ライフサイエンスコーパス: channel protein

1 ine and lysine residues within N-terminus of channel protein.

2 lding and biosynthetic maturation of the ion channel protein.

3 ic complex formed by PKD1L3 and TRPP3, a TRP channel protein.

4 llular distribution of STREX-containing BKCa channel protein.

5 t with the idea of recognizing a new site on channel protein.

6 ding of phosphoinositides to the full-length channel protein.

7 t of trafficking or surface targeting of the channel protein.

8 eptide of the influenza A M2 (AM2-TM) proton channel protein.

9 d conformational defect directly in the hERG channel protein.

10 g the tyrosine phosphorylation of the mutant channel protein.

11 sociated glycoprotein (RhAG), a putative gas channel protein.

12 ite for the Akt protein kinase on the Kv11.1 channel protein.

13 he decreased tyrosine phosphorylation of the channel protein.

14 is an intrinsically disordered region of the channel protein.

15 ty in tsA201 cells by phosphorylation of the channel protein.

16 et of mutants with alterations in their MscK channel protein.

17 lated with a 62.8% (P<0.01) reduction in Na+ channel protein.

18 2 ionic current occurs by endocytosis of the channel protein.

19 li that interact with different parts of the channel protein.

20 r SNAREs in positional anchoring of the K(+) channel protein.

21 a premature stop codon disrupting the Kv1.5 channel protein.

22 ial for normal physiological function of the channel protein.

23 tivity by reducing the surface expression of channel protein.

24 activity of positive IgG with the alpha1D Ca channel protein.

25 n-insensitive mechanism at, or close to, the channel protein.

26 ial duration by directly binding to the HERG channel protein.

27 e autophagy depends on the Matrix 2 (M2) ion-channel protein.

28 on involves widespread rearrangements of the channel protein.

29 interacts with the extracellular part of the channel protein.

30 ether-a-go-go related gene (hERG) potassium channel protein.

31 he regulatory sites are not intrinsic to the channel protein.

32 ic theories concerning direct effects on ion channel proteins.

33 nd lipid phosphates to activate or bind to M-channel proteins.

34 that PTPepsilon in the brain modulates these channel proteins.

35 ly inhibited IKr and cross reacted with hERG-channel proteins.

36 potential canonical (TRPC) subfamily of ion channel proteins.

37 ere isolated for analysis of PSD95 and K(V)1 channel proteins.

38 for distinct beta-subunit regulation of ion channel proteins.

39 onal analysis of amino acid substitutions in channel proteins.

40 r recording the activity of incorporated ion channel proteins.

41 in Lotus japonicus that encode putative ion channel proteins.

42 ersity are the complex targeting patterns of channel proteins.

43 that is structurally more closely related to channel proteins.

44 anonical transient receptor potential (TRPC) channel proteins.

45 ugh enhanced expression of specific types of channel proteins.

46 on of multiple water and ion transporter and channel proteins.

47 ediate family of calcium-activated potassium channel proteins.

48 ease in PKC-dependent phosphorylation of the channel proteins.

49 paradigm for the control of activity of FNT channel proteins.

50 Viroporins are small virus-encoded ion channel proteins.

51 e ion-channel electrical measurements of ion-channel proteins.

52 h any of the known prokaryotic or eukaryotic channel proteins.

53 ing and electric current measurements of ion channel proteins.

54 ficant changes in expression of Gi/o or GIRK channel proteins.

55 er membrane do so through substrate-specific channels proteins.

56 %), fascin (40%), and chloride intracellular channel protein 1 (51%).

57 ulation of voltage-dependent anion-selective channel protein 2 (Vdac2) and downregulation of parvalbu

58 We discover that the chloride intracellular channel protein 3 (CLIC3) is an abundant component of th

59 nd down-regulated the chloride intracellular channel protein 3 (CLIC3), which induces the recycling o

60 on channel voltage-dependent anion-selective channel protein 3 (VDAC3), and complement inhibitor CD55

61 ion of PKC with phorbol ester increased HERG channel protein abundance and K(+) current density in a

62 s in SCN5A mRNA abundance but reduced sodium channel protein abundance and peak sodium current amplit

63 Many K+ channel proteins, after initial channel opening, show a

64 iggers a conformational change in the M2 ion channel protein, altering membrane curvature and leading

65 cherichia coli, each subunit of the trimeric channel protein AmtB carries a hydrophobic pore for tran

66 um channel function, discovery of the sodium channel protein, analysis of its structure and function,

67 ve trafficking of OSM-9, a polymodal sensory channel protein and a functional homolog of TRPV1 or TRP

68 Na+ channel protein and current amplitudes were reduced in n

69 expressed reduced levels of Ca(v)1.2(I1624E) channel protein and I(Ca).

70 ce variations may help explain a loss of Na+ channel protein and may contribute to the increased arrh

71 AKAP in the functional regulation of an ion channel protein and postphosphorylation allosteric modul

72 ated in the transmembrane portion of the ion channel protein and the degree of ion channel dysfunctio

73 conductance by attaching ferritin to an ion channel protein and then tugging the ferritin or heating

74 Silencing aborted production of the channel protein and was directly responsible for reduced

75 ry myocytes have similar properties to TRPC3 channel proteins and indicate that these proteins may ha

76 control in exocytosis and endocytosis of ion channel proteins and their organization within the plane

77 oscale events, such as Ca(2)(+) binding to a channel protein, and macroscale phenomena, such as excit

78 or transferring a cDNA encoding an enzyme or channel protein, and targeting expression to one cell ty

79 s included 5 RAB family members, 3 potassium channel proteins, and 2 peroxisome family members.

80 ntified antibodies against myelin, potassium-channel proteins, and T-cell profiles that support an ad

81 autoantibody reactivity against the chloride-channel protein anoctamin 2 (ANO2) in MS cases compared

82 sses the importance of the three brain water-channel proteins (AQP1, AQP4, AQP9) in brain physiology.

83 5'-flanking regions of genes coding for the channel proteins Aqp2, Aqp3, Scnn1b (ENaCbeta), and Scnn

84 IgG1 antibodies against the astrocyte water channel protein aquaporin 4 (AQP4) and the evidence that

85 ymer vesicles containing the bacterial water-channel protein Aquaporin Z (AqpZ) were investigated.

86 omain-ligand interaction involving the water channel protein aquaporin-2.

87 c autoantibodies against the astrocyte water channel protein aquaporin-4 (AQP4).

88 with autoantibodies against the glial water channel protein aquaporin-4.

89 termed NMO-IgG, against the astrocytic water channel protein aquaporin-4.

90 ions were identified in AQP5, encoding water-channel protein aquaporin-5 (AQP5).

91 Induction of an astrocytic water channel protein, Aquaporin 4 (AQP4), is known to predomi

92 the mRNA and protein expression of the water channel protein, aquaporin 4 in these mice.

93 y collecting duct system including the water channel protein, Aquaporin-3 and the tight junction prot

94 It is proposed that TRPC6 and TRPC1 channel proteins are important components of Ang II-indu

95 Mechanosensitive channel proteins are important safety valves against osm

96 Large conductance, Ca(2+)-activated K channel proteins are involved in a wide range of physiol

97 Membrane channel proteins are of great interest as pulse EPR repo

98 Ion channel proteins are required for both the establishment

99 An important group of OM channel proteins are the porins, which mediate the non-s

100 uctance, Ca(2+)- and voltage-gated K(+) (BK) channel proteins are ubiquitously expressed in cell memb

101 soon taking their place alongside other ion channel proteins as therapeutically important drug targe

102 ithelial sodium channel and acid-sensing ion channel proteins, as well as sodium/hydrogen antiporters

103 ein expression and in localization of sodium channel proteins at nodes of Ranvier.

104 ulum (ER) Ca(2+) sensor, and Orai1, the CRAC channel protein, at overlapping sites in the ER and plas

105 Compared with focusing in an open channel, protein bands in the monolith-filled EFGF chann

106 se forces must inevitably originate from the channel protein, because in bulk water, which, by defini

107 tivation gate are spatially separated in the channel protein, but the mechanism by which Ca(2+) bindi

108 receptor potential channel (TRPC)1 and TRPC3 channel proteins by short hairpin RNA reduces the sensit

109 lar parasites, viruses also have evolved ion channel proteins, called viroporins, which disrupt norma

110 The ion flux through individual channel proteins can be observed directly with a patch c

111 ozoa lacking the sperm-specific putative ion channel protein, CatSper1.

112 d for immunohistochemical detection of the L-channel protein, Cav1.2-alpha1c.

113 e, we report that the chloride intracellular channel proteins CLIC1 and CLIC4 participate in the regu

114 lear translocation of chloride intracellular channel protein CLIC4 is essential for its role in Ca(2+

115 r levels and focuses on the discovery of ion channel proteins coexpressed in the mechanoreceptors of

116 against known transporter and outer membrane channel proteins; comparison of transporter and outer me

117 h a dramatic reduction in the level of I(SA) channel protein complex found in CG cells.

118 1) Is acute tolerance observed in a single channel protein complex within a lipid environment reduc

119 that normally separates juxtaparanodal K(+) channel protein complexes located beneath the myelin she

120 clustering, and/or maintenance of axonal Kv1 channel protein complexes, we immunoprecipitated Kv1.2 a

121 and molecular movements of voltage-gated K+ channel protein complexes.

122 We also determined ion channel protein composition within the endothelium of in

123 ptors (iGluRs), tetrameric, ligand-gated ion channel proteins comprised of three subfamilies, AMPA, k

124 n families, including the human gap junction channel protein connexin 26, the ATP binding cassette tr

125 Loss of the GJA1-encoded gap junction channel protein connexin43 is known to underlie formatio

126 uses a modified conformation in the purified channel protein consistent with a more open state in sol

127 nd involve new molecular determinants on the channel protein, consistent with the idea of recognizing

128 ved across the members of the family of K(+) channel proteins, consistent with their presently disclo

129 tibodies that selectively recognize Ca(V)1.2 channel proteins containing sequences encoded by either

130 iatek et al. (p. 1174) report that the TRPC1 channel protein contains a C-terminal CSD-consensus bind

131 The influenza virus M2 ion channel protein contains in its cytoplasmic tail a membr

132 lation, or "phosphorylopathy," of the CaV1.2 channel protein contributes to the excitotoxicity associ

133 The present data show Ca(v)1.2 channel protein decreases concurrently with reduced spon

134 MEC-10 belong to a large superfamily of ion channel proteins (DEG/ENaCs) that form nonvoltage-gated,

135 bodies against a putative retrotranslocation channel protein, derlin-1, but not Sec61alpha.

136 ted by HpUreI, a proton-gated inner membrane channel protein essential for gastric survival of H. pyl

137 Aquaporin-4 (AQP4) is a water channel protein expressed in astrocytes throughout the C

138 Pannexins are newly discovered channel proteins expressed in many different tissues and

139 ented by AtNIP5;1 and AtNIP6;1, which encode channel proteins expressed in roots and leaf nodes, resp

140 escent protein to the N or C terminus of the channel protein, expressed in transfected HEK 293 cells

141 from sham and CHF rabbits; (3) changes in Kv channel protein expression (Kv3.4 versus Kv4.3) in the C

142 osphate receptor and voltage-dependent anion channel protein expression and elevated the number of ER

143 on abbreviation, secondary to functional ion channel protein expression changes (CaV1.2, NaV1.5, and

144 er, there was a significant increase in HCN2 channel protein expression with no change in HCN4 expres

145 stsynaptic density and voltage-gated calcium channel protein expression.

146 pilepticus (SE), accompanied by loss of HCN1 channel protein expression.

147 lecular architecture distinct from other ion channel protein families, and have several unique functi

148 ously uncharacterized member of the two-pore channel protein family, as a new voltage-gated Na(+) cha

149 C5 is a member of the chloride intracellular channel protein family, its association with actin-based

150 upregulation of aquaporin-4 (AQP4), a water channel protein, following brain injury.

151 Mammalian TRP channel proteins form six-transmembrane (6-TM) cation-pe

152 sient receptor potential-vanilloid-5 (TRPV5) channel protein forms a six- transmembrane Ca(2+)-permea

153 receptors (GluRs) are ligand-gated membrane channel proteins found in the central neural system that

154 test this hypothesis, we expressed P/Q-type channel protein fragments from two different human CT sp

155 MspA, an octameric transmembrane channel protein from Mycobacterium smegmatis, is one of

156 Many SUR1 mutations prevent trafficking of channel proteins from the endoplasmic reticulum to the c

157 Although SLO3 channel proteins from these two species lack conservatio

158 iators and expression of chemosensory cation channels, protein gene product 9.5 (PGP 9.5), and the ma

159 Structural changes in channel proteins give critical insights required for und

160 Aquaporin 3 (AQP3), a water/glycerol channel protein, has been found to transport hydrogen pe

161 Large conductance, Ca(2+)-sensitive K(+) channel proteins have been shown to localize to caveolae

162 Channel proteins have evolved such that they can be dire

163 Recent crystal structures of channel proteins have revealed novel architectures showi

164 alothane to an anesthetic-binding, model ion channel protein hbAP-Phe(CN).

165 larization-activated cyclic nucleotide-gated channel proteins (HCN proteins) that form Ih channels, i

166 n in retina, that Thy1 complexes with an ion channel protein in any tissue, and that a GPI-anchored p

167 nt proteomics study has identified the TRPV2 channel protein in EE, suggesting that transient recepto

168 increased the Kv1.1 voltage-gated potassium channel protein in hippocampal neurons and promoted Kv1.

169 the influenza virus M2 proton-selective ion channel protein in mediating virus budding.

170 of TRPV6, we purified and reconstituted the channel protein in planar lipid bilayers.

171 These findings show a decrease in Kv3.1b channel protein in SZ neocortex, a deficit that is resto

172 ced expression of small-conductance Kca (SK) channel protein in the BLA of socially isolated (SI) rat

173 aquaporin-4 (AQP4), the most abundant water channel protein in the CNS, which is highly concentrated

174 cluded volume of ions and side chains of the channel protein in the highly concentrated and charged (

175 s that selectively modulate the stability of channel protein in the membrane as an approach for treat

176 gested that BACE1 physically associates with channel proteins in a beta-subunit-like fashion.

177 (MscL) belongs to a family of transmembrane channel proteins in bacteria and functions as a safety v

178 Purified ion channel proteins in detergent micelles are combined with

179 abeling has demonstrated the presence of NaF channel proteins in GP dendrites, but the quantitative e

180 ant change was found in the expression of BK channel proteins in IC neurons of SN-GEPR-3s.

181 pleiotropic effects on the expression of ion channel proteins in myocytes and profibrotic molecules i

182 ne domains and does not have homology to ion channel proteins in other organisms.

183 e aquaporin family co-orthologous to known B channel proteins in other species.

184 amily did not reveal a role for any of these channel proteins in store-operated Ca2+ entry in HEK293

185 ght junction, polarity, ion gradient and H2O channel proteins in the outer cell membranes.

186 Notably, all the key transporter and channel proteins in this process appear to be activated,

187 oles of aquaporins (AQPs), a family of water channel proteins, in the hepatobiliary system.

188 erminus of NIL-16 interacts with several ion channel proteins, including the Kv4.2 subunit of A-type

189 tula venom alter the activity of diverse ion channel proteins, including voltage, stretch, and ligand

190 ulation, lipids that directly associate with channel proteins influence gating by incompletely unders

191 nding, human ether-a-go-go-related potassium channel protein inhibition, and CYP3A4 (CYP = cytochrome

192 s in ion channels; however, genes within the channel protein interactome might also represent pathoge

193 y been carried out by incorporating purified channel protein into artificial lipid membranes.

194 ns and is critical for the insertion of this channel protein into the outer membrane.

195 intronic to KCNN3, which encodes a potassium channel protein involved in atrial repolarization.

196 The ryanodine receptor type 2 channel protein is modulated by various post-translation

197 The mutant channel protein is stable in vivo.

198 How each channel protein is transported within the cytoplasm is p

199 The Kv3.4 channel protein is widely distributed throughout the cen

200 en anterograde and retrograde trafficking of channel proteins is vital in regulating steady-state cel

201 ib, which belongs to the aquaporin family of channel proteins, is required for endosome maturation in

202 To design antibiotics that target substrate-channel proteins, it is essential to first identify the

203 ds and a nanodisc-encapsulated potassium ion channel protein, KcsA-Kv1.3.

204 code for functional potassium ion-selective channel proteins (Kcv) that are considered responsible f

205 anced glycation end products, L-type calcium channels, protein kinase C, Rho-kinase, actin polymeriza

206 hat encodes the strong inward rectifier K(+) channel protein (Kir2.1), in an 11-y-old boy.

207 modulation of expression of their respective channel proteins (Kir2.1 and Na(V)1.5) within a macromol

208 ata correlate with a similar reduction in BK channel protein levels and transcripts in the cortex and

209 termate controls, and alpha1C L-type calcium channel protein levels were significantly lower in PC-1

210 defects, including mutations and decrease of channel protein levels, have been linked to the developm

211 bility of re-entry and affected specific ion channel protein levels, whereas excitability was unalter

212 olerance can be an intrinsic property of the channel protein-lipid complex, and bilayer thickness pla

213 an important role in regulating receptor and channel protein localization within synapses and tight j

214 As such, a correlation between channel protein location and channel function remains in

215 peractivation mutant of a mammalian DEG/ENaC channel protein, MDEG G430F, in murine kidney epithelial

216 e pore helices of the small mechanosensitive channel protein, MscS, to monitor conformational transit

217 nano solar cell containing the mycobacterial channel protein MspA has been successfully designed.

218 ich encodes the transient receptor potential channel protein mucolipin-1.

219 art to activation of expression of the Na(+) channel protein Nav1.5.

220 ore extensively with MAL than does the water channel protein not phosphorylated at this serine.

221 SecY is the central channel protein of the SecYEbeta translocon, the structu

222 The channel proteins of gap junctions are encoded by two dis

223 1-3 and MCOLN1-3) are presumed to encode ion channel proteins of intracellular endosomes and lysosome

224 e P2X receptors are not related to other ion channel proteins of known structure, there is at present

225 However, the full-length channel proteins of Kv3.1b display stronger association

226 These light-gated channel proteins of microbial origin are of interest for

227 e subcellular localization and the number of channel proteins on the cell surface membrane, which is

228 e subcellular localization and the number of channel proteins on the cell surface membrane.

229 e subcellular localization and the number of channel proteins on the cell surface membrane.

230 an represent a different conformation of the channel protein or a different number of bound ligands.

231 ults directly from oxygen deprivation on the channel protein or is mediated by intermediary proteins

232 ion, the ER Ca(2+) sensor STIM1 and the CRAC channel protein Orai1 redistribute to ER-plasma membrane

233 plasma membrane where it binds to the Ca(2+) channel protein Orai1 to activate Ca(2+) influx.

234 d the Ca(2+) release-activated Ca(2+) (CRAC) channel protein Orai1.

235 the STIM1 gating mechanism in the human CRAC channel protein, ORAI1, and identify V102, a residue loc

236 r, Stim1, and calcium release-activated Ca2+ channel protein, Orai1, and provide further support for

237 odel in which the gene for the calcium entry channel protein, Orai1, has been deleted.

238 genous PC2 (PC2hst), and in vitro translated channel protein (PC2iv).

239 or proteolytic site, and the 6-transmembrane channel proteins (PKD2, PKD2L1 and PKD2L2; TRPPs).

240 The calcium-permeable cation channel protein polycystin 2 (PC2) is overexpressed in k

241 ational changes and (de)stabilisation of the channel protein, possibly as a platform for transmission

242 ation layer of various membranes and through channel proteins, problems that are at the core of cellu

243 Together these channel proteins promote K(Na) channel activity and damp

244 osphorylation of Kv1.3, as well as increased channel protein-protein interactions with IR and postsyn

245 ensatory mechanisms acting on a reservoir of channels proteins regulated at the level of gene express

246 nsparency, however, the identity of specific channel proteins regulating calcium influx within the le

247 S800 and enhanced surface trafficking of the channel protein, resulting in increased I(DR)/Kv2.1 curr

248 osis (Mtb) mutant lacking the outer membrane channel protein Rv1698 accumulated 100-fold more Cu and

249 The SAM core complex contains the channel protein Sam50, which cooperates with Sam35 in pr

250 Water-filled hydrophobic cavities in channel proteins serve as gateways for transfer of ions

251 tion by direct interaction between lipid and channel protein sites has received increasing attention.

252 epresents the first member of a new class of channel proteins specific for mycolic acid-containing ou

253 Each of the CRAC channel proteins' specific functional features and the p

254 revealed the presence of the canonical CRAC channel proteins STIM1 and Orai1.

255 Remarkably, the proton channel protein strongly resembles the voltage-sensing d

256 n the pancreatic ATP-sensitive K(+) (K(ATP)) channel proteins sulfonylurea receptor 1 (SUR1) and Kir6

257 hannel expression caused by mutations in the channel proteins: sulfonylurea receptor 1 (SUR1) and Kir

258 tor potential melastatin-like 7 (TRPM7) is a channel protein that also contains a regulatory serine-t

259 tracellular late endosomal and lysosomal ion channel protein that belongs to the mucolipin subfamily

260 f the SCN5A gene, encoding the Nav1.5 sodium channel protein that cosegregated with the arrhythmia ph

261 se experiments demonstrated that Rv1698 is a channel protein that is likely involved in transport pro

262 ation induces a conformational change in the channel protein that prevents access of cysteine-modifyi

263 Aquaporins (AQPs) are water channel proteins that are essential in biological organi

264 interactions of conductances carried by ion channel proteins that are homeostatically regulated to m

265 modify expression of genes encoding the ion channel proteins that contribute to the electrophysiolog

266 ily expansions for the major families of ion-channel proteins that drive nervous system function.

267 the structure as well as a repertoire of ion channel proteins that govern this complex conduction pat

268 all cilia contain specific receptors and ion channel proteins that initiate signaling pathways contro

269 Aquaporins are water channel proteins that mediate the fine-tuning of cell me

270 negative bacteria contains a large number of channel proteins that mediate the uptake of ions and nut

271 ependent Ca(2+) (CaV1.2) channels, other ion channel proteins that modulate myogenic tone.

272 ns represent a family of transmembrane water channel proteins that play a major role in trans-cellula

273 Primary cilia contain specific receptors and channel proteins that sense the extracellular milieu.

274 tly linked to bioelectric signaling, via ion channel proteins that shape the gradients, downstream ge

275 l energy by interacting with the rest of the channel protein through a combination of non-covalent in

276 reatly impact the distribution of the BK(Ca) channel protein to dendritic spines and intrinsic firing

277 embrane voltage, or lateral tension) cause a channel protein to gate.

278 , but it also inhibits the biogenesis of the channel protein Tom40.

279 Mammalian two-pore channel proteins (TPC1, TPC2; TPCN1, TPCN2) encode ion c

280 PC6 gene on chromosome 11q, encoding the ion-channel protein transient receptor potential cation chan

281 ly, the transient receptor potential calcium channel protein TRPC1 redistributed to raft fractions in

282 anonical transient receptor potential (TRPC) channel protein TRPC5, in addition to STIM1 and Orai1, a

283 e a unique role for the Ca(2+)-permeable ion channel protein TRPC6 as a regulator of glomerular ultra

284 Given the challenges of both normal channel protein turnover and short-term plasticity, how

285 ane protein (JAMP) that links ER chaperones, channel proteins, ubiquitin ligases, and 26S proteasome

286 Previously, we have shown that K(ATP) channel proteins undergo endoplasmic reticulum (ER)-asso

287 ism is to dynamically regulate production of channel protein via feedback that constrains relationshi

288 T421M, an S1 domain mutation in the Kv11.1 channel protein, was identified in a resuscitated patien

289 nels were significantly decreased, while SK2 channel proteins were increased in IC neurons of seizure

290 otassium-channel gene activity (KCNMB1), the channel protein, were powerfully attenuated in the Srf(C

291 ikely due to enhanced forward trafficking of channel proteins, whereas the extracellular action is du

292 2(P1018L), produces a missense change in the channel protein whereby proline 1018 (Pro(1018)) is repl

293 in the "viroporin" family of virus-coded ion channel proteins, which includes the influenza A virus (

294 In particular, EV-associated annexin calcium channelling proteins, which form a nucleational core wit

295 Crosslinking of the channel protein with an extracellular Ab limits Kv1.3 mo

296 ow that the M. tuberculosis protein Rv3903c (channel protein with necrosis-inducing toxin, CpnT) cons

297 d from (1) a partially trafficking-deficient channel protein with reduced cell surface expression and

298 These small viral encoded K(+) channel proteins, with a monomer size of only 82 amino a

299 ed here highlight a functional role for this channel protein within neurons of the dorsal vagal nucle

300 urements of mRNA transcripts that encode ion channel proteins within motor neurons in the crustacean