ライフサイエンスコーパス: challenge to

1 Subjects underwent an open challenge to 4000 mg of peanut protein 12 weeks after st

2 designs, it remains a formidable scientific challenge to access Earth-abundant transition-metal comp

3 In addition, it remains challenging to access small luminal organs or pass throu

4 l RNA sequencing (sRNA-Seq) data, it remains challenging to accurately analyze the small RNA populati

5 ty or a high power density, but it is a huge challenge to achieve both the demands of a high energy d

6 en reported in the literature, it has proven challenging to achieve high binding selectivity for diff

7 This may pose challenges to achieving optimal efficacy, safety, and pa

8 ing in the post-genomic age, it is an urgent challenge to acquire the information of DNA recombinatio

9 le bonds between carbon atoms are inherently challenging to activate using transition metals; however

10 inders from non-binders and demonstrates the challenges to address for the methods to be widely appli

11 This makes it very challenging to address the functions of individual wall

12 ong DFS and OS in these patients represent a challenge to adjuvant ccRCC drug development.

13 eic acid therapeutics, articulating the main challenges to advance this promising approach to the cli

14 sitive double-blind, placebo-controlled food challenges to an eliciting dose of 300 mg or less of pea

15 nated paraffins (SCCPs) poses an exceptional challenge to analytical chemists.

16 First, the resulting large video data is challenging to analyze.

17 ibiotic activity and thus pose a significant challenge to antibiotic treatment.

18 Most centres were able to provide diagnostic challenges to antibiotics [40/44 (91%]) and local anaest

19 gely restricted to dividing cells, making it challenging to apply the technique in postmitotic neuron

20 ange of nanoarchitectures that are typically challenging to assemble and load with therapeutics for c

21 ation studies (GWAS) are noncoding and it is challenging to assess their functional impacts.

22 g that the condition is under-recognized and challenging to assess.

23 cipants with knowledge of private-well water challenges to attend the Summit.

24 to the complex nature of honey, it is often challenging to authenticate the purity and quality by us

25 However, it has proved to be more challenging to base DRI values on chronic disease endpoi

26 ative tissues in vitro remains a significant challenge to be addressed.

27 There are, however, challenges to be addressed when developing a common onto

28 of these technologies also carries technical challenges to be met before traditional cell culture and

29 filling tools require experimentation, it is challenging to benchmark performance and make improvemen

30 luidic size-based particle/cell sorting is a challenge to better address the need for generating more

31 was administered at 2 hours after bacterial challenge to better reflect the real life infectious con

32 private health care settings where there are challenges to blood-based malaria diagnosis testing.

33 , the capacity to respond to a physiological challenge to body fluid homeostasis may be compromised f

34 tural product analogs presents a significant challenge to both biosynthetic assembly and synthetic ch

35 a combination thereof, and thus presents new challenges to both theory and the empirical criterion of

36 However, it is challenging to breed varieties with resistance that is e

37 nanometers, it presents a major experimental challenge to capture the CT process simultaneously in th

38 Both aspects are challenging to capture in experimental models.

39 e chronic pain, and chronic opioid users are challenging to care for perioperatively.

40 cerns facing wealth research: how to address challenges to causal inference posed by wealth's cumulat

41 red for this mechanism, it has remained very challenging to characterize the initial events leading t

42 d Aspergillus species is one of the greatest challenges to clinical success, followed by echinocandin

43 e new program requirements were perceived as challenging to communicate, difficult to understand, unr

44 rtant for cognitive function, but it remains challenging to construct anatomically plausible individu

45 citrus pathogen into Florida and has been a challenge to control to date.

46 However, enantioselective optical forces are challenging to control and quantify because their magnit

47 ous catalytic reactions, but it has remained challenging to correlate structure and reactivity becaus

48 V) ("the switch") presented an unprecedented challenge to countries.

49 However, it remains a fundamental challenge to create a wireless power transfer system in

50 ing significant medical, social and economic challenges to current and future generations.

51 onclusions of this sobering analysis present challenges to current silvicultural practices and to tho

52 d in the past few years, which poses a great challenge to data interpretation.

53 rder of 100 nm with acoustophoresis has been challenging to date because of the competing natures of

54 inctive TMSs is highly desirable but remains challenging to date.

55 Although challenging to decipher, the details of these routes are

56 However, it remains a challenge to deduce from these data chromosome regions t

57 However, it is a challenge to define the complete molecular exchange betw

58 BACKGROUND & AIMS: It is a challenge to deliver nucleic acids to gastrointestinal (

59 y some primates and humans; thus it has been challenging to demonstrate experimental proof of causali

60 However, it is challenging to derive the QSS in the presence of nonline

61 Despite advances, it has remained challenging to design analogs of many electronic compone

62 Nowadays, it is still a challenge to detect low-abundance miRNAs.

63 sease still represents a significant, albeit challenging to detect, public health problem.

64 Moreover, it is currently very challenging to determine the molecular-level structure(s

65 ation among GP of Ebola viruses, it would be challenging to determine the propensity of acquiring mut

66 It, however, remains challenging to determine which structures are adopted in

67 r cereals, maize and rice, but it has been a challenge to develop a viable hybrid system for bread wh

68 as led to a persistent, and as yet unsolved, challenge to develop cures for this disease.

69 Its discovery posts a challenge to develop effective countermeasures, provides

70 t of the yellowhead jawfish, managers face a challenge to develop strategies that allow connectivity

71 xplosive growth of protein sequences, we are challenged to develop fast and effective method to annot

72 ately reflect the pathology of LAM have been challenging to develop.

73 nds that block protein binding are much more challenging to develop; attenuating the number of false

74 underpinnings of Treg therapy and technical challenges to developing successful cell therapy.

75 Here, we present the challenges to development and evaluation of novel diagno

76 This shortcoming makes it very challenging to diagnose and treat the many psychiatric d

77 Each of these 3 RCMs is challenging to diagnose, and recognition of each disease

78 able to neuroinvasive infections that can be challenging to diagnose.

79 However, it is still quite challenging to directly measure the birefringent phase r

80 However, it has been challenging to directly observe these complexes and thei

81 However, it remains a challenge to discover the human-specific cardiac regulat

82 much less explored because such aptamers are challenging to discover.

83 ity, dynamics, and function, but it has been challenging to disentangle their ultimate relationships.

84 There is a longstanding challenge to disperse metal nanoparticles uniformly in b

85 ations that result in varying phenotypes are challenging to dissect, but can be delineated through fo

86 It is challenging to distinguish ILS and introgression because

87 differentiate intracellular events that are challenging to distinguish with standard flow cytometry.

88 It has long been a challenge to dope metal nanoparticles with a specific nu

89 s and among communities, poses a substantial challenge to efforts to interrupt transmission.

90 such assembly phenomena and it remains a key challenge to elucidate how these systems can be engineer

91 models, psychiatric genetics, pharmacologic challenge) to elucidate brain-based pathways that give r

92 om interactions between molecules, which are challenging to elucidate with current techniques.

93 rocesses on two similar PG walls have proved challenging to elucidate.

94 patterns and physiological functions remain challenging to elucidate.

95 and geographical access represent particular challenges to ensuring universal access to maternal care

96 Environmental challenges to epithelial cells trigger gene expression c

97 went a double-blind, placebo-controlled food challenge to establish changes in eliciting dose.

98 omatin marks through correlation, it remains challenging to establish which marks actually have causa

99 It is very challenging to estimate power for RNA-Seq differential e

100 lex composition and dimensionality make them challenging to evaluate in a real-time manner.

101 However, it was challenging to evaluate the significance of targeting Pi

102 s of the approach were identified, including challenges to evaluating the outcomes of a research prog

103 The challenge to evoke spikes with high spatial and temporal

104 To date, it has remained a major challenge to experimentally disentangle the complex kine

105 Highly excited electronic states are challenging to explore experimentally and theoretically-

106 imensional structures, it becomes a critical challenge to extract key geometric characteristics of RN

107 However, it is still a major challenge to fabricate the flexible SERS substrate on la

108 otective antibodies, but it is still a major challenge to find a suitable classification that include

109 been traditionally conceived as the chemical challenge to find the type of molecule and free-solution

110 Our results show that the bacterium is challenged to find a delicate equilibrium between expres

111 ogy models illustrates the possibilities and challenges to find novel ligands for chemokine receptors

112 for high-throughput schemes has been proven challenging to find.

113 ers due to processing constraints, making it challenging to further suppress the on-state current and

114 However, it is a challenge to gather sufficiently large datasets to disse

115 The complexity of the channel and the challenges to generate recombinant cell lines with high

116 However, it still remains challenging to generate deep-UV SHs especially in optica

117 damaging agents, representing a significant challenge to genome stability and genome integrity over

118 Pakistan currently provides a substantial challenge to global polio eradication, having contribute

119 However, it is still challenging to grow HCV clinical isolates in cell cultur

120 sequencing (GBS) generates datasets that are challenging to handle by current genetic mapping softwar

121 A major challenge to harnessing these natural products is that t

122 Klebsiella pneumoniae poses a major challenge to healthcare worldwide as an important cause

123 A significant challenge to HIV eradication is the elimination of viral

124 resources and their markets are a ubiquitous challenge to human communities.

125 ponsibility to rebut and decry these serious challenges to human health and scientific integrity.

126 One of the greatest current challenges to human society is ensuring adequate food pr

127 scape of cancer mutations poses a formidable challenge to identify cancer genes among the large lists

128 However, it remains a challenge to identify suitable allosteric binding sites.

129 heir potentially important roles, it remains challenging to identify functional lncRNA loci and disti

130 , and cis-eQTLs occur frequently, it remains challenging to identify specific instances of disease-re

131 ral variations (SVs) within genomes are more challenging to identify than smaller genetic variants bu

132 These motifs are challenging to identify, but once found they can point t

133 ective and cellular potent inhibitors remain challenging to identify.

134 es across large spatial scales remains a key challenge to illuminating the resilience of earth's syst

135 dynamic macromolecular assembly, it remains challenging to image many species with high selectivity

136 etinal ganglion cells, have proven much more challenging to image.

137 However this step is challenging to implement in droplet microfluidics.

138 digm-chronic social defeat stress-has proven challenging to implement in females.

139 techniques to molecules, which has been more challenging to implement owing to the complexity of mole

140 erapy, GC resistance represents an important challenge to improving the outcome for these patients.

141 Challenges to improving ST-segment elevation myocardial

142 ucational institutions are continually being challenged to increase the diversity of their faculty, p

143 current in vitro testing battery is a major challenge to industry and regulatory agencies.

144 ions, including those that are synthetically challenging to install.

145 It remains a major challenge to integrate such data from various complement

146 ardial infarction, but concentrations can be challenging to interpret in patients with renal impairme

147 ritis are difficult to conduct and even more challenging to interpret.

148 Calcific atherosclerosis is a major challenge to intraluminal drug delivery in peripheral ar

149 gents, pH, and mechanical force, it is still challenging to introduce multiple external switches usin

150 nent of Critical Zone science, but is highly challenging to investigate across the enormous physical

151 from latency and re-enter the lytic phase is challenging to investigate and control, it is known that

152 ptor heterojunctions, whilst it has remained challenging to investigate the detail.

153 exemplifies such a species and faces extreme challenges to its survival.

154 tity-protective cognition to pose a friendly challenge to Jussim (2012).

155 well as the hydrophobic nature of Wnt, poses challenges to laboratory-based investigations of interac

156 However, it has been challenging to localize regions in the developing human

157 It is extremely challenging to look at them individually using conventio

158 However, it has been a grand challenge to maintain the viability, functionality, and

159 R, the rapid pace of drug discovery makes it challenging to maintain a strong insight into DDIs.

160 ght frequency and severity pose a formidable challenge to maintaining soybean yield progress that is

161 mptomatic and submicroscopic and represent a challenge to malaria control.

162 cryopreserved, non-irradiated PfSPZ ('PfSPZ Challenge') to malaria-naive, healthy adult volunteers t

163 recent advances in optogenetics, it remains challenging to manipulate gene expression in specific po

164 inhibitory neurons are becoming known, it is challenging to map these details onto function.

165 It is challenging to measure dietary exposure with techniques

166 amin D3 (25(OH)D3), however, is particularly challenging to measure in such a format due to complexit

167 ly understood because the entire quantity is challenging to measure.

168 A challenge to meeting ART retention targets is developing

169 try-based metabolomics data presents a major challenge to metabolism researchers, as it requires down

170 resilience in mosquitoes poses a significant challenge to mosquito control.

171 r novel or familiar represents a fundamental challenge to neural processing.

172 Reverse Engineering Assessments and Methods) challenge to not only identify a better prognostic model

173 It is challenging to observe MOFs with transmission electron m

174 It was challenging to obtain these compounds as single enantiom

175 s of developmental evolution are necessarily challenging to obtain.

176 Such heightened variability poses greater challenges to operational forecasting and, consequently,

177 s than conjugated polymers, and that the key challenge to optimize photocatalytic activity of these m

178 cycle (FTC) frequency pose great ecological challenges to organisms in alpine and polar ecosystems.

179 ver, are still unclear and represent a major challenge to our understanding of glacial climates.

180 of hearing in rodents such as gerbil pose a challenge to our understanding of the cochlea, however,

181 pitation extremes, but there are many design challenges to overcome (e.g., cost, comparability, stand

182 , adolescent type 2 diabetes now poses major challenges to paediatric and adult diabetes services in

183 The challenges to parametrizing such Hamiltonians have been

184 rgoing double-blind, placebo-controlled food challenge to peanut.

185 mized, double-blind, placebo-controlled oral challenges to peanut.

186 ut, as T1D is rare, intervention studies are challenging to perform.

187 forthcoming biologic therapy, and discusses challenges to performing clinical trials in this complic

188 h-charge recombination rate has been the big challenge to photocatalytic conversion efficiency.

189 ene expression have proven to be significant challenges to pre-clinical to clinical progression.

190 It is a challenge to predict outcomes of patients with severe AH

191 in complexes which have traditionally been a challenge to predict.

192 exes bound by RBPs, including those that are challenging to predict computationally, such as intermol

193 It is therefore usually extremely challenging to predict cyclic behaviour and fatigue life

194 g the biogeochemical influence of this group challenging to predict.

195 reocontrol, but certain stereoisomers remain challenging to prepare.

196 gress in this field has been hindered by the challenge to probe optical and transport properties of t

197 very poorly understood since it is extremely challenging to probe the structure of buried interfaces

198 the other hand, this same property makes it challenging to probe their structural changes during the

199 These asymmetric responses pose a tractable challenge to process-based models attempting to isolate

200 ut well-ordered clade C Env trimers are more challenging to produce due to their instability.

201 l biology and interpreting genomic data, but challenging to produce experimentally.

202 is necessarily constrained by the consequent challenge to protein folding and function.

203 Competent authorities are faced with the challenge to provide adequate regulation.

204 The most challenging to purify, tobacco epi-aristolochene synthas

205 tor lizards; NALs), in response to a thermal challenge to quantify variation in physiological perform

206 Although there are many challenges to quantifying cancer epidemiology and assess

207 based on carbon optimisation principles are challenging to quantitatively assess because of uncertai

208 Suboptimal retention is among the biggest challenges to realize the full benefits of combination a

209 Future directions and grand challenges to realize these goals are highlighted for bo

210 us nanosensor technologies, it still remains challenging to realize a reliable ultrasensitive electri

211 developed to produce such beams, it is still challenging to realize a tunable non-diffracting beam.

212 and Barry Popkin discuss the urgent need and challenges to reduce intergenerational transmission of o

213 ure permanent teeth represents a generalized challenge to regenerate diseased pediatric tissues that

214 It remains a grand challenge to replace platinum group metal (PGM) catalyst

215 cial and technological systems, but has been challenging to reproduce in silico.

216 equencing (RNA-Seq) data poses an increasing challenge to researchers wishing to discover, analyse an

217 the pathogenesis, however, pose considerable challenges to researchers.

218 In engineering MPs, it can be extremely challenging to retain membrane localization capability w

219 s with extended implantation times present a challenge to retrieval, where standard techniques often

220 After a 4-day baseline challenge to rye grass in the environmental exposure uni

221 However, it remains challenging to scale up these circuits owing to the limi

222 the fine details of this synergy has proven challenging to scientific research.

223 he 120 human SH2 domains poses a significant challenge to selectively perturb the interactions of eve

224 However, it has been a challenge to separate spatial patterns related to direct

225 This poses a challenge to single molecule image analysis.

226 Transcriptionally active regions present a challenge to SIR complex-mediated de novo heterochromati

227 mong genes that affect a single trait pose a challenge to soybean breeding.

228 s fleeting lifetime, it has been a synthetic challenge to stabilize the tetrapyrrolic isophlorin.

229 r DC production, although it remains a major challenge to steer directional differentiation because E

230 nts with celiac disease underwent oral wheat challenge to stimulate recirculation of gluten-specific

231 nditioning literature in humans and describe challenges to study contextual learning in humans.

232 care data, which creates oppor- tunities and challenges to study them.

233 on by varicella-zoster virus (VZV) have been challenging to study due to the relatively strict human

234 nism of voltage-gated processes but has been challenging to study experimentally.

235 occur in many central neurons but have been challenging to study in vivo in the vertebrate brain.

236 Their small size has made it challenging to study them directly in live cells.

237 It has however proven technically challenging to study this parameter during diabetes prog

238 extremely homologous, these PE/PPEs are very challenging to study, and it is difficult to be certain

239 The biology of aging is challenging to study, particularly in humans.

240 hese so-called pi interactions has made them challenging to study, theory and modelling have now reac

241 Wolbachia are obligately intracellular and challenging to study; there are no genetic tools for man

242 grees of freedom and lack of symmetry pose a challenge to studying the chemical details of the HIV ca

243 for GBM has been dismal, we also review the challenges to successful therapeutic and biomarker devel

244 in which we neutralized IFN-gamma during HDM challenge to support the TH2 response and exacerbate ast

245 Mussels live in stream sediments and can be challenging to survey given constraints related to water

246 Since phages present a major challenge to survival in most environments, bacteria exp

247 of dissimilar materials make it still a big challenge to synthesize high-quality single-crystalline

248 roisoquinolines (THIQs), structures that are challenging to synthesize and yet are present in a numbe

249 idespread applications, it is beneficial yet challenging to synthesize hollow nanostructures in large

250 usceptible to proteolytic degradation and is challenging to synthesize in high yield.

251 nocrystals with no elemental ordering, it is challenging to synthesize intermetallic nanocrystals wit

252 However, it is challenging to systematically investigate the interplay

253 s virus and these glycoproteins a formidable challenge to target by vaccination, requiring a systemat

254 ain of function for chemotherapy, it remains challenging to target downregulation in cancer cells.

255 It has been challenging to target maladaptive generalized memories w

256 tment are urgently required, however a major challenge to TB drug development is the lack of predicti

257 One challenge to the deployment of such gastroresident elect

258 igid structure of tRNA has been presenting a challenge to the development of such methods.

259 t article, Keven & Akins (K&A) put forward a challenge to the developmental psychology community to c

260 This underlies a new challenge to the experimentalist because neither intuiti

261 ources to viral replication, it also poses a challenge to the maintenance of cellular functions neces

262 able, which presents a significant enzymatic challenge to the polysaccharide lyases and sulfatases th

263 This currently represents the major challenge to the understanding of human movement.

264 ct metal at the proper binding site presents challenges to the cell.

265 is especially concerning and may pose unique challenges to the development and deployment of safe and

266 e, certain genomic loci/regions pose greater challenges to the DNA replication machinery (i.e., the r

267 eduction of carbon emissions are significant challenges to the enhanced sustainability of wastewater

268 The key accomplishments and future challenges to the field are discussed, with particular e

269 ple cellular heterogeneity presents numerous challenges to the identification of biomarkers in large

270 The complex structure of the limb poses challenges to the investigation of the cellular and mole

271 f the field over the next 2 years, and three challenges to the pancreatic cancer research community a

272 impose several statistical and computational challenges to the reliable detection of variants.

273 One of the major challenges to the widespread adoption of plasmonic and n

274 to the EGFR-targeting drug cetuximab poses a challenge to their effective clinical management.

275 nolattice fabrication is currently the major challenge to their widespread use in technological appli

276 ly may confer protection presents additional challenges to their clinical development.

277 l structures present long-standing practical challenges to their synthesis.

278 potential clinical applications; we identify challenges to their technical refinement.

279 his small molecule has presented significant challenges to theoretical chemistry.

280 ell type that requires Clrn1 expression pose challenges to therapeutic investigation.

281 organoids and gastruloids may pose a slight challenge to this novel ethical approach.

282 ments in biopharmaceutical companies poses a challenge to those interested in funding such enterprise

283 e features of these data, however, present a challenge to traditional statistical tests.

284 It is challenging to transform an arbitrary quantum circuit in

285 A critical challenge to translating field effect transistors into b

286 compounds and has presented a long-standing challenge to transport theory.

287 It is a challenge to treat patients with cirrhosis using anticoa

288 wounds following ablative procedures, EPD is challenging to treat and may require the use of anti-inf

289 Metastatic breast cancer remains challenging to treat, and most patients ultimately progr

290 However, it is a great challenge to understand fundamentally the complex intera

291 Our microbiome is complex and challenging to understand, but evolutionary theory provi

292 % of cases, which remains the most important challenge to understanding lower respiratory infection.

293 A central challenge to understanding the role of double diffusive

294 ctors (e.g. WS2) is one of the most pressing challenges to unleash the potential of these materials a

295 alterations of cancer; however, it has been challenging to use genetic profiles of individual patien

296 erived from human pluripotent stem cells and challenges to using these cells in treating end-stage li

297 ly new cancer genes; but such approaches are challenging to validate at scale, and their predictive v

298 the conformational ensemble are particularly challenging to visualize for large RNAs.

299 variability in streamflow responses poses a challenge to water resource management in the northeaste

300 However, H doping is a challenge to WO3, the relevant mechanisms being hardly u