ライフサイエンスコーパス: checkpoint kinase 2

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1 horylation-deficient mutant (T68A mutant) of checkpoint kinase 2.

2 ylation by the tumor-suppressor kinase Chk2 (checkpoint kinase 2) and that this regulation is require

3 Here, we report that checkpoint kinase 2 (Chk2 or Chek2), is essential for cu

4 ication at Ser1981 and by phosphorylation of checkpoint kinase 2 (CHK2) and chromatin/transcription r

5 ectasia mutated, checkpoint kinase 1 (CHK1), checkpoint kinase 2 (CHK2) and poly(ADP-ribose) polymera

6 ules ataxia-telangiectasia mutated (ATM) and checkpoint kinase 2 (CHK2) are inhibited by rLOX-PP expr

7 ation of H(2)A.X at Ser139 and activation of checkpoint kinase 2 (Chk2) in all the three cell lines.

8 thermore, FoxM1 protein is phosphorylated by checkpoint kinase 2 (Chk2) in response to DNA damage.

9 all interfering RNA to assess the effects of checkpoint kinase 2 (Chk2) inhibition on G(1)-S progress

10 Checkpoint kinase 2 (Chk2) is a DNA damage-activated pro

11 Here, we show that the DNA damage-activated Checkpoint kinase 2 (Chk2) is a novel tau kinase and enh

12 In response to ionizing radiation, checkpoint kinase 2 (Chk2) is activated in an ataxia tel

13 Checkpoint kinase 2 (CHK2) is an important serine/threon

14 Checkpoint kinase 2 (Chk2) is known to mediate diverse c

15 Through its interactions with the checkpoint kinase 2 (Chk2) kinase and Rad51, BRCA1 promo

16 Checkpoint kinase 2 (CHK2) kinase is a key mediator in m

17 cancer cell growth led to our discovery that checkpoint kinase 2 (CHK2) knockdown dramatically increa

18 ently reported that the DNA damage-activated Checkpoint kinase 2 (Chk2) phosphorylates tau at Ser262

19 assays and gammahistone 2AX (gammaH2AX) and checkpoint kinase 2 (CHK2) phosphorylation.

20 The human checkpoint kinase 2 (Chk2) plays a central role in regul

21 asia mutated) DNA damage response kinase and checkpoint kinase 2 (CHK2), a known ATM substrate.

22 s independent of p53, and requires activated checkpoint kinase 2 (Chk2), a putative tumor suppressor.

23 orylated p53, gamma-H2AX, and phosphorylated checkpoint kinase 2 (Chk2), although E235 does not appea

24 axia-telangiectasia mutated kinase (ATM) and checkpoint kinase 2 (Chk2), two protein kinases that reg

25 The mnk (also known as loki) gene encodes Checkpoint kinase 2 (Chk2), which functions in DNA-damag

26 ent with SFN was the result of activation of checkpoint kinase 2 (Chk2), which was associated with Se

27 blocked at the level of the effector kinase, checkpoint kinase 2 (Chk2).

28 show that PRD-4 is an ortholog of mammalian checkpoint kinase 2 (Chk2).

29 been reported to be physiological targets of checkpoint kinase 2 (Chk2).

30 3 and Schizosaccharomyces pombe Cds1, called checkpoint kinase 2 (chk2).

31 of the DNA damage response signaling enzyme checkpoint kinase 2 (CHK2).

32 Cellular stress by DNA damage induces checkpoint kinase-2 (CHK2)-mediated phosphorylation and

33 h patterning defects that result from Chk-2 (checkpoint kinase-2) DNA damage checkpoint activation.

34 The lack of a role of checkpoint kinase 2 in diallyl trisulfide-induced phosph

35 The protein kinase Chk2 (checkpoint kinase 2) is a major effector of the replicat

36 by expression of very low baseline levels of checkpoint kinase 2 mRNA and protein.

37 R abundance after HS, and (3) the HuR kinase checkpoint kinase 2 protected against the loss of HuR by

38 On the other hand, depletion of checkpoint kinase 2 protein did not have any appreciable

39 A null mutation in the Drosophila checkpoint kinase 2 tumor suppressor homolog (DmChk2) bl

40 caused activation of checkpoint kinase 1 and checkpoint kinase 2, which are intermediaries of DNA dam

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