ライフサイエンスコーパス: chalcone

1 critical role of SHP-1 in the action of this chalcone.

2 ro were predominantly CTAL and low levels of chalcone.

3 cetin, kaempferol, naringenin and naringenin chalcone.

4 ared to normal breast cells than other known chalcones.

5 s of the corresponding quinone methides with chalcones.

6 of gamma-butyrolactam onto the corresponding chalcones.

7 aldehydes and ethoxide to give a variety of chalcones 10a-k in excellent yield (82-99%) upon TFA cle

8 Oral administration of chalcone 16, at a concentration of 100 mg/kg of body wei

9 Transcription of chalcone 2'-O-methyltransferase (CHOMT), and 1,3-beta-D-

10 his study, using a novel chalcone derivative chalcone-24 (Chal-24), we identified a novel anticancer

11 We show that the compound, carbonitrile-chalcone 4, blocks the recruitment of eosinophils to the

12 d on the CXCL12-neutralizing small molecule, chalcone 4, which blocks binding of CXCL12 to CXCR4.

13 elo 'Inodorous Group') accumulate naringenin chalcone, a yellow flavonoid pigment.

14 s of a population segregating for naringenin chalcone accumulation followed by fine mapping and genet

15 n expressed, negatively regulates naringenin chalcone accumulation.

16 The chalcone alpha,beta-unsaturated ketone moiety seemed to

17 These chalcones also showed reduction in parasitemia and incre

18 his study, we report the identification of a chalcone analogue called Amt-87 that can significantly r

19 hmanial activities of a library of synthetic chalcone analogues have been examined.

20 in, chlorogenic acid, naringenin, naringenin chalcone and ascorbic acid have been obtained.

21 se to UV-B or Phoma medicaginis, whereas the chalcone and flavanone precursors of these compounds acc

22 zapentadienyl anion generated in situ from a chalcone and glycine ester is the key step of an efficie

23 id compounds; we also tested our findings on chalcone and nitrone data from the current literature.

24 Although the models for the chalcone and stilbene series appeared slightly different

25 oding a polyketide synthase with homology to chalcone and stilbene synthases from plants.

26 5-10 mg/kg fresh weight), mainly naringenin chalcone and the flavonol rutin, a quercetin glycoside.

27 icity were investigated among a series of 44 chalcones and analogues (1,3-diarylpropenones), by evalu

28 loaddition, for example, the dimerization of chalcones and cinnamic acid derivatives, is a unique str

29 yrrole-2-carboxylates and -carboxamides from chalcones and glycine esters or amides.

30 direct synthesis of some electron-deficient chalcones and heterocyclic chalcones from cinnnamic acid

31 for the enantioselective addition of FNSM to chalcones and the catalysts CN I, CD I, QN I-IV, and QD

32 Chalcones and their derivatives have been shown to have

33 4,2',4',6'-Tetrahydroxychalcone (chalcone) and 4,2',4'-trihydroxychalcone (deoxychalcone)

34 iles (arylidenemalononitrile and substituted chalcone) and those calculated from E, N, and sN shows t

35 or hydroxycinnamates, acyl-sugar, naringenin chalcone, and a range of glycoalkaloids.

36 including depletion of rutin and naringenin chalcone, and enhanced levels of anthocyanins and phenyl

37 ons, neutral quinoidal bases, hemiketals and chalcones, and negatively charged phenolates) by means o

38 A series of 31 chalcone- and flavonoid-based derivatives were synthesiz

39 cid derivatives, their ketone analogues, and chalcones; and (b) bis(benzylidene)cycloalkanones, Ar-CH

40 The results show the boronic-chalcones are more toxic to breast cancer cells compared

41 he soybean type I CHI, which uses naringenin chalcone as substrate, is coordinately regulated with ot

42 typical naringenin CHS that synthesizes the chalcone as the main reaction product, and p-coumaryltri

43 Together, our data reveal chalcones as a promising category of compounds that shou

44 to be tolerated at several positions of the chalcone backbone as long as the compounds fell into the

45 This study aims to establish SAR of chalcone-based compounds to NF-kappaB inhibition, to exp

46 The structures of chalcone-based NF-kappaB inhibitors vary significantly t

47 explore the feasibility of developing simple chalcone-based potent NF-kappaB inhibitors, and to evalu

48 ces not only acridone and quinolone but also chalcone, benzophenone, and phloroglucinol from 4-coumar

49 a CAN-catalyzed multicomponent reaction from chalcones, beta-dicarbonyl compounds, and ammonium aceta

50 n rate for the unimolecular rearrangement of chalcone (CHN) into flavanone by seven orders of magnitu

51 c route to derivatives of styrene, stilbene, chalcone, cinnamic acid, various fused carbo- and hetero

52 ve to inhibition by trans-4-iodo, 4'-boranyl-chalcone, consistent with HDM2-catalyzing ubiquitination

53 were undertaken with the synthesis of 21 new chalcones containing two allyloxy moieties that resulted

54 Chalcones continue to attract considerable interest due

55 sults indicated that S17 is a leadbrominated chalcone derivate and deserves further investigation for

56 ed study describes the identification of the chalcone derivative 15 on different types of human malig

57 The newly identified chalcone derivative 15 showed a higher therapeutic poten

58 her, these results indicate that the boronic chalcone derivative AM114 induces significant cytotoxic

59 In this study, using a novel chalcone derivative chalcone-24 (Chal-24), we identified

60 oducts, we have designed and synthetized the chalcone-derivative 8 possessing Notch inhibitory activi

61 ries of carboxylated, heteroaryl-substituted chalcone derivatives as novel, potent inhibitors of vasc

62 Curcumin and its chalcone derivatives inhibit the growth of human cancer

63 Among the eight chalcone derivatives tested, 3,5-bis-(4-boronic acid-ben

64 A new series of etherification chalcone derivatives were designed and synthesized throu

65 ing and the lipophilic substituted B ring of chalcone derivatives were pharmacophoric elements for an

66 A series of boronic-chalcone derivatives were synthesized and tested for ant

67 -trisubstituted cyclopentenes from enals and chalcone derivatives with high levels of diastereoselect

68 lationship study of a series of 30 synthetic chalcone derivatives with hydroxyl, methoxyl, and haloge

69 An efficient approach to cyclohexenyl chalcones employing highly electron rich 2'-hydroxychalc

70 The indirect anodic oxidation of chalcone epoxides in the presence of electron-rich heter

71 ogeneous electron transfer between Med*+ and chalcone epoxides is facilitated by an electron-rich het

72 potential is less than that of the starting chalcone epoxides.

73 The barley and rice chalcone flavonone isomerase (Cfi) genes were isolated a

74 study, we have evaluated a series of boronic chalcones for their anticancer activity and mechanisms o

75 Slow rate of chalcone formation and resistance to C-ring fission were

76 catalyze malonyl-CoA decarboxylation without chalcone formation.

77 n we demonstrate that flavokawain B (FKB), a chalcone from kava root, is a potent hepatocellular toxi

78 ) catalyzes formation of the phenylpropanoid chalcone from one p-coumaroyl-CoA and three malonyl-coen

79 cavity resulting in production of naringenin chalcone from p-coumaroyl-CoA.

80 lectron-deficient chalcones and heterocyclic chalcones from cinnnamic acids.

81 ype is characterized by the presence of both chalcone (heretofore not reported in pre-Columbian texti

82 A series of novel hydroxy-coumarin-chalcone hybrid compounds 2a-i has been synthesized by e

83 tive individual stilbene (IC(50) > 100 muM), chalcone (IC(50) = 11.5 muM), or an equimolar mixture of

84 uM), or an equimolar mixture of stilbene and chalcone (IC(50) = 32.5 muM) were less potent than 11.

85 flavanones by selectively binding an ionized chalcone in a conformation conducive to ring closure in

86 We found that this chalcone inhibited both constitutive and interleukin-6-i

87 Potent bis-chalcone inhibitors were identified, the efficiency depe

88 catalyzes the intramolecular cyclization of chalcones into (S)-flavanones with a second-order rate c

89 ically defined intramolecular cyclization of chalcones into biologically active (2S)-flavanones by se

90 trates that efficient cyclization of various chalcones into their respective flavanones requires both

91 s the intramolecular cyclization of bicyclic chalcones into tricyclic (S)-flavanones.

92 Chalcone is a privileged structure, demonstrating promis

93 Naringenin chalcone is only detectable in the fruit, while naringen

94 amolecular and stereospecific cyclization of chalcones is a committed step in the production of flavo

95 benzaldehydes with acetophenones, to produce chalcones, is the final loss of hydroxide and formation

96 Xanthohumol (XN), a prenylated chalcone isolated from hop plant, exhibits anti-inflamma

97 mpferol, the isoflavone biochanin A, and the chalcone isoliquiritigenin.

98 o inhibition by flavonoids, particularly the chalcone isoliquiritigenin.

99 isoflavonoid, and anthocyanin biosynthesis, chalcone isomerase (CHI) catalyzes the intramolecular cy

100 Chalcone isomerase (CHI) catalyzes the intramolecular cy

101 In aqueous solution, Medicago savita chalcone isomerase (CHI) enhances the reaction rate for

102 However, the lineage of the enzyme chalcone isomerase (CHI) remained unknown.

103 Chalcone synthase (CHS) and chalcone isomerase (CHI) were overexpressed and purified

104 rid assays indicated that chalcone synthase, chalcone isomerase (CHI), and dihydroflavonol 4-reductas

105 mmonia-lyase (PAL), chalcone synthase (CHS), chalcone isomerase (CHI), and dihydroflavonol reductase

106 ies indicating that chalcone synthase (CHS), chalcone isomerase (CHI), flavanone 3-hydroxylase (F3H),

107 Cinnamic acid 4-hydroxylase (C4H), chalcone isomerase (CHI), isoflavone reductase (IFR) and

108 lar locations of chalcone synthase (CHS) and chalcone isomerase (CHI), the first two enzymes of this

109 SlCHI1) of the flavonoid biosynthetic enzyme chalcone isomerase (CHI), which catalyzes the conversion

110 sly distribute to the terrestrial plants and chalcone isomerase (CHI)-catalyzed intramolecular and st

111 ments from the known flavonoid genes, except chalcone isomerase (chi1), were induced in the CRC-expre

112 Madicago sativa chalcone isomerase (CI) catalyzes the isomerization of c

113 gulates the expression of chalcone synthase, chalcone isomerase and dihydroflavonol reductase genes r

114 intermediate naringenin, the product of the chalcone isomerase enzyme.

115 nt cellular processes, we used wild-type and chalcone isomerase mutant (transparent testa 5, tt5) see

116 d by threefold on introduction of an alfalfa chalcone isomerase transgene.

117 TT5, and TT3 loci encode chalcone synthase, chalcone isomerase, and dihydroflavonol 4-reductase, res

118 increased by expressing both IFS and alfalfa chalcone isomerase, but levels of flavonol conjugates we

119 genes included phenylalanine ammonia lyase, chalcone isomerase, isoflavone reductase, cinnamoyl-CoA

120 t the accumulation of the chalcone synthase, chalcone isomerase, or flavanone-3-hydroxylase proteins.

121 tomato with the Petunia chi-a gene encoding chalcone isomerase.

122 nd including phenylalanine ammonia lyase and chalcone isomerase.

123 lly characterized five soybean (Glycine max) chalcone isomerases (CHIs), key enzymes in the phenylpro

124 inately expressed with chalcone synthase and chalcone isomerases is seedlings, whereas dihydroflavono

125 We recently described a chalcone-like compound, 3-(2-methyl-1H-indol-3-yl)-1-(4-

126 g discovery program, we isolated two similar chalcones, medicagenin (II) and munchiwarin (III), from

127 The intermediate 3 contains a chalcone motif.

128 There was also induction of several chalcone O-methyltransferases involved in the synthesis

129 Isoliquiritigenin, the precursor chalcone of liquiritigenin, demonstrated significant est

130 we investigated in detail the effect of this chalcone on NF-kappaB activity.

131 oieties such as alkenes (stilbenes), enones (chalcones), or ethers was selected for the study.

132 The kinetics of chalcone oxide hydrolysis show that mutation of Tyr(465)

133 lding of the tetraketide intermediate to the chalcone (PKS3) and which are in general essential for C

134 hydrochalcones and their dihydrochalcone and chalcone precursors was synthesized and tested as SGLT1/

135 erize 16 point mutants of these residues for chalcone production, malonyl-CoA decarboxylation, and th

136 ural products and their analogues, including chalcones, pyrazoles, chromones, coumarins, xanthines, i

137 ng of genes for isoflavone synthase (IFS) or chalcone reductase (CHR) was achieved in soybean roots t

138 nia-lyase (PAL), chalcone synthase (CHS) and chalcone reductase (CHR) were most rapidly activated, wi

139 Interestingly, chalcone reductase adopts the three-dimensional structur

140 e the three-dimensional structure of alfalfa chalcone reductase bound to the NADP+ cofactor and propo

141 nhanced expressions of chalcone synthase and chalcone reductase genes, mainly in the exposed and imme

142 Silencing of chalcone reductase led to very low levels of daidzein an

143 In addition, the chalcone reductase structure represents the first protei

144 plex, the quality of the refined NADP+-bound chalcone reductase structure serves as a template for co

145 Therefore, the chalcone reductase structure serves as a template for th

146 cone reductase; however, the identity of the chalcone reductase substrate out of the possible substra

147 arity to other aldo-keto reductases, such as chalcone reductase, an enzyme of flavonoid biosynthesis,

148 Introduction of a third gene, chalcone reductase, provided the ability to synthesize a

149 e formation depends on chalcone synthase and chalcone reductase; however, the identity of the chalcon

150 Novel stilbene-chalcone (S-C) hybrids were synthesized via a sequential

151 activity relationships were afforded for the chalcone scaffold.

152 First a model was generated for the chalcone series (19 compounds, 71 conformations), then f

153 pounds, including six homoisoflavonoids, one chalcone, six amides, one lignan, one fatty acid derivat

154 ven to the extent that an enzyme of the same chalcone/stilbene synthase family used to produce phytoa

155 e presence of a glycosyl moiety bound to the chalcone structure dramatically decreases the antimicrob

156 eported are based on the benzalacetophenone (chalcone) structure, again coupling the boronic acid and

157 ramatically lowers the triplet energy of the chalcone substrate.

158 d step of isoflavonoid biosynthesis, various chalcone substrates added to the culture media were conv

159 ile the type II CHIs, which use a variety of chalcone substrates, are coordinately regulated with an

160 ne after hormone induction, whereas only the chalcone synthase (c2) and flavanone/dihydroflavonol red

161 it ripening is accompanied by an increase in CHALCONE SYNTHASE (CHS) activity and flavonoid biosynthe

162 Chalcone synthase (CHS) and chalcone isomerase (CHI) wer

163 The cellular and subcellular locations of chalcone synthase (CHS) and chalcone isomerase (CHI), th

164 ncoding L-phenylalanine ammonia-lyase (PAL), chalcone synthase (CHS) and chalcone reductase (CHR) wer

165 Chalcone synthase (CHS) belongs to the family of type II

166 Chalcone synthase (CHS) catalyzes formation of the pheny

167 Chalcone synthase (CHS) catalyzes the first step of flav

168 ctures and floral pigmentation patterns from chalcone synthase (chs) co-suppression among 47 Petunia

169 Infection with TRV containing a chalcone synthase (CHS) fragment resulted in silencing o

170 identified in previous work as essential for chalcone synthase (CHS) function.

171 trefoil) were transformed with an antisense chalcone synthase (CHS) gene construct made using a stre

172 Three of the chalcone synthase (CHS) gene family members are arranged

173 nerated, containing additional copies of the chalcone synthase (CHS) gene.

174 s of the I locus in Glycine max silence nine chalcone synthase (CHS) genes to inhibit function of the

175 n earlier study we reported HDG silencing of chalcone synthase (CHS) in Arabidopsis.

176 Chalcone synthase (CHS) is a ubiquitous plant PKS and th

177 coding the key flavonoid biosynthesis enzyme chalcone synthase (CHS) is regulated by several environm

178 Five new alleles of the Arabidopsis chalcone synthase (CHS) locus, tt4, have been characteri

179 Expression of chalcone synthase (CHS) mRNA was shown to be constitutiv

180 ng small interfering RNAs (siRNAs) targeting chalcone synthase (CHS) mRNAs.

181 Measurements of rbcS and chalcone synthase (CHS) transcript levels in the protopl

182 gmentation patterns were scored in 185 sense Chalcone synthase (Chs) transgenotes and 85 antisense Ch

183 Crystallographic and functional studies of chalcone synthase (CHS), a plant-specific PKS, indicate

184 Chalcone synthase (CHS), a type III plant polyketide syn

185 that simultaneous RNAi silencing of HCT and chalcone synthase (CHS), an enzyme essential for flavono

186 cS), the gene family that encodes the enzyme chalcone synthase (Chs), and the gene family that encode

187 ties with C. microcarpa ACS, Medicago sativa chalcone synthase (CHS), and the previously reported Aeg

188 examining phenylalanine ammonia-lyase (PAL), chalcone synthase (CHS), chalcone isomerase (CHI), and d

189 istent with previous studies indicating that chalcone synthase (CHS), chalcone isomerase (CHI), flava

190 re well illustrated by the genes that encode chalcone synthase (CHS), the first committed step in fla

191 Expression of chalcone synthase (CHS), the first enzyme in the flavono

192 operties of three recombinant Fragaria vesca chalcone synthase (FvCHS) proteins.

193 ], 4-coumarate coenzyme A:ligase [4-CL], and chalcone synthase [CHS]) are conserved in the t-CAH prom

194 petunia plants can result in degradation of chalcone synthase A RNAs and loss of chalcone synthase,

195 The introduction of chalcone synthase A transgenes into petunia plants can r

196 A lack of chalcone synthase activity has a pleiotropic effect in m

197 psis F3H gene is coordinately expressed with chalcone synthase and chalcone isomerases is seedlings,

198 ype, lactofen caused enhanced expressions of chalcone synthase and chalcone reductase genes, mainly i

199 Deoxychalcone formation depends on chalcone synthase and chalcone reductase; however, the i

200 nous biosynthetic genes (c2 and a1, encoding chalcone synthase and flavanone/dihydroflavonol reductas

201 arent testa4-2, which has a null mutation in CHALCONE SYNTHASE and therefore synthesizes no flavonol

202 Chalcone synthase catalyzes the initial step of that bra

203 adjacent H-box in the proximal region of the chalcone synthase chs15 promoter.

204 (inhibitor diffuse) mutant, defective in the CHALCONE SYNTHASE Colorless2 (C2) gene.

205 the introduction of a heterologous antisense chalcone synthase construct into L. corniculatus resulte

206 ile element dynamics in seven alleles of the chalcone synthase D locus (CHS-D) of the common morning

207 tion and CHLOROPHYLL a/b BINDING PROTEIN3 or CHALCONE SYNTHASE expression under red light.

208 PqsD is structurally similar to the FabH and chalcone synthase families of fatty acid and polyketide

209 P-glucose pyrophosphorylase gene (APL3), and chalcone synthase gene (CHS), whereas the mybs2 mutant e

210 In this study, we demonstrate that chalcone synthase gene (chsA) expression is developmenta

211 Down-regulation of the CHALCONE SYNTHASE gene and concomitant induction of FaPR

212 vergence times based on sequence data of the chalcone synthase gene are congruent with comparative pa

213 e 3' splice acceptor site in the Arabidopsis chalcone synthase gene completely disrupts synthesis of

214 ontrolled post-transcriptional regulation of chalcone synthase gene expression by influencing the sur

215 Ppr also regulates chalcone synthase gene expression in response to blue li

216 C2-Idf is a stable dominant mutation of the chalcone synthase gene, c2, which encodes the first dedi

217 ctly repeated and inverted clusters of three chalcone synthase genes (CHS1, CHS3, and CHS4).

218 -mediated induction of flavonoids and blocks chalcone synthase mRNA and protein induction.

219 al roots under the Pi- Suc- condition in the chalcone synthase mutant (tt4-2) indicated a potential r

220 the H-box (CCTACC) element in the bean CHS15 chalcone synthase promoter was purified, and internal pe

221 d during the multistep reaction catalyzed by chalcone synthase remains experimentally elusive.

222 ved from an evolutionarily related member of chalcone synthase superfamily by mere substitution of tw

223 e pathway branch for flavonoid biosynthesis (chalcone synthase), a key enzyme in medicarpin biosynthe

224 n (a commonly reported derailment product of chalcone synthase), while similar in vitro analyses usin

225 sion of a reporter driven by the promoter of CHALCONE SYNTHASE, a gene encoding a flavonol biosynthet

226 de anther-specific proteins with homology to chalcone synthase, a key flavonoid biosynthesis enzyme.

227 Chalcone synthase, a key regulatory enzyme in the flavon

228 tion of chalcone synthase A RNAs and loss of chalcone synthase, a process called cosuppression or pos

229 he heterologous phenylalanine ammonia lyase, chalcone synthase, and DRR206 promoter-beta-glucuronidas

230 l pea PR genes: phenylalanine ammonia lyase, chalcone synthase, and DRR206.

231 pression levels (most notably those of NDL1, CHALCONE SYNTHASE, and MYB DOMAIN PROTEIN44) in plants c

232 Two-hybrid assays indicated that chalcone synthase, chalcone isomerase (CHI), and dihydro

233 ain protein that regulates the expression of chalcone synthase, chalcone isomerase and dihydroflavono

234 The TT4, TT5, and TT3 loci encode chalcone synthase, chalcone isomerase, and dihydroflavon

235 also did not inhibit the accumulation of the chalcone synthase, chalcone isomerase, or flavanone-3-hy

236 ys further demonstrated interactions between chalcone synthase, CHI, and flavonol 3-hydroxylase in ly

237 Adding tt4, which disables chalcone synthase, had little effect, but adding the tgd

238 nd Glycine max chalcone synthase1 (Gmachs1), chalcone synthase, involved in phytoalexin production.

239 ch have a null mutation in the gene encoding chalcone synthase, the first enzyme in flavonoid synthes

240 Silencing of chalcone synthase, the key entry-point enzyme for flavon

241 omatized coumaryl-trione intermediate of the chalcone synthase-catalyzed cyclization of the fully ext

242 N), which is biosynthesized in bacteria by a chalcone synthase-like (CS-like) type III polyketide syn

243 s, we disrupted a mas-like gene, msl7, and a chalcone synthase-like gene, pks10, with phage-mediated

244 oester, which then serves as a substrate for chalcone synthase.

245 ion of CHLOROPHYLL A/B BINDING PROTEIN 3 and CHALCONE SYNTHASE.

246 the first enzyme in flavonoid biosynthesis, chalcone synthase.

247 oid pathway, phenylalanine ammonia-lyase and chalcone synthase.

248 nvolved in pathogen defense, and Glycine max chalcone synthase1 (Gmachs1), chalcone synthase, involve

249 stilbene backbone, seem to have evolved from chalcone synthases (CHSs) several times independently in

250 s related to beta-ketoacyl-CoA synthases and chalcone synthases.

251 ve SAR analysis of saturated and unsaturated chalcone synthetic intermediates, led to the identificat

252 Starting from a simple chalcone template, structure-activity relationship (SAR)

253 under Claisen-Schmidt conditions afforded a chalcone that was deprotected and cyclized in the presen

254 We here synthesized symmetric bis-chalcones that were differently substituted and screened

255 enzyme A thioesters to synthesize naringenin chalcone through a polyketidic intermediate.

256 somerase (CI) catalyzes the isomerization of chalcone to flavanone, whereas E. coli chorismate mutase

257 which catalyzes the conversion of naringenin chalcone to naringenin and is strictly required for flav

258 vascular plants, CHI-catalysed conversion of chalcones to chiral (S)-flavanones is a committed step i

259 l of benzils in a Stetter-like reaction with chalcones to give 2-benzoyl-1,4-diones (double aroylatio

260 alyst efficiently activates the o-homoformyl chalcones to provide the chiral isochromenes in moderate

261 hiles), and the reactions can lead to either chalcone-type products or indanone products.

262 In this work, 100 chalcones were designed, synthesized, and investigated f

263 Chalcones were identified as the major heat degradation

264 amates, crotonates, coumarins, sulfones, and chalcones were successfully functionalized.

265 A library of 88 chalcones were synthesized and evaluated for their in vi

266 Three series of chalcones were synthesized in one to three steps with th

267 phenone, respectively, and formed naringenin chalcone when 4-coumaroyl-CoA was used as starter molecu

268 ids are accumulated together with naringenin chalcone, whereas CmKFB expression diverts the biochemic

269 the discovery of 2',4'-diallyloxy-6'-methoxy chalcones with improved selectivity against this parasit