RNA chain elongation in vitro.

177 ties to bind nucleotides and to catalyze RNA chain elongation in vitro.

178 ing 1 kg caproic acid from organic waste via chain elongation, in both a lab-scale and a pilot-scale

179 events use of the clamp by the polymerase in chain elongation, indicating that the polymerase has an

180 hains immobilized on ribosomes by antibiotic chain elongation inhibitors followed by detection of pur

181 acid was elongated with three synthetic Crp chain elongation intermediate analogues through ester bo

182 mployed to generate the tylactone hexaketide chain elongation intermediate that was accepted by the j

183 triketide analogue of the natural triketide chain elongation intermediate to cultures of S. coelicol

184 on in the processing of the natural diketide chain elongation intermediate.

185 ctive processing of the ACP-bound polyketide chain elongation intermediate.

186 tion of a 2-hydroxy acid moiety in the final chain elongation intermediate.

187 a hydrolytic chain release of the polyketide chain elongation intermediate.

188 sized the natural pentaketide and hexaketide chain elongation intermediates as N-acetyl cysteamine (N

189 s function evaluated with a series of linear chain elongation intermediates in developing a novel che

190 ion of the unit A delta-hydroxy octadienoate chain elongation intermediates.

191 Chain elongation into medium-chain carboxylates, such as

192 d out by highly similar organisms for direct chain elongation irrespective of the substrate.

193 RNA chain elongation is a highly processive and accurate pro

194 In fact, chain elongation is controlled at a docking site remote

195 Adozelesin inhibition of nascent chain elongation is first observed at concentrations abo

196 synthase (DEBS) has yielded a model in which chain elongation is governed by interactions between the

197 Rather, the onset of RNA chain elongation is inhibited because TRIM25 prohibits t

198 The process of chain elongation is likely to be distinct from the proce

199 e LUBAC components, whereas linear ubiquitin chain elongation is realized by a specific interplay bet

200 f the ribosome in either chain initiation or chain elongation is still unknown.

201 Z-double bond isomers by FPP synthase during chain elongation is unexpected for a highly evolved enzy

202 an N-terminal loading unit, seven polyketide chain elongation modules, and a carboxy terminator unit.

203 When (R)-[2-2H]IPP was a substrate for chain elongation, no deuterium was found in the chain el

204 However, one feature of RNA chain elongation not predicted by the model is that the

205 cetyl-CoA, which is subsequently used in the chain elongation of a second stearate molecule to form v

206 t CDC34 or rabbit reticulocyte E232K but not chain elongation of alternate linkages formed by yeast R

207 Chain elongation of DNA requires a sufficient supply of

208 ity of catalyzing both de novo synthesis and chain elongation of fatty acids has been purified and ch

209 Chain elongation of fatty acids is an important cellular

210 ynthesis (primary metabolism) and methionine chain elongation of glucosinolates (specialized metaboli

211 PICS module 5+TE could catalyze the chain elongation of only the syn diketide (2S,3R)-4, whi

212 Chain elongation of palmitate to stearate appeared to oc

213 ll dimensions of the resulting spectrum, and chain elongation of sequential amino acids can be effect

214 rboxylic acid cycle (glutamate pool), and in chain elongation of stearate (peroxisomal pool).

215 esyl diphosphate synthase (FPPase) catalyzes chain elongation of the C(5) substrate dimethylallyl dip

216 ments suggested that this deficiency in pRNA chain elongation of the K241R mutant primase is unlikely

217 zyl ester to a solid support; (ii). stepwise chain elongation of the peptide by standard Fmoc/tBu sol

218 ide E3 ubiquitin ligase to promote ubiquitin chain elongation on a substrate.

219 ty of LUBAC, priming on a lysine on NEMO and chain elongation on the N terminus of the priming ubiqui

220 cts with an efficiency of 14-35% compared to chain elongation on undamaged DNA, which is second only

221 a dominant-negative ubiquitin that prevents chain elongation or by small interfering RNA directed ag

222 g genes at G1/S was fully independent of DNA chain elongation or initiation.

223 D important for virus growth but not for RNA chain elongation or polyprotein processing.

224 ck base pair or if it forces replicative DNA chain elongation past a mismatch before DNA polymerase c

225 branched-chain amino acids and/or in the Met chain elongation pathway, the initial steps towards the

226 e, the key enzyme for a proposed peroxisomal chain elongation pathway.

227 The methionine chain-elongation pathway is required for aliphatic gluco

228 ation, especially in combination with carbon chain elongation pathways.

229 eplication, with only a modest inhibition of chain elongation per se.

230 ), the processivity factor necessary for the chain elongation phase of DNA replication.

231 ce of CPPase aligns closely with that of the chain elongation prenyltransferase farnesyl diphosphate

232 Chain elongation prenyltransferases catalyze the additio

233 provide important new insights into the RNA chain elongation process and offer the prospect of under

234 The data suggest that the chain elongation process is localized on the outer surfa

235 ths observed, suggesting that the fatty acid chain elongation process was not affected.

236 ters introduced into the backbone during the chain elongation process.

237 ADPH generated the fully saturated triketide chain elongation product as a 5:3 mixture of (2S,4R)-2,4

238 e C9-lactone is also produced as an abortive chain elongation product with a k(cat) of 0.23 min(-1),

239 ynthesized farnesyl diphosphate as the final chain elongation product, but their kinetic behavior var

240 in elongation, no deuterium was found in the chain elongation products.

241 . tridentata FPPase and CPPase belong to the chain elongation protein family (PF00348), a subgroup of

242 The value of the rRNA chain elongation rate in bacteria is an important physio

243 ependent methodologies show that the peptide chain elongation rate increases as a function of tempera

244 perature shift experiments show that peptide chain elongation rate increases immediately, which suppo

245 acement distribution, diffusion coefficient, chain elongation rate, and distribution of molecule numb

246 o acid sequence, its cotranslational nascent-chain elongation rate, and folding.

247 upled ribosomes, a 20% decreased polypeptide chain elongation rate, and increased resistance to the r

248 to known regions of the tunnel and measured chain elongation rates.

249 diates and directly uses acetyl-CoA for acyl-chain elongation (rather than first requiring ATP-depend

250 substantially less reactive than GPP in the chain elongation reaction and was an excellent competiti

251 enerate (3S)-beta-hydroxyacyl-ACP during the chain-elongation reaction of bacterial fatty acid biosyn

252 iphosphate synthase catalyzes the sequential chain elongation reactions between isopentenyl diphospha

253 rgoes two consecutive sets of alpha-ketoacid chain elongation reactions to produce alpha-ketosuberate

254 synthesis and polymerase delta-catalyzed DNA chain elongation reactions.

255 iosynthetic pathways that comprise iterative chain elongation, reduction, and dehydration reactions.

256 48 side chain can be positioned properly for chain elongation regardless of chain length.

257 e frequency of initiation events because DNA chain elongation remains practically unchanged.

258 ixed-disulfide intermediate is, upon further chain elongation, resolved, releasing the oxidized polyp

259 phate (ara-GTP), which acts to terminate DNA chain elongation, resulting in cell death.

260 tightly bound in a cavity distinct from the chain elongation site described for farnesyl pyrophospha

261 s (rosettes) and are thought to catalyze the chain elongation step in glucan polymerization.

262 that normally catalyzes the first polyketide chain elongation step of 6-dEB biosynthesis.

263 in Hus1-deficient cells reflected mainly the chain elongation step of DNA replication and was correla

264 er-unit selection and catalysis of the first chain elongation step.

265 alonyl-coenzyme A (mMCoA) are substrates for chain elongation steps carried out by the Rf PKS.

266 diketide analogues of the natural polyketide chain elongation substrates.

267 es involved in the membrane-bound fatty acid chain elongation system.

268 es encounter specific DNA sites at which RNA chain elongation takes place in the absence of enzyme tr

269 ein structure evolves during the polypeptide chain elongation that accompanies cotranslational protei

270 genin-labeled nucleotides as a substrate for chain elongation, the neo-synthetic DNA is labeled by an

271 Alternatively, during UB chain elongation, the RING does not bind UBE2S but rathe

272 of nucleotides downstream and resume protein chain elongation there.

273 both probably suppress rho201 by slowing RNA chain elongation, these differences may lead to terminat

274 ited to the transcription complex during RNA chain elongation through specific interactions with a DN

275 s revealed dramatic bathochromic shifts upon chain elongation, thus suggesting highly effective exten

276 ding the methyl-branched carbon, followed by chain elongation to 19 carbons.

277 n selectively during different iterations of chain elongation to afford structural diversity.

278 re, we utilized the carboxylate platform and chain elongation to produce n-butyric acid and n-caproic

279 er was necessary and sufficient to block RNA chain elongation, two interacting dimers of RTP were nee

280 d lowers the efficiency of clamp loading and chain elongation under conditions of elevated salt.

281 In addition to its roles in polypeptide chain elongation, unique cellular and viral activities h

282 is controlled at different interfaces during chain elongation versus chain transfer.

283 t these MID1 domain constructs facilitate Ub chain elongation via Lys63 of Ub.

284 seHAS has an intrinsic 2-fold faster rate of chain elongation (Vmax) than spHAS.

285 DNA chain elongation was also inhibited in a concentration-d

286 n acylcarnitine demonstrated that fatty acyl chain elongation was prominent in ischemic myocardium (e

287 Chain elongation was the dominant activity during the N-

288 ansferase activity, a key enzyme for peptide chain elongation, was also significantly decreased.

289 ently, a novel biorefinery process, that is, chain elongation, was developed to convert mixed organic

290 detail the role of EXTL2 in heparan sulfate chain elongation, we tested the ability of the overexpre

291 hat cells have a mechanism for arresting DNA chain elongation when dNTP levels are not maintained abo

292 Ura individually interfered with nascent DNA chain elongation, whereas the three-drug combination pro

293 Chain elongation with amanitin can continue for hours at

294 First, wild-type modules catalyzed chain elongation with comparable efficiency regardless o

295 lucose and increased fatty acid synthesis by chain elongation with either PGC-1alpha or -1beta expres

296 of 3-OPP and 4-OPP were similar to those for chain elongation with IPP and DMAPP.

297 replicase, DNA polymerase III holoenzyme, in chain elongation with the beta clamp demonstrate that up

298 emonstrated that BCAT6 can contribute to Met chain elongation with the triple mutant line lacking BCA

299 compounds and sugars into SCCAs, subsequent chain elongation with undistilled ethanol in beer, and h