ライフサイエンスコーパス: channel activity

1 ther important regulatory events to modulate channel activity.

2 base proton transfer and strongly inhibited channel activity.

3 s could have completely different effects on channel activity.

4 stimulation, suggesting a reduction in RyR1 channel activity.

5 es is, in part, due to METH regulation of BK channel activity.

6 e-cell electrophysiology was used to monitor channel activity.

7 g stomatal opening, CO2 assimilation and ion channel activity.

8 CSD- and the NMDA-triggered increase in Kir channel activity.

9 rge-conductance Ca(2+)-activated K(+) (BKCa) channel activity.

10 rgely on the opposite side of S6, suppressed channel activity.

11 oreceptor synaptic output by altering Ca(2+) channel activity.

12 alters the effects of intracellular MTSET on channel activity.

13 o stabilizes TRPC3 proteins to enhance TRPC3 channel activity.

14 unctional channels, or resulted in a reduced channel activity.

15 ionylation and a concomitant loss in calcium channel activity.

16 counted for by their ability to modulate ion channel activity.

17 participates in the observed stimulation of channel activity.

18 escued by pharmacological augmentation of SK channel activity.

19 lasmic reticulum to regulate hERG levels and channel activity.

20 to restore protein expression and polymodal channel activity.

21 gnature of calcium-activated potassium (Kca) channel activity.

22 pool of plasma membrane STIM1 regulates ARC channel activity.

23 fold, and a potentiator that increases CFTR channel activity.

24 s of TRPV1 and are required for heat-induced channel activity.

25 oncentrations, resulting in an inhibition of channel activity.

26 gating, thereby establishing authentic CRAC channel activity.

27 in the C-terminus of human TALK-1, increases channel activity.

28 bitory and basolateral increases stimulating channel activity.

29 e secretory pathway are independent of E ion channel activity.

30 el CFTR on the plasma membrane, which showed channel activity.

31 es a novel mechanism for modulation of TRPM8 channel activity.

32 Q2/3 channel activity and a reduction in HCN channel activity.

33 stitutive CB1R-mediated inhibition of Ca(2+) channel activity.

34 that the R1420H substitution decreases KATP channel activity.

35 eraction is critical for maintaining maximal channel activity.

36 cts with the STIM1-Orai1 complex to increase channel activity.

37 uce barttin palmitoylation and CLC-K/barttin channel activity.

38 owth in a manner dependent on L-type calcium channel activity.

39 d CPVT mutation (RyR2-A4860G) that depresses channel activity.

40 R domain (e.g. by PKA) is also required for channel activity.

41 sal method for quantitatively monitoring ion-channel activity.

42 ow the pore is a crucial determinant of KAT2 channel activity.

43 diated intracellular Ca2+ waves, SK and TRPC channel activity.

44 regulates channel trafficking and stabilizes channel activity.

45 accessory proteins, or CaMKII that modulate channel activity.

46 tail length and tertiary structure on sodium channel activity.

47 l class of small molecules that inhibit CRAC channel activity.

48 le mechanism by which glibenclamide inhibits channel activity.

49 egulator (CFTR) that compromise its chloride channel activity.

50 y protein kinase A (PKA) is required for its channel activity.

51 otential drug target to interfere with TRPC6 channel activity.

52 signaling, gene expression, and membrane ion channel activity.

53 t the nucleotide-binding domain and inhibits channel activity.

54 iable DHB tension, which could be related to channel activity.

55 a synthetic peptide of the NSP4 VPD has ion channel activity.

56 act with the KATP channel complex to inhibit channel activity.

57 uses Liddle syndrome by increasing intrinsic channel activity.

58 rat hippocampal neurons resulted in enhanced channel activity.

59 te for the ERK-dependent modulation of TRPV3 channel activity.

60 d vesicles using a fluorescence assay for gA channel activity.

61 eillance and cytokine release require THIK-1 channel activity.

62 effect when co-produced with wild-type ITPR1 channel activity.

63 g link between metabolic regulation and TRPV channel activity.

64 he C-terminus resulted in constitutive anion channel activity.

65 vanilloids in their binding site, prolonging channel activity.

66 and the long-range allosteric regulation of channel activities.

67 ogical roles of heat-induced variation in Kv channel activities.

68 armacological exposure, we show that AmTRPV4 channel activity affects gene expression patterns associ

69 ibers subjected to voltage-clamp and on RyR1 channel activity after incorporating sarcoplasmic reticu

70 cted with VPD unexpected alterations in K(+) channel activities and changes in stomatal conductance o

71 made it possible to investigate directly ion channel activities and characteristics in isolated endol

72 in mice that show a re-emergence of KCNQ2/3 channel activity and a reduction in HCN channel activity

73 Functional analysis showed reduced channel activity and alterations in voltage sensitivity

74 sterically coupled to each other, control BK channel activity and are potential targets for regulatio

75 Noradrenaline also evoked TRPC1 channel activity and associations between TRPC1, STIM1,

76 phosphate kinase B (NDPK-B), activates TRPV5 channel activity and Ca(2+) flux, and this activation re

77 he concentration of calcium required for PC2 channel activity and cellular function.

78 revealed links between modifications of ion channel activity and changes in neuronal excitability, s

79 age-clamp fluorometry was used to record ion channel activity and conformational changes simultaneous

80 vating mutations, and Rac1 induces TRPC5 ion channel activity and cytoskeletal remodeling in podocyte

81 strated that SlPIP2s protein displayed water channel activity and facilitated water transport into th

82 nctionally important for mechanotransduction channel activity and for proper localization of synaptic

83 on of AVs with lysosomes through its calcium channel activity and hence functions in maintaining neur

84 uanosine monophosphate (cGMP) analog on KATP channel activity and insulin secretion point to particip

85 To define the nuances of TRPM3 channel activity and its modulators, we succeeded in inc

86 ng TRPM7 kinase activity does not impair its channel activity and kinase activity is not essential fo

87 metic mutants of ALMT4 S382 showed increased channel activity and Mal(2-) efflux.

88 ivation process enables fine tuning of PANX1 channel activity and may be a generalized regulatory mec

89 ption produces a long-lasting enhancement of channel activity and persistent alterations of neuronal

90 synaptic terminals, thereby altering Ca(2+) channel activity and photoreceptor output.

91 s of TRPM8 that contribute differentially to channel activity and proper folding and assembly.

92 ned whether urinary MUC1 also enhances TRPV5 channel activity and protects against nephrolithiasis.

93 eased sAHP results from elevated L-type Ca2+ channel activity and ryanodine receptor (RyR)-mediated C

94 lso causes ligand-independent changes in ion channel activity and second-messenger signaling.

95 d state of RyR2, resulting in enhanced basal channel activity and sensitivity to activation and incre

96 ed activity of dozens of genes linked to ion channel activity and synaptic function.

97 co-incubation greatly increased F508del-CFTR channel activity and temporal stability in most, but not

98 NHERF proteins are direct regulators of ion channel activity and that DAG sensitivity is a distincti

99 oV E to infer the residues important for ion channel activity and the oligomerization of IBV E.

100 helix that faces the U motif, enhanced basal channel activity and the sensitivity to Ca(2+) or caffei

101 recording and Ca(2+) imaging to examine the channel activity, and (4) gene manipulations and other m

102 (R204A) reduces apparent PIP2 sensitivity of channel activity, and here we show that Ala or Cys subst

103 phenotypes, ion transporter expression, ROMK channel activity, and localization under normal and high

104 n PKA, CaMKII, and phosphatase modulation of channel activity, and on molecular tolerance to alcohol.

105 r its formation of multimeric complexes, ion channel activity, and, ultimately, release of infectious

106 The mechanism by which p75 regulates SK channel activity appears to involve its ability to activ

107 ns within the same gene suggests that unique channel activities are influenced by each class of mutat

108 stress-induced activation of L-type calcium channel activity are obscure.

109 Our data indicate that SOCE and KATP channel activity are regulated by STIM1.

110 -sensitive potassium channel and P/Q calcium channel activity are required for glucokinase-mediated g

111 stent with this hypothesis, NPPB blocked ion channel activity associated with ABCB19 expressed in hum

112 in-induced translocation system enhances the channel activity at physiological membrane potentials, s

113 ltage relationship, suggesting loss of KCNQ2 channel activity at subthreshold membrane potentials is

114 ce (IC50 of 14 muM), with no effect on water channel activity (at up to 200 muM).

115 itant loss of both Shaker and slowpoke (slo) channel activity because of the low extracellular calciu

116 addition, we observed notable differences in channel activity between C6 glioma cells and tsA201 cell

117 entify Kidins220 as a novel modulator of Nav channel activity, broadening our understanding of the mo

118 a misfolded CFTR protein, which has residual channel activity but is prematurely degraded.

119 ic changes were independent of l-type Ca(2+) channel activity but were contingent on the crucial AIS

120 ght into the mechanisms which control TWIK-1 channel activity, but also have important implications f

121 ne residues by palmitoylation, which enhance channel activity by altering interactions of the channel

122 e not SLO2 pore blockers, but rather inhibit channel activity by an allosteric modification of channe

123 Regulation of channel activity by Ca(2+) , nucleotides, phosphorylatio

124 at low levels of RyR2 oxidation increase the channel activity by decreasing the threshold for SOICR,

125 ) signalling cascade, which heightens K(ATP) channel activity by destabilizing the long closed states

126 PIP2 inhibits the channel activity by directly binding to a short N-termin

127 r results indicate that D207E increases KATP channel activity by increasing intrinsic stability of th

128 oxia has a direct effect in suppressing BKCa channel activity by increasing oxidative stress.

129 Specifically, increasing channel activity by introducing the mutation K1250A or p

130 The modulation of ion channel activity by lipids is increasingly recognized as

131 strate an electrical assay of individual ion channel activity by measuring the dynamic opening and cl

132 confirming functional downregulation of KCa2 channel activity by mGlu5 receptors.

133 ts indicate that such mutations can increase channel activity by multiple molecular mechanisms.

134 that H2 S may act in a novel manner to alter channel activity by potentiating the zinc sensitivity/af

135 Inhibition of channel activity by the pharmacological inhibitor GsMTx-

136 +) entry exerts a feedback control on T-type channel activity, by modulating the channel availability

137 utations which cause small changes in sodium channel activity can have devastating consequences for t

138 irect pharmacological modulation of VSMC Kv7 channel activity can influence blood vessel contractilit

139 the ability of Klotho to down-regulate TRPC6 channel activity confirm the importance of these residue

140 TRPM7 channel activity contributes to the maintenance of store

141 induces Ca(2+) imbalance by depressing RyR2 channel activity during excitation-contraction coupling,

142 LCS are triggered by both L-type Ca(2+) channel activity during the action potential plateau, as

143 Interestingly, single-channel activity elicited by GABA is similar to that eli

144 In addition, the L273D mutation depressed channel activity equally regardless of which Orai1 subun

145 Enhanced T-type channel activity, especially Cav3.2, contributes to dise

146 dings therefore suggest that the duration of channel activity evoked by vanilloids is regulated by th

147 sient receptor potential canonical 3 (TRPC3) channel activity exhibited resistance to Rho-mediated ma

148 hat is mediated by neurotransmitters and ion channel activity.Functions of the embryonic brain prior

149 Whereas anion channel activity has been extensively investigated, phos

150 ling with K(+) nutrition and guard cell K(+) channel activities have not been fully explored in Arabi

151 To date, suitable PET markers of NMDA ion channel activity have not been available.

152 However, their effects on TRPV1 channel activity have not been conclusively determined.

153 eolysis experiments indicated that M2 proton channel activity helped to protect (H1N1)pdm09 HA from p

154 r Ca(2+) signaling pathways through multiple channel activities: hemichannels, endoplasmic reticulum

155 L-type Ca(2+) channel activity however, was not important for pacemake

156 , let-7b induces TLR7/TRPA1-dependent single-channel activities in DRG neurons and HEK293 cells overe

157 unctions in mesenteric arteries (MA) and ion channel activities in smooth muscle cells.

158 proteins as critical components of the SOCE channel activity in a wide variety of cell types.

159 ration of 6 mmol/L and decreased KATP single-channel activity in beta-cells of control mice but not o

160 the N-terminal isoforms can fine-tune BK(Ca) channel activity in cells, highlighting a novel mechanis

161 induces, on average, a reduction in KCNQ2/3 channel activity in fusiform cells in noise-exposed mice

162 cule, AC1903, that specifically blocks TRPC5 channel activity in glomeruli of proteinuric rats.

163 potentiated pinacidil-preactivated sarcKATP channel activity in intact cardiomyocytes, but the H2O2-

164 ar [K(+)] resulting in the activation of Kir channel activity in microglia.

165 gomyelinase C (SMase) inhibits CFTR chloride channel activity in multiple cell systems, an effect tha

166 ors, which may explain why ATD regulates ion channel activity in NMDA receptors but not in non-NMDA r

167 hich the bi-lobe motion in ATD regulates the channel activity in NMDA receptors.

168 hether noradrenaline can down-regulate TRPV1 channel activity in nociceptors and reduce their synapti

169 n H441 monolayers and of alphabetagamma-ENaC channel activity in oocytes.

170 kout (dKO) mice to genetically upregulate BK channel activity in the absence of FMRP and determine it

171 were generated to genetically upregulate BK channel activity in the absence of FMRP.

172 8-Br-cAMP also stimulated spontaneous PC2hst channel activity in the absence of the exogenous kinase.

173 ced ATP sensitivity and a marked increase of channel activity in the intact cell irrespective of the

174 PKA increased by 566% the spontaneous PC2hst channel activity in the presence of ATP.

175 Our results suggest a role for GluA3 channel activity in the regulation of sleep behavior in

176 solated glomeruli showed enhanced basal TRPC channel activity in the STZ-SS rats, and increased respo

177 s in hypoxia-mediated inhibition of the BKCa channel activity in uterine arteries and new insights in

178 hannel beta1 subunit and inhibiting the BKCa channel activity in uterine arteries of pregnant sheep.

179 ect effect of hypoxia in inhibiting the BKCa channel activity in uterine arteries via increased oxida

180 d to Golgi complex membranes, and has cation channel activity in vitro.

181 ), define how hyper-SUMOylation impacts K(+) channel activity in vivo and could serve as a potential

182 ment of PLCdelta4 in the regulation of TRPM8 channel activity in vivo.

183 Here, we show that inhibition of Orai1 channel activity increases average cell velocities by re

184 tablished to identify modulators of NBD1/CL1 channel activity independent of F508del CFTR and pharmac

185 ertheless, CfPutA exhibited normal substrate-channeling activity, indicating that it isomerizes into

186 nstrated in multiple cancer cell types where channel activity induces invasive activity.

187 Attenuation of hERG ion channel activity inherent within the initial chemotype w

188 ptor phenotype required Cav1.3 L-type Ca(2+) channel activity, internal Ca(2+), and the interaction o

189 and identified novel mutations that affected channel activity, intracellular trafficking, or localiza

190 ity and intracellular trafficking as well as channel activity, ion conduction, and gating.

191 ontaining a GluN2A subunit is that their ion channel activity is allosterically inhibited by a nano-m

192 Accordingly, channel activity is almost entirely abolished by elimina

193 KCNQ2/3 channel activity is augmented in vivo by phosphatidylino

194 However, when K(V)7/M channel activity is compromised, SK channel activation s

195 utrition and a robust guard cell K(+) inward channel activity is considered critical for plants' adap

196 TRPC6 channel activity is controlled by protein expression and

197 L-type calcium channel activity is critical to afterload-induced hypert

198 LMT4 can mediate Mal(2-) efflux and that the channel activity is dependent on a phosphorylatable C-te

199 simulations, we show that PKC modulation of channel activity is dependent on Ser-196 in Kir3.2 such

200 Channel activity is determined using a channel-permeable

201 TRPC6 channel activity is enhanced via translocation to the ce

202 We also found that P2X7 channel activity is facilitated by phosphatidylglycerol

203 1 channels and subsequent recruitment of Slo channel activity is important, in concert with Shaker, t

204 Both hTASK3 and mTASK3 channel activity is increased by incubation with recombi

205 Anion channel activity is known to depend on phosphorylation b

206 or experience-dependent reduction of KCNQ2/3 channel activity is linked with disorders that are chara

207 RyR1 channel activity is modulated by the beta1a subunit and

208 ient for channel activation, whereas TRPC4/5 channel activity is potentiated by phosphatidylinositol

209 expression system to shed light on how CFTR channel activity is reduced by SMase.

210 athway coupling blue light perception to ion channel activity is relatively well understood [3], we k

211 However, the physiologic regulation of Kv7 channel activity is still poorly understood.

212 In this study, we demonstrate that KirBac3.1 channel activity is strongly pH-dependent, and we used x

213 The channel activity is susceptible to blockage by known dru

214 abolic syndrome and diabetes mellitus change channel activity leading to changes in insulin secretion

215 creased KCa3.1 histidine phosphorylation and channel activity, leading to increased calcium flux and

216 the positive modulators in potentiating SK2 channel activity may be attributed primarily to specific

217 This finding suggests that M2 proton channel activity may play a wider role in preserving HA

218 BABR function requires a loss of GABABR-Kir3 channel activity mediated by 14-3-3eta.

219 y the putative cGMP and Ca(2+) pathways, ion-channel activity modulation, gene expression regulation,

220 studies thus suggest that upregulation of BK channel activity normalizes multi-level deficits caused

221 locked both the water (IC50 117 muM) and ion channel activities of AQP1 but did not alter AQP4 activi

222 d bilayer experiments were used to study the channel activities of the viral protein.

223 Here we report light-induced chloride channel activity of a purified ACR protein reconstituted

224 These results identify ion channel activity of ABCB19 that is blocked by NPPB, a co

225 our data demonstrate that inhibition of the channel activity of ANO1 is not sufficient to inhibit AN

226 -regulation of both the expression and water channel activity of AQP4 is likely to originate from a d

227 is thought to be critical for the regulated channel activity of CFTR.

228 the effect of hypoxia on the expression and channel activity of connexin 43 (Cx43) in melanoma cells

229 ntraburst gating, we investigated the single-channel activity of human CFTR at different intracellula

230 cultured cortical neurons in which both the channel activity of NMDARs and the glycine receptors are

231 ls regulate the subcellular localization and channel activity of the polycystin complex through its i

232 cantly amplified, which, in turn, affect the channel activity of the portal protein, GP10, embedded i

233 As mutations that alter ion channel activity of the TMEM16 proteins localize around

234 Most importantly, the ion channel activity of this G-C dinucleoside can be inhibit

235 6 and report induced expression and enhanced channel activity of TRPC6 in association with glomerular

236 y inhibit the ion channel, but not the water channel, activity of AQP1.

237 BKCa-channel activity often affects the firing properties of

238 rified human TRPA1 showed substantial single-channel activity only in the presence of protoporphyrin

239 We found that BKCa channel activity opposes pressure-induced constriction i

240 binding (P = 3.55 x 10(-)(1)(5)), and cation channel activity (P = 2.77 x 10(-)(1)(4)) were significa

241 f RIM1/2 at rod ribbons is to enhance Cav1.4 channel activity, possibly through direct or indirect mo

242 Thus, alterations in M-channel activity rapidly trigger unique AIS plasticity t

243 ployed computational modeling of single IP3R channel activity records obtained under optimal Ca(2+) a

244 that phosphorylation-dependent reductions in channel activity require an intact Bateman domain dimer

245 Restoring authentic CRAC channel activity required both the presence of STIM1 and

246 We propose a model in which prolonged channel activity results in calcium accumulation, trigge

247 subunit interactions and their link with the channel activity, sensitivity to icilin, menthol and col

248 tant variant of ALMT9 that exhibits enhanced channel activity showed higher Cl(-) and Na(+) accumulat

249 odel exhibit proexcitatory alterations in Na channel activity, some of which were not seen in hippoca

250 terol (ent-cholesterol) does not inhibit Kir channel activity, suggesting that inhibition results fro

251 rm, AtMCU1, gives rise to a Ca(2+)-permeable channel activity that can be observed even in the absenc

252 yclic-nucleotide (CN)-linked neuronal Ca(2+) channel activity that could provide the trigger for the

253 hannel rundown, which is the gradual loss of channel activity that follows prolonged CaCC activation

254 and CaMKII could generate a facilitation of channel activity that outlasts a depolarizing stimulus.

255 fic localized calcium signal mediated by RyR channel activity that stimulates regenerative outgrowth,

256 aling a strong functional coupling to CaV1.3 channel activity that was accentuated by densin and CaMK

257 e studies of AKAP79/150 in regulation of ion channel activity, the major questions to be posed centre

258 AMP-dependent protein kinase (PKA) increases channel activity, thereby allowing more Ca(2+) entry int

259 potassium channels helps fine-tune long-term channel activity through conformational changes at the s

260 -coupled receptor stimulation inhibits TRPM3 channel activity through direct binding of the Gbetagamm

261 horylate human TRPC6 at serine 14 to control channel activity through increased membrane expression.

262 of their inability to functionally link ion channel activity to cellular pathways.

263 ted invasion on the basis of reports linking channel activity to gene expression changes in excitable

264 scues the channel phenotype and restores ion channel activity to levels seen in normal neurons.

265 , and slow deactivation kinetics, which tune channel activity to provide vital repolarizing current d

266 r that of VX-770 alone, normalizing CFTR1281 channel activity to that of wild type CFTR.

267 dence of G551D-CFTR without restoring single-channel activity to wild-type levels.

268 f yeast mitochondria and identified four new channel activities: two anion-preferring channels and tw

269 bilayers preincubated with gA, which reduced channel activity up to 10-fold.

270 Genetic upregulation of BK channel activity via deletion of BKbeta4 normalized acti

271 Genetic upregulation of BK channel activity via deletion of BKbeta4 was sufficient

272 rding the lateral positions of the probe and channel activity via ionic current.

273 asmic domain, unique to BASIC, that controls channel activity via membrane interaction.

274 TNF-alpha effects, suggesting modulation of channel activity via p38 MAPK.

275 This enhanced channel activity was accompanied by phospho-p38 mitogen-

276 Kv7 channel activity was also augmented by stimulation of G-

277 Channel activity was assayed as ionic currents under pat

278 xpressed equally as wild type (WT) RyR2, but channel activity was dramatically inhibited, as inferred

279 TRPV4 channel activity was elevated when cells were plated on

280 Channel activity was enhanced by co-expression with the

281 Store-operated TRPC1 channel activity was inhibited by TRPC1 and STIM1 antibo

282 In these experiments, sustained channel activity was observed long after fusion had been

283 PD was selective for cations over anions and channel activity was observed to have both well-defined

284 Channel activity was reduced in response to restraining

285 Gates that control K(+) channel activity were found both at an intracellular por

286 the amplitude and properties of ensemble HCN channel activity were uniform in patches excised from di

287 if on the lower, D2 lobe of the LBD prolongs channel activity when auxiliary subunits are present.

288 e demonstrate that FaPIP1;1 has a high water channel activity when coexpressed as well as how PIP1-PI

289 planar bilayers, which produced much higher channel activity when the gA-containing vesicles were ad

290 y data shows that the N-helix is crucial for channel activity, whereas NTE sensitizes this isoform to

291 v7.4 activation and crucial for vascular Kv7 channel activity, which has major consequences for the r

292 Inhibition of Kv7.4 channel activity, which plays a permissive role in myoge

293 doplasmic reticulum membrane regulating CRAC channel activity, whilst the minor pool of plasma membra

294 covered that SMA MNs exhibit enhanced sodium channel activities with increased current amplitude and

295 nfantile epilepsy result in increased sodium channel activity with gain-of-function, characterized by

296 to simultaneously monitor exocytosis and ion channel activity with high temporal sensitivity without

297 ation of MCU Cys-97 exhibited persistent MCU channel activity with higher [Ca(2+)]m uptake rate, elev

298 yeast mitochondria display Ca(2+)-dependent channel activity with properties resembling those of the

299 iRNA-mediated gene knockdowns, we correlated channel activity with Rap1-dependent persistent MAPK act

300 rent channels that conveys crosstalk between channel activities within single microdomains in tuning