ライフサイエンスコーパス: channel gating

1 he Orai N terminus is indispensable for Orai channel gating.

2 the pathways that couple agonist binding to channel gating.

3 specific genetic perturbations to potassium channel gating.

4 acy, ATP more strongly stimulated ovine CFTR channel gating.

5 the NH2-terminal region is not essential for channel gating.

6 us provides a model of how cAMP controls HCN channel gating.

7 e principles underlying active transport and channel gating.

8 nformational and structural dynamics of CRAC channel gating.

9 that plays a role in subunit association and channel gating.

10 with enhanced conductance and ATP-dependent channel gating.

11 and the potential role of pore hydration in channel gating.

12 is required predominantly for its effects on channel gating.

13 ential connection between ion conduction and channel gating.

14 igates the effect of phosphatidic acid on Kv channel gating.

15 M3 helices that, in turn, are coupled to ion channel gating.

16 ater insight into the role of the CTD in Kir channel gating.

17 nker) to identify structural determinants of channel gating.

18 their conformational rearrangements dictate channel gating.

19 C) motifs, in the cholesterol sensitivity of channel gating.

20 ric and allosteric mechanisms regulating its channel gating.

21 the membrane but rather to an alteration in channel gating.

22 affected by the inherent variability of ion channel gating.

23 cluster near pore constrictions and regulate channel gating.

24 toskeletal proteins in mechanosensitive (MS) channel gating.

25 implicating the STIM1-dependent movement in channel gating.

26 mutations have been associated with altered channel gating.

27 P1 involves loop D, a region associated with channel gating.

28 DPA with the inherent voltage dependence of channel gating.

29 utative pre-M1 cuff helix that may influence channel gating.

30 rrounding bilayer, were actively involved in channel gating.

31 these barriers can be regulated to simulate channel gating.

32 tage- nor use-dependent, and does not affect channel gating.

33 cAMP, the flavonoid fisetin potentiates HCN2 channel gating.

34 nit and is essential for rapid and efficient channel gating.

35 significant structural rearrangement during channel gating.

36 ed to generate high PIP2 sensitivity of Kir2 channel gating.

37 lpy (DeltaH(o)) and entropy (DeltaS(o)) upon channel gating.

38 l domains whose global properties can modify channel gating.

39 are essential for coupling ligand binding to channel gating.

40 hair bundle motion due to mechanotransducer channel gating.

41 ins and the characteristic burst kinetics of channel gating.

42 tion where agonist binding is uncoupled from channel gating.

43 racellular N-terminal domain, which inhibits channel gating.

44 sterically modulates both ion conduction and channel gating.

45 e effect of ivermectin on Ca(2+) current and channel gating.

46 ractions of abnormal protein trafficking and channel gating.

47 s new insights into allosteric modulation of channel gating.

48 cluding pore block and allosteric effects on channel gating.

49 independent structural rearrangements during channel gating.

50 determinant for hyperpolarization-activated channel gating.

51 phy are incorporated into a revised model of channel gating.

52 The leucine zipper is essential for HCN channel gating.

53 h each subunit incrementally contributing to channel gating.

54 lator (CFTR) leads to defects in folding and channel gating.

55 the ICDI domain on voltage-dependent Cav1.4 channel gating.

56 g the initial coupling of agonist binding to channel gating.

57 in is organized as a tether that can trigger channel gating.

58 on effects play only minor roles in GLIC ion channel gating.

59 wo ATP sites reveals their distinct roles in channel gating.

60 PC2 EF-hand is a Ca(2+) sensor required for channel gating.

61 t modify their intracellular trafficking and channel gating.

62 included in quantitative descriptions of ion channel gating.

63 ting to the plasma membrane and its chloride channel gating.

64 late Galphaq/PLCbeta1/PKC activity to induce channel gating.

65 y to induce PKC phosphorylation of TRPC1 and channel gating.

66 ch is responsible for proton selectivity and channel gating.

67 nding to the VAMP721 SNARE domain suppressed channel gating.

68 shown to antagonize NsVBa without affecting channel gating.

69 ular loop D domain, a region involved in AQP channel gating.

70 trigger that is necessary and sufficient for channel gating.

71 driving force for calcium entry and calcium channel gating.

72 el activity by an allosteric modification of channel gating.

73 ity is responsible for driving PKC-dependent channel gating.

74 a Markov chain 36-state model (MC36SM) of GJ channel gating.

75 hanisms of blocker-induced modulation of ion channel gating.

76 s in the M3 transmembrane domain involved in channel gating.

77 hat is crucial for protein translocation and channel gating.

78 1 complexes that lead to PKC stimulation and channel gating.

79 and were associated with alterations in K(+) channel gating.

80 ferent cyclic nucleotides on the CNBD and on channel gating.

81 tage-dependent structural changes related to channel gating.

82 plied to real-time structural studies of ion channel gating.

83 main (LBD), which is incapable of triggering channel gating.

84 differential effects of blocker molecules on channel gating.

85 bind to TRPV1 with high affinity to modulate channel gating.

86 how small molecules inhibit or activate ion channel gating.

87 and that the Ala1632Gly mutation may affect channel gating.

88 ains via interactions with CL1 and result in channel gating.

89 troke of the action potential (AP) due to GJ channel gating.

90 otentiator ("Po", normalizing DeltaF508-CFTR channel gating) activities.

91 s by NUDT9, but nevertheless supported TRPM2 channel gating, albeit with reduced apparent affinity.

92 R and GLIC, does not undergo agonist-induced channel gating, although it does not exhibit the expecte

93 o indicates that the lipid bilayer modulates channel gating, although it is not clear how.

94 We address this issue using detailed single-channel gating analysis, mathematical modeling, and ener

95 ees C to study the physiological kinetics of channel gating and action potentials.

96 Voltage-dependent hERG channel gating and activity were evaluated as expressed

97 sly thought to be the target of PKC promotes channel gating and acts as an allosteric modulator of PK

98 Our findings suggest a model for CaV1.2 channel gating and Ca(2+)-influx amplification that unif

99 The F448L mutation alters channel gating and causes early-onset SCA13.

100 tiple discrete open states, each with unique channel gating and conductance properties that reflect c

101 Inactivation is a complex aspect of Nav channel gating and consists of fast and slow components,

102 ell-free membrane patches and showed altered channel gating and current flow through open channels.

103 movement of the helix bundle crossing during channel gating and demonstrate how this method might be

104 tly to the Nav1.6 channel C-tail, regulating channel gating and expression, properties that are requi

105 Moreover, flecainide did not alter RyR2 channel gating and had negligible effect on the mechanis

106 ant molecular determinants involved in Na(V) channel gating and inactivation.

107 G4934 and -G4941 in the pore-lining helix in channel gating and ion permeation was probed by replacin

108 we investigated the molecular mechanisms of channel gating and ion permeation.

109 ata explain the close coupling between ORAI1 channel gating and ion selectivity, and open a new avenu

110 o explains the dynamic coupling between CRAC channel gating and ion selectivity.

111 on, the presence of mutant Cx26 shifted Cx43 channel gating and kinetics toward a more Cx26-like beha

112 nal states revealing the structural basis of channel gating and ligand-dependent activation.

113 ations in the intrinsic ligand affected hERG channel gating and LQTS mutations abolished hERG current

114 However, the molecular mechanism of TRAAK channel gating and mechanosensitivity is unknown.

115 ion with STIM1 and couple STIM1 binding with channel gating and modulation of ion selectivity.

116 e structures provide new insights into Na(V) channel gating and novel avenues to drug development and

117 a(V) channels acts synergistically to modify channel gating and paralyze prey.

118 dynamics simulations that shed light on Orai channel gating and permeation.

119 as led to the elucidation of many details of channel gating and pore properties.

120 Our study provides insights into features of channel gating and proton permeation pathway.

121 rnal pore in the allosteric control of TRPV1 channel gating and provide essential constraints for und

122 ever, little is known about the mechanism of channel gating and regulation of ANO1 activity.

123 , we examined the effects of A760G on CaV1.3 channel gating and regulation.

124 )(+) channels in ways that oppose defects in channel gating and synaptic transmission resulting from

125 tic process of the type used to describe ion channel gating and synaptic transmission.

126 linker is a critical constituent of TRPC4/C5 channel gating and that disturbance of its sequence allo

127 and nonelectrophiles are important in hTRPA1 channel gating and that targeting chemical interaction s

128 he structural mechanism of ATP-dependent ion channel gating and the architecture of the open ion chan

129 raged by the amplifier effect of cooperative channel gating and the high Ca(2+) sensitivity of IK and

130 coproduction of two inactive SecYs, one for channel gating and the other for SecA binding, recreates

131 for investigating beta-cell physiology, KATP channel gating, and a new chemical scaffold for developi

132 acilitate stomatal movements, the effects on channel gating, and by inference on K(+) accumulation, c

133 For example, phosphorylation regulates Nav channel gating, and has been proposed to contribute to a

134 stinct transitions, independently coupled to channel gating, and that (2) TRPV1 and Ca(2+)-bound CaM

135 igher in smokers, blocked CFTR by inhibiting channel gating, and was attenuated by antioxidant N-acet

136 ue example of targeted modulation of the Kir channel gating apparatus.

137 nisms whereby chemical ligands impact on TRP channel gating are poorly understood.

138 However, the mechanisms that control channel gating are unclear.

139 hese TMs and their relative movements during channel gating are unknown.

140 ectively disrupts adenylate kinase-dependent channel gating at physiologic nucleotide concentrations.

141 ovide a general model for ligand-induced Kir channel gating at the molecular level.

142 ) density, whereas the voltage dependence of channel gating became WT-like.

143 of the structural rearrangements underlying channel gating behavior; by contrast, gating currents di

144 ated the effects of Rg3 on voltage-dependent channel gating but did not prevent the increase in curre

145 PAS and CNBh domains participate in channel gating, but at least twice in evolutionary histo

146 Glycine 4864 is not absolutely required for channel gating, but some flexibility at this point in th

147 eta-, and -subunits also suppresses apparent channel gating, but the suppression is much greater in t

148 s in the TRP domain raised the energetics of channel gating by altering the coupling of stimuli sensi

149 changes were not secondary to variations in channel gating by Ca(2+) or voltage, nor were they due t

150 g EF-hand domain, the molecular basis of PC2 channel gating by Ca(2+) remains unknown.

151 olenoid scaffold, suggesting a mechanism for channel gating by Ca(2+).

152 was to identify regions of Ano1 involved in channel gating by Ca2+.

153 cular mechanism for allosteric regulation of channel gating by intracellular signals.

154 Ca(2+)-CaM perform the same function on IKS channel gating by producing a left shift in the voltage

155 Gly-4934 and Gly-4941, that facilitate RyR1 channel gating by providing S6 flexibility and minimizin

156 A749G and p.G407R caused dramatic changes in channel gating by shifting (~15 mV) the voltage dependen

157 (CRAC) channels, the molecular mechanism of channel gating by the CRAC channel activator, stromal in

158 the 986-990 region had a profound impact on channel gating by voltage and menthol, as evidenced by t

159 tochastic simulation algorithm that includes channel gating, Ca(2+) buffering, and Ca(2+) diffusion.

160 Channel gating causes changes in the relative position o

161 resent in Cr-TRP1, suggesting that basic TRP channel gating characteristics evolved early in the hist

162 ow, in an insect ear, that directionality of channel gating considerably sharpens the neuronal freque

163 TRPV1 C terminus with the bilayer modulates channel gating, consistent with phylogenetic data implic

164 he protein, only one of which contributes to channel-gating control.

165 2-M3 loop (A305V) that form the GABA binding/channel gating coupling junction and the channel pore (T

166 s itself in defective channel processing and channel gating defects.

167 at the interface produced marked effects on channel gating, demonstrating the important physiologica

168 e whether the contribution of alphaArg209 to channel gating depends on additional anionic or electron

169 veal that the contribution of alphaArg209 to channel gating depends on additional nearby electron-ric

170 lective pLGICs, and the modulatory effect on channel gating depends on the M2 18' residue.

171 owed that the contribution of alphaArg209 to channel gating depends strongly on alphaGlu45, also with

172 ded detailed insights into the mechanisms of channel gating, desensitization, and ion permeation.

173 Thus, channel gating does not involve rigid body movements of

174 ently with SYP121, thereby coordinating K(+) channel gating during SNARE assembly and vesicle fusion.

175 the hydrophobic solvent-accessible surface, channel gating dynamics, water permeability (p(f)), and

176 re-lining transmembrane helix that underlies channel gating either directly or through the interface

177 Channel gating, especially of the dominant K(+) channels

178 he mechanisms involved in regulation of K(+) channel gating, expression and membrane localization.

179 ge in the coupling of temperature sensing to channel gating generates this sensitivity to warm temper

180 ophysical basis of temperature-sensitive ion channel gating has been a tough nut to crack.

181 Although TRPM8 channel gating has been characterized at the single chan

182 ) regulation, and its composite effect(s) on channel gating, has been shrouded in much controversy ow

183 ular nicotinic acetylcholine receptor (AChR) channel gating have been measured by using single-channe

184 ested coupling of this enzymatic activity to channel gating implied a potentially irreversible gating

185 2E/K701R/S704T) was not sufficient to rescue channel gating, implying that other residues in the TRP

186 Next, we simulate stochastic ion-channel gating in a calcium channel with multiple subuni

187 lying Gloeobacter violaceus ligand-gated ion channel gating in a membrane environment and report the

188 the Cys loop, a region that is critical for channel gating in all pentameric ligand-gated ion channe

189 release channels resulting in enhanced IP3R channel gating in an amyloid beta (Abeta) production-ind

190 el mutation had reduced impact on ovine CFTR channel gating in contrast to its marked effects on huma

191 re (DHF); however, the role of altered Na(+) channel gating in CRT remains unexplored.

192 To probe the role of channel gating in mammalian proteasomes, we deleted the

193 latform for transmission and coordination of channel gating in response to external K(+) .

194 investigate the role of the wrist domain in channel gating in response to extracellular factors.

195 ssociated with LQT3 promote a mode of sodium channel gating in which some channels fail to inactivate

196 creasing single-channel conductance, slowing channel gating, increasing calcium permeability, and rel

197 revertants had marked effects on G551D-CFTR channel gating, increasing strongly opening frequency, w

198 membrane, allows PKC to further suppress the channel gating independent from voltage and calcium.

199 n the control of both surface expression and channel gating, indicating that this I-II loop plays an

200 annels and was unaffected by modification of channel gating induced by anemone toxin (rATX-II).

201 To investigate the stoichiometry of altered channel gating induced by RPR, we constructed and charac

202 gs suggest that the allosteric modulation of channel gating involves distinct mechanisms of coupling

203 omain is critical for CFTR function, because channel gating involves NBD1/NBD2 dimerization, and NBD2

204 hat the specific heat capacity change during channel gating is a major determinant of thermosensitive

205 led by a single histidine (His(37)), whereas channel gating is accomplished by a single tryptophan (T

206 ELIC and the proton-activated GLIC, suggests channel gating is associated with rearrangements in thes

207 Because G551D-CFTR channel gating is ATP independent, we investigated wheth

208 n mechanism would reveal how STIM1-dependent channel gating is enhanced, and benefit the future immun

209 Ion channel gating is essential for cellular homeostasis and

210 ata describe a novel mechanism by which hERG channel gating is modulated through physiologically and

211 nts, so that voltage-dependent activation of channel gating is no longer conflated with Ca(2+) entry,

212 viously reported voltage-dependence of Panx1 channel gating is not directly mediated by the membrane

213 ular mechanism by which PIP(2) regulates Kir channel gating is poorly understood.

214 CFTR channel gating is strictly coupled to phosphorylation an

215 Hence in GtCCR2, cation channel gating is tightly coupled to intramolecular prot

216 lar mechanism that links effector binding to channel gating is unknown due to lack of structural data

217 significance of the S6 cytoplasmic region in channel gating is unknown.

218 The molecular mechanism of channel gating is yet elusive.

219 In voltage-gated K(+) channels, gating is the result of the coordinated action

220 e ability to appropriately open or close the channel (gating) is critical to bacterial survival.

221 f the hydrophobicity of specific residues in channel gating, it has remained unclear whether electros

222 ith soluble chimeras retained ADPR-dependent channel gating (K1/2~1-5 muM), confirming functionality

223 speculate that modulation of tight junction channel gating kinetics may be an unappreciated mechanis

224 The detailed single-channel gating kinetics of mouse pannexin 1 (mPanx1) rem

225 T9-H catalytic activity all failed to affect channel gating kinetics.

226 tageous to improve the optical resolution of channel gating kinetics.

227 oduced an approximate 2-fold speeding of the channel-gating kinetics.

228 the localization pattern in conjunction with channel gating may be indicative of AqpB functions in os

229 This study proposes a unique channel gating mechanism and delivers detailed molecular

230 We found that within the seven-state single-channel gating mechanism, inhibition of TRPM8 by short s

231 For a multitude of channels, gating models suggested by paths within the co

232 fore concluded to represent the first sodium channel gating modifier from an araneomorph spider and f

233 determine the mechanism of action for sodium channel gating modifiers with high precision.

234 bilayer embody independent modules linked to channel gating modulation.

235 putations show that even without significant channel-gating motions, a subtle change in the number of

236 alter binding and secretion in parallel with channel gating, net K(+) concentration, osmotic content

237 By regulating channel gating, Neto1 and Neto2 can increase the diversi

238 that a number of mutations that affect TREK1 channel gating occlude the action of fenamates but only

239 cid analogue N-arachidonoyl taurine restores channel gating of many different mutant channels, even t

240 ent results from a distinctive form of Na(+) channel gating, originally identified in cerebellar Purk

241 ion of deflections that elicited significant channel gating, plummeted upon application of a channel

242 Understanding plant K(+) channel gating poses several challenges, despite many si

243 enuates cell surface expression and apparent channel gating, predicting a reduced magnitude and an ac

244 hich electrical driving force is balanced by channel gating, prevents changes in calcium influx from

245 involved in the dynamic regulation of Cav3.2 channel gating properties.

246 xpression of KATP channels without affecting channel gating properties.

247 ced by Ppk1 activation is the result of Ppk1 channel gating properties.

248 rve to further diversify Nematostella Shaker channel gating properties.

249 ant for AMPA receptor surface expression and channel gating properties; and (2) trans-synaptic organi

250 ects of FKBP12 and FKBP12.6 on RyR1 and RyR2 channel gating provide scope for diversity of regulation

251 ptide, LS3, has a unique action, suppressing channel gating rather than blocking the pore of heterolo

252 s opposing, consequences on agonist binding, channel gating, receptor biogenesis, and forward traffic

253 We determined that although GJ channel gating reduces junctional current, it does not s

254 r functioning, the molecular mechanism of MS channel gating remains elusive and controversial.

255 mponents that transduce bilayer tension into channel gating remains incomplete.

256 The mechanism of channel gating remains undefined.

257 how PKC and PI(4,5)P2 act together to induce channel gating remains unresolved.

258 An adequate model of channel gating requires accurate, high-resolution models

259 of response consistent with the rapidity of channel gating response to changes in the external ionic

260 Kinetic analysis of channel gating revealed that AITC acts by destabilizing

261 ch we faithfully reproduced by an allosteric channel gating scheme where the channel is able to open

262 were faithfully reproduced by an allosteric channel gating scheme.

263 How KCNE1 and KCNE3 subunits modify KCNQ1 channel gating so differently is largely unknown.

264 Glu-68 site (the E68R mutation) inverted the channel gating so that it was open in the dark and close

265 mplementary electrophysiological analysis of channel gating, suggests chemical interactions that are

266 tward movements and thus contributed more to channel gating than the GluN1 subunits.

267 rst dynamic molecular view of PIP(2)-induced channel gating that is consistent with existing experime

268 ed a stochastic 36-state model (S36SM) of GJ channel gating that is sensitive to transjunctional volt

269 cribe conformational changes associated with channel gating, the fluorescent non-canonical amino acid

270 a predominance of the GluN2A subunit in ion channel gating, the GluN2A subunit interacts more extens

271 tion where agonist binding is uncoupled from channel gating, the underlying mechanism remains to be d

272 al for STIM1, as it fine-tunes the open Orai channel gating, thereby establishing authentic CRAC chan

273 ur study aims to uncover novel insights into channel gating through in-depth structure-function analy

274 y or post-M4 region increase the efficacy of channel gating through interactions with the Cys loop.

275 t, and highlight the power of describing ion channel gating through the lens of allosteric coupling.

276 nges in electrical driving force and calcium channel gating to cancel each other out.

277 calcium driving force and changes in calcium channel gating to effectively cancel each other out.

278 channel open probability, (2) a shift of MS channel gating to larger pressures, (3) appearance of mo

279 ng of the intracellular Ca(2+) signal to the channel gating to regulate membrane excitability and spi

280 uations and a 36-state model of gap junction channel gating to simulate electrical signal transfer th

281 of the conformational change associated with channel gating to tip-link tension.

282 nd/or CFTR potentiators, drugs that increase channel gating, to reach approximately 25% of the chlori

283 tage sensor and inner pore gates of a sodium channel, gating transitions in the selectivity filter re

284 on and inactivation of ion channels, and how channel gating varies with changes in the channels' lipi

285 s (CD-Is) of eukaryotic Kir channels control channel gating via stability of a novel inactivated clos

286 proton transfer reactions play a key role in channel gating, we determined vibrational as well as kin

287 the structural basis of CD-I control of Kir channel gating, we examined the effect of the R165A muta

288 Using an allosteric model of channel gating, we found that the underlying mechanism o

289 embrane are altered by pH and thereby affect channel gating, we measured patch capacitance during mec

290 ngements of TMHs within them responsible for channel gating, we perform cross-linking by bifunctional

291 t became clear that processes other than ion channel gating were also critical in generating electric

292 Both intrinsic ATPase activity and CFTR channel gating were inhibited severely by CL1 peptide, s

293 We demonstrate that the channel gating, which acts on chordotonal stretch recept

294 ing flexibility in terms of the mechanism of channel gating, which allows KCNQ1 to play different phy

295 amino acid at Kir6.2 position 68 for normal channel gating, which is potentially necessary to locali

296 residue A110 to E118) dissociates during the channel gating, while the rest of the C-terminus stays a

297 e conformational changes associated with ion channel gating, will stimulate development of new pharma

298 uced cell surface expression and (2) altered channel gating with a positive shift in the voltage depe

299 subunits, and that probing the mechanisms of channel gating with concatenated heterotypic channels sh

300 the CF mutant G551D, which impairs severely channel gating without altering protein processing and w