ライフサイエンスコーパス: checkpoint kinase 1

1 checkpoint arrest due to phosphorylation of checkpoint kinase 1.

2 CX-5461 is associated with activation of the checkpoint kinases 1/2, an aberrant G2/M cell-cycle prog

3 We have determined that checkpoint kinase 1 and 2 signaling is important for apo

4 The DATS treatment caused activation of checkpoint kinase 1 and checkpoint kinase 2, which are i

5 rowth-arrest DNA damage-45 (GADD45), and the checkpoint kinases-1 and -2.

6 mber of downstream substrates, such as Chk1 (checkpoint kinase 1) and H2AX (histone 2A variant X).

7 nse pathway, such as ATM, ATR, histone H2AX, checkpoint kinase 1, and tumor suppressor p53.

8 I dose regimen of LY2606368, an inhibitor of checkpoint kinase 1, as monotherapy.

9 elangiectasia-mutated (ATM) and Rad3-related-checkpoint kinase 1 (ATR-CHK1)) is not activated in hTER

10 n of a number of cell cycle genes, including checkpoint kinase 1 (Chek1), which we identified as a hi

11 Zeneca compound collection was performed for checkpoint kinase-1 (Chk-1 kinase) using a knowledge-bas

12 We find that RPA is dispensable for checkpoint kinase 1 (Chk1) activation and that RPA direc

13 ) cell signalling network is activated, with checkpoint kinase 1 (Chk1) activation indicating prolong

14 cells expressing apoptin with inhibitors of checkpoint kinase 1 (Chk1) and Chk2 causes apoptin to lo

15 sponses (DDRs) through its interactions with checkpoint kinase 1 (CHK1) and microcephalin (MCPH1).

16 regionally with increased phosphorylation of checkpoint kinase 1 (Chk1) and STAT3.

17 Inhibitors of checkpoint kinase 1 (CHK1) are of current interest as po

18 elangiectasia mutated and Rad3-related (ATR)-checkpoint kinase 1 (Chk1) axis is the major signaling p

19 d through regulated degradation of activated checkpoint kinase 1 (Chk1) by this pathway after the gen

20 d on the crystallographic analysis of a urea-checkpoint kinase 1 (Chk1) complex and molecular modelin

21 In higher eukaryotic organisms, the checkpoint kinase 1 (Chk1) contributes essential functio

22 vealed that human Chk2 and a closely related checkpoint kinase 1 (Chk1) directly phosphorylate human

23 lated (ATR) kinase and its downstream target checkpoint kinase 1 (Chk1) facilitate survival of cells

24 eplication stress triggers the activation of Checkpoint Kinase 1 (Chk1) in a pathway that requires th

25 Although the essential function of checkpoint kinase 1 (Chk1) in DNA damage response has be

26 The functional roles of Cdc2 and checkpoint kinase 1 (Chk1) in synergistic interactions b

27 of MK-8776 (SCH 900776), a potent, selective checkpoint kinase 1 (Chk1) inhibitor, as monotherapy and

28 The present studies sought to define whether checkpoint kinase 1 (CHK1) inhibitors and poly(ADP-ribos

29 We have used two parent checkpoint kinase 1 (Chk1) inhibitors to exemplify the p

30 ave been synthesized as potent and selective checkpoint kinase 1 (Chk1) inhibitors via structure-base

31 onse of human multiple myeloma (MM) cells to checkpoint kinase 1 (Chk1) inhibitors.

32 The DNA damage effector Checkpoint kinase 1 (Chk1) is a critical component of DN

33 Checkpoint kinase 1 (Chk1) is a key effector protein kin

34 Checkpoint kinase 1 (CHK1) is a key element in the DNA d

35 Checkpoint kinase 1 (Chk1) is a key element in the DNA-d

36 Checkpoint kinase 1 (Chk1) is a key regulator of checkpo

37 The checkpoint kinase 1 (Chk1) is an essential component of

38 Human checkpoint kinase 1 (Chk1) is an essential kinase requir

39 Checkpoint kinase 1 (CHK1) is an oncology target of sign

40 us work indicates that the checkpoint kinase Checkpoint kinase 1 (Chk1) is capable of phosphorylating

41 report that depletion or acute inhibition of checkpoint kinase 1 (Chk1) is sufficient to restore gamm

42 diated by the ATM and Rad3-related (ATR) and checkpoint kinase 1 (CHK1) kinases to transiently suppre

43 h BRCA1-associated ring domain 1 (BARD1) and checkpoint kinase 1 (Chk1) levels.

44 Checkpoint kinase 1 (Chk1) mediates diverse cellular res

45 rogates for the LRRK2 kinase domain based on checkpoint kinase 1 (CHK1) mutants were designed, expres

46 ia telangiectasia and Rad3-related (ATR) and checkpoint kinase 1 (Chk1) pathway in p53-deficient cell

47 elangiectasia and Rad3-related protein (ATR)/checkpoint kinase 1 (Chk1) pathway.

48 elangiectasia and Rad3-related protein (ATR)-checkpoint kinase 1 (Chk1) pathway.

49 owing that hydrogen peroxide (H2O2) triggers checkpoint kinase 1 (Chk1) phosphorylation in an ATR [at

50 Checkpoint kinase 1 (ChK1) plays a key role in the DNA d

51 The checkpoint kinase 1 (Chk1) preserves genome integrity wh

52 in loss of the G1 checkpoint and reliance on checkpoint kinase 1 (Chk1) to arrest cells in response t

53 The checkpoint kinase 1 (Chk1) was up-regulated and activate

54 Expression of ERH, ATR as well as checkpoint kinase 1 (CHK1) were higher in HCCs than in n

55 In this study, we found that checkpoint kinase 1 (Chk1), a component of the G2 DNA da

56 actor intimately involved in this process is checkpoint kinase 1 (Chk1), a DNA damage repair inducing

57 Checkpoint kinase 1 (Chk1), a serine/threonine protein k

58 Embryos mutant for grp, which encodes Checkpoint kinase 1 (Chk1), are DNA-replication-checkpoi

59 teins including ATM, ATR (ATM-Rad3-related), checkpoint kinase 1 (CHK1), BRCA1, NBS1, and RAD51 by We

60 otein kinase, ataxia-telangiectasia mutated, checkpoint kinase 1 (CHK1), checkpoint kinase 2 (CHK2) a

61 ia mutated and Rad3-related kinase (ATR) and checkpoint kinase 1 (Chk1), leading to changes that bloc

62 Suppression of ATR, or its downstream target checkpoint kinase 1 (Chk1), selectively sensitizes DNA-d

63 Inhibition of a central ATR target, checkpoint kinase 1 (Chk1), through siRNA or a new and h

64 is induced by genotoxic stress in a p53- and Checkpoint kinase 1 (CHK1)-dependent manner.

65 y when depleted, with loss of the cell cycle checkpoint kinase 1 (CHK1/CHEK1) being the most potent.

66 activity of virally induced AID resulted in checkpoint kinase-1 (chk1) phosphorylation and ultimatel

67 that, in the absence of induced DNA damage, checkpoint kinase-1 (CHK1), an enzyme essential for prev

68 inding motif of Rad18 is phosphorylated in a checkpoint kinase 1-dependent manner in genotoxin-treate

69 of the present study suggest existence of a checkpoint kinase 1-dependent mechanism for diallyl tris

70 Upon activation of the Grapes(checkpoint kinase 1) (Grp(Chk1))-dependent S-phase check

71 nown to phosphorylate Cdc25C on Ser216, both checkpoint kinase 1 (hChk1) and Cdc25C-associated protei

72 1 mutant that was proficient for ATR-induced checkpoint kinase 1 phosphorylation nevertheless conferr

73 ociated with elevated levels of IL-1beta and checkpoint kinase 1 phosphorylation.

74 n of gemcitabine metabolites, and diminished checkpoint kinase 1, thereby sensitizing cells in the SN