ライフサイエンスコーパス: channel

1 andmark genes are designed to share a single channel.

2 ers are staggered, leading to a kinked axial channel.

3 (LF) N-terminal segment through the anthrax channel.

4 cyclization to become a competitive reaction channel.

5 -PLC-dependent gating of a receptor-operated channel.

6 ocked chloride transport through the central channel.

7 +)-water wires observed for the natural KcsA channel.

8 h may provide a permanent energy dissipation channel.

9 ases calcium influx across the L-type Ca(2+) channel.

10 domain next to Rrp6 and the exosome central channel.

11 the strand that is excluded from the central channel.

12 pores blocked away from the main adsorption channels.

13 channel gating and current flow through open channels.

14 ransient receptor potential canonical cation channels.

15 act distinct stimulus features into parallel channels.

16 shift or hysteresis has been reported in ion channels.

17 alter the surface membrane expression of SK2 channels.

18 could also occur in the gating of other ion channels.

19 al properties of wild-type and mutant KV 3.1 channels.

20 ypothesized temperature mechanism in TRP ion channels.

21 and the subsequent closure of KCNQ potassium channels.

22 hat this mechanism is conserved in other Kir channels.

23 e that encompasses many different glomerular channels.

24 ce an acidosis and activate acid sensing ion channels.

25 structural basis for gating in potassium ion channels.

26 (2+) influx through T-type and L-type Ca(2+) channels.

27 e primary cyclic nucleotide modulator of HCN channels.

28 ing the properties of F1.Q54 neuronal sodium channels.

29 s extendable to other toxin peptides and ion channels.

30 metabolic enzymes communicate via substrate channeling.

31 easured values of whole blood from the micro-channel (4.17cP) and the vacuum method (4.22cP) at 500 s

32 nnel, transient receptor potential canonical channel 6 (Trpc6), in isolated myocytes.

33 ding the SNAREs [3], SM proteins [4, 5], ion channels [6, 7], and receptors (e.g., [8]).

34 results indicate that ZO-1 binding regulates channel accrual, while disengagement from ZO-1 is critic

35 important mechanism in Zn(2+)-induced TRPM2 channel activation and, TRPM2-mediated increase in the [

36 feedback mechanism that amplifies the TRPM2 channel activation.

37 uanosine monophosphate (cGMP) analog on KATP channel activity and insulin secretion point to particip

38 Our data indicate that SOCE and KATP channel activity are regulated by STIM1.

39 r results indicate that D207E increases KATP channel activity by increasing intrinsic stability of th

40 LCS are triggered by both L-type Ca(2+) channel activity during the action potential plateau, as

41 cule, AC1903, that specifically blocks TRPC5 channel activity in glomeruli of proteinuric rats.

42 expression system to shed light on how CFTR channel activity is reduced by SMase.

43 +) entry exerts a feedback control on T-type channel activity, by modulating the channel availability

44 act with the KATP channel complex to inhibit channel activity.

45 d vesicles using a fluorescence assay for gA channel activity.

46 The channel adopts an open conformation.

47 We have shown that treatment with the KATP channel agonist pinacidil increases survival of bees whi

48 speech communities, then languages should be channeled along uniparental lines.

49 ings demonstrate that the loss of the Ca(2+) channel alpha2delta-1 subunit function increases the sus

50 PKA-induced retrograde trafficking of Slack channels also occurs in intact spinal cord slices and th

51 e protonated glutamate encounters the matrix channel and deprotonates.

52 the olfactory cyclic nucleotide-gated (CNG) channel and stimulates a depolarizing chloride current b

53 citation and inhibition are driven by the ON channel and that chromatic opponency results from M-cone

54 cluding the abundant voltage-dependent anion channel and the cation-preferring protein-conducting cha

55 ed by redocking of peptide toxins to two ion channels and a binding protein in which the peptide toxi

56 of infection, such as induction of potassium channels and amino acid transporters, derepression of ge

57 by regulating the localization of potassium channels and AMPA receptors, respectively.

58 ation or on Ca(2+) influx via TRPC6 or Orai1 channels and caused only a minor inhibition of P2X1-depe

59 n and inactivation of the underlying calcium channels and correctly identified the accepted mechanism

60 Selective inhibition of T-channels and global deletion of CaV 3.1 channels complet

61 y Ca(2+) influx through voltage-gated Ca(2+) channels and synaptically activated NMDA receptors.

62 cAMP activates cyclic nucleotide-gated (CNG) channels and thereby induces a Ca(2+) influx, which lead

63 transport mechanisms is puzzling because CLC channels and transporters are expected to share the same

64 Although other CLC channels and transporters form stable dimers, ClC-4 was

65 -1 gp41 fusion protein, the influenza proton channel, and the MCU pore.

66 development of a porous altered layer, flow channeling, and increasingly limited calcite dissolution

67 alpha-SNAP is a crucial component of Orai1 channels, and its depletion disrupts the functional asse

68 of N-Methyl-D-aspartic acid receptor (NMDAR) channels, and this occurred in the absence of agonists.

69 splicing also changes the activity of sodium channels, and while it is highly conserved, it is not kn

70 on with FHV, whereas treatment with the KATP channel antagonist tolbutamide decreases survival and in

71 reover, these findings demonstrate that KCa2 channels are a novel target to facilitate long-lasting e

72 Our results indicate that KATP channels are activated to a greater extent in perfused h

73 Large conductance calcium-activated (BK) channels are broadly expressed in neurons and muscle whe

74 Cyclic-nucleotide-gated channels are essential for vision and olfaction.

75 edge plasmons, a signature that robust edge channels are intrinsic to this material system.

76 CAN channels are involved in cellular responses such as neur

77 receptor potential canonical type 3 (TRPC3) channels are involved in hypothalamic glucose detection

78 Because ice-shelf channels are loci where intense melting occurs to thin a

79 arising from measurement using multiple ion channels are more complicated to interpret.

80 ic modulators of pentameric ligand-gated ion channels are thought to act on elements of the pathways

81 ide that targets the nociceptor-specific ion channel ASIC3.

82 d ion channel: normal mechanotransducer (MT) channels at the tips of the stereocilia, activated by te

83 n T-type channel activity, by modulating the channel availability, a mechanism that critically links

84 model reproducing the effects of splicing on channel behaviour suggests that the voltage sensor in th

85 utations within this motif, which suppressed channel binding and its effects on gating, also altered

86 arge-conductance calcium-activated potassium channels (BK) are composed of pore-forming BKalpha and a

87 Moreover, the SK channel blocker apamin enhanced the input-output functio

88 mechanism of action of nifedipine, a calcium-channel blocker clinically used in patients with cardiov

89 th sepsis, of which, 19,742 received calcium channel blocker treatments prior to the admission.

90 een age at disease onset, response to sodium channel blockers and the functional properties of mutati

91 the association between prior use of calcium channel blockers and the outcome of patients admitted to

92 nylureas tolbutamide and glibenclamide (KATP channel blockers), and diazoxide (KATP channel opener).

93 ntine and ketamine are NMDA receptor (NMDAR) channel-blocking drugs with divergent clinical effects.

94 influenza M2 protein not only forms a proton channel but also mediates membrane scission in a cholest

95 ortant for the interaction of Pre1a with NaV channels but cannot account for its unique subtype selec

96 ties for a greatly extended number of volume channels, but also enables new analysis functions for ma

97 y rows are not only natural oxygen diffusion channels, but also preferred sites for the induced oxyge

98 sistent with inhibition of presynaptic TRPV1 channels by alpha2 adrenergic receptors.

99 ine diphosphoribose insensitive TRPM2 mutant channel (C1008-->A) in ECs suppressed the Ca(2+) entry r

100 Calcium-activated chloride channels (CaCCs) encoded by TMEM16A control neuronal sig

101 The incorporation of short channels can be adopted in the designs of dosage forms,

102 Cas9 was utilized to successfully target the channel catfish, Ictalurus punctatus, muscle suppressor

103 generally accepted that voltage-gated Ca(2+) channels, CaV, regulate Ca(2+) homeostasis in excitable

104 arizine - a well-known anti-migraine calcium channel (CC) blocker - being able to diminish intracellu

105 e disengagement from ZO-1 is critical for GJ channel closure and transitioning GJ channels for endocy

106 Cyclic nucleotide-gated channel (CNGC) family members mediate Ca(2+) influx from

107 of T-channels and global deletion of CaV 3.1 channels completely suppressed development of long-term

108 d a positive correlation between KCNQ1:KCNE3 channel complex expression and disease-free survival.

109 lcium uniporter is a Ca(2+)-activated Ca(2+) channel complex mediating mitochondrial Ca(2+) uptake, a

110 sulfonylureas and ATP interact with the KATP channel complex to inhibit channel activity.

111 Voltage-gated CaV2.1 channels comprise a pore-forming alpha1A subunit with au

112 as F57Bpa interacts predominantly in resting channel conformations.

113 s, which are knock-outs for the gap-junction channels connexin 26 and connexin 30 genes, we show that

114 nce, calcium- and voltage-activated K(+)(BK) channel consists of the pore-forming alpha subunits (BKa

115 changes in Ca(2+) -mediated activation of SK channels, contributes to exacerbated MNC activity in HF

116 Mass channels corresponding to the isotopes of a single eleme

117 the redox state, hence suggesting that the H channel could play a more general role as a dielectric w

118 Furthermore, the channel crosstalk decreases with an increase in OAM mode

119 By using single-channel current recording, we define discrete assembly i

120 presence of tRNA, blocking events of single-channel currents through the pore formed by recombinant

121 also enables new analysis functions for many-channel data from emerging biomedical-imaging techniques

122 estimate the number of molecules in such two channel ddPCR data.

123 port that TRIP8b binding to the CNBD of HCN2 channels decreases the apparent affinity of cAMP for the

124 maintained stimulation, and reduced membrane channel density causes hyperexcitability.

125 e within the predicted transporter substrate channel differentially altered the potency for individua

126 k of large, laterally situated, anastomosing channels, discovered via micro-focus computed tomography

127 highlights the functional specialization of channel domains.

128 Ca(2+) entry through mechanosensitive TRPV4 channels during bladder filling stabilizes detrusor exci

129 ss the electrophysiological properties of CI channels during mapping with the IntellaMap Orion basket

130 glucose, importing it via the chitin-uptake channel EcChiP for processing by the glucosamine catabol

131 pathway that impinges on specific potassium channel effectors.

132 tors distinguish ACh and Cho, we used single-channel electrophysiology to measure resting affinities

133 yers, a large number of parallel information channels emerge, each encoding a highly processed featur

134 Multi-channel EMG and M-mode ultrasound revealed regional diff

135 Channel-encoding models offer the ability to bridge diff

136 rapezoid nucleus (RTN), but the specific ion channels essential to these activities remain to be iden

137 For the same channel thickness, the bilayer channels exhibit up to two orders of magnitude higher re

138 e slow spontaneous inactivation of potassium channels exhibits classic signatures of transmembrane al

139 Heterologously expressed NaV1.2 channels exposed to activated CaMKII had enhanced persis

140 Slack channel expression at the DRG membrane is necessary for

141 Our studies suggest that a reduction in SK channel expression, but not changes in Ca(2+) -mediated

142 chemical agents, and mutations at predicted channel-facing positions modulate this effect.

143 The one channel flow-cell is attached and directly changeable wi

144 While studies on vegetated channel flows have been developed in many research cente

145 uggest that Hrd1 forms a retro-translocation channel for the movement of misfolded polypeptides throu

146 for GJ channel closure and transitioning GJ channels for endocytosis.

147 ne contains a considerably larger variety of channel-forming proteins than assumed thus far.

148 served subdomains generally are critical for channel function and are enriched with dysfunctional var

149 viability and invasion, including potassium channel function and EPH receptor signaling.

150 ng that the isoboles for drug actions on ion channel function are not linear.

151 these data suggest that SMase inhibits CFTR channel function by locking channels into a closed state

152 RG helix, finding important contributions to channel function.

153 ell-free membrane patches and showed altered channel gating and current flow through open channels.

154 ur study aims to uncover novel insights into channel gating through in-depth structure-function analy

155 o indicates that the lipid bilayer modulates channel gating, although it is not clear how.

156 he Orai N terminus is indispensable for Orai channel gating.

157 the pathways that couple agonist binding to channel gating.

158 Among those, we found potassium channel genes KCNA4 and KCNIP4, involved in electrical c

159 Here we examined a role for HCN channels, given their ability to alter synaptic integrat

160 with fully atomistic simulations of the ion channel gramicidin embedded in a POPC membrane.

161 Malfunctioning of these channels has been implicated in human diseases such as l

162 Modulators of transmitter-gated ion channels have a wide range of maximal effects as well as

163 systems of subglacial conduits and ice-shelf channels have been changing over the past few centuries.

164 15 different K2P channels have been identified in mammals and these chann

165 enges of docking large toxin peptides to ion channel homology models, as exemplified by the alpha-GID

166 ed to be neuronal membrane receptors and ion channels, however new evidence points to critical effect

167 tative components of the mechanotransduction channel in hair cells and is essential for the transport

168 (2+) sensor, and Orai1, the Ca(2+)-permeable channel in the TT.

169 Mice lacking GIRK channels in DA neurons exhibited increased locomotor act

170 BKCa channels in diabetic cells exhibited reduced Ca(2+) sens

171 we report that CaCCs coexist with BK and SK channels in inferior olivary (IO) neurons that send clim

172 a molecular rotor with no permanent voids or channels in its crystal structure.

173 transporters (ALMTs) form a family of anion channels in plants, but little is known about most of it

174 f mechanosensitive (MS) Ca(2+)-permeable ion channels in platelets is unclear, despite the importance

175 d increased expression of specific potassium channels in the NAc may promote abstinence from drug-tak

176 Furthermore, positive modulation of BK channels in vivo can enhance short-term habituation.

177 emmal ATP-sensitive potassium channels (KATP channels) in cardiac myocytes adjust contractile functio

178 -length wild-type KcsA, a pH-gated bacterial channel, in membrane bilayers.

179 enhanced persistent current and depolarized channel inactivation resembling the properties of F1.Q54

180 erestingly, the store-operated calcium entry channel inhibitor (SK&F96365) also reduced MSU crystal-i

181 cilia and further investigated ENKUR, a TRP channel-interacting protein identified in the cilia of a

182 se inhibits CFTR channel function by locking channels into a closed state and that endogenous CFTR in

183 temperature-dependent gating of thermal TRP channels involving an intracellular region assembled aro

184 Two-pore domain potassium (K2P) channel ion conductance is regulated by diverse stimuli

185 en Slo2.2, the ion permeation pathway of the channel is closed by a constriction of the inner pore fo

186 only quasi-occupation of the silver transfer channel is possible.

187 does the brain reorganize when one of these channels is absent?

188 A minority of the detector channels is affected by spurious signals inherent to thi

189 Here, we discovered that KCNQ2/3 channels isoform-specifically colocalize with SMIT1 and

190 , it is unclear to what extent different NaV channel isoforms are distributed along the peripheral an

191 discovered that a pair of two-pore potassium channel (K2P) subunits, largely dispensable early in lif

192 Sarcolemmal ATP-sensitive potassium channels (KATP channels) in cardiac myocytes adjust cont

193 eptor GluR6/7 and inward rectifier potassium channel Kir2.1, closely associated with SAP102 in photor

194 ne encodes the inwardly rectifying potassium channel, Kir7.1.

195 All mitochondrial outer membrane channels known to date are beta-barrel membrane proteins

196 soma: the voltage-gated potassium and sodium channels Kv1.4 and Nav1.6 and the glycoprotein CD4.

197 extensively interacts with the transmembrane channel layer.

198 is caused by mutations in the CFTR chloride channel, leading to reduced airway surface liquid secret

199 At the single channel level, UBP684 produced a dramatic reduction in l

200 of axonal and dendritic L-type like calcium channels likely operate synergistically to maximize firi

201 g, activation of voltage-gated L-type Ca(2+) channels (LTCCs) in the plasma membrane can initiate a s

202 tric THz detection mechanism in a transistor channel made of flakes of black-phosphorus or InAs nanow

203 results suggest that the modulation of Kv3.1 channels may provide a novel approach to the treatment o

204 Pannexin-1 (Panx1) channels mediate the efflux of ATP and AMP from cancer c

205 sduction where each tip link attaches to two channels, mobile within the membrane.

206 Importantly, we find that our open-channel model is consistent with the RyR1 and cardiac Ry

207 dine, a large natural cation involved in ion channel modulation, revealing a previously unrecognized

208 The large conductance mechanosensitive channel (MscL), acts as an osmoprotective emergency valv

209 proton transport through several important D-channel mutants.

210 ABSTRACT: Voltage-gated sodium channel NaV 1.7 is required for acute and inflammatory p

211 rates, target conserved voltage-gated sodium channels (NaV) of nerve and muscle, causing paralysis.

212 ene that disrupt the encoded neuronal sodium channel NaV1.2 are important risk factors for autism spe

213 ion and function of the voltage-gated sodium channel Nav1.7 are increased in a preclinical model of c

214 at least two types of mechanically gated ion channel: normal mechanotransducer (MT) channels at the t

215 l protein Rps3/uS3 resides in the mRNA entry channel of the 40S subunit and contacts mRNA via conserv

216 xyl terminus of each protomer in the central channel of the hexamer and hinders the interaction of Mp

217 easurements of 1000 genes in the 500 color channels of LINCS L1000, every two landmark genes are de

218 Both YebT and PqiB create channels of sufficient length to span the periplasmic sp

219 ng potential using an Ag-coated microfluidic channel on a p-type silicon nanowire (SiNW) array measur

220 ided any evidence for dilation of the hP2X7R channel on sustained stimulation with ATP(4).

221 p links, and anomalous mechanosensitive (MS) channels on the top surface of the cells.

222 exhibited reduced Ca(2+) sensitivity, single-channel open probability and tamoxifen sensitivity.

223 When channels open, the tip links relax, reducing the hair-bu

224 (KATP channel blockers), and diazoxide (KATP channel opener).

225 increasing the probability of L-Type Ca(2+) channel opening events.

226 inding has been shown to promote CNG and HCN channel opening, the precise mechanism underlying gating

227 which the membrane deformation changes upon channel opening.

228 150c was proposed to be a component of an MA channel partly based on a heterologous expression approa

229 ls have been identified in mammals and these channels perform important roles in a wide number of phy

230 presents the first direct evidence that Kir channels play a critical role in physiological endotheli

231 considered, a transient structure, so-called channel, plays a fundamental role in the transition.

232 Aquaporin- (AQP) 3, a water and glycerol channel, plays an important role in epidermal function,

233 These motions result in a minimum open-channel pore radius of approximately 3 A formed by Gln-4

234 The K(+) channel pore-forming subunit Kv4.3 is expressed in a sub

235 tage sensor movement and current through the channel pore.

236 rd rectifier K(+) channel subfamily 2 (Kir2) channels primarily maintain the resting membrane potenti

237 However, systemic blockade of HCN channels produces cardiac effects that limit this approa

238 ine and lysine residues within N-terminus of channel protein.

239 nd Sm(3+)'s action was tested on single RyR1 channels reconstituted into planar lipid bilayers.

240 on of parvalbumin neurons, as well as single channel recordings, indicates that heteromeric alpha/bet

241 Channel regulation is also compromised since cAMP-depend

242 er-scale fabrication, single-digit nanometre channels, reliable fluidic sealing and low thermal budge

243 tage-triggered Ca(2+) influx through the Cav channels reliably initiates enzymatic activity within mi

244 Calcium channels required for symbiosis signaling have been iden

245 However, the channels responsible for generating electrical signals d

246 physiology and pharmacology showed that HCN1 channels restrict the rate of exocytosis from a subset o

247 ein biogenesis or its function as a chloride channel, resulting in dysregulation of epithelial fluid

248 During periods without updates from official channels, rumors and distress increased.

249 indicates that KCNE1 is displaced within the channel's cleft early during activation, or that conform

250 flammation in juvenile beta-epithelial Na(+) channel (Scnn1b)-transgenic (Tg) mice.

251 stimuli that directly or indirectly gate the channel selectivity filter (SF).

252 ecules, transmitter-modulator receptors, ion channels, signaling proteins, neuropeptides and vesicula

253 acuole, cooperating with the vacuolar cation channel SlTPC1 and the two vacuolar H(+)-pumps, SlAVP1 a

254 Gln-4933, rather than Ile-4937 in the closed-channel structure.

255 nt with the RyR1 and cardiac RyR (RyR2) open-channel structures reported while this paper was in prep

256 Inward rectifier K(+) channel subfamily 2 (Kir2) channels primarily maintain t

257 from the transient receptor potential cation channel subfamily M member 8 (TRPM8(EGFPf/+)) locus in t

258 n of the transient receptor potential cation channel subfamily V, receptor 1 (TRPV1)-substance P noci

259 Specifically, voltage-gated sodium channel subtype NaV 1.7 is required for sensing acute an

260 xpression of the voltage-dependent potassium channel subunit Kv1.1 substantially contributes to both

261 Real-time PCR measurements of SK channel subunits mRNA in supraoptic nucleus punches reve

262 The protein expression of M-channel subunits, KCNQ2/3 in the LHb was also smaller.

263 nserved in CaV2 or CaV3 voltage-gated Ca(2+) channel subunits.

264 losteric modulation of ligand-gated chloride channels, such as hetero-oligomeric alpha1beta2gamma2 GA

265 Stochastic events in a single ion channel system can be measured using current-time traces

266 -dose TNFalpha (0.3 ng/ml) in a microfluidic channel that produced a linear SS gradient over a 20mm f

267 um uniporter (MCU) is a highly selective ion channel that transports Ca(2+) into the mitochondrial ma

268 n doubles the number of non-trivial physical channels that can be collected with a regular sub-resona

269 presence of (*)OH and Mn(IV)-oxo species by channeling these oxidants toward the synthesis of a func

270 For the same channel thickness, the bilayer channels exhibit up to tw

271 vely with the share of total health spending channelled through social security funds and other gover

272 bankfull hydraulic geometry of gravel bedded channels through its control on bed surface grain size.

273 ormation is processed in segregated parallel channels throughout much of human visual cortex; the M-P

274 ibitor of the ATP-dependent potassium (KATP)-channels, thus suggesting a possible mechanism underlyin

275 ning the olfactory Ca(2+)-activated chloride channel to amplify the response.

276 n turn pathologically recruits l-type Ca(2+) channels to facilitate coincidence detection during t-LT

277 ted voltage sensor limits the return of hERG channels to rest.

278 MPK)-dependent trafficking of KATP and Kv2.1 channels to the plasma membrane.

279 y links cellular properties of T-type Ca(2+) channels to their physiological roles.

280 and the cation-preferring protein-conducting channels Tom40, Sam50, and Mdm10.

281 o hyperactivation of the nonselective cation channel, transient receptor potential canonical channel

282 nvier and in axon initial segments, and form channel-transporter complexes in vitro and in vivo KCNQ2

283 humans, as linear sums of groups of neurons (channels) tuned for visual stimulus properties.

284 an optimized protocol for simultaneous dual-channel two-photon fluorescence anisotropy microscopy ac

285 ylbenzimidazolin-2-one (EBIO), activate both channel types with similar potencies.

286 monkeys (female Macaca nemestrina), using 96-channel "Utah" arrays to record from populations of neur

287 exon 47) of the Cav2.1 voltage-gated calcium channel (VGCC) gene produces two major isoforms in the b

288 g and sequencing of the voltage gated sodium channel (VGSC) gene did not detect the common L1014F mut

289 The DII and DIV S3-S4 loops of NaV channel voltage sensors are important for the interactio

290 A 3.7 Fr catheter with a fiber-optic channel was constructed based on a 40 MHz clinical IVUS

291 with the hypothesis of an apoptotic ceramide channel, we have used here assays of calcein release fro

292 SK channels were activated by intracellular Ca(2+) sparks a

293 SK channels were also activated by Ca(2+) influx through vo

294 bit the structures capped on one side of the channel, whereas the compounds based on [3-(2,3-dihydro-

295 5) and a lower-sensitivity ex situ detection channel which may be useful in a wider variety of condit

296 (2+)-dependent inactivation of L-type Ca(2+) channels, whose alteration contributes to the dramatic d

297 on, consisting of a high-sensitivity in situ channel with signal-to-noise of 10(5) and a lower-sensit

298 A-GFP chimera was utilized to jam the SecYEG channels with an arrested substrate protein to "freeze"

299 t viroporins are monovalent selective cation channels, with few showing the ability to conduct divale

300 y affecting betaIV spectrin, followed by NaV channels, with modest impact on neurofascin 186.