ライフサイエンスコーパス: challenge

1 responses were measured 48 h after the last challenge.

2 reduction to $0.20, and is a critical, key challenge.

3 ace systems represents a major environmental challenge.

4 jellyfish allergy diagnosed via an oral food challenge.

5 ration 24 hour and 48 hour after the last AP challenge.

6 umbing within 5 to 6 days after subcutaneous challenge.

7 s in artificial systems remains a scientific challenge.

8 ng amorphous structure remains a significant challenge.

9 in a treated group, 14 days post-Salmonella challenge.

10 ty is a serious and growing worldwide health challenge.

11 y, and controlling its properties, remains a challenge.

12 sequence-preference continues to be a major challenge.

13 nd lung viral reduction against lethal viral challenge.

14 or specificity is a difficult yet appealing challenge.

15 rtners has been established to overcome this challenge.

16 acrophages from male mice following allergen challenge.

17 utrophil/lymphocyte ratio after the allergen challenge.

18 static adaptive responses to a physiological challenge.

19 plitude of scattered light is posing a great challenge.

20 oms of different species can be a diagnostic challenge.

21 s with microscopic resolution has remained a challenge.

22 r to develop new strategies to confront this challenge.

23 ivity were measured before and 8 weeks after challenge.

24 ype of oscillation during recovery from H2O2 challenge.

25 histology within 2 weeks without oral gluten challenge.

26 tory cytokines in response to the infectious challenge.

27 esponse, conferring complete protection upon challenge.

28 acy and sterile protection following malaria challenge.

29 or quality of life, a view that is now being challenged.

30 those results in clinical practice has been challenged.

31 It also brings challenges.

32 ation probes (M-Probes) that overcomes these challenges.

33 netic diversity is crucial for meeting these challenges.

34 educing multi-photon emission presented open challenges.

35 sented considerable logistical and technical challenges.

36 n MS-based HTS workflow that addresses these challenges.

37 inical and research opportunities as well as challenges.

38 ings formidable socioeconomic and healthcare challenges.

39 mbs can be generated, as well as fabrication challenges.

40 nability of marine ecosystems presents major challenges.

41 mportant in confronting and overcoming these challenges.

42 heart disease (CIHD), 126 of whom underwent challenges.

43 t evaluate the sense of smell face two major challenges.

44 ct proteins, but this technology still faces challenges.

45 gy has also raised several new computational challenges.

46 lving combinatorial optimization problems is challenging.

47 Childhood TB diagnosis is challenging.

48 mensional imaging of defect dynamics remains challenging.

49 ions in specific autoimmune diseases remains challenging.

50 ed, and its experimental characterization is challenging.

51 ation of natural antibodies has proven quite challenging.

52 s of sparse compositional microbiome data is challenging.

53 extreme dimensions has proven exceptionally challenging.

54 ify the genes influencing these decisions is challenging.

55 ility properties has proved to be especially challenging.

56 mechanisms underlying folate action has been challenging.

57 elevant htt exon-1 (Httex1) protein has been challenging.

58 characterization in humans in vivo is still challenging.

59 ntal identification of these gaps has proved challenging.

60 t therapies offers great promise but remains challenging.

61 with local but no long-range order, remains challenging.

62 e function from cannabis-induced deficits is challenging.

63 t producing antihydrogen in large amounts is challenging.

64 r assays (MPRAs) and similar methods remains challenging.

65 protection against the heterosubtypic virus challenge after immunization with PC nanogel-adjuvanted

66 Induced by metabolic challenge, amoeboid movement may thus constitute a commo

67 equencing methods is both a major scientific challenge and a strategic priority.

68 individual virulent serotypes, both in early challenge and after 5 months of challenge without any cl

69 theoretical studies, and insights about the challenges and future directions for the field.

70 Finally, we discuss major challenges and open questions related to the application

71 To review the most salient health challenges and opportunities facing the United States, t

72 litated the cell swelling induced by osmotic challenges and thereby activated TRPV4-mediated transmem

73 w contemporary approaches are tackling these challenges and will ultimately serve as an engine for bi

74 ve, selective and stable electrocatalysts is challenging and entails material structure design and ta

75 vidual behaviour under natural conditions is challenging and there is currently little data from the

76 ncer in indeterminate cytological samples is challenging and ultrasonographic features can be mislead

77 Clinical demands, funding challenges, and other factors play important roles, but

78 ar and organismal functions, discuss current challenges, and present our outlook.

79 communities, outline the underlying research challenges, and suggest directions to advance the obesit

80 nasal swab samples collected from laboratory-challenged animals or during influenza surveillance at c

81 olled manner, including the stereochemically challenging anti-anti isomers.

82 In this review, emerging opportunities and challenges are identified for MOF-enabled device functio

83 valve replacement patient presents a unique challenge as many patients are at high or prohibitive su

84 standing and treating this disease remains a challenge, as seizures manifest through mechanisms and f

85 lectron microscopy (cryo-EM) maps is a major challenge, as the moderate resolution makes accurate pla

86 coring of IHC images represents a logistical challenge, as the process is labor intensive and time co

87 Branched ubiquitin chains are particularly challenging, as multiple modifications on a single ubiqu

88 ) sphingolipids has been slow as a result of challenges associated with the extractability of GIPCs,

89 atment reduced plasma LPS content in E. coli-challenged baboons, implying reduced complement-mediated

90 ization of the full-length oligomeric p53 is challenging because of its complex architecture and mult

91 e most evolved giant and supergiant stars is challenging because their photospheres are obscured by d

92 namely the definition of a module, has been challenged by Abe and co-workers in their recent study.

93 However, this proposal has been challenged by both theoretical and empirical studies.

94 wall mechanics and growth, but this view is challenged by newer results.

95 lithium-air batteries, whereas this view is challenged by recent contrasting observations.

96 The computational challenge can be dealt with, in part, by endowing RL sys

97 Importantly, following a high-fat challenge, carriers in the Amish Complex Disease Researc

98 2X7 antagonists that contain a synthetically challenging chiral center.

99 flicts between replication and transcription challenge chromosome duplication.

100 Elderly adults may master challenging cognitive demands by additionally recruiting

101 The aim of this study was to examine the challenges confronting surgeons performing basic science

102 These findings challenge consensus that because the left hemisphere in

103 Although clinical trial design is challenging, due in part to a lack of robust biomarkers

104 c indicator species, but data patchiness has challenged efforts to link population dynamics to key dr

105 re organisations seeking to be inclusive and challenges employers and educators to acknowledge inequa

106 a complex quaternary system has been a great challenge, especially in the presence of high Ni content

107 targeted proteomics approaches still remains challenging, especially for these samples without availa

108 However, significant challenges exist for structural characterization of the

109 ge to this hopeful era of possibilities, new challenges expectedly arise, and our focus now must shif

110 mall molecule inhibitors represent important challenges faced by current anti-AXL therapeutics.

111 Current challenges facing the field of metabolomics include scal

112 r metabolism in mammalian cells represents a challenge for analytical chemistry in the context of cur

113 totemporal dementia (bvFTD) poses a daunting challenge for clinicians but will be critical for the su

114 Their repetitive nature poses a challenge for genome assembly and makes progress on the

115 during adolescence constitutes a significant challenge for the key stakeholders due to the combined e

116 This under-determinedness poses a challenge for the quantitative characterization of flux

117 substrates in various forms, imposes a major challenge for these studies.

118 LAIR-1(-/-) and B6.DR1/LAIR-1(+/+) mice were challenged for CIA and mean severity scores were recorde

119 Rare cancers pose challenges for diagnosis, treatments, and clinical decis

120 their radiative impact is one of the largest challenges for global climate models.

121 -up duration, and vaccine composition posing challenges for public health decision making.

122 This requirement is fundamentally challenging for airborne acoustics because the sound spe

123 c shift continue to make refractive outcomes challenging for IOL implantation during infancy.

124 l sclerosis (ALS) and fragile X syndrome, is challenging for short-read whole-genome sequencing (WGS)

125 for identifying new conditions that tolerate challenging functional groups.

126 the survival strategy of C. difficile in the challenging gut environment still remains incompletely u

127 view, we begin with an overview of the major challenges GxE studies have faced (e.g., difficulties re

128 This challenge has grown as cancer datasets become increasing

129 Indeed, several recent challenges hosted by the U.S. government have fostered a

130 An artificial, disruptive challenge; i.e., introduction of a novel object, is used

131 Direct O2 utilization suffers from intrinsic challenges imposed by the triplet ground state of O2 and

132 ccurate investigation is specific inhalation challenge in an experienced centre, this is a scarce res

133 We are facing a major challenge in bridging the gap between identifying subtyp

134 r dissolution of large blood clots remains a challenge in clinical treatment of acute thrombo-occlusi

135 these glycan epitopes remains a significant challenge in mAb preclinical development.

136 dered halides persists as a largely unsolved challenge in organic synthesis.

137 Pancreatitis remains a diagnostic challenge in patients with mild to moderate disease, wit

138 ferent retinal images represents a tractable challenge in sensory neuroscience that has so far evaded

139 actable therapeutic targets is a significant challenge in the discovery of new medicines.

140 Chronic norovirus infection is an emerging challenge in the immunocompromised host, in whom it may

141 ity worldwide, remains a major public health challenge in the most severely affected countries despit

142 his treatment.Significance: Illustrating the challenge in treating cancers with targeted drugs, which

143 t for opposite reasons, highlighting a major challenge in tuberculosis vaccine design.

144 times for appointments, which suggests that challenges in access to care persist.

145 d by the half-life of the contrast agent and challenges in accurate control of large volume tumor hyp

146 ed by the complex cellular abnormalities and challenges in achieving effective, persistent inhibition

147 s in TMDs are not well understood due to the challenges in characterizing anisotropic thermal conduct

148 We evaluate the major challenges in choosing therapeutics to prevent congenita

149 One of the major challenges in ecology is to understand how ecosystems re

150 l populations has been hindered by technical challenges in isolating single cells during genome prepa

151 for these materials remains one of the great challenges in polymer synthesis.

152 fficult to study, primarily due to technical challenges in probing these materials in situ.

153 We describe opportunities and challenges in RNA structural modeling and design, as rec

154 al of tritium from nuclear waste are the key challenges in separation of light isotopes.

155 Nevertheless, the system still faces challenges in structural characteristics, incentives and

156 ermediate.Reduction of allenes poses several challenges in terms of chemo-, regio- and enantio-select

157 Here we assess the current landscape and challenges in the treatment of antibiotic resistance mec

158 logical condition and the benign one is very challenging in the surgical setting; therefore, accurate

159 gms at baseline and after psychotogenic drug challenge, in conjunction with remodeling of local conne

160 Challenges include accurately estimating chemical exposu

161 llected disease data is hampered by numerous challenges, including short-term surveillance that focus

162 In the new era of genomics, the challenging interpretation of individual genetic variati

163 l significant retinal diseases, describe the challenges involved and discuss how basic developmental

164 An ongoing challenge is the identification of biomarkers that predi

165 A major challenge is the lack of a rapid and accurate point-of-c

166 The greatest challenge is the safe and efficient delivery of the CRIS

167 Recent advances and the current status of challenging light-harvesting nanomaterials, such as semi

168 nophils isolated from the lungs A. alternata-challenged mice are cytokine-enriched compared to those

169 s increased in peanut extract-sensitized and challenged mice, whereas in tolerized mice levels were s

170 tween activity, stability and conductivity-a challenging mission of great importance for delivering a

171 s have highlighted the need for a human DENV challenge model to better evaluate the candidate live at

172 We performed a double-blind crossover challenge of 59 individuals on a self-instituted gluten-

173 The subsequent challenge of examining, visualizing, and presenting mass

174 t sensitizes the liver to insulin during the challenge of HF feeding.

175 cooperation from group members a fundamental challenge of social life.

176 lowed by epicutaneous sensitization and oral challenge of their offspring with OVA.

177 A significant challenge of traditional glycan mapping techniques is th

178 Conservation of migratory species faces the challenge of understanding the ecological requirements o

179 te that ToxDock can overcome two fundamental challenges of docking large toxin peptides to ion channe

180 The principles, sensitivity, selectivity and challenges of electrochemical biosensors are discussed i

181 prepare future nephrologists for the growing challenges of kidney care.

182 resents one of the biggest and most exciting challenges of systems neuroscience.

183 y of multiscale flux measurement to overcome challenges of wetland heterogeneity.

184 ces available to cope with two physiological challenges (ovarian development after queen loss and imm

185 ses in predicting behaviors and describe the challenges over the next few years.

186 phosphorylation and aggregation has proven a challenge owing to the multiple potential phosphorylatio

187 mice (P < .005) and in vivo after ovalbumin challenge (P < .05), higher levels of apoptosis (Annexin

188 or interphase design to address the dendrite challenge, paving the way for the development of robust,

189 Two fundamental challenges plague clinical translation of vaccine-adjuva

190 mary care nursing roles and responsibilities challenges policy makers' abilities to develop recommend

191 patient safety, particularly in the areas of challenging poor practice, and recognising, responding t

192 tigate the ItchyQuant further in cognitively challenged populations.

193 The present article reviews the challenges posed by infective endocarditis and outlines

194 or ancient DNA preservation in these regions challenged previous attempts to resolve these questions

195 'em, the leading benchmark and long-standing challenge problem in imperfect-information game solving.

196 e nucleotide polymorphisms (tag SNPs) in 367 challenge-proven food allergic cases, 199 food-sensitize

197 To identify genetic variants associated with challenge-proven peanut allergy.

198 ults suggest that it is possible, even under challenging real-world conditions, to improve quality of

199 r (Compound 20) administered during allergen challenge reduced ILC2 numbers and activation, as well a

200 However, substantial challenges remain in the scalability, stability and fund

201 rapid growth, conceptual and methodological challenges remain.

202 inating and quantifying these processes is a challenge, requiring tracking of rapidly moving, sub-dif

203 Here we challenged rRNA 2'-O-Me globally by inhibiting the rRNA

204 tes of inflammation after segmental allergen challenge (SAC).

205 we apply the PFM approach to the study of a challenging set of sequences-the bacterial chemotaxis pr

206 d self-organizing communities is technically challenging since no adequate quantification has been de

207 this astonishing rate of success, the major challenge still remains to not only confirm that the gen

208 morbidity continue to be major global health challenges strongly associated with prematurity and redu

209 After an allergen challenge, subjects with atopy displayed rapid induction

210 mple chemical approach addresses several key challenges, such as control over phase purity, uniformit

211 uitable model cathode host for unveiling the challenging surface chemistry issue in Li-S batteries.

212 ation has, however, been severely limited by challenging synthetic requirements that incorporate unst

213 But it is a challenging task due to the additive solid supports in t

214 llowed up clinically with repeated bronchial challenge tests over 1 year.

215 ulting in better protection against a lethal challenge than that seen with rLBNSE.

216 did not show any greater responses to these challenges than before grafting.

217 tion and functional maturation remains a key challenge that hampers the routine application of hPSC-d

218 s, however, these phenomena face fundamental challenges that arise from the multimodal nature of the

219 the considerable progress made and remaining challenges that must be met to ensure a fair and meritoc

220 Finally, we identify the challenges that the field currently faces and look forwa

221 These initial results challenge the belief that metastatic uveal melanoma is i

222 ssils and stone tools from a cave in Morocco challenge the notion that East Africa was the birthplace

223 Humans challenge the phenotypic, genetic, and cultural makeup o

224 The findings also challenge the prospect of using neuroscientific methods

225 DNA viruses replicating in the nucleus challenge the resident genome and must overcome cellular

226 These findings challenge the safety of pure nicotine inhalation, i.e.,

227 Our results challenge the trait-based approach to predicting ecosyst

228 3 in preserving reproductive immaturity, and challenge the view that stimulatory peptides are the ult

229 observational data for this trace metal has challenged the prevailing view of the ocean iron cycle.

230 d operating room team training strategy that challenges the communication abilities and teamwork comp

231 This challenges the idea that ants use egocentric visual memo

232 wever, the repetitive composition of genomes challenges the identification of target-specific oligonu

233 Recent evidence challenges the MD view by demonstrating that a preferenc

234 This challenges the popular conception of "the ribosome" as a

235 r of distinct cell types being identified is challenging the current paradigm for cell type definitio

236 for linear, time-invariant resonant systems, challenging the doctrine that high-quality resonances mu

237 are in clinical trials, but escape mutations challenge their potential.

238 early-career academic cardiologists remains challenging; therefore, the authors recommend a set of a

239 Here we report evidence challenging this view, with implications for therapeutic

240 Here we address this challenge through the analysis and modelling of human br

241 ty or a high power density, but it is a huge challenge to achieve both the demands of a high energy d

242 ing in the post-genomic age, it is an urgent challenge to acquire the information of DNA recombinatio

243 A significant challenge to HIV eradication is the elimination of viral

244 tity-protective cognition to pose a friendly challenge to Jussim (2012).

245 ver, are still unclear and represent a major challenge to our understanding of glacial climates.

246 is necessarily constrained by the consequent challenge to protein folding and function.

247 A critical challenge to translating field effect transistors into b

248 It is a challenge to treat patients with cirrhosis using anticoa

249 sitive double-blind, placebo-controlled food challenges to an eliciting dose of 300 mg or less of pea

250 underpinnings of Treg therapy and technical challenges to developing successful cell therapy.

251 nditioning literature in humans and describe challenges to study contextual learning in humans.

252 In addition, it remains challenging to access small luminal organs or pass throu

253 en reported in the literature, it has proven challenging to achieve high binding selectivity for diff

254 ation among GP of Ebola viruses, it would be challenging to determine the propensity of acquiring mut

255 ately reflect the pathology of LAM have been challenging to develop.

256 nds that block protein binding are much more challenging to develop; attenuating the number of false

257 Each of these 3 RCMs is challenging to diagnose, and recognition of each disease

258 om interactions between molecules, which are challenging to elucidate with current techniques.

259 omatin marks through correlation, it remains challenging to establish which marks actually have causa

260 ral variations (SVs) within genomes are more challenging to identify than smaller genetic variants bu

261 These motifs are challenging to identify, but once found they can point t

262 digm-chronic social defeat stress-has proven challenging to implement in females.

263 nent of Critical Zone science, but is highly challenging to investigate across the enormous physical

264 amin D3 (25(OH)D3), however, is particularly challenging to measure in such a format due to complexit

265 ut, as T1D is rare, intervention studies are challenging to perform.

266 the fine details of this synergy has proven challenging to scientific research.

267 It has however proven technically challenging to study this parameter during diabetes prog

268 roisoquinolines (THIQs), structures that are challenging to synthesize and yet are present in a numbe

269 It has been challenging to target maladaptive generalized memories w

270 Our microbiome is complex and challenging to understand, but evolutionary theory provi

271 alterations of cancer; however, it has been challenging to use genetic profiles of individual patien

272 ked dsRNA sprayed on plants has been a major challenge towards its practical application.

273 immunization with live Pf sporozoites (PfSPZ Challenge) under chloroquine prophylaxis (PfSPZ-CVac), a

274 ospitalized for Worsening Heart Failure With Challenging Volume Management [SECRET of CHF]; NCT015845

275 Allergen challenge was continued during HOCl hydrogel application

276 The design challenge was not just to choose market rules to govern

277 ant protection in mice against the bacterial challenge was observed at a micromolar concentration of

278 Investigating the consequences of this challenge, we have characterized C. neoformans GMP synth

279 To address this challenge, we have implemented ozone-induced dissociatio

280 On day 4 post-challenge, we measured increased antibody levels, ASCs a

281 biomarkers of disease progression presents a challenge when developing new therapies for patients.

282 However, MS-based disulfide mapping is challenged when multiple disulfide bonds are present in

283 nd crossover, placebo-controlled oral gluten challenge, which had a fixed sequence, and biopsy cohort

284 by ligand functions to protect against viral challenge, which probably accounts for its selection wit

285 manufacture, the high pelleting temperatures challenge wild-type xylanases.

286 We solved this challenge with 1,4-bicyclo[2.2.2]octane dicarboxylic aci

287 We rise to the challenge with an alternative to the wave function-cente

288 ally with anti-IgE mAb or PBS 6 hours before challenge with AP or saline.

289 rent vaccines were completely protected from challenge with individual virulent serotypes, both in ea

290 In contrast, following challenge with maH3N2, progestin treatment reduced survi

291 olarization in response to a pharmacological challenge with sotalol.

292 The integrity of our DNA is challenged with at least 100,000 lesions per cell on a d

293 ical disease from beef cattle experimentally challenged with either bovine respiratory syncytial viru

294 Grafted monkeys were also challenged with levodopa but did not show any greater re

295 the ability to survive and proliferate when challenged with stressors such as growth factor insuffic

296 (5) What are the challenges with available data?

297 nes and chemokines in response to sequential challenges with LPS and Poly I:C, a TLR3 ligand, which w

298 Challenges with the production and suboptimal immunogeni

299 oth in early challenge and after 5 months of challenge without any clinical disease.

300 This is a challenging yet important problem since such a predictio